公开(公告)号：US20140371542A1

公开(公告)日：2014-12-18

申请号：US14343085

申请日：2012-09-05

申请人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

发明人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

IPC分类号： A61M5/42 ,  A61M37/00 ,  A61B19/00 ,  A61M5/50

CPC分类号： A61M5/422 ,  A61B90/30 ,  A61M5/50 ,  A61M37/0092 ,  A61M2205/587

摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

摘要翻译： 提供了一种仪器，制品和方法，用于通过注射液体（例如麻醉剂）来最小化施用期间的疼痛。 仪器有一个前端。 自由安装的用于振动的杆或光管从前端突出。 该制品是单个使用的尖端，由可移除地安装在器械前端上的尖端套管和可拆卸地安装在突出的杆或光管上的尖端构件组成，以振动人或动物上的预选注射部位。 尖端套筒和尖端构件由弹性包覆模制物覆盖，使得尖端构件能够相对于尖端套筒自由地振动，并使来自光管的光照亮注射部位。 在从仪器中取出单次使用尖端时，单次使用尖端的包覆模具被撕裂。

公开(公告)号：US08550562B2

公开(公告)日：2013-10-08

申请号：US13404857

申请日：2012-02-24

申请人： Michael Goldberg ,  Ruth G. Timme

发明人： Michael Goldberg ,  Ruth G. Timme

IPC分类号： A47C1/08 ,  A47C7/00

CPC分类号： B60N2/28 ,  B08B3/02

摘要： A child car seat subframe that is easily disassembled into component sections for washing within a residential-sized dishwasher. The car seat subframe can be disassembled by hand, and each individual component is capable of fitting in a residential-sized dishwasher individually and collectively. The component sections are attached by a combination of registration tabs and slots, and held tightly together by fasteners, or attached by a combination of tongue and groove joints. Hanging devices, such as hooks, may be formed on one side of each component section to facilitate hanging on racks in a dishwasher. The car seat subframe back panel and side panels are disassembled into a plurality of segments for easily fitting in a dishwasher.

摘要翻译： 一个儿童汽车座椅子框架，容易拆卸成部件，用于在住宅大小的洗碗机内进行清洗。 汽车座椅子框架可以手动拆卸，每个单独的部件都可以单独和集体地安装在住宅尺寸的洗碗机中。 组件部分通过配准片和槽的组合连接，并通过紧固件紧紧地保持在一起，或者通过舌和槽接头的组合来附接。 可以在每个部件部分的一侧上形成诸如钩子的悬挂装置，以便于挂在洗碗机中的机架上。 汽车座椅副翼后面板和侧板被分解成多个段，以容易地装配在洗碗机中。

公开(公告)号：US20110009641A1

公开(公告)日：2011-01-13

申请号：US11453222

申请日：2006-06-14

申请人： Daniel G. Anderson ,  Andreas Zumbuehl ,  Elizaveta Sergeyevna Leshchiner (Turkhanova) ,  Robert S. Langer ,  Michael Goldberg

发明人： Daniel G. Anderson ,  Andreas Zumbuehl ,  Elizaveta Sergeyevna Leshchiner (Turkhanova) ,  Robert S. Langer ,  Michael Goldberg

IPC分类号： C07D233/61 ,  C07C229/04 ,  C07C233/01

CPC分类号： C07D233/61 ,  A61K9/1617 ,  A61K47/18 ,  A61K47/22 ,  A61K48/00 ,  A61K48/0033 ,  C07C227/10 ,  C07C229/12 ,  C07C229/14 ,  C07C229/16 ,  C07C229/18 ,  C07C231/12 ,  C07C237/06 ,  C07D211/26 ,  C07D243/08 ,  C07D295/12 ,  C07D307/14 ,  C07D317/28 ,  C12N15/88

摘要： Nitrogen-containing lipids prepared from the conjugate addition of amines to acrylates, acrylamides, or other carbon-carbon double bonds conjugated to electron-withdrawing groups are described. Methods of preparing these lipids from commercially available starting materials are also provided. These amine-containing lipids or salts forms of these lipids are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these lipids, they are particularly suited for the delivery of polynucleotides. Complexes or nanoparticles containing the inventive lipid and polynucleotide have been prepared. The inventive lipids may also be used to in preparing microparticle for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

摘要翻译： 描述了从共轭加成胺到丙烯酸酯，丙烯酰胺或与吸电子基团共轭的其它碳 - 碳双键制备的含氮脂质。 还提供了从市售的起始原料制备这些脂质的方法。 这些含脂质的脂质或这些脂质的盐形式优选是可生物降解的和生物相容的，并可用于各种药物递送系统。 鉴于这些脂质的氨基部分，它们特别适用于递送多核苷酸。 已经制备了含有本发明的脂质和多核苷酸的复合物或纳米颗粒。 本发明的脂质也可用于制备用于药物递送的微粒。 考虑到缓冲其周围环境的pH值，它们特别适用于提供不稳定剂。

公开(公告)号：US20090200842A1

公开(公告)日：2009-08-13

申请号：US12027701

申请日：2008-02-07

申请人： Michael Goldberg ,  Ruth Timme

发明人： Michael Goldberg ,  Ruth Timme

IPC分类号： B60N2/28 ,  B08B7/04

CPC分类号： B60N2/28 ,  B08B3/02

摘要： A child car seat subframe that is easily disassembled into component sections for washing within a residential-sized dishwasher. The car seat subframe can be disassembled by hand, and each individual component is cable of fitting in a residential-sized dishwasher individually and collectively. The component sections are attached by a combination of registration tabs and slots, and held tightly together by fasteners, or attached by a combination of tongue and groove joints. Hanging devices, such as hooks, may be formed on one side of each component section to facilitate hanging on racks in a dishwasher. The car seat subframe back panel and side panels are disassembled into a plurality of segments for easily fitting in a dishwasher.

摘要翻译： 一个儿童汽车座椅子框架，容易拆卸成部件，用于在住宅大小的洗碗机内进行清洗。 汽车座椅子框架可以手动拆卸，每个单独的部件是单独和集体地装在家用大小的洗碗机中的电缆。 组件部分通过配准片和槽的组合连接，并通过紧固件紧紧地保持在一起，或者通过舌和槽接头的组合来附接。 可以在每个部件部分的一侧上形成诸如钩子的悬挂装置，以便于挂在洗碗机中的机架上。 汽车座椅副翼后面板和侧板被分解成多个段，以容易地装配在洗碗机中。

公开(公告)号：US20060234913A1

公开(公告)日：2006-10-19

申请号：US10500822

申请日：2003-01-07

申请人： Ehud Arbit ,  Richat Abbas ,  Michael Goldberg ,  T. Woods ,  Steven Dinh ,  Vivien Wong

发明人： Ehud Arbit ,  Richat Abbas ,  Michael Goldberg ,  T. Woods ,  Steven Dinh ,  Vivien Wong

IPC分类号： A61K38/28 ,  A61K31/195

CPC分类号： A61K47/18 ,  A61K9/2013 ,  A61K9/4858 ,  A61K38/28 ,  A61K2300/00

摘要： Pharmaceutical dosage forms for oral administration to a patient for the treatment of diabetes, comprising insulin and a delivery agent that facilitates insulin transport in a therapeutically effective amount to the bloodstream and that result in a lower incidence of vascular diseases associated with the repeated administration of insulin are disclosed. Also disclosed is a method of attenuating the undesirable incidence of diseases associated with chronic dosing of insulin is provided whereby the oral administration to a patient of insulin along with a suitable delivery agent that facilitates the absorption of insulin from the gastrointestinal tract of the patient in a therapeutically effective amount, for treatment of diabetes.

摘要翻译： 用于口服给予患者用于治疗糖尿病的药物剂型，其包含胰岛素和促进胰岛素以治疗有效量转运至血液并导致与重复施用胰岛素相关的血管疾病的较低发生率的递送剂 被披露。 还公开了一种减轻与慢性给药胰岛素相关的疾病的不期望的发病率的方法，其中通过口服给予胰岛素患者以及促进从患者的胃肠道吸收胰岛素的合适的递送剂 治疗有效量，用于治疗糖尿病。

公开(公告)号：US20060179676A1

公开(公告)日：2006-08-17

申请号：US11402421

申请日：2006-04-11

申请人： Michael Goldberg ,  James Truman ,  Alexander Kniffin

发明人： Michael Goldberg ,  James Truman ,  Alexander Kniffin

IPC分类号： F26B21/06 ,  F26B19/00 ,  D06F37/00

CPC分类号： D06F58/206 ,  D06F25/00

摘要： A drying apparatus for drying articles such as clothing is provided. The drying apparatus includes a chamber for containing articles to be dried and a system for supplying heated dry air at a first temperature to the chamber. The air supplying system comprises an air flow pathway having an evaporator for removing moisture from air exiting the chamber and for decreasing the temperature of the air to below dew point temperature. The air supply system further has a condenser for increasing the temperature of the air exiting the evaporator to the first temperature. The drying apparatus further has a heat pump system having a refrigerant loop which includes a compressor, the condenser, a TEV valve, and the evaporator.

公开(公告)号：US6099851A

公开(公告)日：2000-08-08

申请号：US89184

申请日：1998-06-02

申请人： Kenneth M. Weisman ,  Michael Goldberg

发明人： Kenneth M. Weisman ,  Michael Goldberg

IPC分类号： A61K38/09 ,  A61P9/10 ,  A61K9/08

CPC分类号： A61K38/09 ,  Y10S514/824

摘要： A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease comprising administering to a human or animal an amount of Leuprolide acetate is sufficient to decrease atherosclerosis and its complications.

摘要翻译： 一种降低动脉粥样硬化及其并发症的方法，包括但不限于心肌梗塞，中风和外周血管疾病，包括向人或动物施用一定量的醋酸亮丙瑞林足以减少动脉粥样硬化及其并发症。

公开(公告)号：US4744228A

公开(公告)日：1988-05-17

申请号：US789635

申请日：1985-10-21

申请人： Michael Goldberg

发明人： Michael Goldberg

IPC分类号： D06F17/02 ,  D06F17/04

CPC分类号： D06F17/02

摘要： A washing machine has a stationary tub with drain outlets at the bottom periphery. A venturi conduit extends from the bottom of the tub opening upward along the axis of the tub to produce a toroidal flow of water in an open basket in the tub seated on an annular disk surrounding the venturi opening. The annular disk is mounted on rollers at the bottom of the tub and carries permanent magnets. An annular driving member also carrying magnets is located below the bottom of the tub surrounding the conduit connected to the venturi and carries permanent magnets opposite those on the annular disk inside the tub. A pulley at the bottom of the driving member is coupled by a belt to the pulley on a drive motor. A pump is connected between the venturi and the tub outlets. A selectively operable valve controls the flow of water between the venturi and a drain outlet. This assembly is contained in a cabinet having an opening covered by a lid. The opening is large enough to allow removal and insertion of the open basket. A companion dryer has a rearward tilted drum that receives the open basket with the laundered clothes. Alternatively, the dryer may have a lid that opens from the top with the basket inserted between stationary guides to rest on a carriage of rollers in the mid portion of the dryer cabinet. A drive motor drives the roller carriage which rotates the basket. When the lid is closed, a conduit is defined which passes drying air through the basket as it rotates.

摘要翻译： 洗衣机具有在底部周边具有排出口的固定桶。 文丘里导管从桶的底部沿桶的轴线向上延伸，以在围绕文丘里开口的环形盘上的桶中的开放的篮中产生环形水流。 环形盘安装在桶的底部的辊子上并承载永磁体。 还承载磁体的环形驱动构件位于围绕连接到文丘里管的导管的桶的底部下方，并且承载与桶内的环形盘相对的永磁体。 驱动构件底部的滑轮通过皮带连接到驱动马达上的皮带轮上。 一个泵连接在文丘里管和水槽出口之间。 可选择性地操作的阀控制文氏管和排水出口之间的水流。 该组件包含在具有由盖子覆盖的开口的柜中。 开口足够大以允许打开的篮子的移除和插入。 伴随烘干机具有向后倾斜的鼓，其接收带有洗衣服的敞开的篮子。 或者，干衣机可以具有从顶部开口的盖子，其中篮子插入在固定导向件之间，以便搁置在干衣机机壳的中部的辊子的托架上。 驱动马达驱动旋转篮子的滚轮托架。 当盖子关闭时，定义了一种导管，其通过干燥空气通过篮子旋转时通过。

公开(公告)号：US12130083B1

公开(公告)日：2024-10-29

申请号：US18641203

申请日：2024-04-19

申请人： Michael Goldberg

发明人： Michael Goldberg

IPC分类号： F26B25/00 ,  F26B3/04

CPC分类号： F26B25/006 ,  F26B3/04

摘要： Methods, apparatuses, and systems for a closed loop product drying process are disclosed. Heated dry air enters a drying chamber, extracts moisture from a product to be dried, and exits the drying chamber, cooler and wetter. A heat pump air handler dries and warms the air from the drying chamber exhaust, and returns it to the drying chamber, in a closed air loop. The heat pump air handler includes a dehumidifier means in the closed air loop flow path. The dehumidifier means removes entrained moisture from wet air exiting the drying chamber, reheats the air, and returns it to the drying chamber.

公开(公告)号：US09168340B2

公开(公告)日：2015-10-27

申请号：US13253572

申请日：2011-10-05

申请人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

发明人： Steven Goldberg ,  Michael Goldberg ,  David Schiff

IPC分类号： A61H1/00 ,  A61M5/42 ,  A61B19/00 ,  A61M5/50 ,  A61M37/00

CPC分类号： A61M5/422 ,  A61B90/30 ,  A61M5/50 ,  A61M37/0092 ,  A61M2205/587

摘要： An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

摘要翻译： 提供了一种仪器，制品和方法，用于通过注射液体（例如麻醉剂）来最小化施用期间的疼痛。 仪器有一个前端。 自由安装的用于振动的杆或光管从前端突出。 该制品是单个使用的尖端，由可移除地安装在仪器前端上的尖端套管和可拆卸地安装在突出的杆或光管上的尖端构件组成，以振动人或动物上的预选注射部位。 尖端套筒和尖端构件由弹性包覆模制物覆盖，使得尖端构件能够相对于尖端套筒自由地振动，并使来自光管的光照亮注射部位。 在从仪器中取出单次使用尖端时，单次使用尖端的包覆模具被撕裂。