公开(公告)号：US08552366B2

公开(公告)日：2013-10-08

申请号：US12528454

申请日：2008-02-26

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J49/06 ,  H01J49/40 ,  H01J49/42

CPC分类号： H01J49/062 ,  H01J49/408 ,  H01J49/42

摘要： A mass spectrometer is disclosed comprising an ion guide or ion mobility spectrometer having helical, toroidal, part-toroidal, hemitoroidal, semitoroidal or spiral ion guiding region. The ion guide may comprise a tube made from a leaky dielectric wherein an RF voltage is applied to outer electrodes in order to confine ions radially within the ion guide. A DC voltage is applied to a resistive inner layer in order to urge ions along the ion guide. Alternatively, the ion guide may comprise a plurality of electrodes each having an aperture through which ions are transmitted.

摘要翻译： 公开了一种质谱仪，其包括具有螺旋，环形，部分环形，椭圆形，半形或螺旋离子引导区的离子导向或离子迁移谱仪。 离子导向器可以包括由泄漏电介质制成的管，其中RF电压被施加到外部电极以便将离子径向限制在离子引导件内。 DC电压被施加到电阻内层，以沿着离子导向器迫使离子。 或者，离子导向器可以包括多个电极，每个电极都具有一个孔，通过该孔可传输离子。

公开(公告)号：US20090314935A1

公开(公告)日：2009-12-24

申请号：US12373204

申请日：2007-07-09

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J49/26

CPC分类号： H01J49/36 ,  H01J49/0031 ,  H01J49/4235

摘要： A mass analyser (2) is provided comprising a plurality of electrodes having apertures through which ions are transmitted in use. A plurality of pseudo-potential corrugations are created along the axis of the mass ((analyser 2). The amplitude or depth of the pseudo-potential corrugations is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the mass analyser (2) in order to urge ions along the length of the mass analyser (2). The amplitude of the transient DC voltages applied to the electrodes is increased with time and ions are caused to be emitted from the mass analyser (2) in reverse order of their mass to charge ratio. Two AC or RF voltages are applied to the electrodes. The first AC or RF voltage is arranged to provide optimal pseudo-potential corrugations whilst the second AC' or RF voltage is arranged to provide optimal radial confinement of ions within the mass analyser (2).

摘要翻译： 提供质量分析器（2），其包括具有孔的多个电极，在使用中通过该孔具有离子。 沿着质量轴（（分析器2））产生多个伪电位波纹，伪电位波纹的振幅或深度与离子的质荷比成反比，一个或多个瞬态直流电压 被施加到质量分析器（2）的电极，以沿着质量分析器（2）的长度推动离子，施加到电极的瞬态DC电压的幅度随时间增加并且离子被发射 从质量分析器（2）以其质量与电荷比的相反顺序将两个AC或RF电压施加到电极上，第一AC或RF电压被布置成提供最佳伪电位波纹，而第二AC'或RF 电压被布置成在质量分析器（2）内提供离子的最佳径向约束。

公开(公告)号：US07405401B2

公开(公告)日：2008-07-29

申请号：US11483961

申请日：2006-07-10

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： H01J3/14 ,  H01J49/42

CPC分类号： H01J49/427

摘要： There is disclosed a method of selectively extracting ions comprising the steps of:providing a supply of ions in a body of gas;generating a ponderomotive ion trapping potential generally along an axis;generating further potentials to provide an effective potential which prevents ions from being extracted from an extraction region;trapping ions in said effective potential; andselectively extracting ions of a predetermined m/z ratio or ion mobility from the extraction region;in which the characteristics of the effective potential which prevent ions from being extracted from the extraction region are caused, at least in part, by the generation of the ponderomotive ion trapping potential.

摘要翻译： 公开了一种选择性提取离子的方法，包括以下步骤：提供气体中的离子供应; 产生一般沿着轴线的沉淀电势捕获电位; 产生更多的电位以提供有效的电势，防止从提取区域中提取离子; 捕获所述有效电位的离子; 并从提取区域选择性地提取预定m / z比的离子或离子迁移率; 其中，至少部分地通过产生沉淀机电离子俘获电位而引起防止离子从提取区域中提取的有效电位的特性。

公开(公告)号：US07095014B2

公开(公告)日：2006-08-22

申请号：US11002423

申请日：2004-12-03

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： B01D59/44

CPC分类号： H01J49/004 ,  H01J49/401 ,  H01J49/42 ,  H01J49/429

摘要： A mass spectrometer is disclosed wherein ions having a particular desired charge state are selected by operating an ion mobility spectrometer in combination with a quadrupole mass filter. Precursor ions are fragmented or reacted to form product ions in a collision cell ion trap and sent back upstream to an upstream ion trap. The fragment or product ions are then passed through the ion mobility spectrometer wherein they become temporally separated according to their ion mobility. Fragment or product ions are then re-trapped in the collision cell ion trap before being released therefrom in packets. A pusher electrode of a time of flight mass analyser is energised a predetermined period of time after a packet of ions is released from the collision cell ion trap. Accordingly, it is possible to select multiply charged precursor ions from a background of singly charged ions, fragment them, and mass analyse the fragment ions with a near 100% duty cycle across the whole mass range.

公开(公告)号：US06791078B2

公开(公告)日：2004-09-14

申请号：US10603824

申请日：2003-06-26

申请人： Kevin Giles ,  John Brian Hoyes ,  Steve Pringle ,  Jason Lee Wildgoose

发明人： Kevin Giles ,  John Brian Hoyes ,  Steve Pringle ,  Jason Lee Wildgoose

IPC分类号： H01J4940

CPC分类号： G01N27/622

摘要： A mass spectrometer comprising an ion mobility separator for separating ions according to their ion mobility is disclosed. The ion mobility separator comprises a plurality of electrodes and one or more transient DC voltages or one or more transient DC voltage waveforms are progressively applied to the electrodes so that ions having a certain ion mobility are separated from other ions having different ion mobilities.

公开(公告)号：US06570152B1

公开(公告)日：2003-05-27

申请号：US09594022

申请日：2000-06-15

申请人： John Brian Hoyes

发明人： John Brian Hoyes

IPC分类号： B01D5944

CPC分类号： H01J49/406

摘要： A time of flight mass analyzer having a drift region, an ion package generator, first and second ion reflectors and at least one ion detector. The drift region has an axis, an entrance and an exit and provides for a place wherein ions may be temporarily separated according to their mass-to-charge ratios. The ion package generator injects packets of ions into the drift region at the region's entrance from a beam of ions by intermittently applying an electrostatic field such that the packets of ions enter the drift region in an initial direction which is inclined to the direction of said beam of ions. The first ion reflector is disposed at the exit of the drift region to reflect, back towards the entrance, ions which are traveling towards the reflector in the drift region. The second ion reflector is disposed in juxtaposition to the first ion reflector to reflect packets of ions back towards the first ion reflector through at least a portion of the drift region so that the packet of ions may be reflected to and fro between said first and second ion reflectors and undergo a number n of reflections at the second ion reflector. A detector is disposed to detect at least some packets of ions reflected by the first ion reflector which do not enter the second ion reflector. The number of reflections at the second ion reflector may be selected by adjustment of an inclination of the initial direction to the axis.

摘要翻译： 具有漂移区的飞行时间质量分析器，离子封装发生器，第一和第二离子反射器以及至少一个离子检测器。 漂移区域具有轴线，入口和出口，并提供可以根据其质荷比临时分离离子的地方。 离子包装发生器通过间歇地施加静电场将离子包从离子束注入到区域入口处的漂移区域中，使得离子包在初始方向进入漂移区域，该初始方向倾斜于所述束的方向 的离子。 第一离子反射器设置在漂移区的出口处，以朝向入口反射在漂移区域中向着反射器行进的离子。 第二离子反射器与第一离子反射器并置设置，以通过漂移区的至少一部分将离子分组反射回第一离子反射器，使得离子束可以在所述第一和第二离子反射器之间反射 离子反射器并且在第二离子反射器处经历数量n的反射。 设置检测器以检测由第一离子反射器反射的离子的至少一些分组，其不进入第二离子反射器。 可以通过调整初始方向相对于轴的倾斜度来选择第二离子反射器处的反射次数。