公开(公告)号：US06818887B2

公开(公告)日：2004-11-16

申请号：US10723721

申请日：2003-11-24

申请人： Jürgen Grotemeyer ,  Andreas Uphoff ,  Söhnke Schmidt ,  Tassilo Muskat

发明人： Jürgen Grotemeyer ,  Andreas Uphoff ,  Söhnke Schmidt ,  Tassilo Muskat

IPC分类号： H01J4940

CPC分类号： H01J49/405

摘要： A reflector is provided as well as a time-of-flight mass spectrometer with a reflector. The mass spectrometers is used for determining the chemical structure of molecules as well as for the quantitative analysis of unknown mixtures of substances. Design effort is minimized, especially for the reflector. The reflector is present in the time-of-flight mass spectrometer to generate an electrostatic field permitting the best possible focusing for the deflection of the ions. The reflector body is made in one piece as a radially symmetrical trough. The reflector is preferably made of a stainless steel or a carrier material with conductive coating and is polished on the inner side of the trough.

公开(公告)号：US06806463B2

公开(公告)日：2004-10-19

申请号：US10321822

申请日：2002-12-16

申请人： Raanan A. Miller ,  Erkinjon G. Nazarov

发明人： Raanan A. Miller ,  Erkinjon G. Nazarov

IPC分类号： H01J4940

CPC分类号： G01N27/624

摘要： A micromechanical field asymmetric ion mobility filter for a detection system includes a pair of spaced substrates defining between them a flow path between a sample inlet and an outlet; an ion filter disposed in the path and including a pair of spaced filter electrodes, one electrode associated with each substrate; and an electrical controller for applying a bias voltage and an asymmetric periodic voltage across the ion filter electrodes for controlling the paths of ions through the filter.

摘要翻译： 用于检测系统的微机械场非对称离子迁移过滤器包括一对间隔开的基板，在它们之间限定了样品入口和出口之间的流动路径; 离子过滤器，设置在路径中并且包括一对间隔的过滤电极，一个电极与每个衬底相关联; 以及用于在离子过滤器电极两端施加偏压和非对称周期电压的电控制器，用于控制通过过滤器的离子路径。

公开(公告)号：US06744043B2

公开(公告)日：2004-06-01

申请号：US10004800

申请日：2001-12-07

申请人： Alexander V. Loboda

发明人： Alexander V. Loboda

IPC分类号： H01J4940

CPC分类号： G01N27/622 ,  H01J49/004 ,  H01J49/062

摘要： A hybrid mass spectrometer comprises an ion mobility (IMS) section and a mass analysis section that analyses ions based on mass-to-charge ratios. In the IMS section, a DC potential gradient is established and a drift gas provided, so as to separate ions based on varying ion mobilities. Additionally, at least a downstream portion of the IMS section includes a rod set focusing ions along the axis, this prevents loss of ions and gives good transfer of ions into-a-mass analysis section, which can be a time-of-flight mass analyzer or an analyzer including a quadrupole rod set. A collision cell and mass analyzer can be provided between the two sections for MS/MS analysis. The IMS section then provides better utilization of an available sample; as each group of ions is elected from the IMS section, one ion can be mass selected as a precursor, for subsequent fragmentation/reaction and subsequent mass analysis of the product ions. Another aspect of the invention provides the ability to form potential wells, utilizing a segmented rod set configuration, so as to trap and hold ions after separation based on mobility characteristics.

摘要翻译： 杂交质谱仪包括离子迁移率（IMS）部分和基于质荷比分析离子的质量分析部分。 在IMS部分中，建立DC电位梯度并提供漂移气体，以便基于不同的离子迁移率分离离子。 另外，IMS部分的至少下游部分包括一组沿着轴线聚焦离子的棒，这样可以防止离子的损失，并且将离子转移到质量分析部分中，这可以是飞行时间质量 分析仪或包括四极杆组的分析仪。 可以在两个部分之间提供碰撞电池和质量分析器用于MS / MS分析。 IMS部分然后提供可用样本的更好的利用; 由于从IMS部分选出每组离子，可以将一个离子作为前体进行质量选择，用于随后的产物离子的碎裂/反应和随后的质量分析。 本发明的另一方面提供了利用分段棒组构型形成势阱的能力，以便基于移动特性在分离后捕获和保持离子。

公开(公告)号：US06683299B2

公开(公告)日：2004-01-27

申请号：US10155291

申请日：2002-05-24

申请人： Katrin Fuhrer ,  Marc Gonin ,  Kent J. Gillig ,  Thomas Egan ,  Michael I. McCully ,  John A. Schultz

发明人： Katrin Fuhrer ,  Marc Gonin ,  Kent J. Gillig ,  Thomas Egan ,  Michael I. McCully ,  John A. Schultz

IPC分类号： H01J4940

CPC分类号： H01J49/025 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/40

摘要： Time-of-flight mass spectrometer instruments for monitoring fast processes using an interleaved timing scheme and a position sensitive detector are described. The combination of both methods is also described.

摘要翻译： 描述了使用交错定时方案和位置敏感检测器监测快速过程的飞行时间质谱仪仪器。 还描述了两种方法的组合。

公开(公告)号：US06639212B1

公开(公告)日：2003-10-28

申请号：US09762236

申请日：2001-04-12

申请人： Roger Guevremont ,  Randy Purves ,  David Barnett

发明人： Roger Guevremont ,  Randy Purves ,  David Barnett

IPC分类号： H01J4940

CPC分类号： G01N27/624 ,  B01D59/46 ,  B01D59/48 ,  H01J49/004 ,  H01J49/044

摘要： The present invention relates to a method of separating ions having the same mass to charge ratio but different ion mobility characteristics, based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry. Isomers including gas-phase molecular anions of the amino acids leucine and isoleucine are separable by the method of the present invention. Identification of different conformers of ions at the same charge state, including conformers present at certain charge states of the protein bovine ubiquitin, is also possible using the method of the present invention.

摘要翻译： 本发明涉及一种基于高场非对称波形离子淌度光谱法的离子聚焦原理，分离具有相同质荷比但离子迁移特性不同的离子的方法。 包括氨基酸亮氨酸和异亮氨酸的气相分子阴离子的异构体可以通过本发明的方法分离。 使用本发明的方法，可以鉴定在相同电荷状态的不同构象异构体，包括存在于蛋白质牛泛蛋白的某些电荷状态的构象异构体。

公开(公告)号：US06627879B2

公开(公告)日：2003-09-30

申请号：US10223424

申请日：2002-08-19

申请人： James P. Reilly ,  Noah P. Christian

发明人： James P. Reilly ,  Noah P. Christian

IPC分类号： H01J4940

CPC分类号： H01J49/40 ,  H01J49/0009

摘要： One illustrative embodiment of a voltage pulser circuit comprises a voltage source producing a first voltage, and a thyratron tube having an anode coupled to the output of the voltage source, a cathode connected to a reference potential and a grid responsive to a grid control voltage to electrically connect the anode to the cathode to thereby cause the first thyratron tube to switch the anode between the first voltage and the reference potential. A pulse-shaping circuit may be connected to the anode of the tube to effectuate desired rise and fall times of the voltage pulses produced by the voltage pulser circuit. Such a voltage pulser circuit is particularly suited for use in connection with the operation of pulsed spectrometer instruments, such as time-of-flight mass spectrometers and the like.

摘要翻译： 电压脉冲发生器电路的一个说明性实施例包括产生第一电压的电压源和具有耦合到电压源的输出的阳极的闸流管，连接到参考电位的阴极和响应于电网控制电压的电网 将阳极电连接到阴极，从而使第一闸流管在第一电压和参考电位之间切换阳极。 脉冲整形电路可以连接到管的阳极，以实现由电压脉冲发生器电路产生的电压脉冲的期望上升和下降时间。 这种电压脉冲发生器电路特别适用于脉冲光谱仪器的操作，例如飞行时间质谱仪等。

公开(公告)号：US06621073B1

公开(公告)日：2003-09-16

申请号：US09689309

申请日：2000-10-12

申请人： Thomas Dresch

发明人： Thomas Dresch

IPC分类号： H01J4940

CPC分类号： H01J49/405 ,  H01J49/40 ,  H01J49/403

摘要： A Time-of-Flight Mass Spectrometer (TOF-MS) is configured to improve resolution and sensitivity performance. The TOF-MS includes an arrangement of electrodes comprising an ion accelerator with two stages of homogeneous electric fields, an ion reflector with a single stage of a homogeneous electric field, accelerator and reflector being separated by a first drift space, and an ion detector which is separated from the reflector by a second drift space. Contrary to known TOF-MS of similar configuration, the set of electric potentials which must be applied to said electrodes is predetermined for a given geometry in such a way that a spatial distribution of ions initially at rest in the first gap of the said accelerator is compressed at the location of the detector in the longitudinal direction to a focus of first and second order in the initial axial coordinate. Therefore, mass resolution is enhanced over a TOF-MS that provides only for longitudinal focusing of first order, while the number of passages through grid electrodes along the flight path is reduced, and hence ion transmission and instrument sensitivity are improved.

摘要翻译： 飞行时间质谱仪（TOF-MS）被配置为提高分辨率和灵敏度性能。 TOF-MS包括电极的布置，其包括具有两级均匀电场的离子加速器，具有均匀电场的单级的离子反射器，由第一漂移空间分隔的加速器和反射器;以及离子检测器， 通过第二漂移空间与反射器分离。 与已知的类似配置的TOF-MS相反，必须施加到所述电极的电势集合对于给定的几何形状是预定的，使得最初在所述加速器的第一间隙中静止的离子的空间分布是 在检测器的纵向方向上的位置被压缩成在初始轴向坐标中的第一和第二级的焦点。 因此，仅提供一阶纵向聚焦的TOF-MS的质量分辨率提高，而沿着飞行路径的通过网格电极的通道数量减少，因此提高了离子传播和仪器灵敏度。

公开(公告)号：US06437325B1

公开(公告)日：2002-08-20

申请号：US09313923

申请日：1999-05-18

申请人： James P. Reilly ,  Noah P. Christian

发明人： James P. Reilly ,  Noah P. Christian

IPC分类号： H01J4940

CPC分类号： H01J49/40 ,  H01J49/0009

摘要： A time-of-flight mass spectra calibration technique uses time-of-flight mass spectrometer instrument operational parameters and known mass and measured time-of-flight data pairs to optimize values of chosen ones of the instrument operational parameters. Electrostatic time-of-flight calculations are conducted in conjunction with an iterative procedure, preferably a simplex optimization procedure, to thereby minimize a residual error between the electrostatic time-of-flight calculations and the measured time-of-flight data values for each of the known mass values. While conventional curve fitting mass calibration techniques are devoid of information that describe ion behavior, the mass calibration technique of the present invention, by contrast, takes into account all of the instrument operational parameters in arriving at a final calibration. Because the electrostatic TOF calculation is a description of ion behavior in an actual TOF mass spectrometer instrument rather than a polynomial representation of a curve, it is well behaved and does not contain any instabilities where unpredictable calibration errors might occur. Moreover, unlike conventional curve fitting mass calibration techniques, the mass calibration technique of the present invention maintains mass accuracy in extrapolated mass ranges.

摘要翻译： 飞行时间质谱校准技术使用飞行时间质谱仪仪器操作参数和已知质量和测量的飞行时间数据对来优化所选仪器操作参数的值。 静电飞行时间计算结合迭代程序，优选单纯形优化程序进行，从而最小化静电飞行时间计算之间的残余误差和测量的飞行时间数据值 已知的质量值。 虽然传统的曲线拟合质量校准技术没有描述离子行为的信息，但是相比之下，本发明的质量校准技术考虑到达到最终校准的所有仪器操作参数。 因为静电TOF计算是对实际TOF质谱仪器中的离子行为的描述，而不是曲线的多项式表示，因此它的行为良好，并且不包含可能发生不可预测的校准误差的任何不稳定性。 此外，与传统的曲线拟合质量校准技术不同，本发明的质量校准技术保持外推质量范围的质量精度。

公开(公告)号：US06828552B2

公开(公告)日：2004-12-07

申请号：US10452343

申请日：2003-06-02

申请人： Frank T. Hartley

发明人： Frank T. Hartley

IPC分类号： H01J4940

CPC分类号： F03H1/00 ,  H01J27/26 ,  H01J49/168 ,  Y10S977/89

摘要： Various configurations of characterization systems such as ion mobility spectrometers and mass spectrometers are disclosed that are coupled to an ionization device. The ionization device is formed of a membrane that houses electrodes therein that are located closer to one another than the mean free path of the gas being ionized. Small voltages across the electrodes generate large electric fields which act to ionize substantially all molecules passing therethrough without fracture. Methods to manufacture the mass spectrometer and ion mobility spectrometer systems are also described.

摘要翻译： 公开了诸如离子迁移谱仪和质谱仪的表征系统的各种配置，其耦合到电离装置。 电离装置由容纳电极的膜形成，该电极位于比被电离的气体的平均自由程更靠近的位置。 电极两端的小电压产生大的电场，其作用是电离基本上通过其的所有分子而不断裂。 还描述了制造质谱仪和离子迁移谱仪系统的方法。

公开(公告)号：US06794641B2

公开(公告)日：2004-09-21

申请号：US10448059

申请日：2003-05-30

申请人： Robert Harold Bateman ,  Kevin Giles ,  Steve Pringle

发明人： Robert Harold Bateman ,  Kevin Giles ,  Steve Pringle

IPC分类号： H01J4940

CPC分类号： H01J49/062 ,  H01J49/004

摘要： A mass spectrometer is disclosed wherein ions from a pulsed ion source are dispersed in a drift region so that the ions become separated according to their mass to charge ratios. The ions are then received by an ion guide in which multiple trapping regions are created and wherein the multiple trapping regions are translated along the length of the ion guide. The ion guide receives the ions so that all the ions trapped in a particular trapping region have substantially the same or similar mass to charge ratios. The ions are released from the exit of the ion guide and the pusher/puller electrode of an orthogonal acceleration Time of Flight mass analyzer is arranged to be energised in synchronization with the ions emerging from the ion guide. The trapping regions may be translated along the ion guide with a velocity which becomes progressively slower and the delay time of the pusher/puller electrode may be progressively increased.

摘要翻译： 公开了一种质谱仪，其中来自脉冲离子源的离子分散在漂移区域中，使得离子根据其质荷比分离。 然后由离子导向器接收离子，其中产生多个俘获区域，并且其中多个俘获区域沿离子导向件的长度平移。 离子导向器接收离子，使得捕获在特定捕获区域中的所有离子具有基本上相同或相似的质荷比。 离子从离子导向器的出口释放，并且正交加速时间飞行质量分析器的推动器/牵引电极被布置成与从离子导向器出射的离子同步地通电。 俘获区域可以沿着离子导向器平移，速度逐渐变慢，并且推动器/拉电极的延迟时间可以逐渐增加。