公开(公告)号：US08463346B2

公开(公告)日：2013-06-11

申请号：US12797800

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/00

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.

摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。

公开(公告)号：US08463343B2

公开(公告)日：2013-06-11

申请号：US12765396

申请日：2010-04-22

申请人： Jonathan L. Kuhn ,  Thomas A. Anderson ,  Can Cinbis ,  Jeffrey M. Jelen ,  Timothy Davis ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Thomas A. Anderson ,  Can Cinbis ,  Jeffrey M. Jelen ,  Timothy Davis ,  James K. Carney

IPC分类号： A61B5/00

CPC分类号： A61N1/3702 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/6846 ,  A61N1/36557 ,  Y10T29/49002

摘要： An optical sensor for a medical device includes a fixed lens spacing between emit and receive modules to achieve target sensor sensitivity, while varying other sensor parameters in order to increase signal amplitude without increasing power demand. An optical sensor connected to a housing of a medical device includes a circuit board, an opto-electronic component, a wall, a lens, and a ferrule. The circuit board is arranged within the housing. The opto-electronic component is mounted on a surface of the circuit board. The wall protrudes from the surface of the circuit board and surrounds the opto-electronic component. The lens is offset from the surface of the circuit board. The ferrule is connected to the housing, the lens and the wall. An inner surface of the wall mates with an outer surface of the ferrule.

摘要翻译： 用于医疗装置的光学传感器包括发射和接收模块之间的固定透镜间隔，以实现目标传感器灵敏度，同时改变其它传感器参数，以便增加信号幅度而不增加功率需求。 连接到医疗装置的壳体的光学传感器包括电路板，光电子部件，壁，透镜和套圈。 电路板布置在外壳内。 光电子部件安装在电路板的表面上。 壁从电路板的表面突出并围绕光电子部件。 透镜偏离电路板的表面。 套圈连接到外壳，透镜和墙壁。 壁的内表面与套圈的外表面配合。

公开(公告)号：US08346332B2

公开(公告)日：2013-01-01

申请号：US12797811

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/00

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a first combination of a light source and a light detector to emit light into a volume of tissue, detect light scattered by the volume of tissue, and provide a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal, compute a measure of tissue oxygenation in response to the light detector output signal, and detect tissue hypoxia using the measure of tissue oxygenation.

摘要翻译： 用于监测患者状况的医疗装置包括光源和光检测器的第一组合，以将光发射到组织的体积中，检测由组织体积散射的光，并提供对应于组织的强度的第一输出信号 检测到光。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号，计算响应中组织氧合的量度 到光检测器输出信号，并使用组织氧合的测量来检测组织缺氧。

公开(公告)号：US20120130208A1

公开(公告)日：2012-05-24

申请号：US12948884

申请日：2010-11-18

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  James K. Carney

IPC分类号： A61B5/1459

CPC分类号： A61B5/1459 ,  A61B5/0075 ,  A61B5/14535 ,  A61B5/14542 ,  A61B5/14551 ,  A61B5/1495 ,  A61B5/4836

摘要： A first concentration of a chromophore corresponding to a measurement volume of an optical sensor is determined. A second concentration of the chromophore is obtained in the vicinity of the measurement volume corresponding to a change in at least one of a total concentration of the chromophore and a relative concentration of a first form of the chromophore to the total concentration of the chromophore in the measurement volume. Light remittance measurements including a first light wavelength and a second light wavelength are obtained corresponding to the first chromophore concentration and the second chromophore concentration. A coefficient for computing an index of a change in the chromophore concentration is computed using the difference between the first and second chromophore concentrations and the first and second light remittance measurements.

摘要翻译： 确定对应于光学传感器的测量体积的发色团的第一浓度。 在测量体积附近获得发色团的第二浓度，其对应于发色团的总浓度和发色团的第一形式的相对浓度与发色团的总浓度中的至少一个的变化相关 测量体积。 对应于第一发色团浓度和第二发色团浓度获得包括第一光波长和第二光波长的光汇率测量。 使用第一和第二生色团浓度与第一和第二光汇率测量之间的差来计算计算发色团浓度变化指数的系数。

公开(公告)号：US20120108923A1

公开(公告)日：2012-05-03

申请号：US12915984

申请日：2010-10-29

申请人： Can Cinbis ,  Jonathan L. Kuhn

发明人： Can Cinbis ,  Jonathan L. Kuhn

IPC分类号： A61B5/1459

CPC分类号： A61N1/056 ,  A61B5/1455 ,  A61B5/686 ,  A61N1/36557

摘要： Implantable medical devices and methods include an optical sensor that includes at least two optical sensor portions. The light emitting devices of the optical sensor are distributed among the at least two optical sensor portions.

摘要翻译： 植入式医疗装置和方法包括包括至少两个光学传感器部分的光学传感器。 光传感器的发光装置分布在至少两个光传感器部分中。

公开(公告)号：US20100317941A1

公开(公告)日：2010-12-16

申请号：US12797811

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/1455

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a first combination of a light source and a light detector to emit light into a volume of tissue, detect light scattered by the volume of tissue, and provide a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal, compute a measure of tissue oxygenation in response to the light detector output signal, and detect tissue hypoxia using the measure of tissue oxygenation.

摘要翻译： 用于监测患者状况的医疗装置包括光源和光检测器的第一组合，以将光发射到组织的体积中，检测由组织体积散射的光，并提供对应于组织的强度的第一输出信号 检测到光。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号，计算响应中组织氧合的量度 到光检测器输出信号，并使用组织氧合的测量来检测组织缺氧。

公开(公告)号：US20100317938A1

公开(公告)日：2010-12-16

申请号：US12797744

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  James K. Carney

IPC分类号： A61B5/1455

CPC分类号： A61B5/14552 ,  A61B5/0084 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/7239 ,  A61N1/36557

摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway at a plurality of wavelengths to generate corresponding first detected light intensity output signals, detects emitted light scattered by the volume of tissue delivered along a second pathway different from the first pathway at a plurality of wavelengths to generate corresponding second detected light intensity output signals, determines whether a difference between the emitted light detected along the first pathway and the emitted light detected along the second pathway is greater than a predetermined threshold, and alters sensing by the device in response to the determining whether a difference is greater than the predetermined threshold.

摘要翻译： 一种用于检测信号的方法和医疗装置，其检测由沿着第一路径以多个波长传送的组织体积散射的发射光，以产生相应的第一检测到的光强度输出信号，以检测由沿着 在多个波长处与第一路径不同的第二路径以产生相应的第二检测光强度输出信号，确定沿着第一路径检测的发射光与沿着第二路径检测的发射光之间的差是否大于预定阈值 并且改变响应于确定差异是否大于预定阈值的设备的感测。

公开(公告)号：US20100317937A1

公开(公告)日：2010-12-16

申请号：US12797736

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  James K. Carney ,  David A. Anderson

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  James K. Carney ,  David A. Anderson

IPC分类号： A61B5/1455

CPC分类号： A61B5/14552 ,  A61B5/0084 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/7239 ,  A61N1/36557

摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.

摘要翻译： 用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。 光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。 耦合到光学传感器的控制模块控制由发光部分发射的光。 监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。

公开(公告)号：US08918171B2

公开(公告)日：2014-12-23

申请号：US12845843

申请日：2010-07-29

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

IPC分类号： A61N1/365 ,  A61N1/39 ,  A61B5/1455 ,  A61B5/00 ,  A61B5/1459

CPC分类号： A61B5/14551 ,  A61B5/1459 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36557 ,  A61N1/3925 ,  A61N1/3956

摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.

摘要翻译： 一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件，发射光并检测由 与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;控制模块，耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块 以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个 通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。

公开(公告)号：US08666466B2

公开(公告)日：2014-03-04

申请号：US12797770

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  James K. Carney

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  James K. Carney

IPC分类号： A61B5/00

CPC分类号： A61B5/14552 ,  A61B5/0084 ,  A61B5/14546 ,  A61B5/1459 ,  A61B5/7239 ,  A61N1/36557

摘要： A method and medical device for detecting signals that detects emitted light scattered by a volume of tissue delivered along a first pathway and a second pathway different from the first pathway, detects emitted light scattered by a volume of tissue delivered along a third pathway and a fourth pathway different from the third pathway, determines a first uniformity corresponding to the emitted light detected along the first pathway and the second pathway, determines a second uniformity corresponding to the emitted light detected along third pathway and the fourth pathway, determines a total uniformity in response to the determined first uniformity and the determined second uniformity, and alters sensing by the device in response to the determined total uniformity.

摘要翻译： 一种用于检测信号的方法和医疗装置，其检测由沿着第一路径传送的组织体积散射的发射光和不同于第一路径的第二路径的信号，检测由沿着第三路径传送的组织体积散射的发射光， 确定与沿着第一路径和第二路径检测到的发射光相对应的第一均匀度，确定对应于沿着第三路径和第四路径检测的发射光的第二均匀度，确定响应中的总均匀性 到所确定的第一均匀性和确定的第二均匀性，并且改变由所述装置响应于所确定的总均匀性的感测。