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公开(公告)号：US20080188501A1
公开(公告)日：2008-08-07
申请号：US11929737
申请日：2007-10-30
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
IPC分类号： A61K31/506 , C07D401/04 , A61P43/00
CPC分类号： C07D403/04 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.
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公开(公告)号：US08288539B2
公开(公告)日：2012-10-16
申请号：US11929482
申请日：2007-10-30
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
IPC分类号： C07D239/54 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/505 , A61K31/506 , A61P3/10 , A61P19/02 , A61P35/00
CPC分类号： C07D403/04 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.
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公开(公告)号：US07872124B2
公开(公告)日：2011-01-18
申请号：US11305818
申请日：2005-12-16
IPC分类号： C07D239/70
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C═NR4, and L, X, Z, R2 and R3 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含选自以下的成员：其中E是CH或N，Q选自CO，CS，SO ，SO 2或C≡NR4，并且L，X，Z，R 2和R 3如本文所定义。
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公开(公告)号：US07781584B2
公开(公告)日：2010-08-24
申请号：US11929549
申请日：2007-10-30
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
IPC分类号： C07D239/54 , A61K31/505 , A61P19/02
CPC分类号： C07D403/04 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含包含：其中M为N或CR 4的化合物; Q1和Q2各自独立地选自CO，SO，SO2和C≡NR9; 并且每个L，X，R 1，R 2和R 3如本文所定义。
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公开(公告)号：US07687625B2
公开(公告)日：2010-03-30
申请号：US10809637
申请日：2004-03-24
申请人： Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen L. Gwaltney , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号： C07D285/16 , A61K31/5395
CPC分类号： C07D471/04 , C07D401/04 , C07D403/04 , C07D473/18 , C07D487/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 protease that comprise a compound comprising the formula: wherein Q is selected from the group of CO, SO, SO2, or C═NR9; and R1, R2, R3 and R4 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它包含下式的化合物的S9蛋白酶：其中Q选自CO，SO，SO 2或C = NR 9; 并且R 1，R 2，R 3和R 4如本文所定义。
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公开(公告)号：US20090275750A1
公开(公告)日：2009-11-05
申请号：US12066769
申请日：2006-09-15
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Paul R. Brodluahrer , Bruce Elder , Paul Isbester , Richard S. Fornicola , Philip B. Kisanga , Bingidimi I. Mobele , Grant J. Palmer , Maxwell M. Reeve , Jonathon S. Salsbury , Luckner Ulysse , Sripathy Venkatraman
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Paul R. Brodluahrer , Bruce Elder , Paul Isbester , Richard S. Fornicola , Philip B. Kisanga , Bingidimi I. Mobele , Grant J. Palmer , Maxwell M. Reeve , Jonathon S. Salsbury , Luckner Ulysse , Sripathy Venkatraman
IPC分类号： C07D403/04 , C07D401/04
CPC分类号： C07D239/553 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.
摘要翻译： 制备式（I）化合物的方法，其中变量如本文所定义。 另外，制备可用于抑制二肽基肽酶的化合物的方法。
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公开(公告)号：US20080177064A1
公开(公告)日：2008-07-24
申请号：US11928944
申请日：2007-10-30
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
IPC分类号： C07D223/02 , C07D239/24
CPC分类号： C07D403/04 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.
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公开(公告)号：US08329900B2
公开(公告)日：2012-12-11
申请号：US11929673
申请日：2007-10-30
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
IPC分类号： C07D401/04 , C07D403/04 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D403/04 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含包含：其中M为N或CR 4的化合物; Q1和Q2各自独立地选自CO，SO，SO2和C≡NR9; 并且每个L，X，R 1，R 2和R 3如本文所定义。
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公开(公告)号：US08188275B2
公开(公告)日：2012-05-29
申请号：US11928944
申请日：2007-10-30
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
IPC分类号： C07D239/54 , A61K31/505 , A61P19/02
CPC分类号： C07D403/04 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.
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公开(公告)号：US20110087022A1
公开(公告)日：2011-04-14
申请号：US12964410
申请日：2010-12-09
IPC分类号： C07D513/04 , C07D487/04 , C07D498/02
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C═NR4, and L, X, Z, R2 and R3 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含选自以下的成员：其中E是CH或N，Q选自CO，CS，SO ，SO 2或C≡NR4，并且L，X，Z，R 2和R 3如本文所定义。
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