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公开(公告)号：US20120095233A1
公开(公告)日：2012-04-19
申请号：US12103882
申请日：2008-04-16
申请人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Jeffrey A. Stafford , Michael B. Wallace , Hasanthi Wijesekera , Nicholas Scorah
发明人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Jeffrey A. Stafford , Michael B. Wallace , Hasanthi Wijesekera , Nicholas Scorah
IPC分类号： C07D471/04 , C07D209/88
CPC分类号： C07D471/14 , C07D241/18 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供化合物用于与包含选自以下的化合物的激酶一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US08124617B2
公开(公告)日：2012-02-28
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A Stafford , Beverly Wolgast
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A Stafford , Beverly Wolgast
IPC分类号： A61K31/44 , C07D513/02 , C07D515/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。
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公开(公告)号：US08119655B2
公开(公告)日：2012-02-21
申请号：US11539857
申请日：2006-10-09
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： C07D471/04 , C07D471/12 , C07D487/04 , C07D487/14
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.
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公开(公告)号：US20110201818A1
公开(公告)日：2011-08-18
申请号：US12680183
申请日：2008-09-24
申请人： Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
发明人： Takashi Ichikawa , Benjamin Jones , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Sheldon X. Cao , Betty Lam , Victoria Feher , Stephen W. Kaldor , Yan Liu , Jeffrey A Stafford
IPC分类号： C07D211/72
CPC分类号： C07D487/04 , C07D487/14 , C07D519/00
摘要： Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供下式的化合物用于激酶：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US07906523B2
公开(公告)日：2011-03-15
申请号：US11929737
申请日：2007-10-30
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Bruce J. Elder , Paul K. Isbester , Grant J. Palmer , Jonathon S. Salsbury , Luckner G. Ulysse
IPC分类号： C07D401/04 , A61K31/506 , A61P3/10 , A61P19/02 , A61P35/00
CPC分类号： C07D403/04 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含包含：其中M为N或CR 4的化合物; Q1和Q2各自独立地选自CO，SO，SO2和C≡NR9; 并且每个L，X，R 1，R 2和R 3如本文所定义。
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公开(公告)号：US07790736B2
公开(公告)日：2010-09-07
申请号：US10918317
申请日：2004-08-12
申请人： Jun Feng , Stephen L. Gwaltney, II , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
发明人： Jun Feng , Stephen L. Gwaltney, II , Stephen W. Kaldor , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang
IPC分类号： C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , A61K31/506 , A61P19/02
CPC分类号： C07D239/36 , C07D239/47 , C07D239/52 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV inhibitors comprising Formula I: wherein the substituents are as described herein.
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公开(公告)号：US20100075973A1
公开(公告)日：2010-03-25
申请号：US12544419
申请日：2009-08-20
申请人： Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
发明人： Sheldon X. Cao , Takashi Ichikawa , Andre A. Kiryanov , Christopher McBride , Srinivasa Reddy Natala , Stephen W. Kaldor , Jeffrey A. Stafford
IPC分类号： A61K31/5025 , C07D471/14 , A61P35/00
CPC分类号： C07D487/14
摘要： The present invention provides PLK inhibitors of the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using the compounds.
摘要翻译： 本发明提供下式的PLK抑制剂，其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 和使用该化合物的方法。
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公开(公告)号：US20100069431A1
公开(公告)日：2010-03-18
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。
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公开(公告)号：US20100063054A1
公开(公告)日：2010-03-11
申请号：US12541724
申请日：2009-08-14
申请人： Jerome C. Bressi , Shaosong Chu , Philip Erickson , Mallareddy Komandla , Lily Kwok , John D. Lawson , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang , Sanjib Das
发明人： Jerome C. Bressi , Shaosong Chu , Philip Erickson , Mallareddy Komandla , Lily Kwok , John D. Lawson , Jeffrey A. Stafford , Michael B. Wallace , Zhiyuan Zhang , Sanjib Das
IPC分类号： A61K31/5025 , C07D487/04 , A61P35/04 , A61P11/00
CPC分类号： C07D471/04 , C07D487/04 , C07D519/00
摘要： Compounds of the following formula are provided for use with cMET: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供以下配方的化合物与cMET一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US07642253B2
公开(公告)日：2010-01-05
申请号：US11382659
申请日：2006-05-10
IPC分类号： C07D403/02 , A61K31/513
CPC分类号： C07D513/04 , C07D239/80 , C07D285/24 , C07D417/04 , C07D417/06 , C07D417/12
摘要： Compounds, pharmaceutical compositions, kits and methods useful for inhibiting HDAC, thereby treating a disease state for which HDAC possess activity that contributes to the pathology and/or symptomology of the disease state. The compound is selected from the group consisting of: wherein the variables are as defined herein.
摘要翻译： 用于抑制HDAC的化合物，药物组合物，试剂盒和方法，从而治疗HDAC具有促进疾病状态和/或症状的活性的疾病状态。 该化合物选自：其中变量如本文所定义。
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