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    Compositions and methods for mitigating skin irritation
    37.
    发明授权
    Compositions and methods for mitigating skin irritation 失效
    减轻皮肤刺激的组合物和方法

    公开(公告)号：US07547434B2

    公开(公告)日：2009-06-16

    申请号：US11223665

    申请日：2005-09-09

    申请人： Neena Tierney ,  Katharine Martin ,  Phyllis Mitchell ,  Michael Southall

    发明人： Neena Tierney ,  Katharine Martin ,  Phyllis Mitchell ,  Michael Southall

    IPC分类号： A61K8/00 ,  A61Q5/12 ,  A61K36/48 ,  A61K36/28 ,  A61K31/22

    CPC分类号： A61K31/13 ,  A61K36/28 ,  A61K36/48 ,  A61K2300/00

    摘要： The invention relates to a composition and a method for mitigating redness or inflammation of mammalian skin comprising administering to mammalian skin a composition consisting of an effective amount of alkanolamine, feverfew or soy or mixtures thereof, one or more optional benefit agents and one or more cosmetically acceptable carriers. More particularly, it relates to a composition for mitigating skin irritations such as retinol/retinoid irritation and their applications to mammalian skin.

    摘要翻译： 本发明涉及减轻哺乳动物皮肤发红或炎症的组合物和方法，包括向哺乳动物皮肤施用由有效量的链烷醇胺，发烧或大豆或其混合物组成的组合物，一种或多种任选的有益剂和一种或多种化妆品 可接受的运营商。 更具体地说，本发明涉及一种用于缓解皮肤刺激（如视黄醇/类视黄醇刺激）及其在哺乳动物皮肤中的应用的组合物。

    Method for demonstrating efficacy of a topically applied active ingredient
    38.
    发明申请
    Method for demonstrating efficacy of a topically applied active ingredient 审中-公开
    证明局部施用的活性成分的功效的方法

    公开(公告)号：US20070059679A1

    公开(公告)日：2007-03-15

    申请号：US11222887

    申请日：2005-09-09

    申请人： Michelle Garay ,  Michael Southall

    发明人： Michelle Garay ,  Michael Southall

    IPC分类号： C12Q1/00 ,  A61K36/48 ,  A61K36/28

    CPC分类号： G01N33/5044 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/5088

    摘要： A method is disclosed for demonstrating the efficacy of a topically applied active ingredient, which method includes topically applying a composition containing an active ingredient to an area of skin, applying an absorbent material to the area of skin to extract at least a portion of the active ingredient from the skin, thereby incorporating the portion of active ingredient with the absorbent material in a releasable manner, removing the absorbent material from the skin, extracting the active ingredient from the absorbent material, combining the extracted active ingredient with cellular growth media, incubating the cellular growth media with cultured cells for a period of time to produce a biomarker, and measuring the biomarker to indicate efficacy of the active ingredient.

    摘要翻译： 公开了一种用于证明局部施用的活性成分的功效的方法，该方法包括将含有活性成分的组合物局部施用于皮肤区域，将吸收材料施用于皮肤区域以提取至少一部分活性成分 成分从皮肤中分离，从而将活性成分的一部分与吸收材料以可释放的方式并入，从皮肤上除去吸收材料，从吸收材料中提取活性成分，将提取的活性成分与细胞生长培养基组合， 细胞生长培养基与培养细胞一段时间以产生生物标志物，并测量生物标志物以指示活性成分的功效。