公开(公告)号：US11486001B2

公开(公告)日：2022-11-01

申请号：US17666458

申请日：2022-02-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Eli N. Glezer ,  Allen Lipson

IPC: C12Q1/6869 ,  C12Q1/6834

Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.

公开(公告)号：US20220259648A1

公开(公告)日：2022-08-18

申请号：US17666458

申请日：2022-02-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Eli N. Glezer ,  Allen Lipson

IPC: C12Q1/6869 ,  C12Q1/6834

Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.

公开(公告)号：US20210040555A1

公开(公告)日：2021-02-11

申请号：US17030886

申请日：2020-09-24

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Mohammad Vatankhah Varnosfaderani ,  Daan Witters ,  Vahid Karimkhanl

IPC: C12Q1/6869

Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.

公开(公告)号：US12188088B1

公开(公告)日：2025-01-07

申请号：US18335936

申请日：2023-06-15

Applicant: Singular Genomics Systems, Inc

Inventor： Eli N. Glezer ,  Daan Witters ,  Tung Thanh Le

IPC: C12P19/34 ,  B01L3/00 ,  C12Q1/6874

Abstract: Disclosed herein, inter alia, are compositions and methods for efficient amplification and sequencing of nucleic acid templates.

公开(公告)号：US12123055B2

公开(公告)日：2024-10-22

申请号：US17727673

申请日：2022-04-22

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/68 ,  C12Q1/6855 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US12077816B2

公开(公告)日：2024-09-03

申请号：US17500733

申请日：2021-10-13

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Sabrina Shore ,  Daan Witters

IPC: C12Q1/68 ,  C12Q1/6855 ,  C12Q1/6869

CPC classification number: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US12071665B2

公开(公告)日：2024-08-27

申请号：US18176616

申请日：2023-03-01

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Eli N. Glezer ,  Andrew King ,  Sabrina Shore ,  Ryan Shultzaberger

IPC: C12Q1/68 ,  C12Q1/6874

CPC classification number: C12Q1/6874

Abstract: Disclosed herein, inter alia, are compositions and methods for amplification of nucleic acid templates, including hybridizing a linear polynucleotide to an immobilized primer on a surface, circularizing the linear polynucleotide to form a circular polynucleotide, and extending the primer with a polymerase.

公开(公告)号：US12060605B2

公开(公告)日：2024-08-13

申请号：US17542345

申请日：2021-12-03

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Mohammad Vatankhah Varnosfaderani ,  Daan Witters ,  Vahid Karimkhani

IPC: G01N33/544 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/53

CPC classification number: C12Q1/6869 ,  C12Q1/6844 ,  C12Q1/6874 ,  G01N33/5308 ,  G01N33/544 ,  C12Q2533/101 ,  C12Q2565/601 ,  C12Q1/6874 ,  C12Q2563/159 ,  C12Q2565/537 ,  C12Q1/6844 ,  C12Q2535/122 ,  C12Q2563/159 ,  C12Q2565/537

Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.

公开(公告)号：US20240167089A1

公开(公告)日：2024-05-23

申请号：US18511510

申请日：2023-11-16

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Vahid Karimkhani ,  Shahed Kay ,  Mohammad Vatankhah Varnosfaderani ,  Daan Witters

IPC: C12Q1/6874 ,  C12Q1/6876 ,  C40B40/06

CPC classification number: C12Q1/6874 ,  C12Q1/6876 ,  C40B40/06

Abstract: Disclosed herein, inter alia, are nanoarrays and methods of use thereof.

公开(公告)号：US20240093283A1

公开(公告)日：2024-03-21

申请号：US18507761

申请日：2023-11-13

Applicant: Singular Genomics Systems, Inc.

Inventor： Ryan Shultzaberger ,  Allen Lipson ,  Daan Witters

IPC: C12Q1/6855 ,  C12Q1/6874 ,  C12Q1/6876

CPC classification number: C12Q1/6855 ,  C12Q1/6874 ,  C12Q1/6876

Abstract: Disclosed herein, inter alia, are polynucleotides, supports, kits, and methods of use thereof for amplifying, immobilizing, and sequencing polynucleotides.