公开(公告)号：US12215124B2

公开(公告)日：2025-02-04

申请号：US16969879

申请日：2019-02-20

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Ronald Graham ,  Andrew Spaventa ,  Eli Glezer

IPC: C07H21/04 ,  C12Q1/6869

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

公开(公告)号：US12188089B2

公开(公告)日：2025-01-07

申请号：US18439062

申请日：2024-02-12

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Megha Cila

IPC: C12Q1/68 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/6874 ,  C12Q1/6876 ,  C12Q1/6806

Abstract: Disclosed herein, inter alia, are methods and cleavable compounds that minimize byproduct formation following cleavage.

公开(公告)号：US12180542B2

公开(公告)日：2024-12-31

申请号：US17816841

申请日：2022-08-02

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Hu Cang ,  Zhenmin Hong

IPC: C12Q1/6841 ,  C12Q1/6804 ,  G01N33/53

Abstract: Disclosed herein, inter alia, are compositions and methods of use thereof for interrogating a cell.

公开(公告)号：US12158402B2

公开(公告)日：2024-12-03

申请号：US18430467

申请日：2024-02-01

Applicant: Singular Genomics Systems, Inc.

Inventor： Yuji Ishitsuka ,  Zhenmin Hong ,  Eli N. Glezer ,  Hu Cang ,  William Dempsey ,  Weiqiao Ding ,  Jaekyung Koh ,  Mohammad Vatankhah Varnosfaderani

IPC: G01N1/10 ,  A61L27/28 ,  A61L27/52 ,  C12Q1/6841 ,  C12Q1/6874 ,  G01N1/06 ,  G01N1/28 ,  G01N1/30 ,  G01N1/31 ,  G01N1/36 ,  G01N23/2251 ,  G02B21/34

Abstract: Disclosed herein, inter alia, are compositions and methods for efficient transfer and analyses of cellular material, tissue samples, such as tissue sections, using carrier substrates.

公开(公告)号：US20240392348A1

公开(公告)日：2024-11-28

申请号：US18797267

申请日：2024-08-07

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Ronald Graham ,  Michael J. Krause

IPC: C12Q1/6818 ,  C12Q1/6825

Abstract: Disclosed herein, inter alia, are modified nucleotides and methods of using the same in nucleic acid sequencing reactions.

公开(公告)号：US12145960B2

公开(公告)日：2024-11-19

申请号：US17287255

申请日：2019-10-24

Applicant: Singular Genomics Systems, Inc.

Inventor： Ronald Graham ,  Olga Adelfinskaya ,  Megha Cila ,  Rodrigo Rodriguez ,  Abrehet Abdu ,  Eli N. Glezer

IPC: C07H19/14 ,  C07H19/10 ,  C07H19/20 ,  C12Q1/68 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Disclosed herein, interalia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.

公开(公告)号：US12139759B2

公开(公告)日：2024-11-12

申请号：US17934407

申请日：2022-09-22

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Allen Lipson ,  Eli N. Glezer

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6874

Abstract: Disclosed herein, inter alia, are methods of detecting or sequencing circular template polynucleotides on a solid support and/or in cells and tissues.

公开(公告)号：US12139754B2

公开(公告)日：2024-11-12

申请号：US17486656

申请日：2021-09-27

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Ryan Shultzaberger ,  Bharat Sridhar ,  Gudrun Stengel ,  Christopher Jen-Yue Wei

IPC: C12Q1/6853 ,  C12Q1/6869

Abstract: Provided herein are methods of making, amplifying, and sequencing tagged nucleic acid complements, compositions including interposing oligonucleotide barcodes, and kits useful in obtaining long-range sequence data.

公开(公告)号：US12110550B2

公开(公告)日：2024-10-08

申请号：US18588765

申请日：2024-02-27

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Allen Lipson ,  Eli N. Glezer

IPC: C12Q1/68 ,  C12Q1/6874

CPC classification number: C12Q1/6874

Abstract: Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide.

公开(公告)号：US20240279479A1

公开(公告)日：2024-08-22

申请号：US18621997

申请日：2024-03-29

Applicant: Singular Genomics Systems, Inc.

Inventor： Megha Cila ,  Ronald Graham ,  Rodrigo Rodriguez

IPC: C09B62/36 ,  C09K11/06 ,  G01N33/58

CPC classification number: C09B62/365 ,  C09K11/06 ,  G01N33/582 ,  C09K2211/1018

Abstract: Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof. In an aspect is provided a monovalent nucleotide or monovalent nucleoside covalently bound to a monovalent form of a compound described herein (e.g., wherein the R13 moiety of a compound described herein has reacted with a bioconjugate reactive group to form a bioconjugate linker thereby covalently bonding the monovalent compound to the monovalent nucleotide or monovalent nucleoside).