公开(公告)号：US12139759B2

公开(公告)日：2024-11-12

申请号：US17934407

申请日：2022-09-22

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Allen Lipson ,  Eli N. Glezer

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6874

Abstract: Disclosed herein, inter alia, are methods of detecting or sequencing circular template polynucleotides on a solid support and/or in cells and tissues.

公开(公告)号：US12110550B2

公开(公告)日：2024-10-08

申请号：US18588765

申请日：2024-02-27

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Allen Lipson ,  Eli N. Glezer

IPC: C12Q1/68 ,  C12Q1/6874

CPC classification number: C12Q1/6874

Abstract: Disclosed herein, inter alia, are complexes, kits, and efficient methods of sequencing two strands of a double stranded polynucleotide.

公开(公告)号：US20240167087A1

公开(公告)日：2024-05-23

申请号：US18490491

申请日：2023-10-19

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Daan Witters

IPC: C12Q1/6874

CPC classification number: C12Q1/6874

Abstract: Disclosed herein, inter alia, are compositions and methods for detecting polynucleotides within a three-dimensional matrix.

公开(公告)号：US11891660B2

公开(公告)日：2024-02-06

申请号：US18056348

申请日：2022-11-17

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Sabrina Shore ,  Daan Witters

IPC: C12Q1/6869 ,  C12Q1/6855

CPC classification number: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.

公开(公告)号：US11884977B2

公开(公告)日：2024-01-30

申请号：US18111422

申请日：2023-02-17

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Vahid Karimkhani ,  Shahed Kay ,  Mohammad Vatankhah Varnosfaderani ,  Daan Witters

IPC: C12Q1/6874 ,  C12Q1/6876 ,  C40B40/06

CPC classification number: C12Q1/6874 ,  C12Q1/6876 ,  C40B40/06

Abstract: Disclosed herein, inter alia, are nanoarrays and methods of use thereof.

公开(公告)号：US20230287491A1

公开(公告)日：2023-09-14

申请号：US18119393

申请日：2023-03-09

Applicant: Singular Genomics Systems, Inc.

Inventor： Mark Kalaj ,  Daan Witters

IPC: C12Q1/6874

CPC classification number: C12Q1/6874

Abstract: Disclosed herein, inter alia, are degradable nanoparticles, nanoarrays, and methods of use thereof in nucleic acid sequencing.

公开(公告)号：US11629380B2

公开(公告)日：2023-04-18

申请号：US17817960

申请日：2022-08-05

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Vahid Karimkhani ,  Shahed Kay ,  Mohammad Vatankhah Varnosfaderani ,  Daan Witters

IPC: C12Q1/6874 ,  C12Q1/6876 ,  C40B40/06

Abstract: Disclosed herein, inter alia, are nanoarrays and methods of use thereof.

公开(公告)号：US11560590B2

公开(公告)日：2023-01-24

申请号：US17840490

申请日：2022-06-14

Applicant: Singular Genomics Systems, Inc.

Inventor： Daan Witters ,  Eli N. Glezer ,  Allen Lipson

IPC: C12Q1/6869 ,  C12Q1/6834

Abstract: Disclosed herein, inter alia, are substrates, kits, and efficient methods of preparing and sequencing two or more regions of a double-stranded polynucleotide.

公开(公告)号：US20220333190A1

公开(公告)日：2022-10-20

申请号：US17843764

申请日：2022-06-17

Applicant: Singular Genomics Systems, Inc.

Inventor： Eli N. Glezer ,  Mohammad Vatankhah Varnosfaderani ,  Daan Witters ,  Vahid Karimkhani

IPC: C12Q1/6869

Abstract: Provided herein are methods and compositions for improved sequencing techniques using, for example, polymeric particles and/or three-dimensional structures.

公开(公告)号：US20220119878A1

公开(公告)日：2022-04-21

申请号：US17500759

申请日：2021-10-13

Applicant: SINGULAR GENOMICS SYSTEMS, INC.

Inventor： Eli N. Glezer ,  Martin Maria Fabani ,  Timothy Looney ,  Sabrina Shore ,  Ryan Shultzaberger ,  Daan Witters

IPC: C12Q1/6869 ,  C12Q1/6855

Abstract: Provided herein are methods for sequencing both strands of a double stranded nucleic acid fragment that improves fidelity and accuracy of a sequence determination compared to traditional next generation sequencing methods. Compositions and kits for use in the methods are also provided.