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31.BENZYL AMINES, A PROCESS FOR THEIR PRODUCTION AND THEIR USE AS ANTI-INFLAMMATORY AGENTS 有权
标题翻译: 苯甲酰胺,其生产工艺及其作为抗炎剂的用途公开(公告)号:US20080032986A1
公开(公告)日:2008-02-07
申请号:US11777411
申请日:2007-07-13
申请人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schacke
发明人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schacke
IPC分类号: A61K31/135 , A61K31/4164 , A61K31/47 , A61K31/502 , A61K31/517 , A61P29/00 , C07C215/28 , C07D215/38 , C07D233/84 , C07D237/30 , C07D239/74 , C07D301/00 , C07D401/12 , C07D405/12
CPC分类号: C07C215/16 , C07B2200/07 , C07C215/28 , C07C217/70 , C07C317/28 , C07D215/38 , C07D233/84 , C07D401/12 , C07D405/12 , C07D405/14
摘要: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式I化合物,其制备方法及其作为抗炎剂的用途。
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32.Benzyl, amines, a process for their production and their use as anti-inflammatory agents 有权
标题翻译: 苄基胺,它们的生产方法及其作为抗炎剂的用途公开(公告)号:US08173676B2
公开(公告)日:2012-05-08
申请号:US13210173
申请日:2011-08-15
申请人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schäcke
发明人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schäcke
IPC分类号: A61K31/04
CPC分类号: C07C215/16 , C07B2200/07 , C07C215/28 , C07C217/70 , C07C317/28 , C07D215/38 , C07D233/84 , C07D401/12 , C07D405/12 , C07D405/14
摘要: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式I化合物,其制备方法及其作为抗炎剂的用途。
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33.Benzyl amines, a process for their production and their use as anti-inflammatory agents 有权
标题翻译: 苄胺,其生产方法及其用作抗炎剂公开(公告)号:US07999108B2
公开(公告)日:2011-08-16
申请号:US11777411
申请日:2007-07-13
申请人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schaecke
发明人: Markus Berger , Jan Dahmen , Hartmut Rehwinkel , Stefan Jaroch , Heike Schaecke
IPC分类号: C07D215/38
CPC分类号: C07C215/16 , C07B2200/07 , C07C215/28 , C07C217/70 , C07C317/28 , C07D215/38 , C07D233/84 , C07D401/12 , C07D405/12 , C07D405/14
摘要: The present invention relates to the compounds of formula I, processes for their production and their use as anti-inflammatory agents.
摘要翻译: 本发明涉及式I化合物,其制备方法及其作为抗炎剂的用途。
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34.
公开(公告)号:US06841550B1
公开(公告)日:2005-01-11
申请号:US09787396
申请日:1999-09-16
申请人: Peter Hölscher , Hartmut Rehwinkel , Stefan Jaroch , Detlev Sülzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Mcdougall McDonald
发明人: Peter Hölscher , Hartmut Rehwinkel , Stefan Jaroch , Detlev Sülzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Mcdougall McDonald
IPC分类号: C07D319/20 , A61K31/357 , A61K31/538 , A61P1/16 , A61P3/08 , A61P3/10 , A61P9/00 , A61P13/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P29/00 , A61P37/06 , A61P43/00 , C07D265/34 , C07D265/36 , C07D279/16 , C07D413/12
CPC分类号: C07D413/12 , C07D265/34 , C07D265/36 , C07D279/16
摘要: The invention relates to compounds of formula (I) and their tautomeric and isomeric forms and salts, as well as to a method for producing said compounds and their use in medicines.
摘要翻译: 本发明涉及式(I)化合物及其互变异构体和异构体形式和盐,以及用于制备所述化合物的方法及其在药物中的用途。
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35.
公开(公告)号:US06579883B1
公开(公告)日:2003-06-17
申请号:US09831514
申请日:2001-05-10
申请人: Stefan Jaroch , Hartmut Rehwinkel , Peter Hölscher , Detlev Sülzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Macdougall McDonald
发明人: Stefan Jaroch , Hartmut Rehwinkel , Peter Hölscher , Detlev Sülzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Macdougall McDonald
IPC分类号: A61K31473
CPC分类号: C07D221/16
摘要: The invention relates to compounds of formula (I), to a method for producing them and to their use in medicaments as NOS inhibitors.
摘要翻译: 本发明涉及式(I)化合物,其制备方法及其在药物中作为NOS抑制剂的用途。
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36.Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals 失效
标题翻译: 苯并嗪和苯并噻嗪衍生物及其在药物中的应用公开(公告)号:US06365736B1
公开(公告)日:2002-04-02
申请号:US09581119
申请日:2000-06-15
IPC分类号: C07D26536
CPC分类号: C07D231/12 , C07D233/56 , C07D249/08 , C07D265/34 , C07D265/36 , C07D279/14 , C07D279/16 , C07D413/12
摘要: Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.
摘要翻译: 描述了本文定义的式I的苯并嗪和苯并噻嗪化合物,其制备方法及其基于其作为NO-合酶(NOS)抑制剂的活性的药物用途的方法。
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37.Benzoxazine and benzothiazine derivatives and the use thereof in medicaments 失效
标题翻译: 苯并恶嗪和苯并噻嗪衍生物及其在药物中的用途公开(公告)号:US07141566B1
公开(公告)日:2006-11-28
申请号:US10069284
申请日:2000-08-23
申请人: Peter Hölscher , Hartmut Rehwinkel , Stefan Jaroch , Detlev Sülzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Mcdougall McDonald
发明人: Peter Hölscher , Hartmut Rehwinkel , Stefan Jaroch , Detlev Sülzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Mcdougall McDonald
IPC分类号: C07D265/36 , C07D498/04 , A61K31/538 , A61K31/5383
CPC分类号: C07D413/12 , C07D265/34 , C07D265/36
摘要: The invention relates to compounds of formula (I), the tautomeric and isomeric forms and salts thereof, in addition to a method for production and use thereof in medicaments.
摘要翻译: 本发明涉及式(I)化合物,其互变异构体和异构体形式及其盐,除了其在药物中的生产和使用方法之外。
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38.3,4-Dihydroquinoline derivatives as nitrogen monoxide synthase (NOS) inhibitors 失效
标题翻译: 3,4-二氢喹啉衍生物作为一氧化氮合酶(NOS)抑制剂公开(公告)号:US06391887B1
公开(公告)日:2002-05-21
申请号:US09622259
申请日:2000-08-14
申请人: Stefan Jaroch , Hartmut Rehwinkel , Peter Holscher , Detlev Sulzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Mcdougall McDonald
发明人: Stefan Jaroch , Hartmut Rehwinkel , Peter Holscher , Detlev Sulzle , Margrit Hillmann , Gerardine Anne Burton , Fiona Mcdougall McDonald
IPC分类号: A61K31473
CPC分类号: C07D221/12 , C07D221/16 , C07D405/04 , C07D491/04
摘要: The invention relates to compounds of formula (I), as defined herein. The invention also relates to the use of the inventive compounds for treatment of a disease caused by the effects of nitrogen monoxide in pathological conditions.
摘要翻译: 本发明涉及如本文所定义的式(I)化合物。 本发明还涉及本发明化合物用于治疗由一氧化氮在病理状况中的作用引起的疾病的用途。
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39.
公开(公告)号:US20050119481A1
公开(公告)日:2005-06-02
申请号:US10498237
申请日:2002-12-10
申请人: Hartmut Rehwinkel , Peter Hoelscher , Stefan Jaroch , Detlev Suelzle , Margrit Hillmann , Gerardine Burton , Fiona McDonald
发明人: Hartmut Rehwinkel , Peter Hoelscher , Stefan Jaroch , Detlev Suelzle , Margrit Hillmann , Gerardine Burton , Fiona McDonald
IPC分类号: C07D333/38 , C07D279/12 , C07D211/26 , C07D263/02 , C07D265/30
CPC分类号: C07D333/38
摘要: Amidine derivatives of formula I, their tautomeric and isomeric forms and salts as well as the process for their production and their use for the production of a pharmaceutical agent are described.
摘要翻译: 描述了式I的脒衍生物,其互变异构体和异构体形式和盐以及其制备方法及其用于制备药剂的用途。
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40.Benzoxazine and benzothiazine derivatives and their use in pharmaceutical agents 审中-公开
标题翻译: 苯并恶嗪和苯并噻嗪衍生物及其在药剂中的用途公开(公告)号:US20070049583A1
公开(公告)日:2007-03-01
申请号:US11588079
申请日:2006-10-25
申请人: Peter Holscher , Hartmut Rehwinkel , Stefan Jaroch , Detlev Sulzle , Margrit Hillmann , Gerardine Burton , Fiona McDonald
发明人: Peter Holscher , Hartmut Rehwinkel , Stefan Jaroch , Detlev Sulzle , Margrit Hillmann , Gerardine Burton , Fiona McDonald
IPC分类号: A61K31/5415 , C07D279/16
CPC分类号: C07D413/12 , C07D265/34 , C07D265/36
摘要: Compounds of formula (I), their tautomeric and isomeric forms and salts, as well as the process for their production and their use in pharmaceutical compositions, are described.
摘要翻译: 描述了式(I)化合物,其互变异构体和异构体形式和盐,以及其制备方法及其在药物组合物中的用途。
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