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31.发明申请Trisubstituted triazolopyrimidines for use in platelet aggregation inhibition 审中-公开用于血小板聚集抑制的三取代三唑并嘧啶公开(公告)号：US20100069408A1
公开(公告)日：2010-03-18
申请号：US12591395
申请日：2009-11-18
申请人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
发明人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
IPC分类号： A61K31/519 , C07D487/04 , A61P9/00 , A61P9/10
CPC分类号： C07D487/04 , A61K31/519 , C07C211/40 , C07D239/48
摘要： The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
摘要翻译： 本发明提供新的三唑并[4,5-d]嘧啶化合物，它们作为药物的用途，含有它们的组合物及其制备方法。
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32.发明授权公开(公告)号：US07482363B2
公开(公告)日：2009-01-27
申请号：US10508332
申请日：2003-03-17
IPC分类号： A61K31/4468 , C07D211/14
CPC分类号： C07D405/14 , C07D211/58 , C07D409/14
摘要： The present invention provides a compound of formula (I), wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
摘要翻译： 本发明提供式（I）化合物，其中变量在本文中定义; 涉及制备这种化合物的方法; 以及这种化合物在治疗趋化因子（例如CCR3）或H1介导的疾病状态中的用途。
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公开(公告)号：US07348341B2
公开(公告)日：2008-03-25
申请号：US10296034
申请日：2001-05-30
IPC分类号： A61K31/445 , C07D401/12
CPC分类号： C07D401/12 , C07D211/46 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention concerns compounds of formula (I), and their use in therapy, particularly in the modulation of CCR3 activity.
摘要翻译： 本发明涉及式（I）化合物及其在治疗中的用途，特别是在调节CCR3活性方面。
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公开(公告)号：US07238811B2
公开(公告)日：2007-07-03
申请号：US10436582
申请日：2003-05-13
IPC分类号： C07D211/08 , C07D211/26 , A61K31/4465
CPC分类号： C07D401/14 , C07D211/58 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/08 , C07D495/04 , C07D513/04
摘要： The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
摘要翻译： 本发明提供式（I）的化合物：其中变量在本文中定义; 涉及制备这种化合物的方法; 以及在治疗趋化因子（例如CCR3）或H1介导的疾病状态中使用这种化合物。
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35.发明授权Piperidine derivatives and their use as modulators of chemokine (especially CCR3) activity 失效哌啶衍生物及其作为趋化因子（特别是CCR3）活性的调节剂的用途公开(公告)号：US07238691B2
公开(公告)日：2007-07-03
申请号：US10489811
申请日：2002-09-12
IPC分类号： A61K31/5377 , C07D413/06
CPC分类号： C07D413/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00 , C07D495/04
摘要： The invention provides a compound of formula (I): T is C(O) or S(O)2; W is CH2, (CH2)2, CH(CH3), CH(CH3)O or cyclopropyl; X is O, CH2, C(O), S, S(O), S(O)2 or NR3; m is 0 or 1; R1 is optionally substituted aryl or optionally substituted heterocyclyl; R2 is alkyl (optionally substituted by OH), cycloalkyl, optionally substituted aryl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.
摘要翻译： 本发明提供式（I）化合物：T是C（O）或S（O）2; W是CH 2，CH 2（CH 3）2，CH（CH 3）3，CH（CH
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![Triazolo[4,5-D]pyrimidinyl derivatives and their use as medicaments](/abs-image/US/2001/10/02/US06297232B1/abs.jpg.150x150.jpg)
36.发明授权公开(公告)号：US06297232B1
公开(公告)日：2001-10-02
申请号：US09011992
申请日：1999-02-19
IPC分类号： A01N4300
CPC分类号： C07D487/04
摘要： The invention relates to triazolo[4,5-d]pyrimidin-3-yl derivatives which are useful in the treatment of platelet aggregation disorders.
摘要翻译： 本发明涉及可用于治疗血小板聚集障碍的三唑并[4,5-d]嘧啶-3-基衍生物。
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![1,2,3-triazolo[4,5-d]pyrimidines as P2T receptor antagonists](/abs-image/US/2001/06/26/US06251910B1/abs.jpg.150x150.jpg)
37.发明授权公开(公告)号：US06251910B1
公开(公告)日：2001-06-26
申请号：US09155023
申请日：1998-09-21
申请人： Simon Guile , Anthony Ingall , Brian Springthorpe , Paul Willis
发明人： Simon Guile , Anthony Ingall , Brian Springthorpe , Paul Willis
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： Compounds of formula having the following stereochemistry wherein R, R1, R2, R3 and R4 are as defined in the specification. The compounds are useful as P2T receptor antagonists.
摘要翻译： 在R，R 1，R 2，R 3和R 4中具有以下立体化学的式的化合物如说明书中所定义。 该化合物可用作P2T受体拮抗剂。
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公开(公告)号：US07709500B2
公开(公告)日：2010-05-04
申请号：US10504936
申请日：2003-02-17
申请人： Lilian Alcaraz , Mark Furber , Mark Purdie , Brian Springthorpe
发明人： Lilian Alcaraz , Mark Furber , Mark Purdie , Brian Springthorpe
IPC分类号： A61K31/445 , C07D211/44 , C07D41/02
CPC分类号： C07D401/12 , C07D211/14 , C07D211/46 , C07D211/52 , C07D401/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The invention provides compounds of formula (I): wherein: X is CH2, O, S(O)2 or NR10; Y is a bond, CH2, NR35, CH2NH, CH2NHC(O), CH(OH), CH(NHCOR33), CH(NHSO2R34), CH2O or CH2S; Z is C(O), or when Y is a bond Z can also be S(O)2; R1 is optionally substituted aryl, optionally substituted heterocyclyl or C4-6 cycloalkyl fused to a benzene ring; and R2, R3, R4, R5, R6, R7 and R8, R9, R10, R32, R33, R34 and R35 are as defined herein; are modulators of chemokine (especially CCR3) activity (for use in, for example, treating asthma). The invention also provides a process for making 4-(3,4-dichlorophenoxy)piperidine, which is useful as an intermediate for making certain compounds of the invention.
摘要翻译： 本发明提供式（I）化合物：其中：X为CH 2，O，S（O）2或NR 10; Y是键，CH2，NR35，CH2NH，CH2NHC（O），CH（OH），CH（NHCOR33），CH（NHSO2R34），CH2O或CH2S; Z是C（O），或当Y是键时，Z也可以是S（O）2; R1是任选取代的芳基，任选取代的杂环基或稠合至苯环的C 4-6环烷基; R 2，R 3，R 4，R 5，R 6，R 7和R 8，R 9，R 10，R 32，R 33，R 34和R 35如本文所定义; 是趋化因子（特别是CCR3）活性的调节剂（用于例如治疗哮喘）。 本发明还提供了制备4-（3,4-二氯苯氧基）哌啶的方法，其可用作制备本发明某些化合物的中间体。
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公开(公告)号：US20070179297A1
公开(公告)日：2007-08-02
申请号：US11732411
申请日：2007-04-03
IPC分类号： A61K31/4545 , C07D471/02 , C07D413/02 , C07D473/02 , A61K31/4743 , A61K31/4745
CPC分类号： C07D401/14 , C07D211/58 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/08 , C07D495/04 , C07D513/04
摘要： The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
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公开(公告)号：US20060025590A1
公开(公告)日：2006-02-02
申请号：US11230493
申请日：2005-09-21
申请人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
发明人： David Hardern , Anthony Ingall , Brian Springthorpe , Paul Willis , Simon Guile
IPC分类号： A61K31/519 , C07D487/02
CPC分类号： C07D487/04 , A61K31/519 , C07C211/40 , C07D239/48
摘要： The invention provides new triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation.
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