公开(公告)号：US09597530B2

公开(公告)日：2017-03-21

申请号：US14390087

申请日：2012-05-14

申请人： Yuehu Pu ,  Masahiro Ikeda

发明人： Yuehu Pu ,  Masahiro Ikeda

IPC分类号： G01N33/48 ,  G01N33/50 ,  A61N5/10

CPC分类号： A61N5/1043 ,  A61N5/103 ,  A61N5/1044 ,  A61N2005/1087 ,  F04C2270/0421

摘要： A particle beam scanning irradiation system includes a computer establishing a scanning sequence for irradiation of a tumor portion in a patient; and a particle beam irradiation device irradiating the tumor portion in accordance with the established scanning sequence of the particle beam. The computer selects all conceivable combinations of pairs of irradiation spots among the plurality of irradiation spots arranged in the tumor portion, and determines whether each path for the particle beam to shift between two spots constituting the selected pair passes through the tumor portion; determines a penalty matrix expressing whether each path passes through the tumor portion on the basis of the determination result; evaluates a function for the shift paths on the basis of an optimizing algorithm, and establishes the scanning sequence of the particle beam by an optimized solution of the function.

公开(公告)号：US08350234B2

公开(公告)日：2013-01-08

申请号：US13127112

申请日：2008-12-24

申请人： Yuehu Pu ,  Toshihiro Otani

发明人： Yuehu Pu ,  Toshihiro Otani

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N2005/1056 ,  A61N2005/1087

摘要： Light from a light source is made to be reflected by a light source mirror and to pass through a variable collimator, an irradiation field shape shaped by the variable collimator is projected on a photographing screen by the light passed through the variable collimator, a projection portion of the photographing screen is photographed by a photographic device, and an image photographed by the photographic device is analyzed by an image processor.

摘要翻译： 使来自光源的光由光源反射镜反射并穿过可变准直器，通过可变准直仪形成的照射场形状，通过可变准直器的光投射在拍摄屏幕上，突出部 通过摄影装置拍摄拍摄画面，并且通过图像处理器分析由照相装置拍摄的图像。

公开(公告)号：US08193520B2

公开(公告)日：2012-06-05

申请号：US12724844

申请日：2010-03-16

申请人： Yuehu Pu

发明人： Yuehu Pu

IPC分类号： H01J3/08 ,  G21K1/10

CPC分类号： A61N5/1042 ,  A61N5/1043 ,  A61N2005/1087 ,  A61N2005/1095 ,  G21K1/093 ,  G21K1/10 ,  G21K5/04

摘要： There is provided a particle beam therapy system that can rapidly change beam energy without increasing the size of a deflection electromagnet even in the case where the number of required beam-energy changes is large.There is provided a plurality of beam energy changing units each provided with a beam energy attenuation unit; a beam is deflected in such a way as to sequentially passes through the plurality of beam energy changing units; while a beam passes through one of the beam energy changing unit, the beam energy attenuation amount of another beam energy changing unit is changed.

摘要翻译： 提供了一种粒子束治疗系统，即使在所需的束能量变化的数量大的情况下，也可以快速地改变束能量而不增加偏转电磁体的尺寸。 提供了多个光束能量改变单元，每个光束能量改变单元均设有光束能量衰减单元; 光束以这样的方式被偏转，以便顺序地穿过多个光束能量改变单元; 当光束通过光束能量改变单元中的一个时，另一光束能量改变单元的光束能量衰减量改变。

公开(公告)号：US20080298553A1

公开(公告)日：2008-12-04

申请号：US11870512

申请日：2007-10-11

申请人： Osamu Takahashi ,  Yuehu Pu ,  Hisashi Harada ,  Masahiro Ikeda ,  Yasuyuki Takatani ,  Hiroshi Otani

发明人： Osamu Takahashi ,  Yuehu Pu ,  Hisashi Harada ,  Masahiro Ikeda ,  Yasuyuki Takatani ,  Hiroshi Otani

IPC分类号： G21K5/04

CPC分类号： A61N5/1042 ,  A61B5/1127 ,  A61N5/1064 ,  A61N2005/1059 ,  A61N2005/1087 ,  G21K1/046

摘要： Provision is made for a particle-beam treatment system in which, even during particle-beam irradiation, the shape of a multileaf collimator is monitored. The particle-beam treatment system, in which multi-layer conformal irradiation is performed while the setting of the shape of the multileaf collimator in an irradiation head is changed during particle-beam irradiation, is provided with an optical shape-monitoring unit mounted attachably and detachably in the snout portion at the downstream side of the multileaf collimator, the optical shape-monitoring unit having a shape-monitoring mirror, opposing the multileaf collimator, for monitoring the shape of the multileaf collimator; a video camera for shooting the multileaf-collimator shape reflected by the shape-monitoring mirror; and an image monitor for displaying an image of the video camera that shoots the shape of the multileaf collimator.

摘要翻译： 规定了一种粒子束处理系统，其中即使在粒子束照射期间，监视多叶准直器的形状。 在粒子束照射期间，在照射头中的多叶准直器的形状的设定被改变的同时进行多层共形照射的粒子束处理系统设置有可安装地安装的光学形状监视单元， 所述光学形状监视单元具有与所述多叶准直器相对的形状监视镜，用于监视所述多叶准直器的形状; 用于拍摄由形状监视镜反射的多叶准直器形状的摄像机; 以及用于显示拍摄多叶准直器的形状的摄像机的图像的图像监视器。

公开(公告)号：US20150080631A1

公开(公告)日：2015-03-19

申请号：US14390087

申请日：2012-05-14

申请人： Yuehu Pu ,  Masahiro Ikeda

发明人： Yuehu Pu ,  Masahiro Ikeda

IPC分类号： A61N5/10

CPC分类号： A61N5/1043 ,  A61N5/103 ,  A61N5/1044 ,  A61N2005/1087 ,  F04C2270/0421

摘要： A particle beam scanning irradiation system includes a computer establishing a scanning sequence for irradiation of a tumor portion in a patient; and a particle beam irradiation device irradiating the tumor portion in accordance with the established scanning sequence of the particle beam. The computer selects all conceivable combinations of pairs of irradiation spots among the plurality of irradiation spots arranged in the tumor portion, and determines whether each path for the particle beam to shift between two spots constituting the selected pair passes through the tumor portion; determines a penalty matrix expressing whether each path passes through the tumor portion on the basis of the determination result; evaluates a function for the shift paths on the basis of an optimizing algorithm, and establishes the scanning sequence of the particle beam by an optimized solution of the function.

摘要翻译： 粒子束扫描照射系统包括建立用于照射患者肿瘤部分的扫描序列的计算机; 以及根据建立的粒子束扫描顺序照射肿瘤部分的粒子束照射装置。 计算机选择布置在肿瘤部分中的多个照射点之间的所有可能的照射点对的组合，并且确定用于粒子束在构成所选择的对的两个点之间移动的每个路径是否通过肿瘤部分; 根据确定结果确定表示每个路径是否通过肿瘤部分的惩罚矩阵; 基于优化算法对移位路径的功能进行评估，并通过优化的功能解决方案建立粒子束的扫描序列。

公开(公告)号：US08389952B2

公开(公告)日：2013-03-05

申请号：US13322201

申请日：2011-04-13

申请人： Takaaki Iwata ,  Yuehu Pu

发明人： Takaaki Iwata ,  Yuehu Pu

IPC分类号： H01J3/26 ,  H01J1/50 ,  A61N5/00

CPC分类号： G21K1/093 ,  A61N5/1043 ,  A61N2005/1087

摘要： There is provided a particle beam irradiation apparatus in which two or more pairs of scanning electromagnets are utilized so that scanning of a charged particle beam can be performed with a high accuracy and with a high flexibility in the speed, from a low speed to a high speed. In a particle beam irradiation apparatus that scans an incident charged particle beam on X-direction and Y-direction (two-direction) desired orbits perpendicular to the travelling direction of the charged particle beam and irradiates the charged particle beam onto an irradiation subject, there are provided two or more pairs of scanning electromagnets that scan a charged particle beam in the two directions; the desired orbit is given by time-series desired orbit data in which desired irradiation positions corresponding to time are determined; and command values for respective scanning electromagnets in the two or more pairs of scanning electromagnets are generated based on plural pieces of data obtained by frequency-separating the time-series desired orbit data.

摘要翻译： 提供了一种使用两对或更多对扫描电磁体的粒子束照射装置，从而能够以高精度和高速度地从低速到高的灵活性进行带电粒子束的扫描 速度。 在沿着与带电粒子束的行进方向垂直的X方向和Y方向（双向）期望的轨道扫描入射带电粒子束的粒子束照射装置中，将带电粒子束照射到照射对象上， 设置两对或更多对在两个方向扫描带电粒子束的扫描电磁体对; 期望的轨道由时间序列期望的轨道数据给出，其中确定对应于时间的期望的照射位置; 并且基于通过对时间序列期望的轨道数据进行频率分离而获得的多条数据，生成两对以上的扫描电磁体对的各扫描电磁体的指令值。

公开(公告)号：US20110204262A1

公开(公告)日：2011-08-25

申请号：US13127112

申请日：2008-12-24

申请人： Yuehu Pu ,  Toshihiro Otani

发明人： Yuehu Pu ,  Toshihiro Otani

IPC分类号： A61N5/10

CPC分类号： A61N5/1048 ,  A61N2005/1056 ,  A61N2005/1087

摘要： Light from a light source is made to be reflected by a light source mirror and to pass through a variable collimator, an irradiation field shape shaped by the variable collimator is projected on a photographing screen by the light passed through the variable collimator, a projection portion of the photographing screen is photographed by a photographic device, and an image photographed by the photographic device is analyzed by an image processor.

摘要翻译： 使来自光源的光由光源反射镜反射并穿过可变准直器，通过可变准直仪形成的照射场形状，通过可变准直器的光投影在拍摄屏幕上，突出部 通过摄影装置拍摄拍摄画面，并且通过图像处理器分析由照相装置拍摄的图像。

公开(公告)号：US07054801B2

公开(公告)日：2006-05-30

申请号：US09904889

申请日：2001-07-16

申请人： Hidenobu Sakamoto ,  Yuehu Pu

发明人： Hidenobu Sakamoto ,  Yuehu Pu

IPC分类号： G06F17/50 ,  G06G7/62 ,  A61N5/00 ,  G21G5/00

CPC分类号： A61N5/103 ,  A61N2005/1087

摘要： A radiation exposure region to be irradiated with particle beams and a peripheral region thereof are respectively divided into pluralities of exposure regions, radiation treatment simulation for applying particle beams according to the shape of each divided exposure region is performed, and a radiation treatment condition is obtained for causing the flatness of the radiation exposure region to be in a desired range, and a dose of particle beams applied to the unit exposure region of the peripheral region to be minimum. Thus, the problem of low efficiency of radiation is solved.

摘要翻译： 将用粒子束照射的放射线照射区域及其周边区域分别分割为多个曝光区域，进行根据各分割曝光区域的形状施加粒子束的放射线处理模拟，得到放射线处理条件 用于使辐射曝光区域的平坦度处于期望的范围内，并且将施加到周围区域的单元曝光区域的粒子束的剂量最小化。 因此解决了辐射效率低的问题。

公开(公告)号：US08525133B2

公开(公告)日：2013-09-03

申请号：US13501376

申请日：2010-10-01

申请人： Yuehu Pu

发明人： Yuehu Pu

IPC分类号： G21K5/04

CPC分类号： G21K5/04 ,  A61N5/1042 ,  A61N5/1043 ,  A61N2005/1087 ,  G21K1/087 ,  G21K1/093

摘要： A particle beam irradiation system comprising a first deflector having the maximum deflection amount which enables to move a particle beam in one direction to the maximum width of a target and a second deflector having the maximum deflection amount is less than the maximum deflection amount of the first deflector performs a control in which the particle beam is moved by increasing at least a deflection amount of the second deflector when the particle beam is moved, and performs a deflection substitution control in which a deflection of the second deflector is substituted to a deflection of the first deflector by decreasing the deflection amount of the second deflector and changing a deflection amount of the first deflector so as to make a position of the particle beam in the target dwell when the particle beam dwells.

摘要翻译： 一种粒子束照射系统，包括具有最大偏转量的第一偏转器，其能够将一个方向上的粒子束移动到目标的最大宽度，并且具有最大偏转量的第二偏转器小于第一偏转量的最大偏转量 偏转器通过在粒子束移动时至少增加第二偏转器的偏转量来执行粒子束移动的控制，并且执行偏转替换控制，其中第二偏转器的偏转被替换为第二偏转器的偏转 第一偏转器通过减小第二偏转器的偏转量并改变第一偏转器的偏转量，以便当粒子束停留时使粒子束在靶中的位置停留。

公开(公告)号：US20120199757A1

公开(公告)日：2012-08-09

申请号：US13501376

申请日：2010-10-01

申请人： Yuehu Pu

发明人： Yuehu Pu

IPC分类号： G21K5/04

CPC分类号： G21K5/04 ,  A61N5/1042 ,  A61N5/1043 ,  A61N2005/1087 ,  G21K1/087 ,  G21K1/093

摘要： A particle beam irradiation system comprising a first deflector having the maximum deflection amount which enables to move a particle beam in one direction to the maximum width of a target and a second deflector having the maximum deflection amount is less than the maximum deflection amount of the first deflector performs a control in which the particle beam is moved by increasing at least a deflection amount of the second deflector when the particle beam is moved, and performs a deflection substitution control in which a deflection of the second deflector is substituted to a deflection of the first deflector by decreasing the deflection amount of the second deflector and changing a deflection amount of the first deflector so as to make a position of the particle beam in the target dwell when the particle beam dwells.

摘要翻译： 一种粒子束照射系统，包括具有最大偏转量的第一偏转器，其能够将一个方向上的粒子束移动到目标的最大宽度，并且具有最大偏转量的第二偏转器小于第一偏转量的最大偏转量 偏转器通过在粒子束移动时至少增加第二偏转器的偏转量来执行粒子束移动的控制，并且执行偏转替换控制，其中第二偏转器的偏转被替换为第二偏转器的偏转 第一偏转器通过减小第二偏转器的偏转量并改变第一偏转器的偏转量，以便当粒子束停留时使粒子束在靶中的位置停留。