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1.发明授权Particle beam therapy device and particle beam therapy device operation method 有权粒子束治疗装置和粒子束治疗装置的操作方法公开(公告)号：US09067066B2
公开(公告)日：2015-06-30
申请号：US14356629
申请日：2012-03-27
申请人： Yukiko Yamada , Hisashi Harada , Taizo Honda , Masahiro Ikeda , Kazushi Hanakawa , Toshihiro Otani , Tadashi Katayose
发明人： Yukiko Yamada , Hisashi Harada , Taizo Honda , Masahiro Ikeda , Kazushi Hanakawa , Toshihiro Otani , Tadashi Katayose
CPC分类号： A61N5/1048 , A61N5/1043 , A61N5/1077 , A61N2005/1074 , A61N2005/1087 , H05H13/04 , H05H2277/11
摘要： A control unit is provided with, a retaining section that retains a plurality of operation patterns each being a pattern of operation to be periodically repeated by an accelerator, the operation patterns having respective operation conditions adjusted for different emission times of an particle beam, to cause a deflection electromagnet in the accelerator to have an intended magnetic field intensity even under a presence of a hysteresis; a reading section for a plurality of slices of an irradiation target in a depth direction, which reads an irradiation condition for each of the slices; a selection section that selects the operation pattern suitable for each of the slices, on the basis of the read irradiation condition; and a main control section that controls, for each of the slices, the accelerator on the basis of the selected operation pattern and an irradiation device on the basis of the irradiation condition.
摘要翻译： 控制单元设置有保持部，其保持多个操作模式，每个操作模式是由加速器周期性重复的操作模式，所述操作模式具有针对粒子束的不同发射次数调整的各自的操作条件，以使得 加速器中的偏转电磁体即使在滞后的情况下也具有预期的磁场强度; 用于读取每个切片的照射条件的用于在深度方向上的照射目标的多个切片的读取部分; 选择部，其基于读取的照射条件选择适合于每个切片的操作模式; 以及主控制部，其基于所述照射条件，基于所选择的操作模式和照射装置对每个切片进行加速器的控制。
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公开(公告)号：US08933420B2
公开(公告)日：2015-01-13
申请号：US14240197
申请日：2011-11-02
申请人： Masahiro Ikeda , Hisashi Harada , Kazushi Hanakawa , Toshihiro Otani , Tadashi Katayose , Taizo Honda , Yukiko Yamada , Yuehu Pu
发明人： Masahiro Ikeda , Hisashi Harada , Kazushi Hanakawa , Toshihiro Otani , Tadashi Katayose , Taizo Honda , Yukiko Yamada , Yuehu Pu
IPC分类号： A61N5/10
CPC分类号： A61N5/1077 , A61N5/1049 , A61N5/1069 , A61N2005/1087
摘要： A particle beam therapy system comprising a treatment table, a treatment table control unit and an irradiation control unit configured to output an instruction for controlling the treatment table control unit, an accelerator and a scanning electromagnet, wherein after the treatment table control unit controls the treatment table so as for a patient isocenter which is reference position of an affected area of a patient to move to a position of an irradiation isocenter which is set at a position which is closer to an irradiation nozzle than an equipment isocenter which is reference of positional relation of the irradiation nozzle and the treatment table, the irradiation control unit outputs an instruction for irradiating the patient with a particle beam.
摘要翻译： 一种粒子束治疗系统，包括治疗台，治疗台控制单元和照射控制单元，其被配置为输出用于控制治疗台控制单元的指令，加速器和扫描电磁体，其中在治疗台控制单元控制治疗 将患者的中心位置作为患者的受影响区域的基准位置移动到被设定在比作为位置关系的参照的设备等角点更靠近照射喷嘴的位置的照射等角点的位置 的照射喷嘴和处理台，照射控制单元输出用于对粒子束照射患者的指示。
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公开(公告)号：US20120215049A1
公开(公告)日：2012-08-23
申请号：US13260865
申请日：2011-02-23
申请人： Toshihiro Otani , Takeshi Hagino , Koichi Ikuta
发明人： Toshihiro Otani , Takeshi Hagino , Koichi Ikuta
IPC分类号： A61N5/00
CPC分类号： A61N5/1045 , A61N5/1048 , A61N2005/1087 , A61N2005/1095 , G21K1/046
摘要： The objective is to obtain a particle beam therapy system that prevents dispersion of a charged particle beam, reduction of the energy thereof, and upsizing of the system and that can accurately monitor the opening shape of a multileaf collimator so as to perform high-accuracy particle beam therapy. An image-capturing unit that takes an image of an outer end of a respective downstream side face of a leaf plate is provided for each row of leaves in such a way as to be situated at a position that is at an outer side of an irradiation field; and adjusted in such a way that the base of a perpendicular from a viewpoint to the downstream side face, is situated at a position that is at an inner side of the position of the outer end when the leaf plate is maximally driven in the departing direction.
摘要翻译： 目的是获得一种防止带电粒子束分散的粒子束治疗系统，其能量的减少和系统的大型化，并且可以精确地监测多叶准直器的开口形状，从而执行高精度粒子 梁治疗。 为每排叶片提供拍摄叶片的各个下游侧面的外端的图像的图像捕获单元，以便位于位于照射的外侧的位置 领域; 并且以这样的方式进行调节，使得从视点到下游侧面的垂直线的基部位于当沿着离开方向最大程度地驱动叶板时位于外端位置的内侧的位置 。
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公开(公告)号：US20110218429A1
公开(公告)日：2011-09-08
申请号：US12738705
申请日：2009-04-24
申请人： Hisashi Harada , Takaaki Iwata , Taizo Honda , Yuehu Pu , Yuichi Yamamoto , Toshihiro Otani , Hidenobu Sakamoto
发明人： Hisashi Harada , Takaaki Iwata , Taizo Honda , Yuehu Pu , Yuichi Yamamoto , Toshihiro Otani , Hidenobu Sakamoto
CPC分类号： A61N5/1077 , A61N2005/1087 , A61N2005/1095
摘要： There is obtained a particle beam therapy system in which the beam size is reduced. There are provided an accelerator 14 that accelerates a charged particle beam; an irradiation apparatus that has a beam scanning apparatus 5a, 5b for performing scanning with the charged particle beam and irradiates the charged particle beam onto an irradiation subject ; and a beam transport apparatus 15 that has a duct for ensuring a vacuum region or gas region that continues from the accelerator 14 to a beam outlet window 7 disposed at a more downstream position than the beam scanning apparatus 5a, 5b, and that transports the charged particle beam exiting from the accelerator 14 to the irradiation apparatus.
摘要翻译： 获得了粒径减小的粒子束治疗系统。 提供加速带电粒子束的加速器14; 具有用于利用带电粒子束进行扫描并将带电粒子束照射到照射对象上的光束扫描装置5a，5b的照射装置; 以及具有用于确保从加速器14延伸到设置在比光束扫描装置5a，5b的更下游位置处的光束出射窗口7的真空区域或气体区域的管道的光束传送装置15，并且传送带电 粒子束从加速器14离开到照射装置。
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公开(公告)号：US5953466A
公开(公告)日：1999-09-14
申请号：US901336
申请日：1997-07-28
CPC分类号： G02F1/0123 , G02F1/225 , G02F2201/58 , G02F2203/21
摘要： An optical modulator for modulating light emitted from a signal light source has a substrate having electrooptic effect, an optical waveguide of a Mach-Zehnder type formed on the substrate, an electrode formed on the substrate to control light propagated in the optical waveguide, a light guiding unit for guiding light radiated or leaking from the optical waveguide, an interference light generating means for making light emitted from the light guiding unit and signal light leaking from the optical waveguide interfere with each other to generate interference light, and for emitting the interference light from an end surface of the substrate, a photo-detector for monitoring the interference light obtained by the interference light generating means, and a signal controlling circuit for controlling an operating point of the optical modulator according to a change of the interference light monitored by the photo-detector, thereby stably controlling the operating point of the optical modulator while facilitating a design of the mechanism.
摘要翻译： 用于调制从信号光源发出的光的光调制器具有具有电光效应的基板，在基板上形成的马赫 - 策德尔型光波导，形成在基板上的用于控制在光波导中传播的光的电极， 引导单元，用于引导从光波导辐射或泄漏的光;干涉光产生装置，用于使从光导单元发射的光和从光波导泄漏的信号光相互干扰，产生干涉光，并用于发射干涉光 从基板的端面，用于监视由干涉光产生装置获得的干涉光的光检测器，以及信号控制电路，用于根据由所述干涉光监测的干涉光的变化控制所述光调制器的工作点 光电检测器，从而稳定地控制光学模块的工作点 同时促进机制的设计。
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公开(公告)号：US5764400A
公开(公告)日：1998-06-09
申请号：US803377
申请日：1997-02-20
CPC分类号： G02F1/225 , G02F1/0123 , G02F2201/58
摘要： Disclosed herein is an optical modulator module including an optical waveguide structure of a Mach-Zehnder type, for example, an electrode for switching a coupling mode where an output beam is obtained from the optical waveguide structure and a leakage mode where a leakage beam deflects from the optical waveguide structure, a photodetector having a photodetecting surface for receiving the leakage beam, and a mechanism for converting a beam parameter of the leakage beam so as to prevent close contact of the photodetecting surface with the optical waveguide structure. The optical modulator module allows monitoring of optical power by the use of the leakage beam and is improved in manufacturability.
摘要翻译： 这里公开了一种光调制器模块，其包括马赫 - 策德尔型的光波导结构，例如用于切换从光波导结构获得输出光束的耦合模式的电极和泄漏光束从 光波导结构，具有用于接收泄漏光束的受光面的光检测器，以及用于转换漏光束的光束参数的机构，以防止受光面与光波导结构的紧密接触。 光调制器模块允许通过使用泄漏光束来监视光功率并且在可制造性方面得到改善。
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7.发明授权Sensitivity correction method for dose monitoring device and particle beam therapy system 有权剂量监测装置和粒子束治疗系统的灵敏度校正方法公开(公告)号：US08854048B2
公开(公告)日：2014-10-07
申请号：US13262866
申请日：2011-03-10
CPC分类号： H01J37/304 , A61N5/1048 , A61N5/1071 , A61N5/1077 , A61N2005/1087 , H01J47/02
摘要： In a particle beam therapy system which scans a particle beam and irradiates the particle beam to an irradiation position of an irradiation subject and has a dose monitoring device for measuring a dose of the particle beam and an ionization chamber smaller than the dose monitoring device, the ionization chamber measuring a dose of a particle beam passing through the dose monitoring device, the dose of the particle beam irradiated by the dose monitoring device is measured; the dose of the particle beam passing through the dose monitoring device is measured by the small ionization chamber; and a correction coefficient of the dose measured by the dose monitoring device corresponding to the irradiation position is found based on the dose of the particle beam measured by the small ionization chamber.
摘要翻译： 在粒子束治疗系统中，扫描粒子束并将粒子束照射到照射对象的照射位置，并且具有用于测量粒子束的剂量和小于剂量监测装置的电离室的剂量监测装置， 电离室测量通过剂量监测装置的粒子束的剂量，测量由剂量监测装置照射的粒子束的剂量; 通过小电离室测量通过剂量监测装置的粒子束的剂量; 并且基于由小电离室测量的粒子束的剂量，求出由与照射位置对应的剂量监测装置测量的剂量的校正系数。
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公开(公告)号：US5963357A
公开(公告)日：1999-10-05
申请号：US891785
申请日：1997-07-14
CPC分类号： G02F1/0123 , G02F1/225
摘要： An optical modulator for modulating light emitted from a signal light source has a substrate having electrooptic effect, an optical waveguide of a Mach-Zehnder type formed on the substrate, an electrode formed on the substrate to control light propagated in the optical waveguide, an interference light generating means for making radiation light radiated from the optical waveguide and signal light leaking from the optical waveguide interfere with each other to generate interference light, and emitting the interference light from an end surface of the substrate, a photo-detector for monitoring the interference light of the radiation light and the signal light, and a signal controlling circuit for controlling an operating point of the optical modulator according to a change of the interference light monitored by the photo-detector It is thereby possible to prevent degradation of a distinction ratio due to a shift of the operating point of the optical modulator so as to allow stable optical modulation, while facilitating a design of the mechanism of the optical modulator.
摘要翻译： 用于调制从信号光源发出的光的光调制器具有具有电光效应的基板，形成在基板上的马赫 - 策德尔型光波导，形成在基板上的电极，用于控制在光波导中传播的光，干涉 用于产生从光波导辐射的辐射光的光产生装置和从光波导泄漏的信号光相互干扰以产生干涉光，并从基板的端面发射干涉光，用于监测干涉的光检测器 照射光和信号光的光，以及用于根据光检测器所监视的干涉光的变化来控制光调制器的工作点的信号控制电路，从而可以防止由于 到光调制器的工作点的移动，以便允许稳定的光学 l调制，同时有助于光调制器的机制的设计。
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公开(公告)号：US5889912A
公开(公告)日：1999-03-30
申请号：US921014
申请日：1997-08-29
CPC分类号： G02B6/12 , G02B2006/12159 , G02F1/0356 , G02F1/2255 , G02F2001/212
摘要： An optical waveguide device including a package housing having an element mounting surface, an element inserting groove opening to the element mounting surface, and a cutout as a space opening to an inner surface of the element inserting groove; and an optical waveguide element having a dielectric substrate, an optical waveguide formed in a surface of the dielectric substrate, and an electrode formed over the surface of the dielectric substrate, the optical waveguide element being inserted and fixed in the element inserting groove of the package housing by using an adhesive. The cutout opens also to the element mounting surface. In applying the adhesive to the bottom surface of the element inserting groove and inserting the optical waveguide element into the element inserting groove, the adhesive flows into the cutout and is prevented from flowing up to the element mounting surface. Further, a working space for application of the adhesive to the bottom surface of the element inserting groove can be ensured by the cutout.
摘要翻译： 一种光波导装置，包括具有元件安装表面的封装壳体，通向元件安装表面的元件插入槽以及通向元件插入槽内表面的开口的切口; 以及具有电介质基板的光波导元件，形成在电介质基板的表面的光波导，以及在电介质基板的表面上形成的电极，光波导元件被插入并固定在封装的元件插入槽内 通过使用粘合剂进行住房。 切口也打开到元件安装表面。 在将粘合剂施加到元件插入槽的底表面并将光波导元件插入元件插入槽中时，粘合剂流入切口并防止其向元件安装表面流动。 此外，可以通过切口来确保用于将粘合剂施加到元件插入槽的底面的工作空间。
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公开(公告)号：US5215714A
公开(公告)日：1993-06-01
申请号：US709062
申请日：1991-05-30
IPC分类号： G01N35/10
CPC分类号： G01N35/1009 , G01N2035/1025 , G01N2035/1086 , G01N35/1004
摘要： A buffer solution is sampled from a buffer solution vessel and is dispensed into a reaction vessel on a reaction table by first sampling/dispensing means, and a specimen containing an antigen or antibody to be measured is sampled from a specimen vessel and is dispensed into the reaction vessel by second sampling/dispensing means. A reagent containing insoluble carriers to which is bonded an antibody or antigen that specifically reacts with the antigen or antibody in the specimen is sampled from a reagent vessel and dispensed into the reaction vessel by third sampling/dispensing means. The entire reaction table is shaken continuously during mixing of the buffer solution, reagent and specimen, and the reaction vessel is maintained in an isothermal state. A stable antigen-antibody reaction in the resulting reaction solution is thus promoted to form an agglutinate of the insoluble carriers. The reaction solution is sampled from the reaction vessel and dispensed into a sample chamber by fourth sampling/dispensing means. The dispensed reaction solution is transferred to a detector through which the insoluble carriers are passed and in which a signal is generated based upon a difference in terms of electrical or optical characteristics. The degree of agglutination of the insoluble carriers is obtained as a numerical value, thus making it possible to quantify the antigen or antibody of interest contained in the specimen.
摘要翻译： 缓冲溶液从缓冲溶液容器中取样，并通过第一取样/分配装置分配到反应台上的反应容器中，并从样品容器中取出含有待测量的抗原或抗体的样品，并将其分配到 反应容器通过第二采样/分配装置。 从试剂容器中取出含有与试样中的抗原或抗体特异性反应的抗体或抗原结合的不溶性载体的试剂，并通过第三取样/分注装置分配到反应容器中。 在缓冲溶液，试剂和试样的混合过程中，整个反应台连续摇动，反应容器保持在等温状态。 因此促进所得反应溶液中的稳定的抗原 - 抗体反应形成不溶性载体的凝集物。 反应溶液从反应容器中取样并通过第四取样/分配装置分配到样品室中。 分配的反应溶液转移到不可溶载体通过的检测器，并且基于电或光学特性的差异产生信号。 获得不溶性载体的凝集度作为数值，从而可以定量试样中包含的感兴趣的抗原或抗体。
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