公开(公告)号：US08236826B2

公开(公告)日：2012-08-07

申请号：US12095930

申请日：2006-12-04

申请人： Hironori Matsuyama ,  Kenji Ohnishi ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Kumi Higuchi ,  Keisuke Miyajima ,  Satoshi Yamada ,  Masaaki Motoyama ,  Yutaka Kojima ,  Koichi Yasumura ,  Takeshi Kodama ,  Shun Otsuji ,  Keizo Kan ,  Takumi Sumida

发明人： Hironori Matsuyama ,  Kenji Ohnishi ,  Takashi Nakagawa ,  Hideki Takasu ,  Makoto Sakamoto ,  Kumi Higuchi ,  Keisuke Miyajima ,  Satoshi Yamada ,  Masaaki Motoyama ,  Yutaka Kojima ,  Koichi Yasumura ,  Takeshi Kodama ,  Shun Otsuji ,  Keizo Kan ,  Takumi Sumida

IPC分类号： A61K31/44

CPC分类号： A61K31/496 ,  A61K31/495

摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group —CH═, R1 represents a group —Z—R6, in which Z represents a group —CO—, a group —CH(OH)— or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group —O—, a group —CO—, a group —CH(OH)— or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.

摘要翻译： 本发明的目的在于提供一种抗肿瘤活性大大提高的安全性药物。 根据本发明，提供了含有下述通式（1）表示的化合物或其盐作为有效成分的药物：[式1]其中X1表示氮原子或基团-CH =， R1表示基团-Z-R6，其中Z表示基团-CO-，基团-CH（OH） - 等，R6表示5至15元单环，二环或三环饱和或不饱和杂环基 具有1至4个氮原子，氧原子或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基 A表示[式2]其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。

公开(公告)号：US20100261720A1

公开(公告)日：2010-10-14

申请号：US12740684

申请日：2008-10-29

申请人： Takumi Sumida ,  Fujio Tabusa ,  Kazuo Sekiguchi ,  Takeshi Kodama ,  Koichi Yasumura ,  Yutaka Kojima ,  Masaaki Motoyama ,  Keisuke Miyajima ,  Kenji Yoshida ,  Keizo Kan ,  Makoto Sakamoto ,  Hideki Takasu ,  Takashi Nakagawa ,  Naoto Ohi ,  Yasuo Harada ,  Norikazu Hashimoto ,  Hironori Matsuyama ,  Masatoshi Iida ,  Shigekazu Fujita ,  Tae Fukushima

发明人： Takumi Sumida ,  Fujio Tabusa ,  Kazuo Sekiguchi ,  Takeshi Kodama ,  Koichi Yasumura ,  Yutaka Kojima ,  Masaaki Motoyama ,  Keisuke Miyajima ,  Kenji Yoshida ,  Keizo Kan ,  Makoto Sakamoto ,  Hideki Takasu ,  Takashi Nakagawa ,  Naoto Ohi ,  Yasuo Harada ,  Norikazu Hashimoto ,  Hironori Matsuyama ,  Masatoshi Iida ,  Shigekazu Fujita ,  Tae Fukushima

IPC分类号： A61K31/5377 ,  C07D401/14 ,  C07D413/14 ,  A61K31/497 ,  C07D403/14 ,  A61P35/00 ,  A61P43/00

CPC分类号： C07D401/12 ,  C07D403/12

摘要： The present invention provides a heterocyclic compound represented by General Formula (1): wherein R1 is a group R5—Z1—, etc., Z1 is a lower alkylene group, etc., and R5 is a group represented by General Formula; wherein R13 is a hydrogen atom, etc., m is an integer from 1 to 5; R2 is a hydrogen atom: Y is CH or N: A1 is a heterocyclic ring selected from the group consisting of indolediyl groups, wherein the heterocyclic ring may have at least one substituent: T is a group —CO—, etc.: R3 is a hydrogen atom, etc.: R4 is a lower alkyl group optionally substituted by one or more hydroxy groups, etc.: R3 and R4, together with the nitrogen atom to which they bind, may bind to each other and form a 5- to 10-membered saturated heterocyclic ring, wherein the heterocyclic ring may have at least one substituent. The heterocyclic compound of the present invention has excellent effects of suppressing the production of collagen and/or treating tumors.

摘要翻译： 本发明提供由通式（1）表示的杂环化合物：其中R1为R5-Z1-基团等，Z1为低级亚烷基等，R5为通式所示的基团。 其中R 13为氢原子等，m为1至5的整数; R2是氢原子：Y是CH或N：A1是选自吲哚二基的杂环，其中杂环可以具有至少一个取代基：T是-CO-等：R3是 氢原子等：R4是任选被一个或多个羟基取代的低级烷基等：R 3和R 4与它们所键合的氮原子一起可以彼此结合形成5- 10元饱和杂环，其中杂环可以具有至少一个取代基。 本发明的杂环化合物具有抑制胶原蛋白的生成和/或治疗肿瘤的优异效果。

公开(公告)号：US20080110533A1

公开(公告)日：2008-05-15

申请号：US12003387

申请日：2007-12-21

申请人： Makoto Sakamoto

发明人： Makoto Sakamoto

IPC分类号： C21D9/08

CPC分类号： C21D8/10 ,  C21D8/0226 ,  C22C38/02 ,  C22C38/04 ,  C22C38/22

摘要： A non-heat treated seamless steel pipe comprising, by weight, C: 0.10 to 0.25%, Si: 0.05 to 1.00%, Mn: 0.50 to 2.50%, P: not more than 0.03%, S: not more than 0.05%, Cr: 0.40 to 1.50%, Mo: 0.05 to 1.50%, V: 0.02 to 0.30%, Al: 0.003 to 0.10%, B: 0.0003 to 0.01%, and N: 0.001 to 0.02%, in which the balance comprises Fe and impurities. According to this non-heat treated seamless steel pipe, a ferrite area ratio is not more than 10%, and a carbon equivalent Ceq. (%) defined by the following equation is 0.45 to 0.85%. Ceq.=C+Mn/6+(Cr+Mo+V)/5+(Cu+Ni)/15

摘要翻译： 1.一种非热处理无缝钢管，其包含C：0.10〜0.25％，Si：0.05〜1.00％，Mn：0.50〜2.50％，P：0.03％以下，S：0.05％以下， Cr：0.40〜1.50％，Mo：0.05〜1.50％，V：0.02〜0.30％，Al：0.003〜0.10％，B：0.0003〜0.01％，N：0.001〜0.02％ 杂质。 根据该非热处理无缝钢管，铁素体面积率不大于10％，碳当量Ceq。 （％）为0.45〜0.85％。 Ce = C + Mn / 6 +（Cr + Mo + V）/ 5 +（Cu + Ni）/ 15 < in-line-formula description =“In-line Formulas”end =“tail”？>

公开(公告)号：US06511995B1

公开(公告)日：2003-01-28

申请号：US09646935

申请日：2000-09-25

申请人： Kouji Edamatsu ,  Takao Nagahama ,  Satoshi Hayakawa ,  Yutaka Kojima ,  Makoto Sakamoto ,  Koichi Yasumura

发明人： Kouji Edamatsu ,  Takao Nagahama ,  Satoshi Hayakawa ,  Yutaka Kojima ,  Makoto Sakamoto ,  Koichi Yasumura

IPC分类号： C07D21312

CPC分类号： C07D213/643 ,  C07D213/75 ,  C07D213/82 ,  C07D405/12

摘要： A pyridine derivative represented by formula (1) wherein all the variables have been defined in the specification. The compounds are used for inhibiting collagen production and are useful for preventing or treating fibrosis.

摘要翻译： 由式（1）表示的吡啶衍生物，其中所有变量已在说明书中定义。 该化合物用于抑制胶原蛋白的产生，并且可用于预防或治疗纤维化。

公开(公告)号：US5965804A

公开(公告)日：1999-10-12

申请号：US990837

申请日：1997-12-15

申请人： Makoto Sakamoto

发明人： Makoto Sakamoto

IPC分类号： G01H17/00 ,  F02D35/00 ,  G01L23/22 ,  G01M15/00 ,  H01L41/08 ,  G01L1/10

CPC分类号： G01L23/222

摘要： A knock sensor employs a piezoelectric element and includes a ring-shaped weight which has a chamfered surface portion formed at an inner peripheral edge of the weight. The knock sensor basically comprises a housing which includes a disc-shaped flange portion and a cylinder portion covered with an insulating tube. A lower lead plate, the piezoelectric element, an upper lead plate, an insulating sheet, a weight, a disc spring, and a nut are stacked on the flange portion and disposed around the cylinder portion in the order of mention. The nut is tightly screwed to the external thread portion of the cylinder portion to fixedly sandwich the stacked parts with the flange portion of the housing.

摘要翻译： 敲击传感器采用压电元件，并且包括环形重物，其具有形成在重物的内周边缘处的倒角表面部分。 敲击传感器基本上包括壳体，其包括盘形凸缘部分和被绝缘管覆盖的气缸部分。 下引线板，压电元件，上引线板，绝缘片，重物，碟形弹簧和螺母堆叠在凸缘部分上并且以提及的顺序设置在圆筒部分周围。 螺母紧紧地拧入圆筒部分的外螺纹部分，以将壳体的凸缘部分固定地夹在堆叠部分上。

公开(公告)号：US5594006A

公开(公告)日：1997-01-14

申请号：US389645

申请日：1995-02-16

申请人： Makoto Sakamoto ,  Takeshi Imaoka ,  Masaaki Motoyama ,  Yoshihito Yamamoto ,  Hideki Takasu

发明人： Makoto Sakamoto ,  Takeshi Imaoka ,  Masaaki Motoyama ,  Yoshihito Yamamoto ,  Hideki Takasu

IPC分类号： C07D215/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D491/04 ,  C07D215/227 ,  A61K31/47

CPC分类号： C07D215/38 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D491/04

摘要： This invention provides a carbostyril derivative of the formula (1): ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and n are as defined, or its salt. This carbostyril derivative or its salt possess an excellent matrix metalloproteinases inhibitory action.

摘要翻译： 本发明提供式（1）的喹诺酮衍生物：其中R 1，R 2，R 3，R 4，R 5，R 6和n如上所定义，或其盐。 该喹诺酮衍生物或其盐具有优异的基质金属蛋白酶抑制作用。

公开(公告)号：US5043941A

公开(公告)日：1991-08-27

申请号：US467390

申请日：1990-01-19

申请人： Makoto Sakamoto

发明人： Makoto Sakamoto

IPC分类号： G11C17/00 ,  G11C16/04 ,  G11C16/12 ,  H01L21/8247 ,  H01L29/788 ,  H01L29/792

CPC分类号： G11C16/0441 ,  G11C16/12

摘要： A non-volatile memory provides a signal hold circuit which uses a FAMOS instead of an input transistor of a ratiod inverting amplifier and outputs a change in a threshold value of the FAMOS, for the purpose of reducing the number of elements of the signal hold circuit. FAMOSs for programming and latching are provided respectively, and the FAMOSs are interconnected to each other at their floating gate electrodes to isolate the signal hold circuit and a program circuit and hence prevent a DC current path from being formed between those two circuits, for the purpose of miniaturization of a memory cell.

公开(公告)号：US4470688A

公开(公告)日：1984-09-11

申请号：US351930

申请日：1982-02-24

申请人： Sanji Inagaki ,  Makoto Sakamoto

发明人： Sanji Inagaki ,  Makoto Sakamoto

IPC分类号： G03G15/20

CPC分类号： G03G15/2057

摘要： A heat roller fixing device for use in an electrophotographic copying apparatus and the like, which includes a heating roller constituted by laminating a fluorine resin layer on an electrically conductive core member through a primer layer and driven for rotation, and a pressure roller constituted by forming an electrically insulative layer on another electrically conductive core member and held in contact with the heating roller for simultaneous rotation with the heating roller so as to fix a positively charged toner image formed on copy paper onto the copy paper by causing the copy paper to pass between the heating roller and the pressure roller. The primer layer is composed of an offset prevention agent containing carbon black by a predetermined amount, preferably 0.4 to 3.0% by weight.

摘要翻译： 一种用于电子照相复印装置等的加热辊定影装置，其包括通过底漆层将氟树脂层层压在导电性芯材上并被驱动旋转而构成的加热辊和通过成形 在另一个导电芯部件上的电绝缘层，并且与加热辊保持接触，以与加热辊同时旋转，以便将形成在复印纸上的带正电的调色剂图像固定在复印纸上，使得复印纸在 加热辊和加压辊。 底漆层由含有预定量的炭黑的防偏移剂组成，优选为0.4〜3.0重量％。