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公开(公告)号:US4408372A
公开(公告)日:1983-10-11
申请号:US198726
申请日:1980-10-20
申请人: Teiji Kimura , Shigeru Kimura
发明人: Teiji Kimura , Shigeru Kimura
CPC分类号: F16B21/073 , Y10T24/45775
摘要: A coupler for joining two objects comprises an insertion member attached fast to one of the objects and a reception member attached fast to the other object and used for admitting the insertion member into fast engagement therewith. The insertion member is provided with a setting portion for fast attachment to the aforementioned one object and a shaft extended from the setting portion and possessed of a radially expanded engaging portion at the leading end thereof. The reception member is provided with two generally semicylindrical shells connected to each other through a thin-walled hinge portion and adapted to form one cylindrical shape upon being closed onto each other along the matched edges thereof and a plurality of resilient engaging pieces regularly spaced in the longitudinal direction on the inner wall of each of the shells.
摘要翻译: 用于连接两个物体的联接器包括快速附接到物体之一的插入构件和快速附接到另一物体的接收构件,并用于允许插入构件与其快速接合。 插入构件设置有用于快速附接到上述一个物体的设置部分和从设置部分延伸并且在其前端具有径向扩张的接合部分的轴。 接收构件设置有两个通常半圆柱形壳体,通过薄壁铰链部分相互连接,并且适于在沿其匹配边缘彼此闭合时形成一个圆柱形形状,并且多个弹性接合件在该 每个壳体的内壁上的纵向方向。
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公开(公告)号:US5693652A
公开(公告)日:1997-12-02
申请号:US408867
申请日:1995-03-23
申请人: Yasutaka Takase , Nobuhisa Watanabe , Makoto Matsui , Hironori Ikuta , Teiji Kimura , Takao Saeki , Hideyuki Adachi , Tadakazu Tokumura , Hisatoshi Mochida , Yasunori Akita , Shigeru Souda
发明人: Yasutaka Takase , Nobuhisa Watanabe , Makoto Matsui , Hironori Ikuta , Teiji Kimura , Takao Saeki , Hideyuki Adachi , Tadakazu Tokumura , Hisatoshi Mochida , Yasunori Akita , Shigeru Souda
IPC分类号: C07D215/42 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/454 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P37/00 , A61P43/00 , B60S1/16 , B60S1/24 , C07D215/48 , C07D235/06 , C07D235/08 , C07D239/78 , C07D239/84 , C07D239/86 , C07D239/88 , C07D239/90 , C07D239/94 , C07D239/95 , C07D239/96 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D491/04 , C07D491/056 , C07D521/00 , F16C7/02 , F16C11/04 , C07D235/04
CPC分类号: C07D235/06 , C07D215/42 , C07D231/12 , C07D233/56 , C07D239/84 , C07D239/86 , C07D239/88 , C07D239/94 , C07D239/95 , C07D239/96 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/10 , C07D413/12 , C07D471/04 , C07D491/04
摘要: The present invention provides a nitrogenous heterocyclic compound represented by the following general formula (1) or a pharmacologically acceptable salt thereof which is useful for various ischemic heart diseases and the like: ##STR1## �in formula (1), ring A represents a benzene ring, a pyridine ring or a cyclohexane ring: ring B represents a pyridine ring, a pyrimidine ring or an imidazole ring, R.sup.1, R.sup.2, R.sup.3 R.sup.4, R.sup.5 and R.sup.6 are described herein.
摘要翻译: 本发明提供由以下通式(1)表示的含氮杂环化合物或其药理学上可接受的盐,其可用于各种缺血性心脏病等:(1)[式(1)中,环A 表示苯环,吡啶环或环己烷环:环B表示吡啶环,嘧啶环或咪唑环,R1,R2,R3,R4,R5和R6如本文所述。
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33.
公开(公告)号:US5668136A
公开(公告)日:1997-09-16
申请号:US757908
申请日:1991-09-11
申请人: Teiji Kimura , Nobuhisa Watanabe , Yasutaka Takase , Kenji Hayashi , Makoto Matsui , Hironori Ikuta , Youji Yamagishi , Kozo Akasaka , Hiroshi Tanaka , Issei Ohtsuka , Takao Saeki , Motoji Kogushi , Tohru Fujimori , Isao Saito
发明人: Teiji Kimura , Nobuhisa Watanabe , Yasutaka Takase , Kenji Hayashi , Makoto Matsui , Hironori Ikuta , Youji Yamagishi , Kozo Akasaka , Hiroshi Tanaka , Issei Ohtsuka , Takao Saeki , Motoji Kogushi , Tohru Fujimori , Isao Saito
IPC分类号: A61K31/135 , A61K31/165 , A61K31/17 , A61K31/18 , A61K31/27 , A61K31/275 , A61K31/415 , A61K31/505 , A61P3/06 , A61P9/10 , C07C233/18 , C07C255/58 , C07C255/59 , C07C255/60 , C07C275/34 , C07C275/40 , C07D211/14 , C07D213/02 , C07D233/54 , C07D233/60 , C07D233/68 , C07D233/90 , C07D233/96 , C07D235/02 , C07D235/06 , C07D235/12 , C07D235/14 , C07D249/04 , C07D249/06 , C07D249/18 , C07D253/08 , C07D257/04 , C07D295/08 , C07D295/092 , C07D401/04 , C07D401/12 , C07D403/12 , C07D521/00 , A61K31/495 , C07D241/04
CPC分类号: C07D233/64 , C07C275/40 , C07D211/14 , C07D231/12 , C07D233/56 , C07D233/68 , C07D233/90 , C07D235/02 , C07D235/06 , C07D235/12 , C07D235/14 , C07D249/06 , C07D249/08 , C07D249/18 , C07D257/04 , C07D295/088 , C07D401/12 , C07D403/12
摘要: A benzene, pyridine or pyrimidine derivative having the below shown formula is novel and useful as an anti-arteriosclerotic agent. ##STR1## wherein R.sup.1 stands for a lower alkyl group, an amino group which may be substituted, or the like; R.sup.2 stands for a group represented by the formula: ##STR2## (wherein R.sup.16 stands for an alkyl group having 1 to 6 carbon atoms, or the like) or the like; R.sup.3 stands for a group represented by the formula: --O--(CH.sub.2).sub.m --Y (Y stands for an imidazolyl or piperazinyl group, or the like and m is 1 to 6) or the like; R.sup.5 stands for a hydrogen atom, a lower alkyl group, or the like; A stands for a group represented by the formula: ##STR3## (wherein R.sup.6 stands for a hydrogen atom, a lower alkyl group, or the like), --N.dbd., or the like; and B stands for a group represented by the formula: ##STR4## (wherein R.sup.4 stands for a hydrogen or the like), --N.dbd., or the like.
摘要翻译: 具有下式所示的苯,吡啶或嘧啶衍生物是新颖的,可用作抗动脉硬化剂。 (I)其中R1代表低级烷基,可被取代的氨基等; R2代表由下式表示的基团:其中R16表示碳原子数1〜6的烷基等)等。 R3表示由下式表示的基团:-O-(CH 2)m -Y(Y表示咪唑基或哌嗪基等,m为1至6)等; R5代表氢原子,低级烷基等; A表示由下式表示的基团:其中R6表示氢原子,低级烷基等,-N =等; B代表由下式表示的基团:其中R4代表氢等,-N =等。
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公开(公告)号:US5576322A
公开(公告)日:1996-11-19
申请号:US196110
申请日:1994-02-18
申请人: Yasutaka Takase , Nobuhisa Watanabe , Makoto Matsui , Hironori Ikuta , Teiji Kimura , Takao Saeki , Hideyuki Adachi , Tadakazu Tokumura , Hisatoshi Mochida , Yasunori Akita , Shigeru Souda
发明人: Yasutaka Takase , Nobuhisa Watanabe , Makoto Matsui , Hironori Ikuta , Teiji Kimura , Takao Saeki , Hideyuki Adachi , Tadakazu Tokumura , Hisatoshi Mochida , Yasunori Akita , Shigeru Souda
IPC分类号: C07D215/42 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/445 , A61K31/454 , A61K31/4706 , A61K31/4709 , A61K31/496 , A61K31/505 , A61K31/517 , A61K31/519 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P37/00 , A61P43/00 , B60S1/16 , B60S1/24 , C07D215/48 , C07D235/06 , C07D235/08 , C07D239/78 , C07D239/84 , C07D239/86 , C07D239/88 , C07D239/90 , C07D239/94 , C07D239/95 , C07D239/96 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D471/04 , C07D491/04 , C07D491/056 , C07D521/00 , F16C7/02 , F16C11/04
CPC分类号: C07D235/06 , C07D215/42 , C07D231/12 , C07D233/56 , C07D239/84 , C07D239/86 , C07D239/88 , C07D239/94 , C07D239/95 , C07D239/96 , C07D249/08 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/10 , C07D413/12 , C07D471/04 , C07D491/04
摘要: The invention is directed to certain 2,4-diaminoquinazoline compounds, their pharmaceutically acceptable salts, the pharmaceutical compositions comprising those compounds and their therapeutic methods of use. The compounds possess anti-ischemic activity.
摘要翻译: PCT No.PCT / JP92 / 01258 Sec。 371日期1994年2月18日 102(e)日期1994年2月18日PCT提交1992年9月30日PCT公布。 出版物WO93 / 07124 日期1994年4月15日本发明涉及某些2,4-二氨基喹唑啉化合物,其药学上可接受的盐,包含那些化合物的药物组合物及其治疗方法。 该化合物具有抗缺血活性。
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