利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

57 条记录 (耗时 0.051 秒)

    Process for the synthesis of glycolonitrile
    31.
    发明授权
    Process for the synthesis of glycolonitrile 有权
    乙腈的合成方法

    公开(公告)号：US07368492B2

    公开(公告)日：2008-05-06

    申请号：US11314386

    申请日：2005-12-21

    申请人： Thomas Foo ,  Anna Panova

    发明人： Thomas Foo ,  Anna Panova

    IPC分类号： C08J5/15 ,  C08K5/49 ,  C08L5/49

    CPC分类号： C12P7/42 ,  C07C253/00 ,  C07C255/16

    摘要： A process to prepare substantially pure glycolonitrile in an aqueous medium is provided by reacting hydrogen cyanide and formaldehyde. The formaldehyde feed stream is heated prior to reacting with hydrogen cyanide, resulting in an aqueous glycolonitrile solution with fewer impurities, especially less unreacted formaldehyde, than is obtained by other methods. The process enables production of an aqueous glycolonitrile solution that requires less post-reaction purification (if any at all) prior to enzymatically converting the glycolonitrile into glycolic acid.

    摘要翻译： 通过使氰化氢和甲醛反应来提供在水性介质中制备基本上纯的乙醇腈的方法。 在与氰化氢反应之前加热甲醛进料流，得到比通过其它方法获得的少的杂质，特别是较少未反应的甲醛的乙醇腈水溶液。 该方法使得能够在将乙醇腈酶转化为乙醇酸之前，生产需要较少的反应后纯化（如果有的话）的乙醇腈水溶液。

    HYDROCYANATION PROCESS WITH REDUCED YIELD LOSSES
    32.
    发明申请
    HYDROCYANATION PROCESS WITH REDUCED YIELD LOSSES 有权

    公开(公告)号：US20080015382A1

    公开(公告)日：2008-01-17

    申请号：US11776968

    申请日：2007-07-12

    申请人： Thomas Foo ,  James Michael Garner ,  Ron Ozer ,  Paul S. Pearlman

    发明人： Thomas Foo ,  James Michael Garner ,  Ron Ozer ,  Paul S. Pearlman

    IPC分类号： C07C253/10

    CPC分类号： C07C253/10 ,  C07C255/04

    摘要： The invention provides a hydrocyanation process for the production of adiponitrile and other dinitriles having six carbon atoms, the process comprising: a) forming a reaction mixture in the presence of at least one Lewis acid, said reaction mixture comprising ethylenically unsaturated nitriles having five carbon atoms, hydrogen cyanide, and a catalyst precursor composition, by continuously feeding ethylenically unsaturated nitriles, hydrogen cyanide, and a catalyst precursor composition; b) controlling X and Z, wherein X is the overall feed molar ratio of 2-pentenenitriles to all unsaturated nitriles and Z is the overall feed molar ratio of hydrogen cyanide to all unsaturated nitriles, by selecting a value for X in the range from about 0.001 to about 0.5, and a value for Z in the range from about 0.5/1 to about 0.99/1, such that the value of quotient Q, wherein Q = X [ ( moles   3  PN + 4  PN   in   the   feed ) / ( moles   all   unsaturated   nitriles   in   the   feed ) ] - Z is in the range from about 0.2 to about 10, wherein 3PN is 3-pentenenitriles and 4PN is 4-pentenenitrile; and c) withdrawing a reaction product mixture comprising adiponitrile; wherein the ratio of the concentration of 2-pentenenitriles to the concentration of 3-pentenenitriles in the reaction mixture is from about 0.2/1 to about 10/1; wherein the catalyst precursor composition comprises a zero-valent nickel and at least one multidentate phosphorus-containing ligand; wherein the multidentate phosphorus-containing ligand is selected from the group consisting of a phosphite, a phosphonite, a phosphinite, a phosphine, and a mixed phosphorus-containing ligand or a combination of such members; and wherein the multidentate phosphorus-containing ligand gives acceptable results according to at least one protocol of the 2-Pentenenitrile Hydrocyanation Test Method.

    SYSTEM, METHOD, AND ARTICLE OF MANUFACTURE FOR GUIDING AN END EFFECTOR TO A TARGET POSITION WITHIN A PERSON
    33.
    发明申请
    SYSTEM, METHOD, AND ARTICLE OF MANUFACTURE FOR GUIDING AN END EFFECTOR TO A TARGET POSITION WITHIN A PERSON 审中-公开
    系统，方法和制造用于指导终端效应到人员目标位置的制造

    公开(公告)号：US20050267359A1

    公开(公告)日：2005-12-01

    申请号：US10709783

    申请日：2004-05-27

    申请人： Mohammed Hussaini ,  Thomas Foo

    发明人： Mohammed Hussaini ,  Thomas Foo

    IPC分类号： A61B19/00 ,  A61B5/08 ,  A61B6/03 ,  A61B6/12 ,  A61B17/32 ,  A61B5/05

    CPC分类号： A61B5/0816 ,  A61B34/10 ,  A61B34/70 ,  A61B90/11 ,  A61B2562/17

    摘要： A system, method, and article of manufacture for guiding an end effector to a target position within a person are provided. The method includes generating a plurality of digital images of an interior anatomy of the person when the person has a predetermined respiratory state. The method further includes indicating a skin entry position on at least one of the digital images. The method further includes indicating the target position on at least one of the digital images. The method further includes determining a trajectory path based on the skin entry position and the target position. Finally, the method includes moving the end effector along the trajectory path toward the target position when the person has substantially the predetermined respiratory state.

    摘要翻译： 提供了一种用于将末端执行器引导到人的目标位置的系统，方法和制品。 该方法包括当人具有预定呼吸状态时，生成人的内部解剖结构的多个数字图像。 该方法还包括指示至少一个数字图像上的皮肤进入位置。 该方法还包括在数字图像中的至少一个上指示目标位置。 该方法还包括基于皮肤进入位置和目标位置来确定轨迹路径。 最后，该方法包括当人基本上具有预定的呼吸状态时，将末端执行器沿着轨迹路径移动到目标位置。

    MAGNETIC RESONANCE IMAGING WITH IMPROVED DIFFERENTATION OF INFARCTED TISSUE
    34.
    发明申请
    MAGNETIC RESONANCE IMAGING WITH IMPROVED DIFFERENTATION OF INFARCTED TISSUE 审中-公开
    磁共振成像具有改善的感染组织的不同

    公开(公告)号：US20050245809A1

    公开(公告)日：2005-11-03

    申请号：US10709365

    申请日：2004-04-29

    申请人： Steven Wolff ,  Thomas Foo

    发明人： Steven Wolff ,  Thomas Foo

    IPC分类号： A61B5/05 ,  G01R33/28 ,  G01R33/561

    CPC分类号： G01R33/561 ,  G01R33/281

    摘要： A method of generating a magnetic resonance image is provided, comprising subjecting a subject to a magnetic field. The subject comprised of a first tissue a second tissue and a third tissue. The method generates a first pulse sequence at a first TI time and generates a first image after the first pulse sequence. The first image has a first image first tissue magnitude, a first image second tissue magnitude, and a first image third tissue magnitude. The method then generates a second pulse sequence at a second TI time and generates a second image after the second pulse sequence. The second image has a second image first tissue magnitude, a second image second tissue magnitude, and a second image third tissue magnitude. Finally, the method generates a resultant image by combining the first image and the second image. The first image first tissue magnitude and the second image first tissue magnitude combine to form a positive resultant first tissue magnitude. The first image third tissue magnitude and the second image third tissue magnitude combine to form a negative resultant image third tissue magnitude.

    摘要翻译： 提供了一种产生磁共振图像的方法，包括使受试者受到磁场的影响。 受试者由第一组织组成，第二组织和第三组织组成。 该方法在第一TI时间产生第一脉冲序列，并在第一脉冲序列之后产生第一图像。 第一图像具有第一图像第一组织幅度，第一图像第二组织幅度和第一图像第三组织幅度。 然后，该方法在第二TI时间产生第二脉冲序列，并在第二脉冲序列之后产生第二图像。 第二图像具有第二图像第一组织量值，第二图像第二组织量值和第二图像第三组织量值。 最后，该方法通过组合第一图像和第二图像来生成合成图像。 第一图像第一组织幅度和第二图像第一组织幅度组合形成正的合成第一组织幅度。 第一图像第三组织幅度和第二图像第三组织幅度组合形成负的合成图像第三组织幅度。

    Hydrocyanation of pentenenitriles
    36.
    发明授权
    Hydrocyanation of pentenenitriles 有权
    戊烯腈的氢氰化

    公开(公告)号：US08088943B2

    公开(公告)日：2012-01-03

    申请号：US12353584

    申请日：2009-01-14

    申请人： Thomas Foo ,  James Michael Garner ,  Ron Ozer ,  Paul S. Pearlman

    发明人： Thomas Foo ,  James Michael Garner ,  Ron Ozer ,  Paul S. Pearlman

    IPC分类号： C07C253/00

    CPC分类号： C07C253/10 ,  C07C255/04

    摘要： The invention provides a hydrocyanation process to produce adiponitrile and other dinitriles having six carbon atoms, in the presence of catalyst composition comprising a zero-valent nickel and at least one bidentate phosphorus-containing ligand wherein the bidentate phosphorus-containing ligand gives acceptable results according to at least one protocol of the 2-Pentenenitrile Hydrocyanation Test Method.

    摘要翻译： 在含有零价镍和至少一种二齿含磷配体的催化剂组合物的存在下，本发明提供了一种氢氰化方法来生产具有六个碳原子的己二腈和其它二腈，其中二齿含磷配体根据 至少一种2-戊烯腈氢氰化测试方法。

    Process for making and refining 3-pentenenitrile, and for refining 2-methyl-3-butenenitrile
    37.
    发明授权
    Process for making and refining 3-pentenenitrile, and for refining 2-methyl-3-butenenitrile 有权
    制备和精制3-戊烯腈的方法，以及用于精制2-甲基-3-丁烯腈的方法

    公开(公告)号：US07977502B2

    公开(公告)日：2011-07-12

    申请号：US12353410

    申请日：2009-01-14

    申请人： Thomas Foo ,  Sigridur S. Kristjansdottir ,  Ronald J. McKinney ,  Ron Ozer ,  Paul S. Pearlman

    发明人： Thomas Foo ,  Sigridur S. Kristjansdottir ,  Ronald J. McKinney ,  Ron Ozer ,  Paul S. Pearlman

    IPC分类号： C07C253/10

    CPC分类号： C07C253/10 ,  B01J31/185 ,  B01J2231/32 ,  B01J2531/0238 ,  B01J2531/847 ,  C07C255/04 ,  C07C255/07

    摘要： The invention provides an integrated, continuous process for the production of 3-pentenenitrile, the refining of 3-pentenenitrile, and the refining of 2-methyl-3-butenenitrile, the process comprising: (a) contacting, in a reaction zone, a hydrogen cyanide-containing feed, a butadiene-containing feed, and a catalyst composition, wherein the catalyst composition comprises a zero-valent nickel and at least one bidentate phosphorus-containing ligand selected from the group consisting of a phosphite, a phosphonite, a phosphinite, a phosphine, a mixed phosphorus-containing ligand, and combination thereof; (b) maintaining a residence time in the reaction zone sufficient to convert about 95% or more of the hydrogen cyanide and to produce a reaction mixture comprising 3-pentenenitrile and 2-methyl-3-butenenitrile, wherein the 2-methyl-3-butenenitrile concentration is maintained below about 15 weight percent of the total mass of the reaction mixture; (c) distilling the reaction mixture to obtain a first stream comprising 1,3-butadiene, a second stream comprising 3-pentenenitrile, 2-methyl-3-butenenitrile, (Z)-2-methyl-2-butenenitrile, and optionally 1,3-butadiene, and a third stream comprising the catalyst composition; (d) distilling the second stream to obtain a fourth stream comprising 1,3-butadiene, a fifth stream comprising 2-methyl-3-butenenitrile, (Z)-2-methyl-2-butenenitrile, and optionally 1,3-butadiene, and a sixth stream comprising 3-pentenenitrile; and (e) distilling the fifth stream to obtain a seventh stream comprising 1,3-butadiene, an eighth stream comprising (Z)-2-methyl-2-butenenitrile, and a ninth stream comprising 2-methyl-3-butenenitrile.

    摘要翻译： 本发明提供了一种用于生产3-戊烯腈的整合的连续方法，3-戊烯腈的精制和2-甲基-3-丁烯腈的精制，该方法包括：（a）在反应区中将 含有氰化氢的进料，含丁二烯的进料和催化剂组合物，其中催化剂组合物包含零价镍和至少一种选自亚磷酸酯，亚膦酸酯，亚磷酸盐的二齿含磷配位体 膦，混合含磷配体及其组合; （b）保持反应区中的停留时间足以转化约95％或更多的氰化氢并产生包含3-戊烯腈和2-甲基-3-丁烯腈的反应混合物，其中2-甲基-3- 丁烯腈浓度保持在反应混合物总质量的约15重量％以下; （c）蒸馏反应混合物以获得包含1,3-丁二烯的第一料流，包含3-戊烯腈，2-甲基-3-丁烯腈，（Z）-2-甲基-2-丁烯腈和任选的1 1,3-丁二烯和包含该催化剂组合物的第三料流; （d）蒸馏第二物流以获得包含1,3-丁二烯的第四料流，包含2-甲基-3-丁烯腈，（Z）-2-甲基-2-丁烯腈和任选的1,3-丁二烯的第五料流 ，和包含3-戊烯腈的第六料流; 和（e）蒸馏第五料流以获得包含1,3-丁二烯的第七料流，包含（Z）-2-甲基-2-丁烯腈的第八料流和包含2-甲基-3-丁烯腈的第九料流。