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31.发明授权Method of sample control and calibration adjustment for use with a noninvasive analyzer 失效用于无创分析仪的样品控制和校准调整方法公开(公告)号：US07383069B2
公开(公告)日：2008-06-03
申请号：US10849422
申请日：2004-05-18
IPC分类号： A61B5/1455
CPC分类号： G01N21/274 , A61B5/14532 , A61B5/1455 , A61B5/1495 , G01N21/359
摘要： A method and apparatus for easing the use of an optically based noninvasive analyzer is presented. More particularly, a simplified algorithm is used that removes the daily requirement of collecting and using a noninvasive spectrum to update a calibration model. In another embodiment, a guide is used to substantially reduce variation in sample probe placement in relation to a skin tissue sampling site, resulting in the ability to maintain calibration performance with the use of a reference analyte concentration, with or without the use of a reference spectrum collected nearby in time.
摘要翻译： 提出了一种用于缓解光学非侵入式分析仪的使用的方法和装置。 更具体地，使用简化的算法，其消除收集和使用非侵入光谱以更新校准模型的每日需求。 在另一个实施例中，引导件用于相对于皮肤组织取样部位显着减少样本探针放置的变化，从而产生使用参考分析物浓度来维持校准性能的能力，有或没有使用参考 频谱在时间附近收集。
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32.发明授权公开(公告)号：US06675029B2
公开(公告)日：2004-01-06
申请号：US10183660
申请日：2002-06-25
IPC分类号： A61B500
CPC分类号： A61B5/444 , A61B5/0062 , A61B5/0075 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/7264 , G01N21/3554 , G01N21/359 , G01N21/4785 , G01N21/49 , G01N2201/129
摘要： An apparatus and method for non-destructively estimating a tissue property, such as hydration, of a living subject utilizes in vivo spectral measurements made by irradiating skin tissue with near infrared (NIR) light. The apparatus includes a spectroscopic instrument in conjunction with a subject interface. The resulting spectra are passed to an analyzer for further processing, which includes detecting and eliminating invalid spectral measurements, and preprocessing to increase the signal-to-noise ratio. Finally, an estimation model developed from an exemplary set of measurements is applied to predict the tissue hydration for the sample. The method of tissue hydration measurement provides additional information about primary sources of systematic tissue variability, namely, the water content of the epidermal layer of skin and the penetration depth of the incident light. Tissue hydration measurement is therefore suitable for further spectral analysis and quantification of biological and chemical compounds, such as analytes.
摘要翻译： 用于非破坏性地估计活体受试者的组织性质（例如水合）的装置和方法利用通过用近红外（NIR）光照射皮肤组织进行的体内光谱测量。 该装置包括结合主体界面的光谱仪器。 所得到的光谱被传递到分析器以用于进一步处理，其包括检测和消除无效光谱测量以及预处理以增加信噪比。 最后，应用从示例性测量集合开发的估计模型来预测样品的组织水合。 组织水合测量的方法提供关于系统组织变异性的主要来源的附加信息，即皮肤表皮层的水含量和入射光的穿透深度。 因此，组织水合测量适用于生物和化学化合物（如分析物）的进一步光谱分析和定量。
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33.发明申请公开(公告)号：US20080319382A1
公开(公告)日：2008-12-25
申请号：US12109224
申请日：2008-04-24
申请人： Thomas B. Blank , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Christopher Slawinski , Sedar R. Brown
发明人： Thomas B. Blank , Stephen L. Monfre , Kevin H. Hazen , Timothy L. Ruchti , Christopher Slawinski , Sedar R. Brown
IPC分类号： A61M37/00 , A61B5/1455
CPC分类号： G01N21/359 , A61B5/14532 , A61B5/1455 , A61B2562/146
摘要： Sampling is controlled in order to enhance analyte concentration estimation derived from noninvasive sampling. More particularly, sampling is controlled using controlled fluid delivery to a region between a tip of a sample probe and a tissue measurement site. The controlled fluid delivery enhances coverage of a skin sample site with the thin layer of fluid. Delivery of contact fluid is controlled in terms of spatial delivery, volume, thickness, distribution, temperature, and/or pressure.
摘要翻译： 控制采样以增强从无创采样得到的分析物浓度估计。 更具体地，使用受控流体输送到样品探针的尖端和组织测量部位之间的区域来控制取样。 受控的流体输送增强了皮肤样品位点与薄层流体的覆盖。 在空间传送，体积，厚度，分布，温度和/或压力方面控制接触流体的传送。
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34.发明授权Compact apparatus for noninvasive measurement of glucose through near-infrared spectroscopy 有权用于通过近红外光谱法无损测量葡萄糖的紧凑装置公开(公告)号：US07133710B2
公开(公告)日：2006-11-07
申请号：US10472856
申请日：2003-03-07
申请人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
发明人： George M. Acosta , James R. Henderson , N. Alan Abul Haj , Timothy L. Ruchti , Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B5/1495 , A61B5/6833 , A61B5/7203 , A61B5/7225 , A61B5/726 , A61B2560/0223 , A61B2560/0233 , A61B2560/0252 , A61B2560/0412 , A61B2560/0443 , A61B2560/0456 , A61B2562/0242 , A61B2562/146 , A61B2562/227 , A61B2562/228 , G01N21/359 , G01N21/49
摘要： The invention involves the monitoring of a biological parameter through a compact analyzer. The preferred apparatus is a spectrometer based system that is attached continuously or semi-continuously to a human subject and collects spectral measurements that are used to determine a biological parameter in the sampled tissue. The preferred target analyze is glucose. The preferred analyzer is a near-IR based glucose analyzer for determining the glucose concentration in the body.
摘要翻译： 本发明涉及通过紧凑型分析仪监测生物参数。 优选的装置是基于光谱仪的系统，其连续地或半连续地连接到人类受试者并收集用于确定采样组织中的生物学参数的光谱测量。 优选的目标分析是葡萄糖。 优选的分析仪是用于测定体内葡萄糖浓度的基于近红外的葡萄糖分析仪。
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35.发明授权Multi-tier method of developing localized calibration models for non-invasive blood analyte prediction 有权开发用于非侵入性血液分析物预测的局部校准模型的多层方法公开(公告)号：US06512937B2
公开(公告)日：2003-01-28
申请号：US09825687
申请日：2001-04-03
IPC分类号： A61B500
CPC分类号： G01N21/274 , A61B5/1075 , A61B5/14532 , A61B5/1455 , A61B5/1495 , A61B5/7264 , A61B5/7267 , A61B2560/0223 , A61B2560/0233 , G01N21/359 , G01N21/4785 , G01N21/49 , Y10S128/92
摘要： A method of multi-tier classification and calibration in noninvasive blood analyte prediction minimizes prediction error by limiting co-varying spectral interferents. Tissue samples are categorized based on subject demographic and instrumental skin measurements, including in vivo near-IR spectral measurements. A multi-tier intelligent pattern classification sequence organizes spectral data into clusters having a high degree of internal consistency in tissue properties. In each tier, categories are successively refined using subject demographics, spectral measurement information and other device measurements suitable for developing tissue classifications. The multi-tier classification approach to calibration utilizes multivariate statistical arguments and multi-tiered classification using spectral features. Variables used in the multi-tiered classification can be skin surface hydration, skin surface temperature, tissue volume hydration, and an assessment of relative optical thickness of the dermis by the near-IR fat band. All tissue parameters are evaluated using the NIR spectrum signal along key wavelength segments.
摘要翻译： 非侵入性血液分析物预测中的多层分类和校准方法通过限制共同变化的光谱干扰来最小化预测误差。 组织样品根据受试者的人口统计学和仪器皮肤测量进行分类，包括体内近红外光谱测量。 多层智能图案分类序列将光谱数据组织成具有组织性质内部高度一致性的簇。 在每个层次中，使用主体人口统计学，光谱测量信息和适合于开发组织分类的其他设备测量来连续地改进类别。多层分类校准方法利用多变量统计学参数和使用光谱特征的多层次分类。 用于多层分类的变量可以是皮肤表面水合，皮肤表面温度，组织体积水合，以及近红外脂肪带对真皮的相对光学厚度的评估。 使用沿关键波长段的NIR光谱信号评估所有组织参数。
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36.发明授权公开(公告)号：US06487429B2
公开(公告)日：2002-11-26
申请号：US09766872
申请日：2001-01-18
IPC分类号： A61B500
CPC分类号： A61B5/14532
摘要： A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvasive spectral measurements are made using the noninvasive glucose monitor. Through controlled oral ingestion by the subject of calculated amounts of carbohydrate, the subject's blood glucose level is manipulated to mimic the patterns of the targeted profiles. During a first visit, a first profile of a pair is induced; during a second visit the inverse of the first profile is induced. The targeted profiles produce reference blood glucose values in which correlation to sampling factors is reduced or eliminated, thus the resulting calibration is correlated to glucose, and not to other analytes, sampling factors or environmental factors. A formula is provided for calculating the required amount of carbohydrate to ingest to induce a targeted glycemic profile in a test subject.
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37.发明授权公开(公告)号：US08718738B2
公开(公告)日：2014-05-06
申请号：US12393867
申请日：2009-02-26
CPC分类号： A61B5/1455 , A61B5/0075 , A61B5/14532 , A61B2562/146 , G01N21/01 , G01N21/359 , G01N21/474
摘要： The invention comprises method and apparatus for fluid delivery between a sample probe and a sample. The fluid delivery system includes: a fluid reservoir, a delivery channel, a manifold or plenum, a channel or moat, a groove, and/or a dendritic pathway to deliver a thin and distributed layer of a fluid to a sample probe head and/or to a sample site. The fluid delivery system reduces sampling errors due to mechanical tissue distortion, specular reflectance, probe placement, and/or mechanically induced sample site stress/strain associated with optical sampling of the sample.
摘要翻译： 本发明包括用于在样品探针和样品之间流体递送的方法和装置。 流体输送系统包括：流体储存器，输送通道，歧管或增压室，通道或沟槽，沟槽和/或树枝状路径，以将薄的和分布的流体层递送到样品探针头和/ 或到一个样本站点。 流体输送系统减少由于样品的光学取样所引起的机械组织变形，镜面反射率，探针放置和/或机械诱导的样本位点应力/应变引起的采样误差。
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公开(公告)号：US07697966B2
公开(公告)日：2010-04-13
申请号：US11361143
申请日：2006-02-23
申请人： Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen , Alan Abul-Haj , Tim Ruchti , James Ryan Henderson , Tim Stippick , Roxanne Abul-Haj
发明人： Stephen L. Monfre , Thomas B. Blank , Kevin H. Hazen , Alan Abul-Haj , Tim Ruchti , James Ryan Henderson , Tim Stippick , Roxanne Abul-Haj
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/061 , A61B5/1455 , A61B5/1495 , A61B5/489 , A61B5/7264 , A61B2562/0242 , A61B2562/146
摘要： The invention provides a targeting system used to direct a measuring system to a targeted sample site or volume. The targeting system increases analyte estimation performance by increasing precision and accuracy of sampling and/or by targeting an analyte rich tissue volume.
摘要翻译： 本发明提供了一种用于将测量系统引导到目标样品位点或体积的靶向系统。 靶向系统通过提高采样的精度和准确度和/或通过靶向富含分析物的组织体积来增加分析物估计性能。
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公开(公告)号：US06956649B2
公开(公告)日：2005-10-18
申请号：US10723353
申请日：2003-11-25
CPC分类号： G01N21/278 , G01N21/4738 , G01N21/4785 , G01N21/49 , G01N2021/4735
摘要： A ceramic reference in conjunction with a spectrometer, a metallized ceramic material, and a method of utilizing a ceramic material as a reference in the ultraviolet, visible, near-infrared, or infrared spectral regions are presented. The preferred embodiments utilize a ceramic reference material to diffusely reflect incident source light toward a detector element for quantification in a reproducible fashion. Alternative embodiments metallize either the incident surface or back surface of to form a surface diffuse reflectance standard. Optional wavelength reference layers or protective layers may be added to the ceramic or to the metallized layer. The reference ceramic is used to provide a measure of optical signal of an analyzer as a function of the analyzers spatial, temporal, and environmental state.
摘要翻译： 介绍了陶瓷参考文献，结合光谱仪，金属化陶瓷材料以及在紫外线，可见光，近红外或红外光谱区域中利用陶瓷材料作为参考的方法。 优选实施例利用陶瓷参考材料将入射光源漫反射到检测器元件，以便以可再现的方式进行定量。 替代实施例将入射表面或后表面金属化以形成表面漫反射标准。 可选的波长参考层或保护层可以添加到陶瓷或金属化层。 参考陶瓷用于根据分析仪的空间，时间和环境状态提供分析仪的光信号测量。
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40.发明授权Apparatus and method for easing use of a spectrophotometric based noninvasive analyzer 有权用于分光光度计的无创分析仪的装置和方法公开(公告)号：US07505801B2
公开(公告)日：2009-03-17
申请号：US11848139
申请日：2007-08-30
IPC分类号： A61B5/1455
CPC分类号： A61B5/6841 , A61B5/14532 , A61B5/1455 , G01N21/359 , G01N21/474
摘要： A placement guide apparatus with an improved hydration inducing plug used in coupling a noninvasive analyzer to a sampling site to determine analyte in the human body is disclosed. The hydration inducing plug includes at least one fluoropolymer that may be used as a coupling agent. The guide apparatus may further include an automated or semi-automated coupling fluid delivery system. Use of either of these couplers mitigates issues associated with related technology and enhances noninvasive analyte measurements, such as a near-IR diffuse reflectance based noninvasive glucose concentration analyzer.
摘要翻译： 公开了一种具有改进的水合诱导塞的放置引导装置，其用于将非侵入性分析器耦合到取样部位以确定人体中的分析物。 水合诱导塞包括至少一种可用作偶联剂的含氟聚合物。 引导装置还可以包括自动化或半自动化耦合流体输送系统。 使用这些耦合剂中的任一种可减轻与相关技术相关的问题，并增强非侵入性分析物测量，例如基于近红外漫反射的非侵入性葡萄糖浓度分析仪。
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