利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

32 条记录 (耗时 0.044 秒)

    Spectroscopic system and method using a ceramic optical reference
    3.
    发明授权
    Spectroscopic system and method using a ceramic optical reference 有权
    光谱系统和方法使用陶瓷光学参考

    公开(公告)号：US06956649B2

    公开(公告)日：2005-10-18

    申请号：US10723353

    申请日：2003-11-25

    申请人： George M. Acosta ,  Kevin H. Hazen ,  N. Alan Abul-Haj ,  Stephen L. Monfre ,  Thomas B. Blank

    发明人： George M. Acosta ,  Kevin H. Hazen ,  N. Alan Abul-Haj ,  Stephen L. Monfre ,  Thomas B. Blank

    IPC分类号： G01N21/27 ,  G01N21/47 ,  G01N21/49 ,  G01J3/28

    CPC分类号： G01N21/278 ,  G01N21/4738 ,  G01N21/4785 ,  G01N21/49 ,  G01N2021/4735

    摘要： A ceramic reference in conjunction with a spectrometer, a metallized ceramic material, and a method of utilizing a ceramic material as a reference in the ultraviolet, visible, near-infrared, or infrared spectral regions are presented. The preferred embodiments utilize a ceramic reference material to diffusely reflect incident source light toward a detector element for quantification in a reproducible fashion. Alternative embodiments metallize either the incident surface or back surface of to form a surface diffuse reflectance standard. Optional wavelength reference layers or protective layers may be added to the ceramic or to the metallized layer. The reference ceramic is used to provide a measure of optical signal of an analyzer as a function of the analyzers spatial, temporal, and environmental state.

    摘要翻译： 介绍了陶瓷参考文献，结合光谱仪，金属化陶瓷材料以及在紫外线，可见光，近红外或红外光谱区域中利用陶瓷材料作为参考的方法。 优选实施例利用陶瓷参考材料将入射光源漫反射到检测器元件，以便以可再现的方式进行定量。 替代实施例将入射表面或后表面金属化以形成表面漫反射标准。 可选的波长参考层或保护层可以添加到陶瓷或金属化层。 参考陶瓷用于根据分析仪的空间，时间和环境状态提供分析仪的光信号测量。

    Apparatus using reference measurement for calibration
    6.
    发明授权
    Apparatus using reference measurement for calibration 失效
    使用参考测量仪进行校准

    公开(公告)号：US07183102B2

    公开(公告)日：2007-02-27

    申请号：US11122669

    申请日：2005-05-04

    申请人： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

    发明人： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

    IPC分类号： C12M1/34

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  G01N21/274 ,  G01N21/359 ,  G01N21/49

    摘要： A method and apparatus for calibrating noninvasive or implantable glucose analyzers that uses either alternative invasive glucose determinations or noninvasive glucose determinations to calibrate noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variations that are built into the calibration model. An additional embodiment uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The invention provides a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.

    摘要翻译： 一种用于校准无创或可植入的葡萄糖分析仪的方法和装置，其使用替代的侵入性葡萄糖测定或非侵入性葡萄糖测定来校准无创或可植入的葡萄糖分析仪。 在校准中使用替代入侵或非侵入性葡萄糖测定可以最大限度地减少由采样方法引起的误差，以及内置于校准模型中的空间和时间变化。 另外的实施方案使用非侵入性和替代性侵入性葡萄糖测定与传统的侵入性葡萄糖测定之间的统计学相关性来调整对于传统侵入性葡萄糖浓度的非侵入性或替代性侵入性葡萄糖浓度。 本发明提供了一种用于基于反映观察到的基质的葡萄糖测定和由分析仪更仔细测量的变量进行校准的方法。 葡萄糖分析仪将无创手指计与无创葡萄糖分析仪相结合，用于非侵入性分析仪中体现的校准模型的校准，验证，适应和安全性检查。

    Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers
    7.
    发明授权
    Method and apparatus using alternative site glucose determinations to calibrate and maintain noninvasive and implantable analyzers 失效
    使用替代部位葡萄糖测定来校准和维护无创和可植入分析仪的方法和设备

    公开(公告)号：US06998247B2

    公开(公告)日：2006-02-14

    申请号：US10377916

    申请日：2003-02-28

    申请人： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

    发明人： Stephen L. Monfre ,  Kevin H. Hazen ,  Timothy L. Ruchti ,  Thomas B. Blank ,  James R. Henderson

    IPC分类号： C12Q1/54

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B5/1495 ,  G01N21/274 ,  G01N21/359 ,  G01N21/49

    摘要： Methods for calibrating noninvasive or implantable glucose analyzers utilize either alternative invasive glucose determinations or noninvasive glucose determinations for calibrating noninvasive or implantable glucose analyzers. Use of an alternative invasive or noninvasive glucose determination in the calibration allows minimization of errors due to sampling methodology, and spatial and temporal variation that are built into the calibration model. An additional method uses statistical correlations between noninvasive and alternative invasive glucose determinations and traditional invasive glucose determinations to adjust noninvasive or alternative invasive glucose concentrations to traditional invasive glucose concentrations. The methods provide a means for calibrating on the basis of glucose determinations that reflect the matrix observed and the variable measured by the analyzer more closely. A glucose analyzer couples an invasive fingerstick meter to a noninvasive glucose analyzer for calibration, validation, adaptation, and safety check of the calibration model embodied in the noninvasive analyzer.

    摘要翻译： 用于校准无创或可植入葡萄糖分析仪的方法利用替代侵入性葡萄糖测定或非侵入性葡萄糖测定来校准无创或可植入的葡萄糖分析仪。 在校准中使用替代入侵或无创葡萄糖测定可以最小化由采样方法引起的误差，以及内置于校准模型中的空间和时间变化。 一种额外的方法使用非侵入性和替代性侵入性葡萄糖测定与传统侵入性葡萄糖测定之间的统计学相关性来调整传统侵入性葡萄糖浓度的无创或替代侵入性葡萄糖浓度。 这些方法提供了一种基于反映观察到的基质的葡萄糖测定和由分析仪更接近测量的变量进行校准的方法。 葡萄糖分析仪将无创手指计与无创葡萄糖分析仪相结合，用于非侵入性分析仪中体现的校准模型的校准，验证，适应和安全性检查。

    Indirect measurement of tissue analytes through tissue properties
    10.
    发明授权
    Indirect measurement of tissue analytes through tissue properties 失效
    通过组织特性间接测量组织分析物

    公开(公告)号：US07039446B2

    公开(公告)日：2006-05-02

    申请号：US10349573

    申请日：2003-01-22

    申请人： Timothy L. Ruchti ,  Thomas B. Blank ,  Alexander D. Lorenz ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Suresh N. Thennadil

    发明人： Timothy L. Ruchti ,  Thomas B. Blank ,  Alexander D. Lorenz ,  Stephen L. Monfre ,  Kevin H. Hazen ,  Suresh N. Thennadil

    IPC分类号： A61B5/00

    CPC分类号： A61B5/1455 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/14532 ,  A61B5/1495 ,  A61B2560/0223 ,  G01N21/274 ,  G01N21/31 ,  G01N21/33 ,  G01N21/359 ,  G01N21/65 ,  G01N2021/3595

    摘要： Methods and system for noninvasive determination of tissue analytes utilize tissue properties as reflected in key features of an analytical signal to improve measurement accuracy and precision. Physiological conditions such as changes in water distribution among tissue compartments lead to complex alterations in the measured analytical signal of skin, leading to a biased noninvasive analyte measurement. Changes in the tissue properties are detected by identifying key features in the analytical signal responsive to physiological variations. Conditions not conducive to the noninvasive measurement are detected. Noninvasive measurements that are biased by physiological changes in tissue are compensated. In an alternate embodiment, the analyte is measured indirectly based on natural physiological response of tissue to changes in analyte concentration. A system capable of such measurements is provided.

    摘要翻译： 非侵入性测定组织分析物的方法和系统利用分析信号的关键特征反映的组织性质来提高测量精度和精度。 生理条件如组织间隔水分配变化导致测量的皮肤分析信号的复杂变化，导致偏向的非侵入性分析物测量。 通过识别响应于生理变化的分析信号中的关键特征来检测组织性质的变化。 检测到不利于非侵入性测量的条件。 由组织中生理变化偏向的无创测量得到补偿。 在替代实施方案中，基于组织对分析物浓度变化的天然生理反应间接测量分析物。 提供能够进行这种测量的系统。