公开(公告)号：US5795888A

公开(公告)日：1998-08-18

申请号：US544682

申请日：1995-10-18

申请人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

发明人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

IPC分类号： A61K31/00 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P23/00 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D207/10 ,  C07D211/60 ,  C07D211/78 ,  C07D401/06 ,  C07D403/06 ,  C07D405/00 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/645

CPC分类号： C07D401/06 ,  C07D211/60 ,  C07D211/78 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

摘要翻译： 本发明涉及新型N-取代的氮杂杂环羧酸及其酯，其中N-取代基的取代烷基链或其盐，其制备方法，含有它们的组合物及其用于临床治疗的用途 疼痛，痛觉过敏和/或炎症状态，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用。

公开(公告)号：US5688788A

公开(公告)日：1997-11-18

申请号：US444140

申请日：1995-05-18

申请人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

发明人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

IPC分类号： A61K31/00 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P23/00 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D207/10 ,  C07D211/60 ,  C07D211/78 ,  C07D401/06 ,  C07D403/06 ,  C07D405/00 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

CPC分类号： C07D401/06 ,  C07D211/60 ,  C07D211/78 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US5712292A

公开(公告)日：1998-01-27

申请号：US544905

申请日：1995-10-18

申请人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

发明人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

IPC分类号： A61K31/00 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P23/00 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D207/10 ,  C07D211/60 ,  C07D211/78 ,  C07D401/06 ,  C07D403/06 ,  C07D405/00 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D207/08 ,  A61K31/40 ,  C07D211/32

CPC分类号： C07D401/06 ,  C07D211/60 ,  C07D211/78 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US5693649A

公开(公告)日：1997-12-02

申请号：US544502

申请日：1995-10-18

申请人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

发明人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

IPC分类号： A61K31/00 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P23/00 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D207/10 ,  C07D211/60 ,  C07D211/78 ,  C07D401/06 ,  C07D403/06 ,  C07D405/00 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

CPC分类号： C07D401/06 ,  C07D211/60 ,  C07D211/78 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。

公开(公告)号：US06043239A

公开(公告)日：2000-03-28

申请号：US12918

申请日：1998-01-23

申请人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

发明人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

IPC分类号： A61K31/00 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P23/00 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D207/10 ,  C07D211/60 ,  C07D211/78 ,  C07D401/06 ,  C07D403/06 ,  C07D405/00 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

CPC分类号： C07D401/06 ,  C07D211/60 ,  C07D211/78 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。

公开(公告)号：US5721254A

公开(公告)日：1998-02-24

申请号：US544500

申请日：1995-10-18

申请人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

发明人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

IPC分类号： A61K31/00 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P23/00 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D207/10 ,  C07D211/60 ,  C07D211/78 ,  C07D401/06 ,  C07D403/06 ,  C07D405/00 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  C07D405/06 ,  A61K31/40

CPC分类号： C07D401/06 ,  C07D211/60 ,  C07D211/78 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US5668129A

公开(公告)日：1997-09-16

申请号：US626745

申请日：1996-03-27

申请人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

发明人： Knud Erik Andersen ,  Uffe Bang Olsen ,  Hans Petersen ,  Frederik Christian Gr.o slashed.nvald ,  Ursula Sonnewald ,  Tine Krogh J.o slashed.rgensen ,  Henrik Sune Andersen

IPC分类号： A61K31/00 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61K31/535 ,  A61K31/54 ,  A61K31/55 ,  A61P1/00 ,  A61P11/00 ,  A61P17/00 ,  A61P23/00 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D207/10 ,  C07D211/60 ,  C07D211/78 ,  C07D401/06 ,  C07D403/06 ,  C07D405/00 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

CPC分类号： C07D401/06 ,  C07D211/60 ,  C07D211/78 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

公开(公告)号：US5721260A

公开(公告)日：1998-02-24

申请号：US628042

申请日：1996-04-04

申请人： Rolf Hohlweg ,  Knud Erik Andersen ,  Tine Krogh J.o slashed.rgensen ,  Peter Madsen ,  Henrik Sune Andersen

发明人： Rolf Hohlweg ,  Knud Erik Andersen ,  Tine Krogh J.o slashed.rgensen ,  Peter Madsen ,  Henrik Sune Andersen

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61P3/08 ,  A61P3/10 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07D207/08 ,  C07D405/12 ,  C07D409/06 ,  C07D409/12 ,  A61K31/35 ,  A61K31/38

CPC分类号： C07D207/08 ,  C07D405/12 ,  C07D409/06

摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts therefor, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。