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公开(公告)号：US5712292A
公开(公告)日：1998-01-27
申请号：US544905
申请日：1995-10-18
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D207/08 , A61K31/40 , C07D211/32
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US5693649A
公开(公告)日：1997-12-02
申请号：US544502
申请日：1995-10-18
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5795888A
公开(公告)日：1998-08-18
申请号：US544682
申请日：1995-10-18
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , A61K31/645
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新型N-取代的氮杂杂环羧酸及其酯，其中N-取代基的取代烷基链或其盐，其制备方法，含有它们的组合物及其用于临床治疗的用途 疼痛，痛觉过敏和/或炎症状态，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用。
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公开(公告)号：US5688788A
公开(公告)日：1997-11-18
申请号：US444140
申请日：1995-05-18
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US06043239A
公开(公告)日：2000-03-28
申请号：US12918
申请日：1998-01-23
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5721254A
公开(公告)日：1998-02-24
申请号：US544500
申请日：1995-10-18
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06 , C07D405/06 , A61K31/40
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US5668129A
公开(公告)日：1997-09-16
申请号：US626745
申请日：1996-03-27
申请人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
发明人： Knud Erik Andersen , Uffe Bang Olsen , Hans Petersen , Frederik Christian Gr.o slashed.nvald , Ursula Sonnewald , Tine Krogh J.o slashed.rgensen , Henrik Sune Andersen
IPC分类号： A61K31/00 , A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P1/00 , A61P11/00 , A61P17/00 , A61P23/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/10 , C07D211/60 , C07D211/78 , C07D401/06 , C07D403/06 , C07D405/00 , C07D407/06 , C07D409/06 , C07D413/06 , C07D417/06
CPC分类号： C07D401/06 , C07D211/60 , C07D211/78 , C07D409/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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公开(公告)号：US6110913A
公开(公告)日：2000-08-29
申请号：US55633
申请日：1998-04-06
申请人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Sindelar Karel , Silhankova Alexandra
发明人： Florenzio Zaragossa Dorwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Sindelar Karel , Silhankova Alexandra
IPC分类号： A01N43/46 , A61K31/40 , A61K31/44 , A61K31/451 , A61K31/54 , A61P19/02 , C07D207/08 , C07D207/10 , C07D207/12 , C07D211/20 , C07D211/26 , C07D211/70 , C07D223/18 , C07D265/38
CPC分类号： C07D207/16 , C07D211/60 , C07D211/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5874428A
公开(公告)日：1999-02-23
申请号：US623289
申请日：1996-03-28
申请人： Florenzio Zaragossa D.o slashed.rwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Silhankova Alexandra , Sindelar Karel
发明人： Florenzio Zaragossa D.o slashed.rwald , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen , Henrik Sune Andersen , Svend Treppendahl , Polivka Zdenek , Silhankova Alexandra , Sindelar Karel
IPC分类号： C07D223/28 , A61K31/40 , A61K31/4427 , A61K31/445 , A61K31/535 , A61K31/538 , A61K31/55 , A61P3/08 , A61P3/10 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D207/16 , C07D211/60 , C07D211/62 , C07D401/06 , C07D403/06 , C07D413/06 , C07D453/02 , A01N43/46 , C07D223/18
CPC分类号： C07D401/06 , C07D207/16 , C07D211/60 , C07D211/62 , C07D403/06 , C07D413/06 , C07D453/02
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
摘要翻译： 本发明涉及新的N-取代的氮杂杂环羧酸及其酯，其中取代的烷基链形成N-取代基或其盐的一部分，其制备方法，含有它们的组合物及其用于临床的用途 治疗C型纤维通过引起神经源性疼痛或炎症而发挥病理生理作用的疼痛，痛觉过敏和/或炎性病症。
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公开(公告)号：US5716949A
公开(公告)日：1998-02-10
申请号：US625562
申请日：1996-03-28
申请人： Henrik Sune Andersen , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen
发明人： Henrik Sune Andersen , Knud Erik Andersen , Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Uffe Bang Olsen
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/55 , A61P3/08 , A61P3/10 , A61P25/00 , A61P25/04 , A61P29/00 , A61P43/00 , C07D211/60 , C07D401/06 , C07D409/06 , C07D417/06 , C07D207/12 , A61K31/38 , A61K31/40 , C07D211/42
CPC分类号： C07D401/06 , C07D211/60 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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