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公开(公告)号：US20100069433A1
公开(公告)日：2010-03-18
申请号：US12593356
申请日：2008-03-28
CPC分类号： C07D263/58 , A61K31/423 , A61K31/47
摘要： The present invention provides a therapeutic agent for hyperlipidemia having an excellent effect of lowering the cholesterol and triglyceride level in blood plasma.The present invention relates to a prophylactic and/or therapeutic agent for hyperlipidemia, a prophylactic and/or therapeutic agent for obesity or diabetes mellitus, and a prophylactic and/or therapeutic agent for metabolic syndrome, each agent including a compound represented by the following formula (1): , wherein: R1 and R2, which may be identical or different, each represent a hydrogen atom, a methyl group or an ethyl group; R3a, R3b, R4a and R4b, which may be identical or different, each represent a hydrogen atom, a halogen atom, a nitro group, a hydroxyl group, a C1-4 alkyl group, a trifluoromethyl group, a C1-4 alkoxy group, a C1-4 alkylcarbonyloxy group, a di-C1-4 alkylamino group, a C1-4 alkylsulfonyloxy group, a C1-4 alkylsulfonyl group, a C1-4 alkylsulfinyl group, or a C1-4 alkylthio group, or R3a and R3b, or R4a and R4b are joined to represent an alkylenedioxy group; X represents an oxygen atom, a sulfur atom or N—R5 (wherein R5 represents a hydrogen atom, a C1-4 alkyl group, a C1-4 alkylsulfonyl group, or a C1-4 alkyloxycarbonyl group); Y represents an oxygen atom, a S(O)l group (l represents a number from 0 to 2), a carbonyl group, a carbonylamino group, an aminocarbonyl group, a sulfonylamino group, an aminosulfonyl group, or an NH group; Z represents CH or N; n represents a number from 1 to 6; and m represents a number from 2 to 6, or a salt thereof, and a statin, particularly pitavastatin, in combination.
摘要翻译： 本发明提供了具有降低血浆中胆固醇和甘油三酯水平的优异效果的高脂血症治疗剂。 本发明涉及高脂血症的预防和/或治疗剂，肥胖症或糖尿病的预防和/或治疗剂，以及代谢综合征的预防和/或治疗剂，每种试剂包括由下式表示的化合物 （1）表示：其中：R 1和R 2可以相同或不同，各自表示氢原子，甲基或乙基; R3a，R3b，R4a和R4b可以相同或不同，分别表示氢原子，卤素原子，硝基，羟基，C1-4烷基，三氟甲基，C1-4烷氧基 ，C 1-4烷基羰基氧基，二-C 1-4烷基氨基，C 1-4烷基磺酰氧基，C 1-4烷基磺酰基，C 1-4烷基亚磺酰基或C 1-4烷硫基，或R 3a和R 3b ，或R4a和R4b连接以代表亚烷基二氧基; X表示氧原子，硫原子或N-R5（其中，R5表示氢原子，C1-4烷基，C1-4烷基磺酰基或C1-4烷氧基羰基）。 Y表示氧原子，S（O）1基（l表示0〜2的数），羰基，羰基氨基，氨基羰基，磺酰基氨基，氨基磺酰基或NH基。 Z表示CH或N; n表示1〜6的数; m代表2至6的数，或其盐，他汀类，特别是匹伐他汀组合。
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公开(公告)号：US07033262B2
公开(公告)日：2006-04-25
申请号：US10668724
申请日：2003-09-22
IPC分类号： B24D17/00
摘要： An abrasive substrate is removably provided between a head portion and an abrasive member in a carry type abrasive machine. The abrasive substrate is constituted by a single synthetic resin molded member formed of the same material, and a hardness in a peripheral portion is set to be lower than that in a central portion excluding the peripheral edge portion. A difference in the hardness between the central portion and the peripheral portion is regulated by a concavo-convex surface formed on a surface at the fixing side to the head portion of the carry type abrasive machine. It is desirable that the concavo-convex surface should be constituted by a plurality of rib-shaped projections formed on the same plane. The abrasive substrate of the carry type abrasive machine can be manufactured inexpensively and can carry out a reliable and stable abrasion work.
摘要翻译： 磨料基材可移除地设置在进料型研磨机中的头部和研磨部件之间。 磨料基材由相同材料形成的单一合成树脂模塑构件构成，并且周边部分的硬度设定为低于除了周边部分之外的中心部分的硬度。 中心部分和周边部分之间的硬度差异是通过形成在携带型研磨机的头部的固定侧的表面上形成的凹凸表面来调节的。 希望凹凸表面应由形成在同一平面上的多个肋状突起构成。 携带式研磨机的磨料基材可以廉价制造，可以进行可靠稳定的磨损加工。
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公开(公告)号：US06659851B2
公开(公告)日：2003-12-09
申请号：US10122044
申请日：2002-04-12
IPC分类号： B24B2300
摘要： A fastening device for a polishing paper cloth of a portable polishing machine. The device comprises an attaching portion which can be detachably attached to a base plate of the polishing machine and a fastening device main body for winding the polishing paper cloth thereon to engage therewith. Multiple concave grooves, which are continuous in the winding direction of the polishing paper cloth in parallel, and a cavity portion formed inside are provided. Therefore, by giving flexibility to the main body to allow it to be deformed in many directions, it is possible to prevent a reaction to the operator due to oscillation of the polishing machine generated during the polishing and to improve a discharging function for the polishing waste to the outside by allowing the polishing waste generated during the polishing to easily intrude in the concave grooves. Additionally, during the polishing, the air from the outside is flown through the concave grooves so as to increase the contacts with the outside air, which enables to improve the discharge efficiency of the friction heat generated in the polishing.
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公开(公告)号：US06423049B1
公开(公告)日：2002-07-23
申请号：US09628898
申请日：2000-07-31
IPC分类号： A61F1315
CPC分类号： A61F13/5644 , A61F13/622
摘要： The present invention provides a disposable diaper, which is easy to put on the wearer, and which is possible to be put on easily while the wearer is standing on both legs. The disposable diaper according to the present invention includes a diaper body having a hip portion and a belly portion, which are spread out with a crotch portion between them. The diaper further includes male members which are protrusively arranged from side portions of one of the hip portion and said belly portion in a face direction and female members, which are arranged on side portions of the other and in which the male members engage in a face direction of the side portions. The female members are provided with receiving portions in which the male members are inserted in a face direction of the side portions. Engaged surfaces perpendicular to the inserting direction of the male member are formed on the inner walls of the receiving portions and the male members are provided with engaging surfaces opposing to the engaged surfaces.
摘要翻译： 本发明提供一种便于穿戴者使用的一次性尿布，并且在穿戴者站立在两条腿上时可以容易地放置。 根据本发明的一次性尿布包括具有臀部和腹部的尿布主体，它们之间具有裆部部分。 尿布还包括从面部方向的臀部部分和所述腹部部分之一的侧部突出设置的阳部件，以及阴部件，其设置在另一个的侧部，并且阳部件接合在面部 侧面方向。 阴构件设置有阳部件沿着侧部的面方向插入的接纳部。 在接收部分的内壁上形成垂直于阳构件的插入方向的接合表面，并且阳构件设置有与接合表面相对的接合表面。
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公开(公告)号：US06379236B1
公开(公告)日：2002-04-30
申请号：US09453381
申请日：1999-12-02
申请人： Toshiaki Takizawa , Mitsuru Akeno
发明人： Toshiaki Takizawa , Mitsuru Akeno
IPC分类号： B24B2300
CPC分类号： B24B23/04
摘要： This invention provides a fixture for an abrasive cloth paper in which a surface fastener does not have to be bonded prior to fixing of the abrasive cloth paper onto the fixture and in which hook-shaped engaging elements are disposed accurately at portions directly related to polishing by an abrasive cloth paper fastening portion of the fixture with precedence. A fixture made of synthetic resin comprises a mounting portion which is engaged with/disengaged from a base plate of a sander and a fastening portion on which an abrasive cloth paper is wound and fastened. In the fastening portion, a plurality of surface fastener engaging element rows which are parallel to a direction of winding of the abrasive cloth paper are formed integrally so as to form a fastening surface. A hollow portion is formed in the fastening portion. Consequently, a complicated work for bonding a male surface fastener to the fixture integrally is eliminated and surface fastener engaging element rows can be arbitrarily formed integrally at required portions on a surface of the fastening portion of the fixture. As a result, the fastening surface composed of the surface fastener engaging element rows can be formed accurately only at portions in which a fastening strength with respect to the abrasive cloth paper needs to be ensured, and no fastening surface FS is formed in a portion not requiring the fastening-strength, thereby leading to reduction of production cost.
摘要翻译： 本发明提供了一种用于研磨布的固定装置，其中在将研磨布固定到固定装置上之前不需要粘合表面紧固件，并且其中钩形接合元件精确地设置在与抛光直接相关的部分处 固定装置的磨料布紧固部分优先。 由合成树脂制成的夹具包括与砂光机的基板接合/分离的安装部分和缠绕并紧固磨料布的紧固部分。 在紧固部中，与研磨布的卷绕方向平行的多个表面紧固件卡合元件列一体形成，形成固定面。 在紧固部中形成有中空部。 因此，消除了将凸形表面紧固件一体地结合到固定器上的复杂工作，并且表面紧固件接合元件排可以在固定件的紧固部分的表面上的所需部分上任意地一体地形成。 结果，由表面紧固件卡合元件排组成的紧固面只能在需要确保相对于研磨布的紧固强度的部分被精确地形成，而不会形成紧固面FS 需要紧固强度，从而降低生产成本。
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公开(公告)号：US06254304B1
公开(公告)日：2001-07-03
申请号：US09376952
申请日：1999-08-18
IPC分类号： A44B1800
CPC分类号： A44B18/0046 , A44B18/0073 , A47H13/00 , A47H2201/02 , Y10T24/2725 , Y10T24/2792 , Y10T403/7043 , Y10T428/24017
摘要： A fastening surface body which can mount a sheet-like fastening body to a sheet-like mounting body having various kinds of cross-sectional shapes with no play. The fastening surface body can securely engage a surface fastener of a sheet member to which a female surface fastener is mounted, where the fastening body includes a flat substrate having a surface comprising male engaging elements. The fastening body is structured so as to be fitted and fixed to fitting groove portions of the mounting body so as to bond and fix various kinds of sheet members. Each fitting groove portion of the of the mounting body generally has a C-shaped cross section formed with openings along both end edges of a widthwise direction. The fastening body has at least a protrusion having a height so that that the protrusion contacts a surface of the mounting body when the fastening body is fitted and fixed to the mounting body. The protrusion also extends in parallel to the fitting groove portions at least at a center portion in a widthwise direction on a surface opposite to the surface from which the male engaging elements protrude. Accordingly, it is possible to mount the sheet-like fastening body with no play even when the fastening body is thinner than a height of the opening of the fitting groove portions of the mounting body. Further, the protrusions can support the fastening body in a horizontal state against an external pressing force.
摘要翻译： 一种紧固表面体，其可以将片状紧固体安装到具有各种横截面形状的片状安装体上，而不发挥。 紧固表面体可以牢固地接合安装有阴表面紧固件的片状构件的表面紧固件，其中紧固体包括具有包括阳接合元件的表面的平坦基底。 该紧固体的结构被安装并固定在安装体的嵌合槽部上，从而固定和固定各种片材。 安装体的每个嵌合槽部分通常具有沿宽度方向的两个端部边缘形成开口的C形横截面。 紧固体具有至少一个具有高度的突起，使得当紧固体装配并固定到安装体时，突起接触安装体的表面。 突起还在与阳接合元件从其突出的表面相对的表面上至少在宽度方向上的中心部分平行地延伸到配合槽部分。 因此，即使紧固体比安装体的嵌合槽部的开口的高度更薄，也可以安装片状的紧固体。 此外，突起可以抵抗外部按压力而以水平状态支撑紧固体。
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公开(公告)号：US06186878B1
公开(公告)日：2001-02-13
申请号：US09204151
申请日：1998-12-03
IPC分类号： B24B2300
摘要： A fixing member is provided for fixing a front end section to the rest of a base plate. The fixing member is provided with a surface fastener which is integrally molded with the fixing member.
摘要翻译： 提供固定构件，用于将前端部固定到基板的其余部分。 固定构件设置有与固定构件一体模制的表面紧固件。
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公开(公告)号：USRE36779E
公开(公告)日：2000-07-18
申请号：US120344
申请日：1998-07-22
IPC分类号： A44B18/00
CPC分类号： A44B18/0061 , Y10T24/27 , Y10T24/2792
摘要： A molded surface fastener comprises a substrate sheet and a multiplicity of engaging elements molded in rows on one surface of the substrate sheet. Each of the engaging elements has a stem standing from the one surface of the substrate sheet, and a pair of hooks extending in opposite directions from a distal end of the stem. And a multiplicity of parting guide members stand from the one surface of the substrate sheet, each of which is situated centrally between adjacent engaging elements for parting loops of a companion surface fastener toward the engaging elements.
摘要翻译： 模制表面紧固件包括基材片和在基片的一个表面上成行成列的多个接合元件。 每个接合元件具有从基片的一个表面竖立的杆，以及从杆的远端沿相反方向延伸的一对钩。 并且多个分离引导构件从衬底片的一个表面站立，每个表面位于相邻的接合元件之间的中心处，用于将配对表面紧固件的环向着接合元件分开。
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39.发明授权
公开(公告)号：US6063067A
公开(公告)日：2000-05-16
申请号：US122084
申请日：1998-07-24
申请人： Toshiaki Takizawa , Masashi Doi , Tsuyoshi Minato
发明人： Toshiaki Takizawa , Masashi Doi , Tsuyoshi Minato
IPC分类号： A61F13/49 , A44B99/00 , A61F5/44 , A61F13/15 , A61F13/551 , A61F13/56 , C09J5/00 , D04H11/00
CPC分类号： A61F13/5512 , Y10T24/2792 , Y10T428/283
摘要： A disposable diaper has a pair of first surface fastener members supported by a rear flap of a diaper body and a second surface fastener member supported by a front flap of the diaper body. The first and second surface fastener members have first and second engaging elements; the first and/or second engaging elements are made of water-soluble resin. After approximately 1/3 to 2/5 of the diaper body on the side of the rear flap is folded inwardly, the diaper body is wound into a roll toward the front flap, and then the water-soluble resin of the first and/or second engaging elements is dissolved with water. Then the first surface fastener members are pressed against the second surface fastener member to fasten the diaper body in roll as waste.
摘要翻译： 一次性尿布具有由尿布主体的后片支撑的一对第一表面紧固件部件和由尿布主体的前片支撑的第二表面紧固件。 第一和第二表面紧固件具有第一和第二接合元件; 第一和/或第二接合元件由水溶性树脂制成。 在大约+ E之后，将1/3 + EE至+ E，尿片主体的后翼片侧面的2/5 + EE向内折叠，尿布主体朝向前折片卷成卷状， 然后第一和/或第二接合元件的水溶性树脂用水溶解。 然后将第一表面紧固件按压在第二表面紧固件上，以便将尿布本体卷成一条浪费。
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公开(公告)号：US5951931A
公开(公告)日：1999-09-14
申请号：US887193
申请日：1997-07-02
CPC分类号： A44B18/0049 , Y10T24/27 , Y10T24/2742 , Y10T24/2775 , Y10T24/2792
摘要： A molded surface fastener is manufactured by supplying molten resin to the circumferential surface of a die wheel rotating in one way to mold a substrate sheet blank and a multiplicity of substantially straight and inclined engaging element blanks in an integral form, and then pressing distal ends of the engaging element blanks by a heat-molding roller in rotation at the same speed to incline the engaging element blanks further toward the substrate sheet blank and also to melt the distal ends to shape each said distal end into an engaging head projecting in a direction opposite to the direction of inclination of the respective engaging element blank. Each of the resulting engaging elements is composed of a stem rising from the substrate sheet surface with inclination by a predetermined angle (.theta.1), and an engaging head projecting from an upper end of the stem in a direction opposite to the direction of inclination of the stem, an extension line of the engaging head crossing the substrate sheet surface at a predetermined acute angle (.theta.2).
摘要翻译： 通过向模制轮的圆周表面提供熔融树脂来制造成型表面紧固件，所述模具轮以一种方式旋转，以模制基板板坯和多个基本上直的和倾斜的接合元件坯件，并且然后将顶端 接合元件通过热成型辊以相同的速度旋转，以使接合元件坯件进一步朝向基板片坯料倾斜，并且还使顶端熔化以使每个所述远端成形为沿相反方向突出的接合头部 到相应的接合元件坯件的倾斜方向。 每个所得到的接合元件由从基板片表面以倾斜预定角度（θ1）上升的杆组成，以及从杆的上端沿与倾斜方向相反的方向突出的接合头 杆，接合头的延伸线以预定的锐角（θ2）与基片表面交叉。
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