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公开(公告)号：US09327134B2
公开(公告)日：2016-05-03
申请号：US13796314
申请日：2013-03-12
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61H39/002 , A61N1/36067 , A61N1/36096 , A61N1/36107 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , H01L2224/48091 , Y10T29/49002 , H01L2924/00014
Abstract: An implantable electroacupuncture device (IEAD) treats a medical condition of a patient through application of electroacupuncture (EA) stimulation pulses applied at a target tissue location, such as an acupoint. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates EA stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在目标组织位置（例如穴位）上施加的电针（EA）刺激脉冲来治疗患者的医疗状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生EA刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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32.发明授权Implantable electroacupuncture device and method for treating depression, bipolar disorder and anxiety 有权可植入式电针装置及治疗抑郁症，双相情感障碍和焦虑症的方法公开(公告)号：US09198828B2
公开(公告)日：2015-12-01
申请号：US13630322
申请日：2012-09-28
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61H39/002 , A61N1/36096 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3782 , Y10T29/49002
Abstract: An implantable electroacupuncture device (IEAD) treats depression, bipolar disorder or Anxiety through application of stimulation pulses applied at acupoints GV20 and/or EXHN3. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在穴位GV20和/或EXHN3处施加的刺激脉冲来治疗抑郁症，双相情感障碍或焦虑症。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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33.发明申请Methods and Systems for Treating Hypertension Using An Implantable Electroacupuncture Device 有权使用植入式电针装置治疗高血压的方法和系统公开(公告)号：US20150321007A1
公开(公告)日：2015-11-12
申请号：US14805355
申请日：2015-07-21
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
CPC classification number: A61N1/0504 , A61H39/002 , A61H2201/5005 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/3605 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10S128/907
Abstract: A method of treating hypertension in a patient includes 1) generating, by an electroacupuncture device implanted beneath a skin surface of the patient at an acupoint corresponding to a target tissue location within the patient, stimulation sessions at a duty cycle that is less than 0.05, wherein the duty cycle is a ratio of T3 to T4, each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes, and the electroacupuncture device comprises a central electrode of a first polarity and an annular electrode of a second polarity and that is spaced apart from the central electrode; and 2) applying, by the electroacupuncture device, the stimulation sessions to the target tissue location by way of the central electrode and the annular electrode in accordance with the duty cycle.
Abstract translation: 一种治疗患者的高血压的方法包括：通过植入患者皮肤表面下方的针刺装置，在对应于患者内的目标组织位置的穴位，产生小于0.05的占空比的刺激会话， 其特征在于，所述占空比为T3〜T4的比例，所述刺激对象中包含的每个刺激对象具有T3分钟的持续时间，以T4分钟为单位的速度发生，所述电针装置包括第一极性的中心电极， 第二极性的环形电极，与中心电极间隔开; 以及2）通过电针装置根据占空比通过中心电极和环形电极施加刺激会话到目标组织位置。
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34.发明授权Implantable electroacupuncture device and method for treating cardiovascular disease 有权植入式电针装置及治疗心血管疾病的方法公开(公告)号：US08938297B2
公开(公告)日：2015-01-20
申请号：US13622497
申请日：2012-09-19
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
CPC classification number: A61N1/362 , A61N1/36114 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782
Abstract: An implantable electroacupuncture device (IEAD) treats heart failure, coronary artery disease, myocardial ischemia or angina through application of stimulation pulses applied at acupoints GV20 and/or EXHN3. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio of T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在穴位GV20和/或EXHN3施加的刺激脉冲来治疗心力衰竭，冠状动脉疾病，心肌缺血或心绞痛。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 T3 / T4的占空比或比例非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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公开(公告)号：US20150012056A1
公开(公告)日：2015-01-08
申请号：US14446512
申请日：2014-07-30
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara
CPC classification number: A61N1/0504 , A61H39/002 , A61H2201/5005 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/3605 , A61N1/36117 , A61N1/36125 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10S128/907
Abstract: Disclosed is an implantable, coin-sized, self-contained, leadless electroacupuncture (EA) device having at least two electrode contacts attached to the surface of its housing. The electrodes include a central cathode electrode on a bottom side of the housing, and a circumferential anode electrode that surrounds the cathode electrode. In one embodiment, the anode annular electrode is a ring electrode placed around the perimeter edge of the coin-shaped housing. The EA device is adapted to be implanted through a very small incision, e.g., less than about 2-3 cm in length, directly adjacent to a selected acupuncture site known to moderate or affect a hypertension condition of a patient. Appropriate power management circuitry within the device allows a primary battery having a relatively high internal impedance to be used without causing unacceptable dips in battery voltage when the instantaneous battery current surges. Stimulation pulses are generated during a stimulation session that has a duration of T3 minutes and which is applied every T4 minutes. The duty cycle, or ratio of T3 to T4, is very low, not greater than 0.05. This low duty cycle, along with careful power management, allows the EA device to perform its intended function for several years.
Abstract translation: 公开了一种植入式，硬币大小的独立的无引线电针（EA）装置，其具有附接到其壳体表面的至少两个电极触点。 电极包括在壳体的底侧上的中央阴极电极和围绕阴极电极的周向阳极电极。 在一个实施例中，阳极环形电极是围绕硬币形壳体的周边边缘放置的环形电极。 EA装置适于通过非常小的切口植入，例如长度小于约2-3厘米，直接与已知中度或影响患者高血压状况的所选择的针灸部位相邻。 器件内的合适的电源管理电路允许使用具有相对较高的内部阻抗的一次电池，而不会在瞬间电池电流骤升时导致电池电压的不可接受的下降。 在刺激会话期间产生刺激脉冲，持续时间为T3分钟，每T4分钟应用一次。 T3到T4的占空比或比例很低，不大于0.05。 这个低占空比，以及仔细的电源管理，允许EA设备执行其预期功能几年。
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Patent Agency Ranking
36.发明申请公开(公告)号：US20140214127A1
公开(公告)日：2014-07-31
申请号：US13736041
申请日：2013-01-07
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
IPC: A61H39/00
CPC classification number: A61H39/002 , A61H2201/5035 , A61H2201/5038 , A61H2201/5097 , A61N1/3606 , A61N1/36085 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
Abstract: An Implantable ElectroAcupuncture Device (IEAD) treats dyslipidemia conditions of a patient through application of stimulation pulses applied at acupoint ST40, or its underlying nerves saphenous and peroneal. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加在穴位ST40施加的刺激脉冲或其潜伏的神经隐匿和腓骨来治疗患者的血脂异常状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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37.发明申请Implantable Electroacupuncture System and Method for Treating Dyslipidemia and Obesity 有权植入式电针系统及治疗脂血症和肥胖的方法公开(公告)号：US20140214125A1
公开(公告)日：2014-07-31
申请号：US13736033
申请日：2013-01-07
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
IPC: A61H39/00
CPC classification number: A61H39/002 , A61F5/0026 , A61H2201/50 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61N1/36085 , A61N1/36117 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49117
Abstract: An Implantable ElectroAcupuncture System (IEAS) treats dyslipidemia or obesity through application of stimulation pulses applied at at least one of acupoints ST36, SP4, ST37, ST40, SP6, SP9, K16, or LR8, or underlying nerves saphenous or peroneal. The IEAS includes an hermetically-sealed implantable electroacupuncture (EA) device having at least two electrodes located outside of its housing. The housing contains a primary power source, pulse generation circuitry, and a sensor that wirelessly senses externally-generated operating commands. The pulse generation circuitry generates stimulation pulses as controlled, at least in part, by the operating commands sensed through the sensor. The stimulation pulses are applied to the specified acupoint or nerve through the electrodes in accordance with a specified stimulation regimen. Such stimulation regimen requires that the stimulation session be applied at a very low duty cycle not greater than 0.05.
Abstract translation: 可植入电针刺系统（IEAS）通过施加在穴位ST36，SP4，ST37，ST40，SP6，SP9，K16或LR8中的至少一个或隐匿性或腓神经的下面的神经施加刺激脉冲来治疗血脂异常或肥胖。 IEAS包括密封的可植入电针（EA）装置，其具有位于其壳体外部的至少两个电极。 外壳包含主电源，脉冲发生电路和无线感应外部生成的操作命令的传感器。 脉冲产生电路至少部分地通过通过传感器感测的操作命令来产生刺激脉冲。 刺激脉冲根据指定的刺激方案通过电极施加到指定的穴位或神经。 这种刺激方案要求在非常低的占空比不大于0.05的情况下施用刺激会话。
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38.发明申请Implantable Electroacupuncture Device and Method for Treating Erectile Dysfunction 有权植入式电针装置及治疗勃起功能障碍的方法公开(公告)号：US20140214112A1
公开(公告)日：2014-07-31
申请号：US13784573
申请日：2013-03-04
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
CPC classification number: A61F5/41 , A61F2005/418 , A61H39/002 , A61H2201/5005 , A61H2201/5038 , A61H2201/5097 , A61H2205/087 , A61N1/18 , A61N1/36107 , A61N1/36125 , A61N1/36153 , A61N1/36157 , A61N1/36175 , A61N1/362 , A61N1/37205 , A61N1/375 , A61N1/3756 , A61N1/3758 , A61N1/3782 , Y10T29/49002
Abstract: An implantable electroacupuncture device (IEAD) treats an erectile dysfunction condition of a patient through application of stimulation pulses applied at a target tissue location underlying, or in the vicinity of, at least one of acupoints BL52, BL23 or GV4. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
Abstract translation: 可植入电针装置（IEAD）通过施加施加在穴位BL52，BL23或GV4中的至少一个穴位下方或附近的目标组织位置处的刺激脉冲来治疗患者的勃起功能障碍状况。 IEAD包括可植入的硬币大小的独立的无引线电针装置，其具有附接到其外壳的外表面的至少两个电极。 该设备根据指定的刺激方案产生刺激脉冲。 设备内的电源管理电路允许使用具有高内部阻抗的一次电池为设备供电。 刺激方案在每T4分钟施用持续时间T3分钟的刺激期间产生刺激脉冲。 占空比或比例T3 / T4非常低，不大于0.05。 低占空比和仔细的电源管理允许IEAD执行其预期功能几年。
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公开(公告)号：US11357984B2
公开(公告)日：2022-06-14
申请号：US16667346
申请日：2019-10-29
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Stacy Greiner Chambliss
Abstract: A method of treating osteoarthritis in a knee includes generating, by an implantable stimulator configured to be implanted beneath a skin surface of a patient, stimulation sessions at a duty cycle that is less than 0.05, and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a location that includes at least one of an acupoint labeled ST35, an acupoint labeled EX-LE-4, and a location on a line that intersects the acupoints labeled ST35 and EX-LE-4. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.
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公开(公告)号：US10792219B2
公开(公告)日：2020-10-06
申请号：US16394932
申请日：2019-04-25
Applicant: Valencia Technologies Corporation
Inventor： Jeffrey H. Greiner , David K. L. Peterson , Chuladatta Thenuwara , Stacy O. Greiner
Abstract: A method comprises generating, by an implantable stimulator, stimulation sessions at a duty cycle that is less than 0.05 and applying, by the implantable stimulator in accordance with the duty cycle, the stimulation sessions to a patient. The duty cycle is a ratio of T3 to T4. Each stimulation session included in the stimulation sessions has a duration of T3 minutes and occurs at a rate of once every T4 minutes. The implantable stimulator is powered by a primary battery located within the implantable stimulator and having an internal impedance greater than 5 ohms.
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