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31.发明授权Biologically compatible linear block copolymers of polyalkylene oxide and peptide units 失效生物相容的聚环氧烷和肽单元的线性嵌段共聚物
公开(公告)号：US5618528A
公开(公告)日：1997-04-08
申请号：US203106
申请日：1994-02-28
IPC分类号： A61K38/00 , A61K47/48 , A61K49/00 , C07K5/087 , C07K5/103 , C07K7/06 , C08G65/32 , A61K47/42 , C08G81/00
CPC分类号： C07K7/06 , A61K47/48215 , A61K47/48238 , A61K49/0002 , C07K5/0812 , C07K5/1005 , A61K38/00
摘要： A linear block copolymer comprising units of an alkylene oxide, linked to units of peptide via a linking group comprising a --CH.sub.2 CHOHCH.sub.2 N(R)-- moiety, is useful as an imaging agent, drug, prodrug or as a delivery system for imaging agents, drugs or prodrugs.
摘要翻译： 包含通过包含-CH 2 CHOHCH 2 N（R） - 部分的连接基团与肽单元连接的环氧烷单元的线性嵌段共聚物可用作成像剂，药物，前药或作为成像剂，药物的递送系统 或前药。
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32.发明授权
公开(公告)号：US4552872A
公开(公告)日：1985-11-12
申请号：US576065
申请日：1984-02-01
CPC分类号： A61K31/57 , A61K47/10 , A61K47/12 , A61K47/14 , A61K9/0014
摘要： Topical pharmaceutical compositions containing a corticosteroid component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C.sub.3 -C.sub.4 diol and a "cell-envelope disordering compound". The vehicle provides marked transepidermal and percutaneous delivery of corticosteroids. A method of treating certain rheumatic and inflammatory conditions, systemically or locally, is also disclosed.
摘要翻译： 公开了含有皮质类固醇成分和穿透增强载体的局部药物组合物。 载体包含C3-C4二醇和“细胞包膜无序化合物”的二元组合。 该车辆提供皮质类固醇的经皮皮肤和经皮皮肤输送。 还公开了一种系统地或局部地治疗某些风湿性和炎性疾病的方法。
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公开(公告)号：US20100016442A1
公开(公告)日：2010-01-21
申请号：US12503929
申请日：2009-07-16
申请人： David M. Cohen , Eugene R. Cooper
发明人： David M. Cohen , Eugene R. Cooper
IPC分类号： A61K31/164 , A61P25/04
CPC分类号： A61K31/164 , A61K9/0014 , A61K47/10 , A61K47/24 , A61K47/38
摘要： The invention relates to a drug delivery system for the topical administration of therapeutic agents.
摘要翻译： 本发明涉及用于局部施用治疗剂的药物递送系统。
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公开(公告)号：US07521068B2
公开(公告)日：2009-04-21
申请号：US09190138
申请日：1998-11-12
IPC分类号： A61K8/00 , A61K9/14 , A61K9/16 , A61K31/12 , A61K31/04 , A61K31/28 , A61K31/33 , A61K31/56 , A61K31/70 , A61K38/00 , A61K38/02
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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公开(公告)号：US07390505B2
公开(公告)日：2008-06-24
申请号：US10766960
申请日：2004-01-30
申请人： Evan Gustow , Tuula Ryde , Eugene R. Cooper
发明人： Evan Gustow , Tuula Ryde , Eugene R. Cooper
IPC分类号： A61K9/14 , A61K31/335 , A01N43/02
CPC分类号： A61K31/7048 , A61K9/145 , A61K9/146
摘要： The present invention is directed to nanoparticulate compositions comprising topiramate. The topiramate particles of the composition have an effective average particle size of less than about 2 microns.
摘要翻译： 本发明涉及包含托吡酯的纳米颗粒组合物。 组合物的托吡酯颗粒具有小于约2微米的有效平均粒度。
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36.发明授权X-ray contrast compositions containing an organic crystalline X-ray contrast agent and a cellulose derivative 失效含有有机晶体X射线造影剂和纤维素衍生物的X射线造影剂组合物
公开(公告)号：US5368837A
公开(公告)日：1994-11-29
申请号：US227423
申请日：1994-04-14
IPC分类号： A61K49/04
CPC分类号： A61K49/0433 , A61K49/0404 , A61K49/0409 , A61K49/0461 , Y10S514/941 , Y10S514/942
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a crystalline contrast agent in a pharmaceutically acceptable carrier comprising a cellulose derivative; and methods for their use in diagnostic radiology of the gastrointestinal tract.
摘要翻译： 公开了用于口服或逆行检查胃肠道的X射线造影剂组合物，其包含在包含纤维素衍生物的药学上可接受的载体中的结晶造影剂; 以及它们用于胃肠道诊断放射学的方法。
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37.发明授权Polymeric x-ray contrast compositions containing an organic crystalline x-ray contrast agent 失效含有有机结晶X射线造影剂的聚合X射线对比组合物
公开(公告)号：US5318768A
公开(公告)日：1994-06-07
申请号：US18606
申请日：1993-02-17
申请人： Carl R. Illig , Eugene R. Cooper
发明人： Carl R. Illig , Eugene R. Cooper
IPC分类号： A61K47/30 , A61K49/04 , A61K31/715
CPC分类号： A61K49/0442 , A61K49/0461 , B82Y5/00 , Y10S514/941 , Y10S514/942
摘要： Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material in combination with a divalent cation capable of forming a coating on the gastrointestinal tract and a crystalline contrast agent in a pharmaceutically acceptable carrier; and methods for their use in diagnostic radiology of the gastrointestinal tract.
摘要翻译： 公开了用于口腔或逆行检查胃肠道的x射线造影剂组合物，其包含与能够在胃肠道上形成涂层的二价阳离子和药学上可接受的载体中的结晶造影剂的聚合物材料; 以及它们用于胃肠道诊断放射学的方法。
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38.发明授权Compositions of iodophenoxy alkanes and iodophenyl ethers for visualization of the gastrointestinal tract 失效碘苯氧基烷烃和碘苯醚的组合物，用于胃肠道的可视化
公开(公告)号：US5316755A
公开(公告)日：1994-05-31
申请号：US12189
申请日：1993-02-02
申请人： Carl R. Illig , Eugene R. Cooper , John L. Toner , Donald A. Upson , Brent D. Douty , Thomas J. Caulfield , Edward R. Bacon , Kimberly G. Estep , Kurt A. Josef , Shaughnessy Robinson , Paul P. Spara
发明人： Carl R. Illig , Eugene R. Cooper , John L. Toner , Donald A. Upson , Brent D. Douty , Thomas J. Caulfield , Edward R. Bacon , Kimberly G. Estep , Kurt A. Josef , Shaughnessy Robinson , Paul P. Spara
IPC分类号： A61K49/00 , A61K49/04 , C07C43/225 , C07C43/247 , C07C255/54 , A61K31/085
CPC分类号： A61K49/0404 , A61K49/04 , A61K49/0409 , A61K49/0433 , Y10S514/941 , Y10S514/942
摘要： Disclosed are contrast agents of the formula ##STR1## contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract whereinZ=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups;R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy,(CR.sub.1 R.sub.2).sub.p -(CR.sub.3 =CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p -C.ident.C-Q; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently lower-alkyl, optionally substituted with halo;x is 1-4;n is 1-5;m is 1-15;p is 1-10; andQ is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl.
摘要翻译： 公开了含水组合物中含有的式“IMAGE”的造影剂及其用于胃肠道诊断放射学的方法，其中Z = H，卤素，C 1 -C 20烷基，环烷基，低级烷氧基，氰基，其中烷基和环烷基 基团可以被卤素或卤代低级烷基取代; R = C1-C25烷基，环烷基或卤代低级烷基，任选被卤素，氟 - 低级 - 烷基，芳基，低级烷氧基，羟基，羧基，低级烷氧基羰基或低级 - 烷氧基 - 羰氧基取代，（CR1R2 ）p（CR 3 = CR 4）mQ，或（CR 1 R 2）p C = CQ; R 1，R 2，R 3和R 4独立地为低级烷基，任选被卤素取代; x为1-4; n为1-5; m为1-15; p为1-10; 并且Q是H，低级烷基，低级烯基，低级炔基，低级亚烷基，芳基或芳基 - 低级烷基。
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公开(公告)号：US4954487A
公开(公告)日：1990-09-04
申请号：US312354
申请日：1989-02-15
CPC分类号： A61K9/0014 , A61K47/10 , A61K47/14 , Y10S514/947
摘要： A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C.sub.3 -C.sub.4 diol, diol ester, or diol ether and (2) a cell envelope-disordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.
摘要翻译： 通过将它们局部应用于含有（1）C 3 -C 4二醇，二醇酯或二醇醚的二元渗透增强载体中，可将大量亲脂性，药理学活性化合物有效递送至完整皮肤，（2）细胞 包络无序化合物。 与单独的组分相比，该载体提供令人惊奇的增强药理活性物质的皮肤渗透性。
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公开(公告)号：US09050293B2
公开(公告)日：2015-06-09
申请号：US12503929
申请日：2009-07-16
申请人： David M. Cohen , Eugene R. Cooper
发明人： David M. Cohen , Eugene R. Cooper
IPC分类号： A61K31/164 , A61K9/00 , A61K47/10 , A61K47/24 , A61K47/38
CPC分类号： A61K31/164 , A61K9/0014 , A61K47/10 , A61K47/24 , A61K47/38
摘要： The invention provides a drug delivery system for the topical administration of therapeutic agents, including therapeutic agent in an amount between 0.001 and 20% by weight, propylene glycol in an amount between 2 and 6% by weight, oleyl alcohol in an amount between 2 and 6% by weight, and a volatile component in an amount between 60 and 95% by weight.
摘要翻译： 本发明提供了用于局部施用治疗剂的药物递送系统，其包括0.001至20重量％的量的治疗剂，量为2至6重量％的丙二醇，量为2至6重量％的油醇 6重量％，挥发性成分为60〜95重量％。
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