公开(公告)号：US09044600B2

公开(公告)日：2015-06-02

申请号：US13087096

申请日：2011-04-14

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00 ,  H05H7/10 ,  H05H13/04 ,  A61N5/10

CPC classification number: A61N5/10 ,  A61N2005/1061 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates to a method and apparatus for charged particle tomographic imaging using a tomography system. The tomography imaging system is optionally simultaneously operational with a charged particle cancer therapy system using common elements, allows tomographic imaging with rotation of the patient, is operational on a patient in an upright, semi-upright, and/or horizontal position, is simultaneously operational with X-ray imaging, and/or allows use of adaptive charged particle cancer therapy. The common tomography and cancer therapy apparatus elements are operational in a multi-axis and/or multi-field raster beam mode.

Abstract translation: 本发明涉及使用断层摄影系统的带电粒子断层成像的方法和装置。 层析成像系统可选地与使用共同元件的带电粒子癌治疗系统同时操作，允许患者旋转的层析成像在直立，半直立和/或水平位置的患者上操作，同时操作 通过X射线成像，和/或允许使用适应性带电粒子癌症治疗。 常见的断层摄影和癌症治疗装置元件在多轴和/或多场光栅束模式中可操作。

公开(公告)号：US20140139147A1

公开(公告)日：2014-05-22

申请号：US13679770

申请日：2012-11-16

Applicant: Vladimir Balakin ,  Yury Valyaev

Inventor： Vladimir Balakin ,  Yury Valyaev

IPC: H05H7/04 ,  A61N5/10

CPC classification number: H05H7/04 ,  A61N5/1077 ,  H05H13/04

Abstract: The invention comprises a flattened magnet coil system that reduces space between a first magnet turning section and a second magnet turning section in a synchrotron accelerator, which reduces or eliminates need for one or more quadrupole focusing elements in the accelerator. Optionally, a coil, in the flattened magnetic coil system, is wrapped about a central metal member between yoke members of a magnet. The coil has a first width and a first thickness along the length of the magnet and a second width and a second thickness along the end of the magnet where the first width is larger than the second width and the second thickness is larger than the first thickness allowing a smaller distance between the first magnet turning section and the second magnet turning section while maintaining current flow in the coil.

Abstract translation: 本发明包括一个扁平化的磁体线圈系统，其减小同步加速器中的第一磁体转动部分和第二磁体转动部分之间的空间，这减少或消除了对加速器中的一个或多个四极聚焦元件的需要。 可选地，平坦化的电磁线圈系统中的线圈围绕磁体的轭构件之间的中心金属构件缠绕。 线圈沿着磁体的长度具有第一宽度和第一厚度，沿着磁体的端部具有第二宽度和第二厚度，其中第一宽度大于第二宽度，第二厚度大于第一厚度 允许第一磁体转动部分和第二磁体转动部分之间的距离更小，同时保持线圈中的电流。

公开(公告)号：US08710462B2

公开(公告)日：2014-04-29

申请号：US12785434

申请日：2010-05-22

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/10 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises a charged particle beam path coupling an injector, synchrotron accelerator, beam transport system, targeting system, and/or patient interface method and apparatus. Preferably, the injector comprises: a negative ion beam source, a two phase ion source vacuum system, an ion beam focusing lens, and/or a tandem accelerator. Preferably, the synchrotron comprises turning magnets, edge focusing magnets, magnetic field concentration magnets, winding and correction coils, flat magnetic field incident surfaces, and/or extraction elements. Preferably, the synchrotron, beam transport system, targeting system, and patient interface combine to allow multi-axis/multi-field irradiation, where multi-axis control comprises control of horizontal and vertical beam position, beam energy, and/or beam intensity and multi-field control comprises control of patient rotation and distribution of delivered energy in and about the tumor in a time controlled, targeted, accurate, precise, dosage controlled, and/or efficient manner.

Abstract translation: 本发明包括连接注射器，同步加速器，束输送系统，靶向系统和/或患者接口方法和装置的带电粒子束路径。 优选地，喷射器包括：负离子束源，两相离子源真空系统，离子束聚焦透镜和/或串联加速器。 优选地，同步加速器包括转动磁体，边缘聚焦磁体，磁场集中磁体，绕组和校正线圈，平坦磁场入射表面和/或提取元件。 优选地，同步加速器，光束传输系统，靶向系统和患者接口组合以允许多轴/多场照射，其中多轴控制包括水平和垂直光束位置，光束能量和/或光束强度的控制，以及 多场控制包括以时间控制的，靶向的，准确的，精确的，剂量控制的和/或有效的方式来控制患者旋转和在肿瘤中和周围分布的能量。

公开(公告)号：US08642978B2

公开(公告)日：2014-02-04

申请号：US12687387

申请日：2010-01-14

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/107 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1081 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates generally to treatment of solid cancers. More particularly, a method and apparatus for efficient radiation dose delivery to a tumor is described. Preferably, radiation is delivered through an entry point into the tumor and Bragg peak energy is targeted to a distal or far side of the tumor from an ingress point. Delivering Bragg peak energy to the distal side of the tumor from the ingress point is repeated from multiple rotational directions. Beam intensity is proportional to radiation dose delivery efficiency. The multi-field irradiation process with energy levels targeting the far side of the tumor from each irradiation direction provides even and efficient charged particle radiation dose delivery to the tumor. Preferably, the charged particle therapy is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，描述了用于向肿瘤有效辐射剂量递送的方法和装置。 优选地，辐射通过入口点输送到肿瘤中，并且布拉格峰值能量靶向肿瘤的远端或远侧与进入点。 从入口点向肿瘤的远端侧提供布拉格峰值能量从多个旋转方向重复。 光束强度与辐射剂量传递效率成正比。 具有针对每个照射方向的肿瘤远侧的能级的多场照射过程提供均匀且有效的带电粒子辐射剂量递送至肿瘤。 优选地，带电粒子治疗通过控制带电粒子束注射，加速，提取和/或靶向方法和装置来计时到患者呼吸。

公开(公告)号：US08627822B2

公开(公告)日：2014-01-14

申请号：US12493205

申请日：2009-06-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A47B13/00 ,  A47C20/00 ,  A61G15/00 ,  A61F5/37 ,  A61F13/00 ,  G01K1/08 ,  H01J3/14 ,  H01J3/26 ,  G21K5/00 ,  A61N5/10 ,  G21K5/08 ,  G21K5/10

CPC classification number: A61N5/10 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention comprises a semi-vertical patient positioning, alignment, and/or control method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. Patient positioning constraints are used to maintain the patient in a treatment position, including one or more of: a seat support, a back support, a head support, an arm support, a knee support, and a foot support. One or more of the positioning constraints are movable and/or under computer control for rapid positioning and/or immobilization of the patient. The system optionally uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子或质子束放射治疗结合使用的半垂直患者定位，对准和/或控制方法和装置。 患者定位限制用于将患者维持在治疗位置，包括以下中的一个或多个：座椅支撑件，背部支撑件，头部支撑件，手臂支撑件，膝盖支撑件和脚部支撑件。 一个或多个定位限制是可移动的和/或在计算机控制下，用于病人的快速定位和/或固定。 系统可选地使用位于与粒子束癌治疗系统的质子束路径基本相同的路径中的X射线束。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US08625739B2

公开(公告)日：2014-01-07

申请号：US13214065

申请日：2011-08-19

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  H05G1/02

CPC classification number: A61N5/00 ,  H05K999/00

Abstract: The invention comprises an X-ray method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子或质子束放射治疗结合使用的X射线方法和装置。 该系统使用位于与粒子束癌治疗系统的质子束路径基本相同的路径上的X射线束。 该系统产生电子束，该电子束撞击X射线产生源，其中X射线产生源位于质子束路径附近。 通过在质子束路径附近产生X射线，产生基本上是质子束路径的X射线路径。 使用生成的X射线，系统收集关于癌性肿瘤的局部的身体组织区域的X射线图像。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US08519365B2

公开(公告)日：2013-08-27

申请号：US13033293

申请日：2011-02-23

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/04

CPC classification number: A61N5/1049 ,  A61N5/10 ,  A61N5/1064 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates to a method and apparatus for treatment of a solid tumor. More particularly, the invention comprises a multi-axis and/or multi-field charged particle cancer therapy system. In one embodiment, the tumor is imaged from multiple directions in phase with patient respiration. The two-dimensional images are combined to produce a three-dimensional picture of the tumor relative to patient features. The resulting three-dimensional image is used in generation of a radiation treatment plan and subsequent radiation therapy with the radiation beam in terms of control of two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, and/or beam velocity each as a function of patient vertical translation position, patient rotation position, and/or patient respiration.

Abstract translation: 本发明涉及一种治疗实体瘤的方法和装置。 更具体地，本发明包括多轴和/或多场带电粒子癌症治疗系统。 在一个实施方案中，肿瘤与患者呼吸同时从多个方向成像。 组合二维图像以产生相对于患者特征的肿瘤的三维图像。 所产生的三维图像用于产生放射治疗计划和随后用辐射束进行的放射治疗，就控制二维束轨迹，输送束能量，输送束强度和/或束速度而言，每一个作为 患者垂直平移位置，患者旋转位置和/或患者呼吸的功能。

公开(公告)号：US08421041B2

公开(公告)日：2013-04-16

申请号：US13456945

申请日：2012-04-26

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: G21K1/087 ,  A61N2005/1087 ,  G21K1/093 ,  H05H7/04 ,  H05H7/12

Abstract: The invention comprises intensity control of a charged particle beam acceleration, extraction, and/or targeting method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Particularly, intensity of a charged particle stream of a synchrotron is described. Intensity control is described in combination with turning magnets, edge focusing magnets, concentrating magnetic field magnets, winding and control coils, and extraction elements of the synchrotron. The system reduces the overall size of the synchrotron, provides a tightly controlled proton beam, directly reduces the size of required magnetic fields, directly reduces required operating power, and allows continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束加速度，提取和/或靶向方法和装置的强度控制。 特别地，描述了同步加速器的带电粒子流的强度。 强度控制与旋转磁体，边缘聚焦磁铁，集中磁场磁体，绕组和控制线圈以及同步加速器的提取元件相结合来描述。 该系统减小同步加速器的总体尺寸，提供严格控制的质子束，直接减小所需磁场的尺寸，直接降低所需的操作功率，并且允许在同步加速器中质子的连续加速，即使在从质子中提取质子的过程中 同步加速器

公开(公告)号：US08415643B2

公开(公告)日：2013-04-09

申请号：US13290068

申请日：2011-11-05

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H13/04 ,  A61N5/10 ,  A61N2005/1074 ,  A61N2005/1087 ,  H05H7/04 ,  H05H7/10

Abstract: The invention comprises a charged particle beam acceleration and/or extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束加速和/或提取方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了旋转磁体，边缘聚焦磁体和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减小所需磁场的尺寸，直接减少所需的操作功率，并且允许连续加速 甚至在从同步加速器提取质子的过程中同步加速器中的质子。

公开(公告)号：US08373143B2

公开(公告)日：2013-02-12

申请号：US12636725

申请日：2009-12-12

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61B6/03 ,  A61B6/04

CPC classification number: H05H7/10 ,  A61N5/1049 ,  A61N2005/1087 ,  A61N2005/1097 ,  H05H13/04

Abstract: This invention relates generally to treatment of solid cancers. More particularly, the invention relates to a computer controlled patient positioning, immobilization, and repositioning method and apparatus used in conjunction with multi-field charged particle cancer therapy coordinated with patient respiration patterns and further in combination with charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地说，本发明涉及一种计算机控制的患者定位，固定和重新定位方法和装置，与多场带电粒子癌症治疗结合使用，与患者呼吸模式协调，并且进一步与带电粒子束注射，加速，提取， 和/或靶向方法和装置。