公开(公告)号：US3985766A

公开(公告)日：1976-10-12

申请号：US873098

申请日：1969-10-31

申请人： Erik Regel ,  Karl Heinz Buchel ,  Manfred Plempel

发明人： Erik Regel ,  Karl Heinz Buchel ,  Manfred Plempel

IPC分类号： C07D233/54 ,  C07D233/62 ,  C07D235/06 ,  C07D235/18 ,  C07D521/00 ,  C07D233/56

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D235/06 ,  C07D235/18 ,  C07D249/08

摘要： Bis-imidazolyl-bisphenylmethane derivatives and pharmaceutically acceptable non-toxic salts thereof are useful as antimycotics especially against dermatomycosis caused by Trichophyton and Microsporium species and also against yeast infections of the skin and internal organs.

摘要翻译： 双咪唑基 - 双苯基甲烷衍生物及其药学上可接受的无毒盐可用作抗霉菌剂，特别是针对由毛癣菌和微孢子菌引起的皮肤真菌病，并且还可用于皮肤和内脏器官的酵母菌感染。

公开(公告)号：US3980780A

公开(公告)日：1976-09-14

申请号：US554203

申请日：1975-02-28

申请人： Wilfried Draber ,  Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

发明人： Wilfried Draber ,  Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

IPC分类号： A61K31/495 ,  A61K31/505 ,  C07D241/12 ,  C07D403/06

CPC分类号： C07D403/06 ,  A61K31/495 ,  A61K31/505 ,  C07D241/12

摘要： N-methyl-imidazole derivatives of the formula: ##EQU1## or a pharmaceutically acceptable non-toxic salt thereof, wherein X is an unsubstituted or substituted 6-membered heteroaromatic moiety having two nitro heteroatoms,Y is an unsubstituted or substituted aliphatic moiety, an unsubstituted or substituted cycloaliphatic moiety, an unsubstituted or substituted aralkyl moiety or an unsubstituted or substituted aryl moiety, andZ is an unsubstituted or substituted aliphatic moiety, an unsubstituted or substituted cycloaliphatic moiety, an unsubstituted or substituted aralkyl moiety, an unsubstituted or substituted aryl moiety, an unsubstituted or substituted pyridyl moiety or an alkoxycarbonyl moiety,Are useful as antimycotic agents.

摘要翻译： 其中X是具有两个硝基杂原子的未取代或取代的6元杂芳族部分，Y是未取代的或未取代的或未取代的 取代的脂族部分，未取代或取代的脂环族部分，未取代或取代的芳烷基部分或未取代或取代的芳基部分，Z是未取代或取代的脂族部分，未取代或取代的脂环族部分，未取代或取代的芳烷基部分， 未取代或取代的芳基部分，未取代或取代的吡啶基部分或烷氧基羰基部分，作为抗菌剂有用。

公开(公告)号：US4499281A

公开(公告)日：1985-02-12

申请号：US352689

申请日：1982-02-26

申请人： Graham Holmwood ,  Erik Regel

发明人： Graham Holmwood ,  Erik Regel

IPC分类号： C07D405/06 ,  A01N43/653 ,  C07D249/08 ,  C07D521/00 ,  A01N43/64

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： A substituted triazolylmethyl-oxirane of the formula ##STR1## in which R is optionally substituted alkyl, aryl or cycloalkyl is prepared by reacting a triazolyl-ketone of the formula ##STR2## with (a) dimethyloxosulphonium methylide of the formula ##STR3## or (b) trimethylsulphonium methylsulphate of the formula[(CH.sub.3).sub.3 S].sup..sym. CH.sub.3 SO.sub.4.sup..crclbar.in the presence of a diluent.The end product can then be reacted with a phenol of the formulaR"--OHto produce known fungicidally active compounds of the formula ##STR4## in which R" is optionally substituted phenyl.

摘要翻译： 其中R为任选取代的烷基，芳基或环烷基的取代三唑基甲基 - 环氧乙烷通过使式（IMAGE）的三唑基酮与（a）式（IMAGE）的二甲基氧基锍甲基化物或（ b）在稀释剂存在下，式[（CH3）3S]（+）CH3SO4（ - ）的三甲基锍甲基硫酸盐。 然后可以使最终产物与式R“-OH的酚反应以产生已知的具有式”IMAGE“的杀真菌活性化合物，其中R”为任选取代的苯基。

公开(公告)号：US4251540A

公开(公告)日：1981-02-17

申请号：US73171

申请日：1979-09-06

申请人： Erik Regel ,  Wilfried Draber ,  Karl H. Buchel ,  Peter Kraus ,  Wilhelm Brandes

发明人： Erik Regel ,  Wilfried Draber ,  Karl H. Buchel ,  Peter Kraus ,  Wilhelm Brandes

IPC分类号： C07D233/56 ,  A01N43/50 ,  A01N43/653 ,  A61K31/41 ,  A61K31/415 ,  A61P31/04 ,  C07D233/58 ,  C07D233/60 ,  C07D233/62 ,  A01N43/56

CPC分类号： A01N43/50 ,  A01N43/653

摘要： .alpha.-(4-Biphenylyl)-benzyl-azolium salts of the formula ##STR1## in which A is CH or N,R.sup.1 and R.sup.2 each independently is hydrogen, alkyl or optionally substituted phenyl,R.sup.3 is hydrogen, alkyl or optionally substituted phenyl, phenylalkyl, phenylcarbonyl or phenylcarbonylalkyl,m is 0, 1, 2, 3, 4 or 5,X each independently is halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro or cyano,n is 0, 1, 2, 3, 4 or 5,Y each independently is halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro, cyano or phenyl which is optionally substituted by halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro or cyano, andZ is the anion of an inorganic or organic acid,are used to combat fungi.

摘要翻译： 其中A为CH或N，R 1和R 2各自独立地为氢，烷基或任选取代的苯基，R 3为氢，烷基或任选取代的苯基，式（II） 苯基烷基，苯基羰基或苯基羰基烷基，m为0,1,2,3,4或5，X各自独立地为卤素，烷基，卤代烷基，烷氧基，烷硫基，硝基或氰基，n为0,1,2,3,4或 5，Y各自独立地是卤素，烷基，卤代烷基，烷氧基，烷硫基，硝基，氰基或苯基，其任选被卤素，烷基，卤代烷基，烷氧基，烷硫基，硝基或氰基取代，Z是无机或有机 酸，用于对抗真菌。

公开(公告)号：US4174398A

公开(公告)日：1979-11-13

申请号：US882833

申请日：1978-03-02

申请人： Erik Regel ,  Paul-Ernst Frohberger ,  Volker Paul

发明人： Erik Regel ,  Paul-Ernst Frohberger ,  Volker Paul

IPC分类号： A01N47/36 ,  C07D285/12 ,  C07D285/135 ,  A01N9/12

CPC分类号： C07D285/135 ,  A01N47/36

摘要： 1-Alkyl-1-(1,3,4-thiadiazol-2-yl)-3-phenyl-ureas of the formula ##STR1## in which R.sup.1 is alkyl,R.sup.2 is phenyl or substituted phenyl, andX is hydrogen or halogen,which possess fungicidal properties.

摘要翻译： 其中R1是烷基，R2是苯基或取代的苯基，X是氢或卤素的1-烷基-1-（1,3,4-噻二唑-2-基）-3-苯基脲，其中R1是烷基， ，具有杀菌性。

公开(公告)号：US4904296A

公开(公告)日：1990-02-27

申请号：US121552

申请日：1987-11-17

申请人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

发明人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D303/22 ,  C07D303/34 ,  C07D405/06 ,  C07D521/00

CPC分类号： C07D303/22 ,  A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Compounds which are substituted 1-hydroxyalkylazolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group, Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.

公开(公告)号：US4875928A

公开(公告)日：1989-10-24

申请号：US792089

申请日：1985-10-28

申请人： Erik Regel ,  Klaus Bockmann ,  Karl H. Buchel ,  Klaus Lurssen ,  Wilhelm Brandes ,  Jorg Konze ,  Paul Reinecke

发明人： Erik Regel ,  Klaus Bockmann ,  Karl H. Buchel ,  Klaus Lurssen ,  Wilhelm Brandes ,  Jorg Konze ,  Paul Reinecke

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D333/00 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D521/00

CPC分类号： C07D231/12 ,  A01N43/50 ,  A01N43/653 ,  C07D233/56 ,  C07D249/08 ,  Y02P60/246

摘要： Substituted azolylcyclopropyl-azolylmethyl-carbinol derivatives of the formula ##STR1## in which Ar is optionally substituted aryl or optionally substituted heteroaryl,R is hydrogen, alkyl, alkenyl, alkinyl, trialkylsilyl, optionally substituted phenylalkyl or an acyl radical, andX and Y each independently is a nitrogen atom or a CH group,and addition products thereof with acids and metal salts are effective in regulating plant growth and combating fungi. New intermediates are described, some of which are themselves active.

摘要翻译： 其中Ar是任选取代的芳基或任选取代的杂芳基，R是氢，烷基，烯基，炔基，三烷基甲硅烷基，任选取代的苯基烷基或酰基，以及X和Y各自独立地取代的具有式“IMAGE”的唑基环丙基 - 甲基 - 甲醇衍生物 独立地是氮原子或CH基团，其与酸和金属盐的加成产物在调节植物生长和对抗真菌中是有效的。 描述了新的中间体，其中一些本身是活性的。

公开(公告)号：US4868196A

公开(公告)日：1989-09-19

申请号：US859276

申请日：1986-05-02

申请人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Klaus Lurssen

发明人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Klaus Lurssen

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D521/00

CPC分类号： C07D231/12 ,  A01N43/50 ,  A01N43/653 ,  C07D233/56 ,  C07D249/08

摘要： Compounds which are ether derivatives of substituted 1-hydroxyalkyl-azoles, of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R.sup.1 represents a substituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl radical or, if either A represents a nitrogen atom, or if A represents the CH group and at the same B represents oxygen or sulphur, R.sup.1 also represents an unsubstituted alkyl radical,R.sup.2 represents an alkyl, alkenyl, alkinyl, optionally substituted phenyl or optionally substituted benzyl radical,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy radical andm is 0, 1, 2 or 3,and acid addition salts and metal salt complexes thereof, are novel, are prepared as described, and find use as fungicides and as agents for regulating plant growth.

摘要翻译： 作为其中A表示氮原子或CH基团的通式为：（I）的取代的1-羟基烷基 - 唑的醚衍生物的化合物，B表示氧，硫或CH2基，R1表示取代的烷基 ，任选取代的环烷基或任选取代的苯基，或者如果A表示氮原子，或者如果A表示CH基团，而相同的B表示氧或硫，则R1还表示未取代的烷基，R2表示烷基，烯基 烷氧基，烷硫基，卤代烷基，卤代烷氧基，卤代烷硫基，任选取代的苯氧基，任意取代的苯基烷基或任意取代的苯基烷氧基，m为0， 1,2或3及其酸加成盐和金属盐络合物是新颖的，按照所述制备，可用作杀真菌剂和如年龄 用于调节植物生长。

公开(公告)号：US4797499A

公开(公告)日：1989-01-10

申请号：US895089

申请日：1986-08-11

申请人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

发明人： Graham Holmwood ,  Erik Regel ,  Gerhard Jager ,  Karl H. Buchel ,  Klaus Lurssen ,  Paul-Ernst Frohberger ,  Wilhelm Brandes ,  Volker Paul

IPC分类号： A01N43/50 ,  A01N43/653 ,  C07D233/60 ,  C07D249/08 ,  C07D303/22 ,  C07D303/34 ,  C07D405/06 ,  C07D521/00 ,  C07D303/08

CPC分类号： C07D303/22 ,  A01N43/50 ,  A01N43/653 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Compounds which are substituted 1-hydroxyalkyl-azolyl derivatives of the general formula ##STR1## in which A represents a nitrogen atom or a CH group,B represents oxygen, sulphur or a CH.sub.2 group,R represents substituted alkyl, and, in the case in which B represents sulphur, also represents an unsubstituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl group,Z represents a halogen atom or an alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl or optionally substituted phenylalkoxy group, andm is 0, 1, 2 or 3,and the acid addition salts and metal salt complexes thereof, are new, are prepared as described and find use as fungicides and plant growth regulators.

摘要翻译： 化合物，其中A表示氮原子或CH基团，B表示氧，硫或CH2基团，其中R表示取代的烷基，且表示取代的烷基， B代表硫的情况也代表未取代的烷基，任选取代的环烷基或任选取代的苯基，Z代表卤素原子或烷基，环烷基，烷氧基，烷硫基，卤代烷基，卤代烷氧基，卤代烷硫基，任选取代的苯基， 苯氧基，任选取代的苯基烷基或任选取代的苯基烷氧基，m为0,1,2或3，其酸加成盐和金属盐络合物是新的，如上所述制备，可用作杀真菌剂和植物生长调节剂。

公开(公告)号：US4618619A

公开(公告)日：1986-10-21

申请号：US589613

申请日：1984-03-14

申请人： Erik Regel ,  Karl H. Buchel ,  Paul Reinecke ,  Wilhelm Brandes

发明人： Erik Regel ,  Karl H. Buchel ,  Paul Reinecke ,  Wilhelm Brandes

IPC分类号： A01N31/14 ,  A01N31/00 ,  A01N31/02 ,  A01N33/04 ,  A01N33/08 ,  A01N43/48 ,  A01N43/50 ,  A01N43/56 ,  A01N43/64 ,  A01N43/653 ,  C07D249/08 ,  C07D303/22 ,  C07D303/24 ,  C07D303/34 ,  C07D303/36 ,  C07D521/00

CPC分类号： C07D303/22 ,  A01N43/50 ,  A01N43/56 ,  A01N43/653 ,  C07C323/00 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D303/24 ,  C07D303/34 ,  C07D303/36

摘要： A method of combating plant pathogenic fungi which comprises administering to such fungi or to a habitat thereof a plant pathogenic fungicidally effective amount of a substituted tert.-butanol derivative of the formula ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 are identical or different and represent azolyl, optionally substituted phenoxy, optionally substituted phenylthio, alkylthio, alkenyl, alkinyl, optionally substituted phenylacetylenyl, alkylamino, dialkylamino, optionally substituted phenylamino, optionally substituted phenyl-N-alkyl-amino, optionally substituted cycloalkylamino, optionally substituted cycloalkyl-N-alkyl-amino, aminoethoxy, alkylaminoethoxy or dialkylaminoethyoxy,or an acid addition salt or metal salt complex thereof.

摘要翻译： 一种防治植物致病真菌的方法，其包括向所述真菌或其栖息地施用植物病原真菌有效量的式（I）的取代的叔丁醇衍生物，其中R 1，R 2和R 3相同 任选取代的苯基乙酰基，烷基氨基，二烷基氨基，任选取代的苯基氨基，任选取代的苯基-N-烷基 - 氨基，任选取代的环烷基氨基，任选取代的环烷基 - N-烷基 - 氨基，氨基乙氧基，烷基氨基乙氧基或二烷基氨基乙氧基，或其酸加成盐或金属盐络合物。