公开(公告)号：US20240132584A1

公开(公告)日：2024-04-25

申请号：US18348244

申请日：2023-07-05

Applicant: Xencor, Inc.

Inventor： Matthew S. Faber ,  Sung-Hyung Lee ,  Yoon Kyung Kim ,  Jing Qi ,  Kendra N. Avery ,  Seung Y. Chu ,  Alex Nisthal ,  Matthew J. Bernett ,  John R. Desjarlais ,  Chad Borchert

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/46 ,  C12N15/63

CPC classification number: C07K16/28 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/468 ,  C12N15/63

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

公开(公告)号：US20230365717A1

公开(公告)日：2023-11-16

申请号：US18308623

申请日：2023-04-27

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K16/468 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/2818 ,  C07K16/3061 ,  A61K2039/505

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20230146665A1

公开(公告)日：2023-05-11

申请号：US17815194

申请日：2022-07-26

Applicant: Xencor, Inc.

Inventor： Alex Nisthal ,  John Desjarlais ,  Gregory Moore ,  Sung-Hyung Lee

IPC: C07K14/54

CPC classification number: C07K14/54 ,  C07K2319/30

Abstract: Provided herein are IL18-Fc fusion proteins that include an empty-Fc domain and an IL18 protein connected to another Fc domain. Also provided herein are additional are IL18-Fc fusion proteins such as IL18 x Fab-Fc fusion proteins that include a first monomer containing an IL18 protein connected to a first Fc domain, a second monomer containing a variable heavy chain connected to a second Fc domain, and a variable light chain, such that the variable heavy and light chains form an empty Fab. Various variant IL18 proteins with modifications to reduce heterogeneity and/or reduce affinity/potency and/or improve stability and/or improve production yield are also described.

公开(公告)号：US20220289839A1

公开(公告)日：2022-09-15

申请号：US17690702

申请日：2022-03-09

Applicant: Xencor, Inc.

Inventor： Matthew S. Faber ,  Sung-Hyung Lee ,  Yoon Kyung Kim ,  Jing Qi ,  Kendra N. Avery ,  Seung Y. Chu ,  Alex Nisthal ,  Matthew J. Bernett ,  John R. Desjarlais ,  Chad Borchert

IPC: C07K16/28 ,  C07K16/46 ,  A61P35/00 ,  C12N15/63

Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

公开(公告)号：US20220162343A1

公开(公告)日：2022-05-26

申请号：US17542342

申请日：2021-12-03

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30 ,  C07K16/40

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20200317814A1

公开(公告)日：2020-10-08

申请号：US16805453

申请日：2020-02-28

Applicant: Xencor, Inc.

Inventor： Rumana Rashid ,  Umesh S. Muchhal ,  Gregory Moore ,  Alex Nisthal ,  Seung Chu ,  Sung-Hyung Lee ,  Yoon Kyung Kim

IPC: C07K16/40 ,  C07K16/46 ,  C07K16/28 ,  C12N15/63

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).

公开(公告)号：US10259887B2

公开(公告)日：2019-04-16

申请号：US15141350

申请日：2016-04-28

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20180282432A1

公开(公告)日：2018-10-04

申请号：US15945679

申请日：2018-04-04

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US09850320B2

公开(公告)日：2017-12-26

申请号：US15185958

申请日：2016-06-17

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/00 ,  C07K16/46 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention is directed to novel heterodimeric antibodies.

公开(公告)号：US20170081424A1

公开(公告)日：2017-03-23

申请号：US15186167

申请日：2016-06-17

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/46 ,  C07K16/30 ,  C07K16/40 ,  C07K16/28

CPC classification number: C07K16/468 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention is directed to novel heterodimeric antibodies.