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公开(公告)号：US20100198308A1
公开(公告)日：2010-08-05
申请号：US12696914
申请日：2010-01-29
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36135 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/36592
摘要： Neurostimulation to mitigate lung wetness is delivered to a patient based on a sensed parameter indicative of lung wetness. The neurostimulation is configured to at least one of increase parasympathetic activity or decrease sympathetic activity within the patient. In some examples, a patient response to the neurostimulation therapy may be detected to modify the neurostimulation therapy. The patient response may include, for example, changes in the contractility of a heart of the patient, changes in the heart rate, heart rate variability or blood pressure of the patient, changes in a bladder size of the patient, changes in bladder functional activity of the patient, changes in urine flow, changes in lung function, changes in lung composition, or changes in the nerve activity of the patient.
摘要翻译： 基于指示肺湿度的感测参数将减轻肺湿润的神经刺激递送给患者。 神经刺激被配置成在患者体内增加副交感神经活动或减少交感神经活动中的至少一种。 在一些实例中，可以检测患者对神经刺激疗法的反应以修饰神经刺激疗法。 患者反应可以包括例如患者的心脏的收缩性变化，心率的改变，患者的心率变异性或血压，患者的膀胱尺寸的变化，膀胱功能活动的变化 的患者，尿流量的变化，肺功能的变化，肺组成的变化或患者的神经活动的变化。
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公开(公告)号：US20100114224A1
公开(公告)日：2010-05-06
申请号：US12362822
申请日：2009-01-30
申请人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
发明人： Paul G. Krause , John E. Burnes , William T. Donofrio , David J. Peichel , Gerald P. Arne , Xiaohong Zhou , James D. Reinke
CPC分类号： A61N1/37 , A61N1/3605 , A61N1/36114 , A61N1/36521 , A61N1/37258 , A61N1/37288
摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.
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33.发明申请Device and Method to Detect The Severity of Ischemia and Heart Attack Risk 有权检测缺血和心脏病发作风险严重程度的装置和方法公开(公告)号：US20100113954A1
公开(公告)日：2010-05-06
申请号：US12263383
申请日：2008-10-31
申请人： Xiaohong Zhou
发明人： Xiaohong Zhou
IPC分类号： A61B5/0402 , A61N1/362
CPC分类号： A61N1/3702 , A61B5/01 , A61B5/0215 , A61B5/024 , A61B5/0452 , A61B5/11 , A61B7/00 , A61N1/3925
摘要： A device and method of detecting the severity of myocardial ischemia and heart attack risk is provided. The method includes obtaining an electrogram signal, determining T-wave measurements based on the electrogram signal, and determining ST segment measurements based on the electrogram signal. The method also includes identifying T-wave alternans based on the T-wave measurements and identifying ST segment changes based on the ST segment measurements. The method further includes correlating the T-wave alternans with the ST segment changes in order to detect a severity of ischemia.
摘要翻译： 提供了一种检测心肌缺血严重程度和心脏病发作风险的方法。 该方法包括获得电描记图信号，基于电描记图信号确定T波测量，以及基于电描记图信号确定ST段测量。 该方法还包括基于T波测量识别T波交替，并基于ST段测量识别ST段变化。 该方法还包括将T波交替与ST段变化相关联，以便检测局部缺血的严重程度。
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34.发明授权Methods and apparatus for sensing cardiac activity via neurological stimulation therapy system or medical electrical lead 有权通过神经系统刺激治疗系统或医用电导体感测心脏活动的方法和装置公开(公告)号：US07672733B2
公开(公告)日：2010-03-02
申请号：US11116970
申请日：2005-04-28
CPC分类号： A61N1/0551 , A61N1/36114 , A61N1/36135
摘要： According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.
摘要翻译： 根据本发明，至少一对神经刺激电极设置在受试者的可兴奋神经组织的内部，之上，大约，相邻和/或之内。 使用适于递送神经刺激疗法（NST）的一个或多个电极检测患者的心脏活动。 在检测到某些类型的心脏活动之后，如果需要，多个刺激电极中的一个或多个刺激电极传递或阻止NST，如果需要与心脏活动同步或响应于检测到的心脏活动。 提供的NST包括但不限于皮下刺激，外周，TENS和/或迷走神经刺激疗法等。
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公开(公告)号：US20080182985A1
公开(公告)日：2008-07-31
申请号：US11939291
申请日：2007-11-13
申请人： Wenlin Huang , Xiaohong Zhou
发明人： Wenlin Huang , Xiaohong Zhou
IPC分类号： C07D239/94
CPC分类号： C07D239/94
摘要： The present invention relates to quinazoline derivatives represented by general formula (I): wherein X, Y, Z, R1, R2, R3, and R4 are as defined herein. The invention also relates to a method of preparing these compounds, and use of these compounds for inhibiting tumor growth.
摘要翻译： 本发明涉及由通式（I）表示的喹唑啉衍生物：其中X，Y，Z，R 1，R 2，R 3， >和R 4'如本文所定义。 本发明还涉及制备这些化合物的方法，以及这些化合物用于抑制肿瘤生长的用途。
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公开(公告)号：US20080140150A1
公开(公告)日：2008-06-12
申请号：US11751813
申请日：2007-05-22
IPC分类号： A61N1/05
CPC分类号： A61N1/36071 , A61N1/205 , A61N1/36021
摘要： A method and apparatus for delivering corrective therapy through hormone regulation is provided. Inhibition of sympathetic fibers by spinal cord stimulation is used to regulate the levels of hormones such as catecholamines, renin, and calcitonin gene-related peptide. The invention utilizes a closed or open loop feedback system in which physiological parameters such as the concentrations of hormones and sympathetic indicators such as heart rate and urine production are monitored and used to determine the appropriate level of neurostimulation. The site of electrical stimulation includes, but is not limited to, the spinal cord at levels T7-L2 and the associated neural fibers within a region of the T7-L2 dermatomes
摘要翻译： 提供了一种通过激素调节进行矫正治疗的方法和装置。 通过脊髓刺激抑制交感神经纤维用于调节激素水平，如儿茶酚胺，肾素和降钙素基因相关肽。 本发明利用封闭或开环反馈系统，其中监测诸如心率和尿液产生之间的激素和交感神经指标的生理参数，并用于确定适当的神经刺激水平。 电刺激部位包括（但不限于）T7-L2级别的脊髓和T7-L2皮肌的区域内的相关神经纤维
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37.发明申请Closed-Loop Neuromodulation for Prevention and Treatment of Cardiac Conditions 审中-公开闭环神经调节预防和治疗心脏病症公开(公告)号：US20070213773A1
公开(公告)日：2007-09-13
申请号：US11748847
申请日：2007-05-15
申请人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou
发明人： Michael Hill , Gary King , Thomas Mullen , Xiaohong Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0504 , A61N1/36585
摘要： A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering electrical stimulation to one or more predetermined portions of the nervous system in a patient's body; and monitoring one or more physiologic indices of the body to determine whether the delivered therapy is effective. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the patient's body, and then the physiologic response of the patient is monitored to determine the efficacy of the stimulation.
摘要翻译： 公开了一种向患者提供治疗以保护心脏组织免受侮辱的方法和装置。 该方法包括将电刺激递送到患者体内神经系统的一个或多个预定部分; 并监测身体的一个或多个生理指标以确定递送的治疗是否有效。 也就是说，使用闭环反馈控制器对患者身体的预选区域施加电刺激，然后监测患者的生理反应以确定刺激的功效。
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38.发明授权公开(公告)号：US07218964B2
公开(公告)日：2007-05-15
申请号：US10035319
申请日：2001-10-26
IPC分类号： A61N1/372
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus to provide therapy to a patient for protecting cardiac tissue from insult is disclosed. The method comprises delivering closed loop electrical stimulation to one or more predetermined portions of a portion of excitable tissue of the spinal cord of a patient; and monitoring one or more physiologic indices of the body. That is, a closed-loop feedback controller is used to apply electrical stimulation to preselected regions of the spinal cord of a patient's body based upon one or more aspects of the physiologic indices.
摘要翻译： 公开了一种向患者提供治疗以保护心脏组织免受侮辱的方法和装置。 该方法包括将闭环电刺激递送到患者脊髓的可激发组织的一部分的一个或多个预定部分; 并监测身体的一个或多个生理指标。 也就是说，使用闭环反馈控制器基于生理指标的一个或多个方面对患者身体的脊髓的预选区域施加电刺激。
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公开(公告)号：US20060116592A1
公开(公告)日：2006-06-01
申请号：US11186552
申请日：2005-07-21
申请人： Xiaohong Zhou , Thomas Mullen , Jeffrey Gillberg , Robert Stadler
发明人： Xiaohong Zhou , Thomas Mullen , Jeffrey Gillberg , Robert Stadler
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0422 , A61N1/365 , A61N1/3702 , A61N1/37258
摘要： A system and method are provided for assessing T-wave alternans (TWA) using cardiac EGM signals received from implanted electrodes. A T-wave signal parameter is measured from signals received by an automatic gain control sense amplifier. A TWA measurement is computed from a beat-by-beat comparison of T-wave parameter measurements or using frequency spectrum techniques. The TWA measurement magnitude and measurement conditions are used in detecting a clinically important TWA. TWA assessment further includes discriminating concordant and discordant TWA in a multi-vector TWA assessment, and determining the association of a TWA measurement with QRS alternans, mechanical alternans, and other physiological events. A prediction of a pathological cardiac event is made in response to a TWA assessment. A response to a cardiac event prediction is provided.
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公开(公告)号：US07010345B2
公开(公告)日：2006-03-07
申请号：US09999723
申请日：2001-10-26
IPC分类号： A61N1/18
CPC分类号： A61N1/36114 , A61N1/3627
摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided at the spinal canal or on the chest wall of the patient through cutaneous electrodes.
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