Electrohydrodynamically patterned colloidal crystals
    33.
    发明授权
    Electrohydrodynamically patterned colloidal crystals 失效
    电流动力学图案胶体晶体

    公开(公告)号:US06533903B2

    公开(公告)日:2003-03-18

    申请号:US09843509

    申请日:2001-04-26

    IPC分类号: C07C600

    CPC分类号: C30B29/60 C30B5/00 C30B30/00

    摘要: A method for assembling patterned crystalline arrays of colloidal particles using ultraviolet illumination of an optically-sensitive semiconducting anode while using the anode to apply an electronic field to the colloidal particles. The ultraviolet illumination increases current density, and consequently, the flow of the colloidal particles. As a result, colloidal particles can be caused to migrate from non-illuminated areas of the anode to illuminated areas of the anode. Selective illumination of the anode can also be used to permanently affix colloidal crystals to illuminated areas of the anode while not affixing them to non-illuminated areas of the anode.

    摘要翻译: 一种利用光敏半导体阳极的紫外线照射来组装胶体颗粒的图案化晶体阵列的方法,同时使用阳极将电场施加到胶体颗粒。 紫外线照射增加了电流密度,从而增加了胶体颗粒的流动。 结果,可以使胶体颗粒从阳极的非照射区域迁移到阳极的照明区域。 阳极的选择性照明也可以用于将胶体晶体永久地粘贴到阳极的照明区域,而不将其粘附到阳极的非照明区域。

    Process for synthesizing carbapenem intermediates
    35.
    发明授权
    Process for synthesizing carbapenem intermediates 失效
    合成碳青霉烯中间体的方法

    公开(公告)号:US06194568B1

    公开(公告)日:2001-02-27

    申请号:US09326762

    申请日:1999-06-04

    IPC分类号: C07D47714

    CPC分类号: C07D477/02 Y02P20/55

    摘要: The invention describes an improved process for synthesizing 1-&bgr;-methyl-2-hydroxymethyl substituted carbapenems as key intermediates for the synthesis of anti-MRSA carbapenem antibiotics. The synthesis eliminates the use of BU3SnCH2OH and HMPA, which are toxic substances and not amenable to industrial scale production. The novel intermediates are also within the scope of this invention. The invention relates to the synthesis of a compound of formula 3: wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents H or methyl; and R5 represents a carboxy protecting group as well as the compounds made therein.

    摘要翻译: 本发明描述了合成1-β-甲基-2-羟甲基取代的碳青霉烯作为合成抗MRSA碳青霉烯类抗生素的关键中间体的改进方法。 合成消除了使用有毒物质的BU3SnCH2OH和HMPA,不适合工业规模生产。 新颖的中间体也在本发明的范围内。本发明涉及式3化合物的合成:其中R1表示H或适当的醇保护基; R2表示H或甲基; 并且R 5表示羧基保护基以及其中制备的化合物。