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    Implantable medical device for generating cardiac pressure-volume loop and optimizing therapy
    31.
    发明申请
    Implantable medical device for generating cardiac pressure-volume loop and optimizing therapy 有权
    用于产生心脏压力 - 体积循环和优化治疗的植入式医疗装置

    公开(公告)号：US20070129765A1

    公开(公告)日：2007-06-07

    申请号：US11296732

    申请日：2005-12-07

    申请人： James Gilkerson ,  Yongxing Zhang ,  Yunlong Zhang ,  Sophia Wang

    发明人： James Gilkerson ,  Yongxing Zhang ,  Yunlong Zhang ,  Sophia Wang

    IPC分类号： A61N1/365

    CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3962

    摘要： An implantable medical device for generating a cardiac pressure-volume loop, the implantable medical device comprising a pulse generator including control circuitry, a first cardiac lead including a proximal end and a distal end and coupled to the pulse generator at the proximal end, a first electrode located at the distal end of the cardiac lead and operatively coupled to the control circuitry, a sound sensor operatively coupled to the control circuitry, and a pressure sensor operatively coupled to the control circuitry, wherein the implantable medical device is adapted for measuring intracardiac impedance. A method of using the implantable medical device to optimize therapy delivered to the heart.

    摘要翻译： 一种用于产生心脏压力 - 体积回路的可植入医疗装置，所述可植入医疗装置包括脉冲发生器，所述脉冲发生器包括控制电路，包括近端和远端的第一心脏引线，并且在近端处耦合到所述脉冲发生器， 电极，位于心脏引线的远端并且可操作地耦合到控制电路，操作地耦合到控制电路的声音传感器和可操作地耦合到控制电路的压力传感器，其中可植入医疗装置适于测量心内阻抗 。 一种使用可植入医疗装置来优化递送至心脏的治疗的方法。

    Intracardiac impedance and its applications
    32.
    发明申请
    Intracardiac impedance and its applications 有权
    心内阻抗及其应用

    公开(公告)号：US20070043394A1

    公开(公告)日：2007-02-22

    申请号：US11208922

    申请日：2005-08-22

    申请人： Yunlong Zhang ,  James Gilkerson ,  Yongxing Zhang ,  Boyce Moon

    发明人： Yunlong Zhang ,  James Gilkerson ,  Yongxing Zhang ,  Boyce Moon

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925

    摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

    摘要翻译： 测量心内阻抗的系统包括可植入电极和医疗装置。 电极感测受试者心脏的电信号。 医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。 心脏信号感测电路提供感测的心脏信号。 阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。 控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

    Atrial pacing lead
    33.
    发明申请
    Atrial pacing lead 审中-公开
    心房起搏引导

    公开(公告)号：US20060241733A1

    公开(公告)日：2006-10-26

    申请号：US11113715

    申请日：2005-04-25

    申请人： Yongxing Zhang ,  Yunlong Zhang

    发明人： Yongxing Zhang ,  Yunlong Zhang

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056

    摘要： A lead includes a lead body having an expandable section. A plurality of electrodes are disposed on the expandable section. The expandable section is adapted to expand against an inner surface of a heart so as to position at least one of the plurality of electrodes at or near an SA node of the heart.

    摘要翻译： 引线包括具有可扩展部分的引线体。 多个电极设置在可扩张部分上。 可膨胀部分适于相对于心脏的内表面扩张，以将多个电极中的至少一个定位在心脏的SA节点处或附近。

    Transeptal lead
    34.
    发明申请
    Transeptal lead 失效

    公开(公告)号：US20060041300A1

    公开(公告)日：2006-02-23

    申请号：US10920695

    申请日：2004-08-18

    申请人： Yongxing Zhang ,  Yunlong Zhang

    发明人： Yongxing Zhang ,  Yunlong Zhang

    IPC分类号： A61N1/05

    CPC分类号： A61N1/057 ,  A61N1/0568 ,  A61N1/0573

    摘要： A lead includes a lead body and an electrode disposed proximate a distal end of the lead body. A retaining member is disposed proximate the distal end of the lead and adapted to retain the electrode proximate an interatrial septum when the retaining member is located on a left atrial side of the interatrial septum.

    Lead system with main lead and transverse lead
    37.
    发明授权
    Lead system with main lead and transverse lead 有权
    主导和铅铅系统

    公开(公告)号：US06574512B1

    公开(公告)日：2003-06-03

    申请号：US09649769

    申请日：2000-08-28

    申请人： Yongxing Zhang ,  Weimin Sun ,  Scott M. Partridge

    发明人： Yongxing Zhang ,  Weimin Sun ,  Scott M. Partridge

    IPC分类号： A61N105

    CPC分类号： A61N1/056 ,  A61N2001/0578 ,  A61N2001/0585

    摘要： A lead comprising both a main lead and a transverse lead. The main lead includes a main lead body with a longitudinal axis and at least one electrode. The Transverse lead includes a transverse lead body and at least one electrode, where the transverse lead body extends laterally from the main lead body and curves around the longitudinal axis of the main lead body to partially encircle at least a portion of the main lead. In one embodiment, the transverse lead is adapted to press the at least one electrode on the transverse lead against endocardial tissue. At least a portion of the main lead and at least a portion of the transverse lead are both adapted to be housed within and pass through an implant catheter. In an alternative embodiment, there is a lead system which comprises a first lead and a second lead, where the second lead includes a sleeve, where the first lead is adapted to move through the sleeve to attach the first lead to the second lead.

    摘要翻译： 包括主引线和横向引线的引线。 主引线包括具有纵向轴线的主引线体和至少一个电极。 横向引线包括横向引线主体和至少一个电极，其中横向引线主体从主引线主体延伸并围绕主引线主体的纵向轴线弯曲，以部分地环绕主引线的至少一部分。 在一个实施例中，横向引线适于将横向引线上的至少一个电极压迫抵抗心内膜组织。 主引线的至少一部分和横向引线的至少一部分都适于容纳在植入物导管内并通过植入物导管。 在替代实施例中，存在引线系统，其包括第一引线和第二引线，其中第二引线包括套管，其中第一引线适于移动穿过套管以将第一引线附接到第二引线。

    MAGNETICALLY GUIDED CATHETER
    39.
    发明申请
    MAGNETICALLY GUIDED CATHETER 有权
    MAGNETICALLY指导导管

    公开(公告)号：US20120265130A1

    公开(公告)日：2012-10-18

    申请号：US13532164

    申请日：2012-06-25

    申请人： Alan de la Rama ,  Kirk Kochin Wu ,  Yongxing Zhang

    发明人： Alan de la Rama ,  Kirk Kochin Wu ,  Yongxing Zhang

    IPC分类号： A61M25/092

    CPC分类号： A61B18/1492 ,  A61B34/73 ,  A61B2018/00577 ,  A61B2218/002 ,  A61M25/0127

    摘要： A catheter includes a flexible tubing having a proximal end and a distal end. The catheter also includes an electrode assembly attached to the distal end of the flexible tubing and having a first magnet therein. The electrode assembly further includes an electrically conductive tip electrode and an electrically nonconductive coupler which is connected between the tip electrode and the distal end of the flexible tubing. The coupler and the tip electrode are coupled by an interlocking connection. The catheter also includes a second magnet spaced from the electrode assembly along a longitudinal axis of the tubing. The first magnet and the second magnet are responsive to an external magnetic field to selectively position and guide the electrode assembly within a body of a patient.

    摘要翻译： 导管包括具有近端和远端的柔性管。 导管还包括附接到柔性管的远端并且其中具有第一磁体的电极组件。 电极组件还包括导电尖端电极和连接在尖端电极和柔性管的远端之间的非导电耦合器。 耦合器和尖端电极通过互锁连接耦合。 导管还包括沿着管道的纵向轴线与电极组件间隔开的第二磁体。 第一磁体和第二磁体响应于外部磁场来选择性地将电极组件定位并引导到患者体内。

    Magnetically guided catheter
    40.
    发明授权
    Magnetically guided catheter 有权
    磁导管

    公开(公告)号：US08206404B2

    公开(公告)日：2012-06-26

    申请号：US12167736

    申请日：2008-07-03

    申请人： Alan de la Rama ,  Kirk Kochin Wu ,  Yongxing Zhang

    发明人： Alan de la Rama ,  Kirk Kochin Wu ,  Yongxing Zhang

    IPC分类号： A61B19/00 ,  A61B18/18 ,  A61M25/00

    CPC分类号： A61B18/1492 ,  A61B34/73 ,  A61B2018/00577 ,  A61B2218/002 ,  A61M25/0127

    摘要： A catheter includes a flexible tubing having a proximal end and a distal end. The catheter also includes an electrode assembly attached to the distal end of the flexible tubing and having a first magnet therein. The electrode assembly further includes an electrically conductive tip electrode and an electrically nonconductive coupler which is connected between the tip electrode and the distal end of the flexible tubing. The coupler and the tip electrode are coupled by an interlocking connection. The catheter also includes a second magnet spaced from the electrode assembly along a longitudinal axis of the tubing. The first magnet and the second magnet are responsive to an external magnetic field to selectively position and guide the electrode assembly within a body of a patient.

    摘要翻译： 导管包括具有近端和远端的柔性管。 导管还包括附接到柔性管的远端并且其中具有第一磁体的电极组件。 电极组件还包括导电尖端电极和连接在尖端电极和柔性管的远端之间的非导电耦合器。 耦合器和尖端电极通过互锁连接耦合。 导管还包括沿着管道的纵向轴线与电极组件间隔开的第二磁体。 第一磁体和第二磁体响应于外部磁场来选择性地将电极组件定位并引导到患者体内。