公开(公告)号：US20070043394A1

公开(公告)日：2007-02-22

申请号：US11208922

申请日：2005-08-22

申请人： Yunlong Zhang ,  James Gilkerson ,  Yongxing Zhang ,  Boyce Moon

发明人： Yunlong Zhang ,  James Gilkerson ,  Yongxing Zhang ,  Boyce Moon

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925

摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

摘要翻译： 测量心内阻抗的系统包括可植入电极和医疗装置。 电极感测受试者心脏的电信号。 医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。 心脏信号感测电路提供感测的心脏信号。 阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。 控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

公开(公告)号：US08494618B2

公开(公告)日：2013-07-23

申请号：US11208922

申请日：2005-08-22

申请人： Yunlong Zhang ,  James O. Gilkerson ,  Yongxing Zhang ,  Boyce Moon

发明人： Yunlong Zhang ,  James O. Gilkerson ,  Yongxing Zhang ,  Boyce Moon

IPC分类号： A61B5/04 ,  A61N1/00

CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925

摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

摘要翻译： 测量心内阻抗的系统包括可植入电极和医疗装置。 电极感测受试者心脏的电信号。 医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。 心脏信号感测电路提供感测的心脏信号。 阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。 控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

公开(公告)号：US20080114258A1

公开(公告)日：2008-05-15

申请号：US12016843

申请日：2008-01-18

申请人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

IPC分类号： A61B5/0452

CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61B5/7264 ,  A61N1/3956

摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.

摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。

公开(公告)号：US20060116594A1

公开(公告)日：2006-06-01

申请号：US11000133

申请日：2004-11-30

申请人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61B5/7264 ,  A61N1/3956

摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.

摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。

公开(公告)号：US20070129765A1

公开(公告)日：2007-06-07

申请号：US11296732

申请日：2005-12-07

申请人： James Gilkerson ,  Yongxing Zhang ,  Yunlong Zhang ,  Sophia Wang

发明人： James Gilkerson ,  Yongxing Zhang ,  Yunlong Zhang ,  Sophia Wang

IPC分类号： A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3962

摘要： An implantable medical device for generating a cardiac pressure-volume loop, the implantable medical device comprising a pulse generator including control circuitry, a first cardiac lead including a proximal end and a distal end and coupled to the pulse generator at the proximal end, a first electrode located at the distal end of the cardiac lead and operatively coupled to the control circuitry, a sound sensor operatively coupled to the control circuitry, and a pressure sensor operatively coupled to the control circuitry, wherein the implantable medical device is adapted for measuring intracardiac impedance. A method of using the implantable medical device to optimize therapy delivered to the heart.

摘要翻译： 一种用于产生心脏压力 - 体积回路的可植入医疗装置，所述可植入医疗装置包括脉冲发生器，所述脉冲发生器包括控制电路，包括近端和远端的第一心脏引线，并且在近端处耦合到所述脉冲发生器， 电极，位于心脏引线的远端并且可操作地耦合到控制电路，操作地耦合到控制电路的声音传感器和可操作地耦合到控制电路的压力传感器，其中可植入医疗装置适于测量心内阻抗 。 一种使用可植入医疗装置来优化递送至心脏的治疗的方法。

公开(公告)号：US08781604B2

公开(公告)日：2014-07-15

申请号：US12384139

申请日：2009-04-01

申请人： Yongxing Zhang ,  Yunlong Zhang

发明人： Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0568 ,  A61N1/0573

摘要： A lead includes a lead body and an electrode disposed proximate a distal end of the lead body. A retaining member is disposed proximate the distal end of the lead and adapted to retain the electrode proximate an interatrial septum when the retaining member is located on a left atrial side of the interatrial septum.

摘要翻译： 引线包括引线体和靠近引线主体的远端设置的电极。 保持构件设置在引线的远端附近，并且当保持构件位于房间隔间隔的左心房侧时适于将电极保持靠近房间隔。

公开(公告)号：US08221323B2

公开(公告)日：2012-07-17

申请号：US11833502

申请日：2007-08-03

申请人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

发明人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

IPC分类号： A61B8/00

CPC分类号： A61B8/12 ,  A61B5/0031 ,  A61B5/08 ,  A61B5/4878 ,  A61B8/4472

摘要： Systems and methods for monitoring lung edema fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about responsive acoustic energy echoes from a lung are described. The system comprises, among other things, an implantable device including an acoustic transducer configured to emit acoustic energy to a lung and to receive one or more responsive acoustic energy echoes from a lung. In an example, the implantable device includes a cardiac function management device having an acoustic window in a body thereof. In another example, the implantable device includes one or more subcutaneous leads. An implantable or external processor circuit is configured to receive information about the acoustic energy echoes to compute and provide a lung edema fluid status indication; such information may include an increased number or special pattern of acoustic energy echoes received or a decreased time between successively received echoes.

摘要翻译： 描述了使用关于来自肺的响应性声能回波的信息来监测受试者肺水肿液体状态的系统和方法，例如监测受试者是否存在肺水肿。 除其他之外，该系统包括可植入装置，其包括被配置为向肺发出声能并且接收来自肺的一个或多个响应声能回波的声学换能器。 在一个示例中，可植入装置包括其身体中具有声窗口的心脏功能管理装置。 在另一示例中，可植入装置包括一个或多个皮下引线。 植入式或外部处理器电路被配置为接收关于声能回波的信息，以计算并提供肺水肿状态指示; 这样的信息可以包括接收的声能回波的增加的数量或特殊模式或连续接收的回波之间的减少的时间。

公开(公告)号：US20120046565A1

公开(公告)日：2012-02-23

申请号：US13286435

申请日：2011-11-01

申请人： Yunlong Zhang ,  Julie A. Thompson ,  James O. Gilkerson ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Julie A. Thompson ,  James O. Gilkerson ,  Yongxing Zhang

IPC分类号： A61B5/0464 ,  A61B5/0468

CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61B5/7264 ,  A61N1/3956

摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.

摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。

公开(公告)号：US20060089693A1

公开(公告)日：2006-04-27

申请号：US10970569

申请日：2004-10-21

申请人： Eric Lovett ,  Bruce Tockman ,  Yongxing Zhang ,  Yunlong Zhang

发明人： Eric Lovett ,  Bruce Tockman ,  Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： A delivery system and method for delivering a right ventricular lead into a right ventricle includes a delivery device having an inflatable balloon at a distal end. The device is inserted into the venous system, the balloon is inflated and the device is floated along a blood flow path within the venous system through the heart and into the pulmonary artery. The lead is delivered into the right ventricle using the device. In one embodiment, the device is a catheter that facilitates placement of a guide wire into the right ventricle for delivery of the lead. The catheter is then removed and the lead is inserted into the right ventricle over the guide wire.

摘要翻译： 用于将右心室导线输送到右心室的输送系统和方法包括具有在远端的可充气气囊的输送装置。 将装置插入静脉系统中，气囊膨胀，并且装置沿静脉系统内的血流通道穿过心脏并进入肺动脉。 使用该装置将铅输送到右心室。 在一个实施例中，该装置是便于将导丝放置到右心室中用于输送引线的导管。 然后取出导管，引导线通过导丝插入右心室。

公开(公告)号：US20080114256A1

公开(公告)日：2008-05-15

申请号：US11559702

申请日：2006-11-14

申请人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

发明人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

IPC分类号： A61B5/021

CPC分类号： A61B5/224 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627

摘要： A method and apparatus permit sensing one or more forces exerted by one or more portions of a heart. A force transducer and displacement sensor are disclosed. A movement of one or more portions of a heart can be translated into one or more signals indicative of force. These signals can be used to provide information such as to diagnose or treat one or more conditions.

摘要翻译： 一种方法和装置允许感测由心脏的一个或多个部分施加的一个或多个力。 公开了一种力传感器和位移传感器。 心脏的一个或多个部分的运动可以被转换为指示力的一个或多个信号。 这些信号可用于提供诸如诊断或治疗一种或多种病症的信息。