公开(公告)号：US20080167304A1

公开(公告)日：2008-07-10

申请号：US12047550

申请日：2008-03-13

Applicant: Jagabandhu Das ,  John Hynes ,  Katerina Leftheris ,  Shuqun Lin ,  Stephen T. Wrobleski ,  Hong Wu

Inventor： Jagabandhu Das ,  John Hynes ,  Katerina Leftheris ,  Shuqun Lin ,  Stephen T. Wrobleski ,  Hong Wu

IPC: A61K31/4965 ,  A61K31/535

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07D495/04

Abstract: Compounds having the formula (I), and pharmaceutically acceptable salts, prodrugs, and solvates thereof, are useful as kinase inhibitors, wherein R, R1, R2, R5, R6a, R6b, J, K, X and Z are as described in the specification.

Abstract translation: 具有式（I）的化合物及其药学上可接受的盐，前药和溶剂合物可用作激酶抑制剂，其中R 1，R 2，R 2，R 2， R 5，R 6a，R 6b，J，K，X和Z如说明书中所述。

公开(公告)号：US07323482B2

公开(公告)日：2008-01-29

申请号：US11633337

申请日：2006-12-04

Applicant: John Hynes ,  Hong Wu ,  Katerina Leftheris ,  Chunjian Liu ,  Jagabandhu Das ,  Robert V. Moquin

Inventor： John Hynes ,  Hong Wu ,  Katerina Leftheris ,  Chunjian Liu ,  Jagabandhu Das ,  Robert V. Moquin

IPC: A61K31/426 ,  C07D277/20

CPC classification number: C07D277/56 ,  C07D417/12

Abstract: The present invention provides thiazolyl-based compounds of formula (I), useful for treating p38 kinase-associated conditions, wherein ring A is phenyl or pyridyl, and X, Y, B, R2, R3, Z1 m and n are as defined herein. The invention further pertains to pharmaceutical compositions containing at least one compound according to the invention useful for treating p38 kinase-associated conditions, and methods of inhibiting the activity of p38 kinase in a mammal.

Abstract translation: 本发明提供了可用于治疗p38激酶相关病症的式（I）的噻唑基类化合物，其中环A是苯基或吡啶基，X，Y，B，R 2， Z 3，Z 1和Z 3如本文所定义。 本发明还涉及含有至少一种可用于治疗p38激酶相关病症的本发明化合物的药物组合物，以及抑制哺乳动物中p38激酶活性的方法。

公开(公告)号：US06245564B1

公开(公告)日：2001-06-12

申请号：US08787788

申请日：1997-01-23

Applicant: Steven A. Goldman ,  Hong Wu

Inventor： Steven A. Goldman ,  Hong Wu

IPC: C12N502

CPC classification number: C12Q1/6897

Abstract: The present invention is directed to a method of separating cells of interest which method comprises: determining cells of interest; selecting a promoter specific for the cells of interest; introducing a nucleic acid molecule encoding green fluorescent protein under control of the promoter into a plurality of cells; and separating cells of the plurality of cells that are expressing said green fluorescent protein, wherein the separated cells are the cells of interest.

Abstract translation: 本发明涉及一种分离感兴趣的细胞的方法，该方法包括：确定感兴趣的细胞; 选择对感兴趣的细胞特异性的启动子; 将编码绿色荧光蛋白的核酸分子引导至多个细胞; 以及分离表达所述绿色荧光蛋白的多个细胞的细胞，其中分离的细胞是感兴趣的细胞。

公开(公告)号：US09684957B2

公开(公告)日：2017-06-20

申请号：US13984808

申请日：2012-02-13

Applicant: Hong Wu ,  Kun Deng ,  Jianming Liang

Inventor： Hong Wu ,  Kun Deng ,  Jianming Liang

IPC: G06K9/00 ,  G06T7/00 ,  G06K9/62

CPC classification number: G06T7/0012 ,  G06K9/6231 ,  G06K9/6257

Abstract: Systems, methods, and media for detecting an anatomical object in a medical device image are provided. In some embodiments, system for detecting an anatomical object in a medical device image are provided, the systems comprising: at least one hardware processor that: applies the medical device image to a classifier having a plurality of stages, wherein a first stage of the plurality of stages and a second stage of the plurality of stages each includes a strong learner formed from a plurality of weak learners, and the weak learners in the second stage include a plurality of the weak learners included in the first stage; and identifies the medical device image as being positive or negative of showing the anatomical object based on the application the medical device image to be classifier.

公开(公告)号：US08921368B2

公开(公告)日：2014-12-30

申请号：US14005570

申请日：2012-03-16

Applicant: Stephen T. Wrobleski ,  Gregory D. Brown ,  Lidia M. Doweyko ,  Jingwu Duan ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Zhonghui Lu ,  Steven H. Spergel ,  John S. Tokarski ,  Hong Wu ,  Bingwei Vera Yang

Inventor： Stephen T. Wrobleski ,  Gregory D. Brown ,  Lidia M. Doweyko ,  Jingwu Duan ,  Junqing Guo ,  John Hynes ,  Bin Jiang ,  James Kempson ,  Shuqun Lin ,  Zhonghui Lu ,  Steven H. Spergel ,  John S. Tokarski ,  Hong Wu ,  Bingwei Vera Yang

IPC: C07D487/04 ,  C07D471/04 ,  A01N43/58 ,  A61K31/50

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I), and pharmaceutically acceptable salts thereof. The compounds of formula (I) inhibit tyrosine kinase activity of JAK3, thereby making them useful for the treatment of inflammatory and autoimmune diseases.

Abstract translation: 公开了式（I）的化合物及其药学上可接受的盐。 式（I）化合物抑制JAK3的酪氨酸激酶活性，从而使其可用于治疗炎性和自身免疫性疾病。

公开(公告)号：US20140185887A1

公开(公告)日：2014-07-03

申请号：US13984808

申请日：2012-02-13

Applicant: Hong Wu ,  Kun Deng ,  Jianming Liang

Inventor： Hong Wu ,  Kun Deng ,  Jianming Liang

IPC: G06T7/00

CPC classification number: G06T7/0012 ,  G06K9/6231 ,  G06K9/6257

Abstract: Systems, methods, and media for detecting an anatomical object in a medical device image are provided. In some embodiments, system for detecting an anatomical object in a medical device image are provided, the systems comprising: at least one hardware processor that: applies the medical device image to a classifier having a plurality of stages, wherein a first stage of the plurality of stages and a second stage of the plurality of stages each includes a strong learner formed fro ma plurality of weak learners, and the weak learners in the second stage include a plurality of the weak learners included in the first stage; and identifies the medical device image as being positive or negative of showing the anatomical object based on the application the medical device image to be classifier.

Abstract translation: 提供了用于检测医疗设备图像中的解剖学对象的系统，方法和介质。 在一些实施例中，提供了用于检测医疗设备图像中的解剖对象的系统，所述系统包括：至少一个硬件处理器，其将所述医疗设备图像应用于具有多个级的分类器，其中，所述多个 多个阶段的阶段和第二阶段各自包括由多个弱势学习者形成的强力学习者，第二阶段的弱学习者包括第一阶段包括的多个弱学习者; 并且基于应用将所述医疗装置图像分类为所述医疗装置图像，将所述医疗装置图像识别为正或负显示解剖体。

公开(公告)号：US08048366B2

公开(公告)日：2011-11-01

申请号：US12249527

申请日：2008-10-10

Applicant: Dejun Zhu ,  Hong Wu ,  York Yuan Chang ,  Ken Kuang

Inventor： Dejun Zhu ,  Hong Wu ,  York Yuan Chang ,  Ken Kuang

IPC: B22F3/26

CPC classification number: C22C1/0475 ,  B22F2998/00 ,  C22C1/0425

Abstract: From tungsten or molybdenum powders, a tungsten or molybdenum compact is pressurized and molded into the same dimensions as or slightly larger than the end product and sintered into tungsten or molybdenum skeleton. After copper infiltration, chemical copper etching is applied to remove excess surface copper. A machining allowance with an absolute value >0-≦0.1 mm may be applied for the machining of uneven surfaces resulting from the chemical process of copper removal.

Abstract translation: 钨或钼粉末由钨或钼粉末加压制成与最终产品相同的尺寸或稍大于烧结成钨或钼骨架的尺寸。 铜渗透后，应用化学铜蚀刻去除多余的表面铜。 绝对值> 0-＆nlE; 0.1mm的加工余量可用于加工由铜除去的化学过程产生的不平坦表面。

公开(公告)号：US07740729B1

公开(公告)日：2010-06-22

申请号：US11670191

申请日：2007-02-01

Applicant: Kai Leung Fan ,  Ming Sang Yeung ,  Guoyong Zhang ,  Congyi Mu ,  Hong Wu ,  Ming Li

Inventor： Kai Leung Fan ,  Ming Sang Yeung ,  Guoyong Zhang ,  Congyi Mu ,  Hong Wu ,  Ming Li

IPC: B32B37/00

CPC classification number: G11B7/263 ,  G11B7/24038

Abstract: Techniques for bonding two disks with a minimized eccentricity (ECC) are disclosed. A positioning header includes an ECC controlling structure that further includes a positioning header. In one embodiment, the position header includes three members that form a round stand with a diameter smaller than the inner diameter of the disks. The round stand expands to the inner diameter of the disks to close the gap as a result of the difference between the two diameters when the three members are caused to expand. In one embodiment, the movement of the three members is controlled by magnetic means. Depending on the positions of the ECC controlling structure, the three members are expanded from or restored to their default positions.

Abstract translation: 公开了以最小偏心度（ECC）键合两个盘的技术。 定位头部包括还包括定位头部的ECC控制结构。 在一个实施例中，位置头部包括形成直径小于盘的内径的圆形支架的三个构件。 当三个构件膨胀时，由于两个直径之间的差异，圆形支架膨胀到盘的内径以封闭间隙。 在一个实施例中，三个构件的移动由磁性装置控制。 根据ECC控制结构的位置，三个成员被扩展或恢复到其默认位置。

公开(公告)号：US20100029000A1

公开(公告)日：2010-02-04

申请号：US12453095

申请日：2009-04-29

Applicant: Shilong Zhong ,  Hong Wu

Inventor： Shilong Zhong ,  Hong Wu

IPC: C12N5/02 ,  C12M1/00

CPC classification number: C12M23/38 ,  C12M23/12 ,  C12M23/40

Abstract: The invention provides an assembly designed under the multiwell plate make and methods of using the same for dynamic-based cell culture and pharmacokinetic-based cell treatment. The assembly comprises a multiwell plate and a lid which permits continuously adding and removing culture medium for culturing cells or tissues in vitro. The dynamic medium makes it possible to culture cells or tissues exposing to changing concentration of a drug candidate over time.

Abstract translation: 本发明提供了一种在多孔板制备下设计的组件，以及将其用于动态细胞培养和基于药代动力学的细胞处理的方法。 组合件包括多孔板和盖，其允许连续添加和除去用于培养细胞或组织的培养基。 动态培养基使得可能随着时间的推移培养暴露于候选药物浓度变化的细胞或组织。

公开(公告)号：US20070146564A1

公开(公告)日：2007-06-28

申请号：US11317502

申请日：2005-12-23

Applicant: Hong Wu ,  Yung-chang Chen ,  Chien-Ting Lai

Inventor： Hong Wu ,  Yung-chang Chen ,  Chien-Ting Lai

IPC: G02F1/1333

CPC classification number: G02F1/136204 ,  H01L27/0266

Abstract: An electrostatic discharge (ESD) protection circuit (140) includes: a first transistor (141), a second transistor (142), a third transistor (143), and a fourth transistor (144). Each transistor includes a source electrode ‘s’, a drain electrode ‘d’ and a gate electrode ‘g’. The gate electrode ‘g’ of the first transistor, the gate electrode ‘g’ of the second transistor, the drain electrode ‘d’ of the third transistor, and the drain electrode ‘d’ of the fourth transistor are connected to each other. The source electrode ‘s’ of the first transistor, the source electrode ‘s’ of the second transistor, and the source and gate electrodes of the third transistor are connected to each other. The drain electrode ‘d’ of the first transistor, the drain electrode ‘d’ of the second transistor, and the source and gate electrodes of the fourth transistor are connected to each other.

Abstract translation: 静电放电（ESD）保护电路（140）包括：第一晶体管（141），第二晶体管（142），第三晶体管（143）和第四晶体管（144）。 每个晶体管包括源电极'，漏电极'd'和栅电极'g'。 第一晶体管的栅极电极“g”，第二晶体管的栅极电极“g”，第三晶体管的漏电极“d”和第四晶体管的漏电极“d”彼此连接。 第一晶体管的源极电极，第二晶体管的源极电极以及第三晶体管的源极和栅极彼此连接。 第一晶体管的漏电极d，第二晶体管的漏电极d'和第四晶体管的源电极和栅电极彼此连接。