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31.发明申请公开(公告)号：US20160000315A1
公开(公告)日：2016-01-07
申请号：US14791104
申请日：2015-07-02
CPC分类号： A61B6/00 , A61B3/0025 , A61B3/0041 , A61B3/102 , A61B3/12 , A61B3/1225 , A61B3/14
摘要： The present invention relates to structural analysis of the optic nerve head (ONH). In one approach, a 3D volume of intensity data which includes the optic nerve head is acquired using an optical coherence tomography (OCT) system. The vitreoretinal interface (VRI) and the optic disc margin are identified from the 3D data. The minimum area of a surface from the optic disc margin to the VRI is determined. This minimum area can be displayed as an image or in the alternative, a value corresponding to this minimum area can be displayed. The minimum area measurement provides relevant clinical information to determine the health of the eye.
摘要翻译： 本发明涉及视神经头（ONH）的结构分析。 在一种方法中，使用光学相干断层摄影（OCT）系统获取包括视神经头的3D体积的强度数据。 从3D数据识别玻璃体视网膜界面（VRI）和视盘边缘。 确定从光盘边缘到VRI的表面的最小面积。 该最小区域可以显示为图像，或者替代地，可以显示与该最小区域对应的值。 最小面积测量提供相关的临床信息以确定眼睛的健康。
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公开(公告)号：USD738510S1
公开(公告)日：2015-09-08
申请号：US29504150
申请日：2014-10-02
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33.发明授权Automated analysis of the optic nerve head: measurements, methods and representations 有权视神经头的自动分析：测量，方法和表示公开(公告)号：US09101293B2
公开(公告)日：2015-08-11
申请号：US13210129
申请日：2011-08-15
CPC分类号： A61B6/00 , A61B3/0025 , A61B3/0041 , A61B3/102 , A61B3/12 , A61B3/1225 , A61B3/14
摘要： The present invention relates to structural analysis of the optic nerve head (ONH). In one approach, a 3D volume of intensity data which includes the optic nerve head is acquired using an optical coherence tomography (OCT) system. The vitreoretinal interface (VRI) and the optic disc margin are identified from the 3D data. The minimum area of a surface from the optic disc margin to the VRI is determined. This minimum area can be displayed as an image or in the alternative, a value corresponding to this minimum area can be displayed. The minimum area measurement provides relevant clinical information to determine the health of the eye.
摘要翻译： 本发明涉及视神经头（ONH）的结构分析。 在一种方法中，使用光学相干断层摄影（OCT）系统获取包括视神经头的3D体积的强度数据。 从3D数据识别玻璃体视网膜界面（VRI）和视盘边缘。 确定从光盘边缘到VRI的表面的最小面积。 该最小区域可以显示为图像，或者替代地，可以显示对应于该最小区域的值。 最小面积测量提供相关的临床信息以确定眼睛的健康。
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34.发明授权Segmentation and enhanced visualization techniques for full-range fourier domain optical coherence tomography 有权全范围傅立叶变换光学相干断层扫描的分割和增强的可视化技术公开(公告)号：US09095281B2
公开(公告)日：2015-08-04
申请号：US13761404
申请日：2013-02-07
CPC分类号： A61B3/102 , G01B9/02091 , G06T7/11 , G06T7/12 , G06T2207/10101 , G06T2207/30041
摘要： Presented here are new processing techniques for optical coherence tomography (OCT) data that allow for improved visualization and use of full-range OCT images. These techniques minimize the central line artifact and the complex conjugate artifact without requiring additional system hardware or significantly increasing post-processing time. The central line artifact is minimized by normalizing each A-scan to account for ripples at the zero-delay position. The complex conjugate artifact is minimized by segmentation of a layer or layers that cross the zero-delay position, and in some embodiments by further segmentation of other surfaces based on the segmentation of the initial layer or layers. The segmentation information is then used to selectively attenuate the complex conjugate image. It may also be used for other purposes, such as dewarping.
摘要翻译： 这里介绍的是用于光学相干断层扫描（OCT）数据的新的处理技术，其允许改进全范围OCT图像的可视化和使用。 这些技术最大限度地减少了中心线伪影和复杂的偶联伪影，而不需要额外的系统硬件或显着增加后处理时间。 通过归一化每个A扫描以考虑零延迟位置处的波纹，使中心线伪影最小化。 通过对穿过零延迟位置的层或层进行分割，并且在一些实施例中，通过对初始层或层的分割进一步分割其它表面，使复共轭伪像最小化。 然后使用分割信息来选择性地衰减复共轭图像。 它也可以用于其它目的，例如脱脂。
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公开(公告)号：US09055892B2
公开(公告)日：2015-06-16
申请号：US13453856
申请日：2012-04-23
摘要： Systems and methods for improving ophthalmic imaging by correlating the location of a measurement on the pupil of the eye with a quality of the measurement and further controlling subsequent measurements based on the quality are presented. Aspects of the invention include obtaining optical coherence tomography (OCT) measurements through cataracts or other media opacities, obtaining B-scans with minimized tilt, and automated OCT data acquisition of select structures in the eye. Embodiments of the invention directed towards imaging tissues with angle dependent layer contrast and mapping the size and location of cataracts in the eye are also described.
摘要翻译： 提出了通过将眼睛瞳孔上的测量位置与测量质量相关联并且基于质量进一步控制后续测量来改善眼科成像的系统和方法。 本发明的方面包括通过白内障或其他媒体不透明度获得光学相干断层摄影（OCT）测量，以最小化倾斜获得B扫描，以及眼睛中选择结构的自动OCT数据采集。 还描述了针对具有角度依赖层对比度的成像组织并且将眼睛中的白内障的大小和位置映射的本发明的实施例。
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36.发明授权公开(公告)号：US09046339B2
公开(公告)日：2015-06-02
申请号：US14503292
申请日：2014-09-30
发明人： Cedric Blatter , Rainer A. Leitgeb
CPC分类号： G01B9/02091 , A61B3/102 , A61B5/0066 , A61B5/0261 , A61B5/6821 , G01B9/02028 , G01B9/02045 , G01B2290/45
摘要： Methods for determining improving quantitative and qualitative motion contrast information collected with optical coherence tomography (OCT) data are presented. In one embodiment, flow within a cross-sectional area of a sample is calculated independent of the Doppler and en face angles using a bidirectional OCT system. In another embodiment, motion contrast images are improved by averaging motion contrast information collected from a bidirectional OCT system.
摘要翻译： 提出了用光学相干断层扫描（OCT）数据收集的改进定量和定性运动对比度信息的方法。 在一个实施例中，使用双向OCT系统，独立于多普勒和正面角度来计算样本的横截面区域内的流动。 在另一个实施例中，通过平均从双向OCT系统收集的运动对比度信息来改善运动对比度图像。
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公开(公告)号：US08998411B2
公开(公告)日：2015-04-07
申请号：US13542516
申请日：2012-07-05
摘要： Systems and methods for applying the concept of lightfield sensors to fundus photography are presented. In one embodiment, the ability to isolate specific regions of the collected lightfield are used to reduce the effects of glare in a fundus image. Additional embodiments in which aberrations can be characterized and removed, an image from a particular plane in the collected light field is used to aid in instrument alignment, and dynamic optimization of collection pupil diameter is accomplished are also presented.
摘要翻译： 介绍了将光场传感器应用于眼底摄影的系统和方法。 在一个实施例中，使用分离所收集的光场的特定区域的能力来减少眼底图像中眩光的影响。 其中可以表征和去除像差的其他实施例，来自收集的光场中的特定平面的图像用于帮助仪器对准，并且还呈现收集光瞳直径的动态优化。
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38.发明授权Method of bioimage data processing for revealing more meaningful anatomic features of diseased tissues 有权生物图像数据处理方法，用于揭示病变组织的更有意义的解剖特征公开(公告)号：US08913793B2
公开(公告)日：2014-12-16
申请号：US13787557
申请日：2013-03-06
发明人： Matthew J. Everett , Scott A. Meyer , Paul F. Stetson , Yan Zhou
CPC分类号： A61B5/0066 , G06T7/0014 , G06T19/00 , G06T2200/24 , G06T2207/10101 , G06T2207/30041 , G06T2210/41
摘要： The present invention discloses a method for generating elevation maps or images of a tissue layer/boundary with respect to a fitted reference surface, comprising the steps of finding and segmenting a desired tissue layer/boundary; fitting a smooth reference surface to the segmented tissue layer/boundary; calculating elevations of the same or other tissue layer/boundary relative to the fitted reference surface; and generating maps of elevation relative to the fitted surface. The elevation can be displayed in various ways including three-dimensional surface renderings, topographical contour maps, contour maps, en-face color maps, and en-face grayscale maps. The elevation can also be combined and simultaneously displayed with another tissue layer/boundary dependent set of image data to provide additional information for diagnostics.
摘要翻译： 本发明公开了一种用于产生相对于拟合的参考表面的组织层/边界的仰角图或图像的方法，包括以下步骤：找到并分割所需的组织层/边界; 将平滑的参考表面拟合到分段的组织层/边界; 计算相对于拟合参考表面的相同或其它组织层/边界的高度; 并产生相对于拟合表面的高程图。 高程可以以各种方式显示，包括三维表面效果图，地形轮廓图，轮廓图，面孔颜色图和面对灰度图。 也可以将高程组合并同时显示另一个组织层/边界依赖的图像数据集，以提供用于诊断的附加信息。
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公开(公告)号：US20140276025A1
公开(公告)日：2014-09-18
申请号：US14207060
申请日：2014-03-12
发明人： Mary K. DURBIN , Utkarsh SHARMA , Harihar NARASIMHA-IYER , Martin HACKER , Allen JONES , Christine N. RITTER
CPC分类号： A61B5/4842 , A61B3/0025 , A61B3/102 , A61B3/18 , G06T7/12 , G06T2207/10101 , G06T2207/30041
摘要： Regions-of-interest discovered from analyses of images obtained from one imaging modality can be further observed, analyzed, supplemented, and further analyzed by one or more additional imaging modalities and in an automated way. In addition, one or more pathologies identified from analyses of these regions-of-interest, and a metric of the likelihood of the presence of disease, and/or a metric of risk of disease progression can be derived therefrom.
摘要翻译： 通过从一种成像模式获得的图像分析发现的兴趣区域可以进一步观察，分析，补充，并通过一个或多个附加成像模式和自动化方式进一步分析。 此外，可以从其中导出从这些感兴趣区域的分析中鉴定的一种或多种病理学，以及疾病存在的可能性的度量和/或疾病进展的风险度量。
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公开(公告)号：US20140240675A1
公开(公告)日：2014-08-28
申请号：US13781051
申请日：2013-02-28
CPC分类号： A61B3/0091 , A61B3/0008 , A61B3/0025 , A61B3/0041 , A61B3/0083 , A61B3/024 , A61B3/107 , A61B3/113 , A61B3/14 , G06F3/013 , G06K9/00604
摘要： Methods for improving gaze tracking are presented. These methods eliminate the need for a separate initial calibration step to determine whether the subject is properly centrally fixated during testing. In one embodiment, whether the subject is centrally fixated is determined by identifying inlier and outlier gaze descriptors; the inliers are assumed to be associated with central fixation. This reduces the total time required for testing. These methods also improve the accuracy of gaze tracking during testing without the need for individual subject calibration. Instead, a database of reference eyes is used. The subject's eye can be compared to the reference eyes, and the mapping function for one or more reference matches can be used to estimate the subject's gaze direction. In another embodiment, previous calibration data from the same subject can be used to determine whether the subject is properly centrally fixated and/or the direction of the subject's gaze.
摘要翻译： 提出了提高注视跟踪的方法。 这些方法消除了单独的初始校准步骤的需要，以确定在测试期间受试者是否适当集中固定。 在一个实施例中，通过识别入射者和离群凝视描述符来确定对象是否集中固定; 假设内镜与中央固定有关。 这减少了测试所需的总时间。 这些方法还提高了测试期间凝视跟踪的准确性，而不需要单独的对象校准。 相反，使用参考眼的数据库。 可以将对象的眼睛与参考眼睛进行比较，并且可以使用一个或多个参考匹配的映射函数来估计被摄体的注视方向。 在另一个实施例中，可以使用来自相同对象的先前校准数据来确定被摄体是否被适当集中地固定和/或被摄体的注视的方向。
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