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公开(公告)号：US20240207459A1
公开(公告)日：2024-06-27
申请号：US18557392
申请日：2022-03-11
发明人： Yukie YOSHII , Hiroki MATSUMOTO , Chika IGARASHI
CPC分类号： A61K51/103 , A61K47/12 , A61K47/183 , A61K47/26 , A61K51/1096
摘要： A storage method according to an aspect of the present invention includes storing an intermediate of a radiopharmaceutical composition in an acetate buffer. The intermediate is a complex of a 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15), 11, 13-triene-3,6,9-triacetic acid (PCTA) and an anti-epidermal growth factor receptor antibody (anti-EGFR antibody). The intermediate is stored for a storage period of not less than 24 hours.
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公开(公告)号：US11982777B2
公开(公告)日：2024-05-14
申请号：US17619962
申请日：2020-06-26
发明人： Eiji Yoshida , Taiga Yamaya
CPC分类号： G01T1/1644 , G01T1/2002 , G01T1/2985
摘要： A radiation position detector includes: a photodetector array constituted of unit-sized unit photodetectors; a scintillator array constituted of a plurality of tetragonal scintillator elements optically connected to the photodetector array, wherein scintillator units are each constituted of a pair of unit scintillators whose individual cross-sectional size of plane facing to right receiving surface is ¼ of the size of the unit photodetector, where at least part of which is optically connected on a surface side opposite to the right receiving surface, the scintillator units being each arranged so as to be positioned over two of the unit photodetectors; and a position evaluation unit configured to identify the scintillator unit by the presence or absence of a signal and furthermore identify one of the unit scintillators of the scintillator unit on the basis of a strength of the signal, to obtain a two-dimensional radiation detection position.
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公开(公告)号：US20230360819A1
公开(公告)日：2023-11-09
申请号：US18245703
申请日：2021-10-29
发明人： Kotaro KONDO , Sadaoki KOJIMA , Hiromitsu KIRIYAMA , Mamiko NISHIUCHI , Hironao SAKAKI , Masaki HASHIDA , Syunsuke INOUE
CPC分类号： G21K5/04 , H01J27/24 , A61N5/10 , G21K1/00 , A61N2005/1088
摘要： Generation of impurity ions is prevented or reduced in a carbon ion generating device in which a laser-driven ion acceleration system is employed. A carbon ion generating device generates a carbonized region by irradiating a film made of an organic compound with a first laser beam, and generates carbon ions by irradiating at least a part of the carbonized region with a second laser beam.
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公开(公告)号：US20230301612A1
公开(公告)日：2023-09-28
申请号：US18002510
申请日：2021-06-03
发明人： Taiga YAMAYA , Miwako TAKAHASHI
CPC分类号： A61B6/425 , G01T1/2002 , A61B17/29 , A61B6/4258 , A61B6/50 , A61B6/4057
摘要： Provided is a radiation detector that can allow an operator to more accurately identify a position of a body tissue into which radionuclides have been taken. A radiation detector includes: a probe which has a radiation detection element housed therein and which is insertable into a body; a reporting part provided to the probe; and a control part configured to cause the reporting part to operate in accordance with a result of detection of radiation, the detection being made by the radiation detection element.
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35.发明申请公开(公告)号：US20230120376A1
公开(公告)日：2023-04-20
申请号：US17798230
申请日：2021-08-06
申请人： TEIKOKU ION CO., LTD , NATIONAL INSTITUTES FOR QUANTUM SCIENCE AND TECHNOLOGY , OKAZAKI MANUFACTURING COMPANY
发明人： Takashi Nakamura , Takuya Kawawaki , Mitsuhiko Terashita , Masahiko Hirakami , Masafumi Hojo , Ryosuke Nakamura , Masao Ishikawa , Taketo Nishikawa , Toshihiko Ryo
摘要： A plating apparatus (10) is disclosed including a plating tank (9), cathodes (1a to 1f), a holding mechanism (2), at least one anode (3), and a rotation mechanism (4). The plating tank (9) contains an annularly or helically wound substrate (90) together with a plating solution. The cathodes (1a to 1f) are placed inside the plating tank (9). The holding mechanism (2) holds the cathodes (1a to 1f) at positions electrically connected to the outer periphery of the substrate (90) and holds the substrate (90) via the cathodes (1a to 1f). The anode (3) is placed at least on the inner periphery side of the substrate (90) held by the holding mechanism (2). The rotation mechanism (4) rotates at least either the substrate (90) and cathodes (1a to 1f) held by the holding mechanism (2) or the anode (3), or both, around the axis of the wound substrate (90).
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36.发明申请公开(公告)号：US20220370651A1
公开(公告)日：2022-11-24
申请号：US17869104
申请日：2022-07-20
发明人： Yoshio HONDA , Taku ITO , Jun ICHINOSE , Hiroaki ICHIKAWA , Tomoyuki IMAI , Kotaro NAGATSU , Hisashi SUZUKI
摘要： A method for producing an 225Ac solution includes a step (I) of irradiating a 226Ra target with particles to generate two or more actinium radioisotopes (Ac) including at least 225Ac, a step (II) of dissolving the 226Ra target after the aforementioned step to obtain a solution (1), a step (III) of separating 226Ra and Ac contained in the solution (1) to obtain a solution (2), a step (IV) of allowing Ac contained in the solution (2) other than 225Ac to decay to obtain a solution (3), and a step (V) of separating Ra and Ac contained in the solution (3) to obtain a solution (4). The solution (4) is used to produce a medicine that contains, as an active ingredient, a conjugate between a chelating agent that has formed a complex with 225Ac, and a targeting agent.
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公开(公告)号：US20220357467A1
公开(公告)日：2022-11-10
申请号：US17619962
申请日：2020-06-26
发明人： Eiji YOSHIDA , Taiga YAMAYA
摘要： A radiation position detector includes: a photodetector array constituted of unit-sized unit photodetectors; a scintillator array constituted of a plurality of tetragonal scintillator elements optically connected to the photodetector array, wherein scintillator units are each constituted of a pair of unit scintillators whose individual cross-sectional size of plane facing to right receiving surface is ¼ of the size of the unit photodetector, where at least part of which is optically connected on a surface side opposite to the right receiving surface, the scintillator units being each arranged so as to be positioned over two of the unit photodetectors; and a position evaluation unit configured to identify the scintillator unit by the presence or absence of a signal and furthermore identify one of the unit scintillators of the scintillator unit on the basis of a strength of the signal, to obtain a two-dimensional radiation detection position.
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公开(公告)号：US20220298021A1
公开(公告)日：2022-09-22
申请号：US17636491
申请日：2020-08-27
发明人： Masaru Nakamichi , Jaehwan Kim , Yoshiaki Akatsu , Suguru Nakano , Tornohiko Kawakami , Kazuo Yonehara
摘要： This invention has an object to provide a method for producing a beryllium solution by dissolving beryllium oxide, the method being novel and having high energy efficiency. A production method (M10) for producing a beryllium solution includes a main heating step (S13) of dielectrically heating an acidic solution containing beryllium oxide to generate a beryllium solution.
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公开(公告)号：US20220296548A1
公开(公告)日：2022-09-22
申请号：US17771136
申请日：2020-10-20
发明人： Haruhisa Inoue , Keiko Imamura , Makoto Higuchi , Naruhiko Sahara , Maiko Ono
IPC分类号： A61K31/197 , A61K45/06 , A61P25/28 , G01N33/50
摘要： A prophylactic or therapeutic agent for tauopathy, containing an inhibitor of α2δ of the voltage-dependent calcium channel is provided by the present invention.
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公开(公告)号：US20220175973A1
公开(公告)日：2022-06-09
申请号：US17598400
申请日：2020-02-14
发明人： Yukie Yoshii , Meiei Cho , Kazunori Kawamura , Hisashi Suzuki , Hiroki Hashimoto
摘要： A method for producing a radiopharmaceutical, the method capable of maintaining a radioactive compound retaining a chemical structure and radioactivity at the time of production and after the production, and maintaining a usable period of a radiopharmaceutical; and a radiopharmaceutical are provided. The method for producing a radiopharmaceutical that has a radioactive component containing a radioactive dithiosemicarbazone copper complex includes: a stabilization step of adding a stabilizing agent containing at least one compound selected from the group consisting of ascorbic acid, methionine, sodium ascorbate, mannitol, and butylhydroxyanisole to a solution containing the radioactive component; and a filtration step of filtering the solution containing the radioactive component or a precursor thereof with a sterilization filter. In the radiopharmaceutical, a concentration of the radioactive component is 200 MBq/mL or more in terms of radioactivity concentrations.
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