公开(公告)号：US20240341270A1

公开(公告)日：2024-10-17

申请号：US18291989

申请日：2021-08-20

Applicant: JTEKT CORPORATION ,  TOKUSHIMA UNIVERSITY

Inventor： Masayuki TAKESHIMA ,  Yoshiyuki SHIBATA ,  Toshimasa SOKU ,  Kazuya NUMAZAKI ,  Fumiki MORIMATSU ,  Kentaroh TAKAGAKI ,  Maki HIRATA

IPC: A01K1/03 ,  A01K1/02 ,  A01K29/00

CPC classification number: A01K1/031 ,  A01K1/0272 ,  A01K29/005

Abstract: A management system for an experimental animal is provided. This management system includes an information identifying unit configured to identify experimental information on the experimental animal to be transported to an experiment site, and a stress value calculating unit configured to calculate a stress value indicating stress to be suffered by the experimental animal during transportation based on the experimental information. The experimental information includes at least a part of a transportation distance for the transportation of the experimental animal, a transportation period for the transportation of the experimental animal, the number of the experimental animals to be transported at a time, an age of the experimental animal, and information on pretreatment given to the experimental animal prior to the transportation.

公开(公告)号：US12012596B2

公开(公告)日：2024-06-18

申请号：US16640521

申请日：2018-08-20

Applicant: Tokushima University

Inventor： Keishi Osakabe ,  Yuriko Osakabe

IPC: C12N15/113 ,  C12N9/22 ,  C12N15/10 ,  C12N15/11

CPC classification number: C12N15/111 ,  C12N9/22 ,  C12N15/102 ,  C12N2310/20

Abstract: Provided is a method for targeting a target nucleotide sequence. The method includes introducing, into a cell: (i) CRISPR type I-D related proteins Cas5d, Cas6d, and Cas7d, or nucleic acids encoding these proteins; and (ii) a guide RNA which includes a sequence complementary to said target nucleotide sequence and common repetitive sequences derived from CRISPR gene locus before and after said complementary sequence, or a DNA encoding said guide RNA.

公开(公告)号：US20240186762A1

公开(公告)日：2024-06-06

申请号：US18523031

申请日：2023-11-29

Applicant: TOKUSHIMA UNIVERSITY ,  NICHIA CORPORATION

Inventor： Tetsuro KATAYAMA ,  Takeshi KIHARA

IPC: H01S3/16 ,  H01S3/02

CPC classification number: H01S3/163 ,  H01S3/027

Abstract: The laser element includes a gain medium and a photochromic compound that receives a carrier from the gain medium. The gain medium may contain: a first ion including at least one selected from the group consisting of an alkali metal ion, an ammonium ion, a formamidinium ion, a guanidium ion, an imidazolium ion, a pyridinium ion, a pyrrolidinium ion, and a protonated thiourea ion; a second ion including at least one selected from the group consisting of lead, germanium, tin, antimony, and bismuth; and an anion or a ligand including at least one selected from the group consisting of a chloride ion, a bromide ion, an iodide ion, a cyanide ion, a thiocyanate, an isothiocyanate, and a sulfide.

公开(公告)号：US11939290B2

公开(公告)日：2024-03-26

申请号：US17270334

申请日：2019-08-22

Applicant: TOKUSHIMA UNIVERSITY ,  AICHI STEEL CORPORATION

Inventor： Kosuke Namba ,  Motofumi Suzuki ,  Akane Mera

IPC: C07D207/16 ,  A01N43/36 ,  A01N59/16 ,  C05C11/00 ,  C07F15/02

CPC classification number: C07D207/16 ,  A01N43/36 ,  A01N59/16 ,  C05C11/00 ,  C07F15/02

Abstract: The present invention is a heterocycle-containing amino acid compound represented by a general formula (1):




wherein R1 and R2 are identical with or different from each other, and each represent a hydrogen atom or a carboxy-protecting group;
R3 represents a carboxyl group or a hydroxyl group; and
n is 1 or 2,
or a salt thereof.

公开(公告)号：US20240074417A1

公开(公告)日：2024-03-07

申请号：US18261759

申请日：2021-03-04

Applicant: JTEKT CORPORATION ,  Tokushima University

Inventor： Nozomu MIURA ,  Yasuhiro MURATA ,  Shigekazu KAWAI ,  Takahito WATANABE ,  Taro MITO

IPC: A01K67/033

CPC classification number: A01K67/0339

Abstract: Provided is a breeding apparatus that can facilitate disposition and collection of a spawning bed. A breeding apparatus includes a breeding area forming member that forms breeding areas for organisms and is open at least at the bottoms of the breeding areas, and a spawning bed sheet that forms the bottom surfaces of the breeding areas, has a belt shape, and is provided so as to be movable in a longitudinal direction of the belt shape relative to the breeding area forming member.

公开(公告)号：US20230137078A1

公开(公告)日：2023-05-04

申请号：US17905238

申请日：2020-12-10

Applicant: AICHI STEEL CORPORATION ,  TOKUSHIMA UNIVERSITY

Inventor： Akane MERA ,  Motofumi SUZUKI ,  Kensuke HOSODA ,  Kosuke NAMBA

IPC: A01N43/36 ,  C07D207/273 ,  A01P21/00 ,  C07F15/02 ,  C05C11/00

Abstract: A lactam compound and a salt thereof, represented by general formulae (1) and (2): In the formulae, R1 and R2 may be the same or different, and each represent a hydrogen atom, a protective group of a carboxyl group or a cation, and X− is a halogen ion, an organic acid ion, or an inorganic acid ion.

公开(公告)号：US20220098256A1

公开(公告)日：2022-03-31

申请号：US17297986

申请日：2019-11-28

Applicant: TOKUSHIMA UNIVERSITY ,  ONCOTHERAPY SCIENCE, INC.

Inventor： TOYOMASA KATAGIRI ,  TETSURO YOSHIMARU ,  AKIRA OTAKA ,  TAKASHI MIYAMOTO ,  YASUHIDE OKAMOTO

IPC: C07K14/47 ,  A61P35/00

Abstract: The present invention provides peptides containing the BIG3 polypeptide-binding site in a PHB2 polypeptide, which inhibit the binding between a PHB2 polypeptide and a BIG3 polypeptide, and pharmaceutical compositions containing the peptide. The peptides of the present invention have the ability to bind not to PHB2, whose expression is found in organs throughout the human body, but to BIG3, which is a protein highly expressed specifically in particularly estrogen receptor-positive cancer, and have excellent growth suppressive effects on BIG3-positive cancer cells. Accordingly, the peptides of the present invention are useful as therapeutic agents for breast cancer which can avoid expression of side effects.

公开(公告)号：US20220025051A1

公开(公告)日：2022-01-27

申请号：US17311148

申请日：2019-12-06

Applicant: ONO PHARMACEUTICAL CO., LTD. ,  TOKUSHIMA UNIVERSITY

Inventor： Taku OKAZAKI ,  Daisuke SUGIURA ,  Takeo MAEDA ,  Shiro SHIBAYAMA

IPC: C07K16/28 ,  A61P37/06

Abstract: An immunosuppressive agent containing a substance that is selected from anti-CD80 antibodies and anti-PD-L1 antibodies and that promotes binding between PD-L1 and PD-1.

公开(公告)号：US20210338809A1

公开(公告)日：2021-11-04

申请号：US17270561

申请日：2019-08-20

Applicant: Tokushima University

Inventor： Hiroshi Kido ,  Etsuhisa Takahashi ,  Takashi Kimoto ,  Satoko Sakai

IPC: A61K39/35 ,  A61K39/39 ,  A61P37/08

Abstract: An object of the present invention is to provide an allergen vaccine for treatment or prevention of an allergic disease, while reducing the risk of developing an immediate type allergy including anaphylaxis. The present inventors have found that (1) oral inoculation of a composition comprising a particular antigen (allergen) and SF10 into subjects having allergic diseases can suppress the development of an immediate type allergy caused by sensitization with the antigen, and (2) oral inoculation of a composition comprising a particular antigen (allergen) and SF10 into subjects not having allergic diseases can inhibit establishment of sensitization to the antigen, and have completed the present invention.

公开(公告)号：US11124881B2

公开(公告)日：2021-09-21

申请号：US17272765

申请日：2020-06-04

Applicant: CHEMICAL DENSHI CO., LTD. ,  Tokushima University

Inventor： Shoichi Yamada ,  Toshio Hyuga ,  Hisao Nemoto

IPC: C23F11/12 ,  C07D319/06 ,  C23F11/16 ,  C07C327/22 ,  C07D317/20

Abstract: The objective of the present invention is to provide a hydrophilic metal surface treatment agent by which a water-repellent property can be given to a metal surface with suppressing a corrosion and a discolorment of the metal, a method for treating a surface of a metal by using the hydrophilic metal surface treatment agent, a synthetic intermediate compound of a branched glycerol derivative as an active ingredient of the hydrophilic metal surface treatment agent, and a method for efficiently producing the synthetic intermediate compound. The hydrophilic metal surface treatment agent of the present invention is characterized in comprising the branched glycerol derivative represented by the following formula (I) as an active ingredient. wherein R1 is a hydrocarbon group having a carbon number of 10 or more and 30 or less, X is S or a carbonyl group, Y is an n+1 valent linker group, n is an integer of 1 or more and 5 or less.