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136 条记录 (耗时 0.037 秒)

    FUSED RING COMPOUND CONTAINING FURAN OR SALT THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME
    32.
    发明申请
    FUSED RING COMPOUND CONTAINING FURAN OR SALT THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME 有权
    含有FURAN或其盐的熔融环化合物和包含其的药物组合物

    公开(公告)号：US20150191478A1

    公开(公告)日：2015-07-09

    申请号：US14416079

    申请日：2013-07-23

    申请人： YUHAN CORPORATION

    发明人： Hyoung Sig Seo ,  Tae Kyun Kim ,  Hyun Joo Lee ,  Dong Hoon Kim ,  Gyu Jin Lee ,  Jun Chul Park ,  Ji Yeong Gal ,  Tae-hoon Kim ,  Kwan Hoon Hyun ,  Kyoung Kyu Ahn ,  Kaapjoo Park ,  Su Youn Nam ,  Ge Hyeong Lee ,  Hee Jong Lim

    IPC分类号： C07D491/048

    CPC分类号： C07D491/048

    摘要： The present invention provides a fused ring compound containing furan or a pharmaceutically acceptable salt thereof, a method for preparing same, a pharmaceutical composition comprising same, and a use thereof. The fused ring compound containing furan or a pharmaceutically acceptable salt thereof inhibits the activity of phosphatidylinositol 3-kinase (PI3K) and can therefore be used in a pharmaceutical composition for treating and preventing respiratory diseases, inflammatory diseases, proliferative diseases, cardiovascular diseases, or central nervous system diseases which occur due to the over-activation of PI3K.

    摘要翻译： 本发明提供含有呋喃或其药学上可接受的盐的稠环化合物，其制备方法，包含其的药物组合物及其用途。 含有呋喃或其药学上可接受的盐的稠环化合物抑制磷脂酰肌醇3-激酶（PI3K）的活性，因此可用于治疗和预防呼吸系统疾病，炎性疾病，增殖性疾病，心血管疾病或中枢的药物组合物 由于PI3K的过度激活而发生的神经系统疾病。

    PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
    33.
    发明申请
    PHENYLIMIDE-CONTAINING BENZOTHIAZOLE DERIVATIVE OF ITS SALT AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 审中-公开
    其含有苯并咪唑的苯并噻唑衍生物及其包含的药物组合物

    公开(公告)号：US20150011528A1

    公开(公告)日：2015-01-08

    申请号：US14346506

    申请日：2012-09-21

    申请人： YUHAN CORPORATION

    发明人： Youn Hur ,  Dong-Hyun Kim ,  Eun-Kyung Kim ,  Jin-Hwi Park ,  Jae-Eun Joo ,  Ho-Woong Kang ,  Se-Woong Oh ,  Dong-Kyun Kim ,  Kyoung-Kyu Ahn

    IPC分类号： C07D277/82 ,  C07D417/12 ,  C07D277/60 ,  C07D513/04

    CPC分类号： C07D277/82 ,  C07D277/60 ,  C07D417/12 ,  C07D513/04

    摘要： Provided is a phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt can selectively inhibit the protein-protein interaction between KRS and a laminin receptor (LR), thereby inhibiting migration of cancer cells. Therefore, the phenylimide-containing benzothiazole derivative or its pharmaceutically acceptable salt may be usefully applied for preventing or treating the diseases associated with cancer cell metastasis.

    摘要翻译： 本发明提供含苯酰亚胺的苯并噻唑衍生物或其药学上可接受的盐，其制备方法和包含该方法的药物组合物。 含苯基酰亚胺的苯并噻唑衍生物或其药学上可接受的盐可以选择性地抑制KRS和层粘连蛋白受体（LR）之间的蛋白质 - 蛋白质相互作用，从而抑制癌细胞的迁移。 因此，含苯亚胺的苯并噻唑衍生物或其药学上可接受的盐可用于预防或治疗与癌细胞转移相关的疾病。

    Method for treating damage to gastric mucosa
    37.
    发明授权
    Method for treating damage to gastric mucosa 有权
    治疗胃粘膜损伤的方法

    公开(公告)号：US07776873B2

    公开(公告)日：2010-08-17

    申请号：US11604269

    申请日：2006-11-27

    申请人： Ki-Baik Hahm ,  Dong-Kyu Kim ,  Mi-Sun Kwak ,  Sang-Aun Joo ,  Byoung-Seok Moon ,  Geun-Seog Song

    发明人： Ki-Baik Hahm ,  Dong-Kyu Kim ,  Mi-Sun Kwak ,  Sang-Aun Joo ,  Byoung-Seok Moon ,  Geun-Seog Song

    IPC分类号： A61K31/506

    CPC分类号： A61K31/505 ,  A61K31/495 ,  A61K31/506

    摘要： Provided is a method for treating damage to the gastric mucosa with a cytoprotective agent, comprising administering to a human in need thereof a pharmaceutical composition comprising an effective amount for treating damage to gastric mucosa of a pharmaceutically acceptable salt of revaprazan as the cytoprotective agent, and a pharmaceutically acceptable carrier. Revaprazan or its salt has an excellent treatment effect for gastrointestinal mucosal damage by potentiating a defensive factor in the gastrointestinal mucosa, simultaneously with acting as an acid pump antagonist.

    摘要翻译： 本发明提供了一种用细胞保护剂治疗对胃粘膜的损害的方法，其包括向有需要的人施用药物组合物，该药物组合物包含治疗对作为细胞保护剂的雷帕沙坦的药学上可接受的盐的胃粘膜的损伤的有效量，以及 药学上可接受的载体。 Revaprazan或其盐通过增强胃肠粘膜中的防御因子，同时作为酸泵拮抗剂，对胃肠粘膜损伤具有极好的治疗作用。