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86 条记录 (耗时 0.03 秒)

    Haemocoagulase
    31.
    发明授权
    Haemocoagulase 有权

    公开(公告)号：US08017750B2

    公开(公告)日：2011-09-13

    申请号：US12952308

    申请日：2010-11-23

    申请人： Xijuan Wang

    发明人： Xijuan Wang

    IPC分类号： C12N9/00 ,  C07H21/04

    CPC分类号： C12N9/6418 ,  A61K38/00 ,  C12N9/6429 ,  C12Y304/21005

    摘要： The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by replacement, depletion, or addition of one or more nucleotide based on the said nucleotide sequence with an equivalent function. The said haemocoagulase has amino acid sequence shown by SEQ ID NO: 2. Haemocoagulase of the present invention has an obvious hemostatic effect, a broad effective dose range, safe and reliable application, which creates good conditions for the development of genetic engineering products of recombinant haemocoagulase in the future.

    Haemocoagulase
    32.
    发明授权
    Haemocoagulase 有权
    血细胞凝集酶

    公开(公告)号：US07993893B2

    公开(公告)日：2011-08-09

    申请号：US12446182

    申请日：2006-12-08

    申请人： Xijuan Wang

    发明人： Xijuan Wang

    IPC分类号： C12N9/00

    CPC分类号： C12N9/6418 ,  A61K38/00 ,  C12N9/6429 ,  C12Y304/21005

    摘要： The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by replacement, depletion, or addition of one or more nucleotide based on the said nucleotide sequence with an equivalent function. The said haemocoagulase has amino acid sequence shown by SEQ ID NO: 2. Haemocoagulase of the present invention has an obvious hemostatic effect, a broad effective dose range, safe and reliable application, which creates good conditions for the development of genetic engineering products of recombinant haemocoagulase in the future.

    摘要翻译： 本发明提供了一种静脉血细胞凝集酶基因及其功能蛋白的表达。 本发明的血细胞凝集酶基因具有序列表SEQ ID NO：1所示的核苷酸序列或通过以相同的功能替换，消耗或添加基于所述核苷酸序列的一个或多个核苷酸而形成的突变核苷酸序列。 所述血细胞凝集酶具有SEQ ID NO：2所示的氨基酸序列。本发明的血细胞凝集酶具有明显的止血效果，广泛的有效剂量范围，安全可靠的应用，为重组的基因工程产物的开发创造了良好条件 血细胞凝集酶在未来。

    HAEMOCOAGULASE
    33.
    发明申请
    HAEMOCOAGULASE 有权

    公开(公告)号：US20110071283A1

    公开(公告)日：2011-03-24

    申请号：US12952308

    申请日：2010-11-23

    申请人： Xijuan WANG

    发明人： Xijuan WANG

    IPC分类号： C12N15/52

    CPC分类号： C12N9/6418 ,  A61K38/00 ,  C12N9/6429 ,  C12Y304/21005

    摘要： The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by replacement, depletion, or addition of one or more nucleotide based on the said nucleotide sequence with an equivalent function. The said haemocoagulase has amino acid sequence shown by SEQ ID NO: 2. Haemocoagulase of the present invention has an obvious hemostatic effect, a broad effective dose range, safe and reliable application, which creates good conditions for the development of genetic engineering products of recombinant haemocoagulase in the future.

    摘要翻译： 本发明提供了一种静脉血细胞凝集酶基因及其功能蛋白的表达。 本发明的血细胞凝集酶基因具有序列表SEQ ID NO：1所示的核苷酸序列或通过以相同的功能替换，消耗或添加基于所述核苷酸序列的一个或多个核苷酸而形成的突变核苷酸序列。 所述血细胞凝集酶具有SEQ ID NO：2所示的氨基酸序列。本发明的血细胞凝集酶具有明显的止血效果，广泛的有效剂量范围，安全可靠的应用，为重组的基因工程产物的开发创造了良好条件 血细胞凝集素在未来。

    ACTIVATING AGENT OF STEM CELLS AND/OR PROGENITOR CELLS
    35.
    发明申请
    ACTIVATING AGENT OF STEM CELLS AND/OR PROGENITOR CELLS 审中-公开
    干细胞和/或祖细胞的激活剂

    公开(公告)号：US20100034803A1

    公开(公告)日：2010-02-11

    申请号：US11993553

    申请日：2006-10-02

    申请人： Hirobumi Senga ,  Zhongchao Han ,  Dingfang Cai ,  Li Li

    发明人： Hirobumi Senga ,  Zhongchao Han ,  Dingfang Cai ,  Li Li

    IPC分类号： A61K38/48

    CPC分类号： C12N5/0647 ,  A61K38/00 ,  C12N5/0623 ,  C12N5/0692 ,  C12N9/6418 ,  C12N2533/56

    摘要： The present invention provides an activating agent of stem cells and/or progenitor cells comprising a thrombin-like enzyme which can be used in regenerative medicine, and particularly in regenerative medicine utilizing self-regeneration, acting promptly and moderately depending on the state of advancement and the degree of injured organs and/or tissues to which regenerative medicine is applied, with few or no side effects. The present invention also provides a method for activating stem cells and/or progenitor cells in an animal comprising the step of administering to the animal an effective amount of a thrombin-like enzyme and use of the thrombin-like enzyme for activating stem cells and/or progenitor cells.

    摘要翻译： 本发明提供一种干细胞和/或祖细胞的活化剂，其包含可用于再生医学中的凝血酶样酶，特别是在利用自我再生的再生医学中，其取决于进展状态及时和适度地起作用， 使用再生药物的受伤器官和/或组织的程度很少或没有副作用。 本发明还提供了一种用于激活动物中的干细胞和/或祖细胞的方法，包括向动物施用有效量的凝血酶样酶和使用凝血酶样酶来激活干细胞和/ 或祖细胞。

    GENETIC RECOMBINANT ECARIN AND PROCESS FOR PREPARING THE SAME
    36.
    发明申请
    GENETIC RECOMBINANT ECARIN AND PROCESS FOR PREPARING THE SAME 审中-公开
    遗传重组蛋白及其制备方法

    公开(公告)号：US20080153132A1

    公开(公告)日：2008-06-26

    申请号：US11950638

    申请日：2007-12-05

    申请人： Hiroshi YONEMURA ,  Takayuki IMAMURA ,  Hiroshi NAKATAKE ,  Kenji SOEJIMA ,  Chikateru NOZAKI

    发明人： Hiroshi YONEMURA ,  Takayuki IMAMURA ,  Hiroshi NAKATAKE ,  Kenji SOEJIMA ,  Chikateru NOZAKI

    IPC分类号： C12P21/04 ,  C07K16/00

    CPC分类号： C12N9/6418

    摘要： A recombinant ecarin protein that specifically activates prothrombin, said protein being efficiently prepared by the genetic engineering technique comprising the steps: (1) culturing a transformant microorganism or animal cell transformed with an expression vector in which a gene encoding ecarin is incorporated to the downstream of a promoter so as to produce and accumulate ecarin in culture supernatant or within said transformant and recovering the produced ecarin; and (2) purifying a solution containing the recovered ecarin to obtain purified ecarin. The present invention allows for production of recombinant ecarin on an industrial scale.

    摘要翻译： 一种特异性激活凝血酶原的重组ecarin蛋白，所述蛋白通过遗传工程技术有效地制备，包括以下步骤：（1）培养用表达载体转化的转化体微生物或动物细胞，其中将编码ecarin的基因并入到 促进剂，以在培养上清液或所述转化体内产生和积累ecarin并回收所产生的ecarin; 和（2）纯化含有回收的ecarin的溶液以获得纯化的ecarin。 本发明允许以工业规模生产重组ecarin。