公开(公告)号：US06872941B1

公开(公告)日：2005-03-29

申请号：US10719330

申请日：2003-11-20

申请人： Craig M. Whitehouse ,  David G. Welkie

发明人： Craig M. Whitehouse ,  David G. Welkie

IPC分类号： H01J49/40 ,  H01J49/42 ,  H01J49/16

CPC分类号： H01J49/40 ,  B82Y30/00 ,  H01J49/0068

摘要： A Time-Of-Flight mass spectrometer is configured with a pulsing region and electronic controls that generate a potential well for ions in the pulsing region, due to the repelling effect of a high-frequency electric field that is created in the space immediately proximate to a surface, and an additional static electric field that accelerates ions toward the surface. Ions can be constrained and accumulated over time in the potential well prior to acceleration into the Time-Of-Flight tube for mass analysis. Ions can also be directed to collide with the surface with high energy to cause Surface Induced Dissociation (SID) fragmentation, or with low energy to effect collisional cooling, hence, better spatial focusing, prior to mass analysis. The apparatus and method described in the invention result in refined control of ion fragmentation energy and improved Time-Of-Flight mass analysis performance.

摘要翻译： 飞行时间质谱仪配置有脉冲区域和电子控制器，由于在紧邻的空间中产生的高频电场的排斥效应，脉冲区域中的离子产生潜在的阱 一个表面和一个额外的静电场，可以将离子加速到表面。 在加速进入飞行时间管以进行质量分析之前，离子可以在潜在的时间内受到约束和积累。 离子也可以被引导与高能量的表面碰撞以引起表面诱导解离（SID）碎裂，或者以低能量来实现碰撞冷却，因此在质量分析之前更好地进行空间聚焦。 本发明描述的装置和方法可以精确控制离子碎片能量，提高飞行时间质量分析性能。

公开(公告)号：US20030003595A1

公开(公告)日：2003-01-02

申请号：US10219367

申请日：2002-08-15

发明人： Aviv Amirav

IPC分类号： G01N024/00

CPC分类号： H01J49/049 ,  G01N30/72 ,  G01N30/7246 ,  G01N30/7273 ,  H01J49/0068 ,  H01J49/045 ,  H01J49/147 ,  H01J49/16 ,  Y10T436/24 ,  Y10T436/25875

摘要： The invention provides a mass spectrometric method for analyzing a sample in a solution, including the steps of directing a flow of a solution containing sample compounds to be analyzed towards a supersonic nozzle having an input end and an output end; vaporizing the solution and sample prior to its expansion from the output end of said supersonic nozzle; allowing expansion of the vaporized sample and solution from said supersonic nozzle into a vacuum system, forming a supersonic molecular beam with vibrationally cold sample molecules; ionizing the vaporized sample compounds with electrons while contained as vibrationally cold molecules in said supersonic molecular beam; mass analyzing the ions formed from said sample compounds; detecting said ions formed from said sample compounds after mass analysis, and processing the data obtained from the resulting mass spectral information, for identifying and/or quantifying the chemical content of said sample. The invention also provides apparatus for analyzing a sample in a solution.

摘要翻译： 本发明提供了一种用于分析溶液中的样品的质谱方法，包括以下步骤：将含有待分析样品化合物的溶液流引向具有输入端和输出端的超音速喷嘴; 在从所述超音速喷嘴的输出端膨胀之前蒸发溶液和样品; 允许将蒸发的样品和溶液从所述超音速喷嘴扩展到真空系统中，形成具有振动冷样品分子的超音速分子束; 用电子电离蒸发的样品化合物，同时在所述超音速分子束中作为振动冷分子包含; 质量分析由所述样品化合物形成的离子; 在质量分析之后检测由所述样品化合物形成的离子，并处理由所得质谱信息获得的数据，以识别和/或定量所述样品的化学成分。 本发明还提供了用于分析解决方案中的样本的装置。

公开(公告)号：US5026987A

公开(公告)日：1991-06-25

申请号：US528900

申请日：1990-05-23

申请人： Mark E. Bier ,  Robert G. Cooks ,  George C. Stafford

发明人： Mark E. Bier ,  Robert G. Cooks ,  George C. Stafford

IPC分类号： H01J49/26 ,  H01J49/42

CPC分类号： H01J49/0068

摘要： A mass spectrometer including at least one mass analyzer into which an ion beam to be analyzed is projected having a collision surface means in-line with the ion beam to form surface collision products which are directed into the in-line mass analyzer.

摘要翻译： 一种质谱仪，包括至少一个质量分析器，其中投射有待分析的离子束具有碰撞表面，其与离子束一致，以形成被引导到在线质量分析器中的表面碰撞产物。