公开(公告)号：US08395112B1

公开(公告)日：2013-03-12

申请号：US12898264

申请日：2010-10-05

申请人： Mark E. Bier

发明人： Mark E. Bier

IPC分类号： H01J49/34 ,  B01D59/44

CPC分类号： H01J49/422 ,  C12Q1/6872 ,  G01N21/53 ,  G01N21/6428 ,  G01N2021/6439 ,  G01N2021/6465 ,  G01N2021/6467 ,  G01N2021/6482 ,  G01N2021/6493 ,  H01J49/4255

摘要： Apparatus including an ion trap, a controller connected to the ion trap, wherein the controller includes a memory containing computer readable instructions which, when executed, cause the controller to send control signals to the ion trap so that the ion trap produce and maintain a trapping field in the ion trap, a waveform generator to change the trapping field so that ions of a predetermined mass in the trapping chamber are selectively moved; a secondary waveform generator to change the orbits of the ions; an energy source to excite ions to emit photons, an optical detector to detect the emitted photons, and a processor which can apply fast-Fourier transform analysis of the time-domain signal of the detected emitted photons to generate a frequency or mass spectrum related to mass-to-charge ratio of the ions.

摘要翻译： 包括离子阱的装置，连接到离子阱的控制器，其中所述控制器包括含有计算机可读指令的存储器，所述计算机可读指令在执行时使所述控制器向所述离子阱发送控制信号，使得所述离子阱产生并保持捕集 波形发生器，用于改变俘获场，使得俘获室中的预定质量的离子被选择性地移动; 次级波形发生器，用于改变离子的轨道; 用于激发离子发射光子的能量源，用于检测发射的光子的光学检测器，以及可以对所检测到的发射光子的时域信号进行快速傅里叶变换分析的处理器，以产生与 离子的质荷比。

公开(公告)号：US5756996A

公开(公告)日：1998-05-26

申请号：US675966

申请日：1996-07-05

申请人： Mark E. Bier ,  John E. P. Syka ,  Dennis M. Taylor ,  William J. Fies

发明人： Mark E. Bier ,  John E. P. Syka ,  Dennis M. Taylor ,  William J. Fies

IPC分类号： H01J49/04 ,  H01J49/14 ,  H01J49/42

CPC分类号： H01J49/147 ,  H01J49/145

摘要： An external ion source assembly in which ion are formed in an ion volume by the interaction of energetic electrons and gas molecules. The effective energy of the electrons entering the ion volume is controlled by changing the voltage between the electron source (filament) and the ionization volume whereby ions having sufficient energy for ionizing atoms and molecules leave the electron source and enter the ionization volume only during an ionization period. The ion source assembly can be used both for electron impact ionization (EI) and for chemical ionization (CI).

摘要翻译： 外部离子源组件，其中通过能量电子和气体分子的相互作用在离子体中形成离子。 通过改变电子源（细丝）和离子化体积之间的电压来控制进入离子体积的电子的有效能量，由此离子具有足够的电离原子和分子的能量离开电子源并且仅在电离过程中进入离子化体积 期。 离子源组件可用于电子碰撞电离（EI）和化学电离（CI）。

公开(公告)号：US5420425A

公开(公告)日：1995-05-30

申请号：US250156

申请日：1994-05-27

申请人： Mark E. Bier ,  John E. P. Syka

发明人： Mark E. Bier ,  John E. P. Syka

IPC分类号： G01N27/62 ,  H01J49/34 ,  H01J49/42

CPC分类号： H01J49/423 ,  H01J49/424

摘要： The present invention relates generally to an ion trap mass spectrometer for analyzing ions and more particularly to a substantially quadrupole ion trap mass spectrometer with an enlarged ion occupied volume. Described herein are electrode geometries that enlarge the ion occupied volume. Improved ion sensitivities, detection limits and dynamic range should be realized for the same charge density in these devices because the increased ion occupied volume allows for the storage of a greater number of ions. The essence of this invention is that these ion trap geometries may apply all modes of operation of substantially quadrupole ion traps such as the mass selective instability mode, resonance excitation/ejection, and MS.sup.n.

摘要翻译： 本发明一般涉及一种用于分析离子的离子阱质谱仪，更具体地涉及具有增大的离子占据体积的基本四极离子阱质谱仪。 这里描述了放大离子占据体积的电极几何形状。 对于这些器件中相同的电荷密度，应该实现改进的离子灵敏度，检测限和动态范围，因为增加的离子占据体积允许存储更多数量的离子。 本发明的实质是这些离子阱几何可以应用基本上四极离子阱的所有操作模式，例如质量选择不稳定模式，共振激发/喷射和MSn。

公开(公告)号：US5162650A

公开(公告)日：1992-11-10

申请号：US645649

申请日：1991-01-25

申请人： Mark E. Bier

发明人： Mark E. Bier

IPC分类号： G01N30/72 ,  H01J49/04 ,  H01J49/42

CPC分类号： H01J49/067 ,  G01N30/7273 ,  G01N30/7293 ,  H01J49/044 ,  H01J49/045 ,  G01N30/724

摘要： Disclosed is a multi-stage particle separator for separating analyte from non-analyte solvent in a fluid sample having nebulizing means to form droplets from the liquid sample and means coupled to the nebulizing means for adding helium to the nebulizing means. Furthermore, the multi-stage particle separator has a desolvation chamber for receiving the droplets, the desolvation chamber terminating in a nozzle, a multi-stage momentum separator including skimmers, and means for introducing a gas into one or more of the states to increase pressure of the latter stage so that the particles leave the multi-stage separator substantially free of solvent.

摘要翻译： 公开了一种多级颗粒分离器，用于在具有雾化装置的流体样品中从非分析物溶剂中分离分析物，以从液体样品形成液滴，并且耦合到雾化装置的装置，用于将氦添加到雾化装置。 此外，多级粒子分离器具有用于接收液滴的去溶剂化室，终止在喷嘴中的去溶剂化室，包含脱水器的多级动量分离器，以及用于将气体引入一种或多种状态以增加压力的装置 使得颗粒离开多级分离器基本上不含溶剂。

公开(公告)号：US4642165A

公开(公告)日：1987-02-10

申请号：US684461

申请日：1984-12-21

申请人： Mark E. Bier

发明人： Mark E. Bier

IPC分类号： B01D1/00 ,  B01D3/42

CPC分类号： B01D1/0082

摘要： A method of vaporizing a multicomponent liquid, such as a hydrogen peroxide and water solution, for injection into a vacuum chamber including the steps of metering successive predetermined increments of the liquid at a predetermined rate onto a heated surface in a vaporization chamber. Upon exposure to the heated surface, each liquid increment is substantially instantaneously vaporized before the next succeeding liquid increment is metered onto the heated surface to produce a multicomponent vapor increment having substantially the same weight percent composition as the multicomponent liquid increment. Each vapor increment is passed into the vacuum chamber.

摘要翻译： 蒸发诸如过氧化氢和水溶液的多组分液体的方法用于注入真空室，包括以预定速率将液体的连续预定增量计量到蒸发室中的加热表面上的步骤。 在暴露于被加热的表面之后，在接下来的后续液体增量计量到加热的表面上之前，每个液体增量基本上瞬间蒸发，以产生具有与多组分液体增量基本相同的重量百分比组成的多组分蒸气增量。 每个蒸汽增量都被送入真空室。

公开(公告)号：USRE33007E

公开(公告)日：1989-08-01

申请号：US153878

申请日：1988-02-09

申请人： Mark E. Bier

发明人： Mark E. Bier

IPC分类号： A61L2/20 ,  B01D3/10 ,  C01B15/01

CPC分类号： A61L2/20 ,  B01D3/10 ,  C01B15/01

摘要： A method of vaporizing a multicomponent liquid, such as a hydrogen peroxide and water solution, for injection into a vacuum chamber including the steps of metering successive predetermined increments of the liquid at a predetermined rate onto a heated surface in a vaporization chamber. Upon exposure to the heated surface, each liquid increment is substantially instantaneously vaporized before the next succeeding liquid increment is metered onto the heated surface to produce a multi-component vapor increment having substantially the same weight percent composition as the multicomponent liquid increment. Each vapor increment is passed into the vacuum chamber.

公开(公告)号：US08809773B2

公开(公告)日：2014-08-19

申请号：US11886890

申请日：2006-03-22

申请人： Mark E. Bier

发明人： Mark E. Bier

IPC分类号： H01J49/00 ,  B01D59/44 ,  G01N1/00 ,  G01N1/28

CPC分类号： B01D59/44 ,  G01N1/00 ,  G01N1/22 ,  G01N1/28 ,  G01N35/1095

摘要： The disclosed method and apparatus couple a membrane interface directly to a mass spectrometer at atmospheric pressure. The membrane may be in capillary or sheet form and allows the introduction of a liquid or gaseous sample to one side of the membrane while the other side of the membrane is bathed with a solution that can easily be used in an atmospheric pressure ionization source. Volatile molecules permeate through a suitable membrane such as poly-dimethyl silicone (PDMS), mix into the appropriate solvent, and are ionized. Because of the rules governing abstracts, this abstract should not be used in construing the claims.

摘要翻译： 所公开的方法和装置在大气压力下将膜界面直接耦合到质谱仪。 膜可以是毛细管或片状，并且允许将液体或气体样品引入膜的一侧，同时膜的另一侧用可容易地用于大气压电离源的溶液洗涤。 挥发性分子渗透通过合适的膜，例如聚二甲基硅氧烷（PDMS），混合到合适的溶剂中并被电离。 由于管理摘要的规则，本摘要不应用于解释索赔。

公开(公告)号：US07807963B1

公开(公告)日：2010-10-05

申请号：US11903018

申请日：2007-09-20

申请人： Mark E. Bier

发明人： Mark E. Bier

IPC分类号： H01J49/00

CPC分类号： H01J49/422 ,  G01N21/53 ,  G01N21/6428 ,  H01J49/4255

摘要： An apparatus including a plurality of electrodes defining a trapping chamber of an ion trap, wherein at least one of the electrodes is a transparent electrode having at least a portion that is both optically transparent and electrically conductive; a controller connected to the plurality of electrodes, wherein the controller includes a memory containing computer readable instructions which, when executed, cause the controller to send control signals to the plurality of electrodes so that: the plurality of electrodes produce and maintain a trapping field in the trapping chamber, and the plurality of electrodes change the trapping field so that ions of a predetermined mass in the trapping chamber are selectively moved; and an optical detector oriented so that the portion of the transparent electrode that is both optically transparent and electrically conductive is between the optical detector and the trapping chamber.

摘要翻译： 一种包括限定离子阱陷阱室的多个电极的装置，其中至少一个电极是至少具有光学透明和导电的部分的透明电极; 连接到所述多个电极的控制器，其中所述控制器包括存储器，所述存储器包含计算机可读指令，所述计算机可读指令在执行时使所述控制器向所述多个电极发送控制信号，使得：所述多个电极产生并保持所述多个电极中的捕获场 捕集室和多个电极改变捕获场，使得俘获室中的预定质量的离子选择性地移动; 以及光学检测器，其被定向成使得透明电极的光学透明和导电的部分在光学检测器和捕获室之间。

公开(公告)号：US20090020696A1

公开(公告)日：2009-01-22

申请号：US11886890

申请日：2006-03-22

申请人： Mark E. Bier

发明人： Mark E. Bier

IPC分类号： B01D59/44 ,  G01N1/00 ,  G01N1/28

CPC分类号： B01D59/44 ,  G01N1/00 ,  G01N1/22 ,  G01N1/28 ,  G01N35/1095

摘要： The disclosed method and apparatus couple a membrane interface directly to a mass spectrometer at atmospheric pressure. The membrane may be in capillary or sheet form and allows the introduction of a liquid or gaseous sample to one side of the membrane while the other side of the membrane is bathed with a solution that can easily be used in an atmospheric pressure ionization source. Volatile molecules permeate through a suitable membrane such as poly-dimethyl silicone (PDMS), mix into the appropriate solvent, and are ionized. Because of the rules governing abstracts, this abstract should not be used in construing the claims.

摘要翻译： 所公开的方法和装置在大气压力下将膜界面直接耦合到质谱仪。 膜可以是毛细管或片状，并且允许将液体或气体样品引入膜的一侧，同时膜的另一侧用可容易地用于大气压电离源的溶液洗涤。 挥发性分子渗透通过合适的膜，例如聚二甲基硅氧烷（PDMS），混合到合适的溶剂中并被电离。 由于管理摘要的规则，本摘要不应用于解释索赔。

公开(公告)号：US5572022A

公开(公告)日：1996-11-05

申请号：US398143

申请日：1995-03-03

申请人： Jae C. Schwartz ,  Xaio-Guang Zhou ,  Mark E. Bier

发明人： Jae C. Schwartz ,  Xaio-Guang Zhou ,  Mark E. Bier

IPC分类号： H01J49/14 ,  H01J49/42 ,  H01J49/00 ,  B01D59/44

CPC分类号： H01J49/4265 ,  H01J49/147

摘要： This invention is directed to a method and apparatus of increasing the dynamic range and sensitivity of an ion trap mass spectrometer with the use of external ionization. An increased number of sample ions are introduced into the mass spectrometer for mass analysis with the aid of an automatic ion supply control, or feedback, feature. The feedback portion of the invention controls the gating time, and hence the number of sample ions gated into the mass spectrometer, based on previous measurements of the ion content in the mass spectrometer to gate an amount relative to where space charge and saturation begins. A mass filter may also be used between the ion source and the mass spectrometer to improve the signal-to-noise ratio and increase the net processing time. This mass analyzing system may be used with various methods of mass analysis including mass selective instability, resonance ejection, MS/MS, and MS/MS with a supplemental AC field.

摘要翻译： 本发明涉及使用外部电离增加离子阱质谱仪的动态范围和灵敏度的方法和装置。 借助于自动离子供应控制或反馈特征，将更多数量的样品离子引入质谱仪进行质量分析。 本发明的反馈部分基于先前对质谱仪中的离子含量的测量来控制门控时间，并因此控制门控量化到质谱仪中的样品离子的数量，以便相对于开始空间电荷和饱和度的位置来控制一定量。 也可以在离子源和质谱仪之间使用质量过滤器来提高信噪比并增加净处理时间。 该质量分析系统可以与包括质量选择不稳定性，共振喷射，MS / MS和具有补充AC场的MS / MS的各种质量分析方法一起使用。