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    Methods and apparatus for trapping and accumulation of ions
    2.
    发明授权
    Methods and apparatus for trapping and accumulation of ions 有权

    公开(公告)号：US11953466B2

    公开(公告)日：2024-04-09

    申请号：US17327159

    申请日：2021-05-21

    申请人： MOBILion Systems, Inc.

    发明人： John Daniel DeBord ,  Liulin Deng ,  Gordon A. Anderson

    IPC分类号： H01J49/16 ,  G01N27/622 ,  H01J49/06

    CPC分类号： G01N27/622 ,  H01J49/061 ,  H01J49/16

    摘要： Methods and apparatus for ion accumulation are disclosed. An apparatus for ion accumulation includes multiple regions. A first region receives and transfers ions to a second region using a first drive potential. The second region is switchable between a first state where it generates a first electric field preventing ions from further movement and entering a third region, and a second state where it generates a second electric field that guides the ions toward the third region. When in the first state, the ions are prevented from further movement by the first electric field, which causes the ions to accumulate in the second region. When in the second state, the ions are moved from the second region to the third region by the second electric field. A method of accumulating ions involves switching an electric field applied to a region between a trap state and a release state.

    Ion source assembly with multiple ionization volumes for use in a mass spectrometer
    5.
    发明授权
    Ion source assembly with multiple ionization volumes for use in a mass spectrometer 有权

    公开(公告)号：US11658020B2

    公开(公告)日：2023-05-23

    申请号：US17357348

    申请日：2021-06-24

    申请人： INFICON, Inc.

    发明人： Michael F. Vollero

    IPC分类号： H01J49/16 ,  H01J49/06 ,  H01J49/26

    CPC分类号： H01J49/16 ,  H01J49/062 ,  H01J49/068 ,  H01J49/26

    摘要： An ion source assembly for use in a mass spectrometer comprises a first anode defining a first ionization volume and a first electron source positioned proximate the first anode and configured to generate electrons that pass through the first anode and into the first ionization volume. The ions source assembly further includes a second anode defining a second ionization volume and a second electron source positioned proximate to the second anode and configured to generate to generate electrons that pass through the second anode and into the second ionization volume. At least one optical element is positioned proximate the first ionization volume and defines an aperture. The first and second anodes and the first and second ionization volumes are positioned along an ion optical axis of the mass spectrometer, and the first anode is positioned between the second anode and the aperture.

    METHOD FOR LIQUID CHROMATOGRAPHIC MASS SPECTROMETRY AND LIQUID CHROMATOGRAPH MASS SPECTROMETER
    7.
    发明申请
    METHOD FOR LIQUID CHROMATOGRAPHIC MASS SPECTROMETRY AND LIQUID CHROMATOGRAPH MASS SPECTROMETER 审中-公开

    公开(公告)号：US20180328898A1

    公开(公告)日：2018-11-15

    申请号：US15973640

    申请日：2018-05-08

    申请人： SHIMADZU CORPORATION

    发明人： Yusaku HIOKI

    IPC分类号： G01N30/38 ,  G01N30/84 ,  G01N30/72 ,  G01N30/28 ,  H01J49/16 ,  G01N33/68

    CPC分类号： H01J49/16 ,  H01J49/0431

    摘要： In an LC/MS analysis of a sample containing various compounds, additive supply pumps 164A and 164B in a post-column adding unit 16 draw and supply different kinds of additives A and B from containers 163A and 163B, respectively. The additives are mixed into an eluate through T-joints 162 and 161. A preferable combination of the additives is the combination of DMSO which produces the effect of gathering charge states and 2-propanol which produces the effect of promoting atomization or vaporization of droplets. By mixing the two additives into the eluate while mixing them at an appropriate flow-rate ratio according to a previously determined flow-rate program, the ionization efficiency can be nearly optimized for each compound during the process of generating ions by spraying electrically charged droplets of the eluate from an ESI spray 21. Consequently, the detection sensitivity becomes higher than conventional levels.