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公开(公告)号：USRE34000E
公开(公告)日：1992-07-21
申请号：US499947
申请日：1990-03-27
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0081 , H01J49/429
摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.
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公开(公告)号：US4066894A
公开(公告)日：1978-01-03
申请号：US650783
申请日：1976-01-20
CPC分类号： H01J49/4215 , H01J49/0095 , H01J49/025
摘要： A method and an apparatus are disclosed for adapting a conventional quadrupole mass spectrometer to substantially simultaneously produce and record both positive and negative ions. The apparatus includes a control circuit for rapidly switching the repeller, source and lens electrodes of a quadrupole mass spectrometer between positive and negative potentials. This switching of the potentials, along with the selection of appropriately favorable ionization conditions, permits the generation of suitable streams of positive and negative ions. A dual electron multiplier detector is used for separately sensing the positive and negative ions transmitted through the quadrupole mass spectrometer. The disclosed method and apparatus are particularly suitable for obtaining accurate mass measurements using a quadrupole mass spectrometer.
摘要翻译： 公开了用于使常规四极质谱仪适应于基本上同时产生和记录正离子和负离子的方法和装置。 该装置包括用于在正电位和负电位之间快速切换四极质谱仪的反射器，源极和透镜电极的控制电路。 这种电位的切换以及合适的电离条件的选择允许产生合适的正离子和负离子流。 双电子倍增器检测器用于单独检测通过四极杆质谱仪传输的正离子和负离子。 所公开的方法和装置特别适用于使用四极质谱仪获得准确的质量测量。
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3.发明申请公开(公告)号：US20090294649A1
公开(公告)日：2009-12-03
申请号：US12473570
申请日：2009-05-28
申请人： Jeffrey Shabanowitz , Philip D. Compton , Lee Earley , George C. Stafford, JR. , Donald F. Hunt , Christopher Mullen
发明人： Jeffrey Shabanowitz , Philip D. Compton , Lee Earley , George C. Stafford, JR. , Donald F. Hunt , Christopher Mullen
CPC分类号： H01J49/12 , H01J49/0072
摘要： A front-end reagent ion source for a mass spectrometer is disclosed. Reagent vapor is supplied to a reagent ionization volume located within a chamber of the mass spectrometer and maintained at a low vacuum pressure. Reagent ions are formed by interaction of the reagent vapor molecules with an electrical discharge (e.g., a glow discharge) within the ionization volume, and pass into the chamber of the mass spectrometer. At least one ion optical element located along the analyte ion path transports the reagent ions to successive chambers of the mass spectrometer. The reagent ions may be combined with the analyte ions to perform ion-ion studies such as electron transfer dissociation (ETD).
摘要翻译： 公开了用于质谱仪的前端试剂离子源。 将试剂蒸气供给到位于质谱仪室内的试剂电离体并保持在低真空压力下。 试剂离子通过试剂蒸气分子与离子化体积内的放电（例如，辉光放电）的相互作用而形成，并进入质谱仪的室。 沿着分析物离子路径定位的至少一个离子光学元件将试剂离子输送到质谱仪的连续室。 试剂离子可与分析物离子组合以进行离子离子研究，例如电子转移离解（ETD）。
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公开(公告)号：US5030878A
公开(公告)日：1991-07-09
申请号：US320277
申请日：1989-03-06
申请人： Raymond L. Roy , Peter W. Graves , Thomas J. Loretz , Jonathan W. Amy , George C. Stafford, Jr.
发明人： Raymond L. Roy , Peter W. Graves , Thomas J. Loretz , Jonathan W. Amy , George C. Stafford, Jr.
IPC分类号： H01J43/24
CPC分类号： H01J43/24
摘要： A segmented electron multiplier is disclosed with front and rear sections. The sections are specially designed so that the length of the rear section compared to the length of the front section is no less than 4:1. This permits multiple replacements of the rear section, after the multiplier wears out, without any unsatisfactory drop in the overall electrical gain produced by the repaired device. In the preferred embodiment, the front portion is a funnel having a tubular stem, and the rear portion is a straight tube with a cylindrical helical inner channel. The length-to-length split is 5:1, which theoretically permits up to six or seven replacements of the rear section before unsatisfactory gain occurs.
摘要翻译： 公开了分段电子倍增器，其具有前部和后部。 这些部分是专门设计的，使得后部的长度与前部的长度相比不小于4：1。 这样可以在乘法器磨损之后对后部进行多次更换，而不会使由修理的设备产生的整体电气增益不会令人满意的下降。 在优选实施例中，前部是具有管状杆的漏斗，后部是具有圆柱形螺旋形内部通道的直管。 长度与长度之间的距离为5：1，理论上允许在不令人满意的增益发生之前最多可以对后部进行六到七次更换。
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公开(公告)号：US4749860A
公开(公告)日：1988-06-07
申请号：US871464
申请日：1986-06-05
CPC分类号： H01J49/424 , H01J49/427
摘要： Method of isolating ions of selected mass in a quadrupole ion trap of the type including a ring electrode and end caps in which RF and AC voltages are applied to the ring electrode and end caps and scanned to trap a single ion of interest.
摘要翻译： 在包括环形电极和端盖的四极离子阱中分离选定质量的离子的方法，其中RF和AC电压施加到环形电极和端盖上并被扫描以捕获单个感兴趣的离子。
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公开(公告)号：US4736101A
公开(公告)日：1988-04-05
申请号：US84518
申请日：1987-08-11
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0081 , H01J49/429
摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.
摘要翻译： 以MS / MS模式通过四极离子阱质谱仪对样品进行质量分析的简单而经济的方法包括以下步骤：在捕获结构内形成离子，改变RF和DC电压，使得离子与 在所需范围内的质荷比将被捕获在陷阱结构内，并且通过碰撞将这些离子解离成碎片，并再次增加场强，使得所产生的片段将变得不稳定并顺序地离开陷阱体积以被检测 。 附加的AC场可以另外施加以提供各种扫描模式以及离子离解。
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7.发明授权Method of mass analyzing a sample over a wide mass range by use of a quadrupole ion trap 失效通过使用四极离子阱在大质量范围内质量分析样品的方法
公开(公告)号：US4650999A
公开(公告)日：1987-03-17
申请号：US663314
申请日：1984-10-22
申请人： William J. Fies, Jr. , Paul E. Kelley , Walter E. Reynolds , George C. Stafford, Jr. , John E. P. Syka
发明人： William J. Fies, Jr. , Paul E. Kelley , Walter E. Reynolds , George C. Stafford, Jr. , John E. P. Syka
CPC分类号： H01J49/424 , H01J49/427
摘要： The method of operating a quadrupole ion trap in which the mass range of interest is analyzed in segments by trapping ions of successive mass ranges within the segments whereby the operating parameters for each segment may be selected to improve sensitivity and resolution.
摘要翻译： 操作四极离子阱的方法，其中通过捕获段内连续质量范围的离子来分段感兴趣的质量范围，由此可以选择每个段的操作参数以提高灵敏度和分辨率。
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8.发明申请Method and Apparatus for Generation of Reagent Ions in a Mass Spectrometer 审中-公开用于在质谱仪中产生试剂离子的方法和装置公开(公告)号：US20080245963A1
公开(公告)日：2008-10-09
申请号：US11962009
申请日：2007-12-20
申请人： Adrian Land , Lee Earley , George C. Stafford
发明人： Adrian Land , Lee Earley , George C. Stafford
IPC分类号： H01J49/14
CPC分类号： H01J49/0072
摘要： A front-end ion source for a mass spectrometer generates both analyte and reagent ions. The reagent source may include a heater for vaporizing a condensed-phase reagent substance and an electron source for ionizing reagent molecules. The interior of the reagent ionization chamber is purged with a purge gas to avoid or minimize reaction of the reagent ions with oxygen or other reactive species, thereby enabling operation of the reagent ionization chamber at or near atmospheric pressure. The reagent and analyte ions are directed into a reduced-pressure chamber through separate passageways. An ion transport optic selectively transmits one of the analyte ions or the reagent ions from the reduced-pressure chamber to downstream regions of the mass spectrometer.
摘要翻译： 用于质谱仪的前端离子源产生分析物和试剂离子。 试剂源可以包括用于蒸发冷凝相试剂物质的加热器和用于电离试剂分子的电子源。 试剂电离室的内部用净化气体吹扫，以避免或最小化试剂离子与氧或其它反应物质的反应，从而使试剂电离室在大气压力或接近大气压力下操作。 试剂和分析物离子通过单独的通道导入减压室。 离子传输光学选择性地将分析物离子或试剂离子中的一种从减压室传输到质谱仪的下游区域。
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公开(公告)号：US4540884A
公开(公告)日：1985-09-10
申请号：US454351
申请日：1982-12-29
CPC分类号： H01J49/424 , H01J49/429
摘要： In a quadrupole ion store or ion trap type mass spectometer, significantly improved mass selection is achieved by simultaneously trapping ions within the mass range of interest and then scanning the applied RF and DC voltages or the frequency .omega. to sequentially render unstable trapped ions of consecutive specific masses. These are passed out through apertures in an end cap to a high gain electron multiplier to provide a signal indicative of the ion mass. Sensitivity and mass resolution is also enhanced by operating the ion trap at a relatively high pressure in the range 1.times.10.sup.-1 to 1.times.10.sup.-5 torr. The presence of collision gas molecules, such as helium, improves sensitivity and mass resolution. In addition, the structure itself is built of stacked units, sealed by O-rings, which are easily disassembled for cleaning.
摘要翻译： 在四极离子存储或离子阱型质谱仪中，通过在感兴趣的质量范围内同时捕获离子然后扫描所施加的RF和DC电压或频率ω，来实现显着改进的质量选择，以顺序地呈现连续特定的不稳定捕获的离子 群众 它们通过端盖中的孔传递到高增益电子倍增器，以提供指示离子质量的信号。 通过在1x10-1至1×10-5乇范围内的较高压力下操作离子阱也可以提高灵敏度和质量分辨率。 碰撞气体分子（如氦气）的存在提高了灵敏度和质量分辨率。 此外，结构本身由堆叠单元构成，由O型圈密封，易于拆卸清洁。
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公开(公告)号：US5055678A
公开(公告)日：1991-10-08
申请号：US487592
申请日：1990-03-02
摘要： A chromium or oxidized chromium surface for use in sample analyzing and ionizing apparatus, such as an ion trap or ionization chamber, which does not degrade or decompose a sample in contact with the surface.
摘要翻译： 用于样品分析和电离装置的铬或氧化铬表面，例如离子阱或电离室，其不会使与表面接触的样品降解或分解。
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