公开(公告)号：US09630940B2

公开(公告)日：2017-04-25

申请号：US15148716

申请日：2016-05-06

Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION

Inventor： Pandurang V. Chouthaiwale ,  Fujie Tanaka

IPC: C07D309/28 ,  C07D309/16 ,  C07C201/14 ,  C07D309/30 ,  C07D317/30 ,  C07D407/04 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07C205/55

CPC classification number: C07D309/28 ,  C07C201/14 ,  C07C205/55 ,  C07C2601/14 ,  C07D241/44 ,  C07D243/02 ,  C07D307/54 ,  C07D309/30 ,  C07D317/30 ,  C07D407/04

Abstract: Disclosed is a process for preparing dihydro-2H-pyran derivatives of formula I: wherein R1 and R2 are defined herein. The process of the invention provides the compound of formula I in concise cascade reactions and in one pot. The compound of formulae I prepared by the process of the invention and its further transformed derivatives are useful for making pharmaceutical composition for the treatment of proliferative diseases.

公开(公告)号：US20150329472A1

公开(公告)日：2015-11-19

申请号：US14652913

申请日：2013-12-20

Applicant: NIPPON SODA CO., LTD.

Inventor： Hiroki Inoue ,  Yuzuru Sakata ,  Shinichi Kobayashi ,  Yoshikazu Ito ,  Takashi Kitayama

IPC: C07C209/74 ,  C07C209/32 ,  C07C17/00 ,  C07C201/14 ,  C07C211/52 ,  C07C205/12

CPC classification number: C07C209/74 ,  C07C17/00 ,  C07C17/06 ,  C07C17/12 ,  C07C201/08 ,  C07C201/14 ,  C07C205/12 ,  C07C209/32 ,  C07C211/52 ,  C07C25/13

Abstract: The present invention provides a halogenated aniline represented by formula (I) (wherein each of X1 and X2 independently represents a chlorine atom, a bromine atom or an iodine atom), a method for producing the halogenated aniline, and other aspects.

Abstract translation: 本发明提供由式（I）表示的卤代苯胺（其中X1和X2各自独立地表示氯原子，溴原子或碘原子），卤代苯胺的制造方法等。

公开(公告)号：US20130204043A1

公开(公告)日：2013-08-08

申请号：US13812690

申请日：2011-07-26

Applicant: Thomas Knauf ,  Michael Merkel ,  Andreas Karl Rausch ,  Peter Lehner ,  Jürgen Münnig

Inventor： Thomas Knauf ,  Michael Merkel ,  Andreas Karl Rausch ,  Peter Lehner ,  Jürgen Münnig

IPC: C07C201/14

CPC classification number: C07C201/14 ,  C07C201/08 ,  C07C201/16 ,  C07C209/36 ,  C07C205/06 ,  C07C211/46

Abstract: The present invention relates to a continuous process for the production of nitrobenzene by nitration of benzene with nitric acid or mixtures of nitric acid and sulfuric acid to give a crude nitrobenzene, washing of the crude nitrobenzene by means of at least one of each of an acid, alkaline and neutral washing, there being obtained a pre-purified nitrobenzene which, as well as containing nitrobenzene, at least contains also low boilers, optionally middle boilers as well as high boilers and salts, wherein the pre-purified nitrobenzene is purified further by separating off low boilers in a distillation apparatus by evaporation of the low boilers, and separation of nitrobenzene from the resulting further purified nitrobenzene in a distillation apparatus by partial evaporation of nitrobenzene, wherein pure nitrobenzene is removed from the distillation apparatus in gaseous form and is subsequently condensed, and wherein the non-evaporated portion of the further purified nitrobenzene is fed back into the washing at any desired point.

Abstract translation: 本发明涉及通过用硝酸或硝酸和硫酸的混合物硝化硝酸生产硝基苯的连续方法，得到粗硝基苯，通过以下各项中的至少一种酸洗粗硝基苯 碱性和中性洗涤，得到预纯化的硝基苯以及含有硝基苯，至少还含有低锅炉，任选的中间锅炉以及高锅炉和盐，其中预纯化的硝基苯进一步通过 通过蒸发低沸点锅炉将蒸馏装置中的低锅炉分离出来，并通过硝基苯的部分蒸发在蒸馏装置中将硝基苯与所得到的进一步纯化的硝基苯分离，其中将纯硝基苯以气态从蒸馏装置中除去，随后 冷凝，并且其中进一步纯化的硝基苯的未蒸发部分进料 回到任何想要的点的洗涤。

公开(公告)号：US20130184504A1

公开(公告)日：2013-07-18

申请号：US13823831

申请日：2011-09-05

Applicant: Shengjian Zhang ,  Yingxian Zhao ,  Hong Zhang

Inventor： Shengjian Zhang ,  Yingxian Zhao ,  Hong Zhang

IPC: C07C201/14

CPC classification number: C07C201/14 ,  C07C201/06 ,  C07C205/02

Abstract: The present invention relates to a method for preparing 2,3-dimethyl-2,3-dinitrobutane (DMNB), which includes the following steps: (1) making titanium-silicate molecular sieve catalyst, acetone, hydrogen peroxide and ammonia contact and react at 65-80° C. to obtain a modified titanium-silicate molecular sieve catalyst; and (2-1) making acetone oxime and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof; or (2-2) making acetone, ammonia and hydrogen peroxide contact and react in the presence of the modified titanium-silicate molecular sieve catalyst and water under the conditions of temperature of 60-90° C. and pH of 8-10, and separating DMNB from the reaction products thereof. By the method provided by the present invention, DMNB can be prepared without having to use dangerous chemicals, such as 2-nitropropane, NaH and the like.

Abstract translation: 本发明涉及一种制备2,3-二甲基-2,3-二硝基丁烷（DMNB）的方法，其包括以下步骤：（1）使钛硅酸盐分子筛催化剂，丙酮，过氧化氢和氨接触并反应 在65-80℃下，得到改性钛酸酯分子筛催化剂; 和（2-1）使丙酮肟和过氧化氢接触并在改性的钛酸硅酸盐分子筛催化剂和水的存在下在60-90℃的温度和pH为8-10的条件下反应，并分离 DMNB反应产物; 或（2-2）使丙酮，氨和过氧化氢接触并在改性钛硅酸盐分子筛催化剂和水的存在下在60-90℃的温度和pH为8-10的条件下反应，和 从其反应产物中分离DMNB。 通过本发明提供的方法，可以制备DMNB，而不必使用危险化学品，例如2-硝基丙烷，NaH等。

公开(公告)号：US20120108838A1

公开(公告)日：2012-05-03

申请号：US12566331

申请日：2009-09-24

Applicant: David E. Chavez ,  Darren L. Naud ,  Michael A. Hiskey

Inventor： David E. Chavez ,  Darren L. Naud ,  Michael A. Hiskey

IPC: C07C205/40 ,  C07C201/14 ,  C07C205/15

CPC classification number: C07C205/15 ,  C07C205/40

Abstract: Preparation of an energetic nitrate ester compound and related intermediates is provided.

Abstract translation: 提供了高能硝酸酯化合物及相关中间体的制备。

公开(公告)号：US4517393A

公开(公告)日：1985-05-14

申请号：US563208

申请日：1983-12-19

Applicant: Shu-Shieh P. Wang ,  Martin B. Sherwin

Inventor： Shu-Shieh P. Wang ,  Martin B. Sherwin

IPC: C07C45/29 ,  C07C201/14 ,  C07C201/16 ,  C07C205/02 ,  C07C79/02

CPC classification number: C07C45/29 ,  C07C201/14 ,  C07C201/16

Abstract: A process for selectively forming nitro compounds by contacting, at elevated temperature and pressure and in a homogeneous gas phase, a ketone having from three to ten carbon atoms with nitrogen dioxide alone or in the presence of oxygen and/or water.

Abstract translation: 通过在升高的温度和压力下，均匀气相中将具有3至10个碳原子的酮与单独的二氧化氮或在氧气和/或水的存在下接触来选择性地形成硝基化合物的方法。

公开(公告)号：US4469904A

公开(公告)日：1984-09-04

申请号：US510858

申请日：1983-07-05

Applicant: Shu-Chieh P. Wang ,  Martin B. Sherwin

Inventor： Shu-Chieh P. Wang ,  Martin B. Sherwin

IPC: C07C201/14 ,  C07C205/02 ,  C07C205/06 ,  C07C76/02 ,  C07C79/10

CPC classification number: C07C201/06

Abstract: A process for selectively forming nitro compounds by contacting, at elevated temperature and pressure and in a homogeneous gas phase, an organic carboxylic acid having from two to ten carbon atoms with NO.sub.2 or HNO.sub.3 alone or in the presence of oxygen and/or water.

Abstract translation: 在升高的温度和压力下，在均相气相中，将具有2-10个碳原子的有机羧酸与NO 2或HNO 3单独或在氧和/或水的存在下接触来选择性地形成硝基化合物的方法。

公开(公告)号：US3950385A

公开(公告)日：1976-04-13

申请号：US519901

申请日：1974-11-01

Applicant: Mahmoud Kablaoui ,  Richard F. Love

Inventor： Mahmoud Kablaoui ,  Richard F. Love

IPC: C07C205/02 ,  C07C67/00 ,  C07C201/00 ,  C07C201/02 ,  C07C201/14 ,  C07C203/02 ,  C07C203/04 ,  C07C203/08 ,  C07C205/15 ,  C07C205/18 ,  C07C205/40 ,  C07C205/41 ,  C07C77/04

CPC classification number: C07C201/14 ,  C07C2101/14 ,  C07C2101/18

Abstract: A method for preparing vicinal nitronitrates by simultaneously contacting an alkene with oxygen and dinitrogen tetroxide in the presence of concentrated sulfuric acid. The nitronitrates so formed are useful as fuel additives as well as intermediates in the preparation of surfactants, fuel and lubricant additives, insecticides, fungicides, pharmaceuticals and polymers.

Abstract translation: 一种通过在浓硫酸存在下同时使烯烃与氧和四氧化二氮接触来制备邻硝基硝酸盐的方法。 如此形成的硝酸盐可用作燃料添加剂以及制备表面活性剂，燃料和润滑剂添加剂，杀虫剂，杀真菌剂，药物和聚合物的中间体。

公开(公告)号：US3192248A

公开(公告)日：1965-06-29

申请号：US34739864

申请日：1964-02-26

Applicant: ATLANTIC REFINING CO

Inventor： BONETTI GIOVANNI A ,  DE SAVIGNY CHESTER B ,  CONRAD MICHALSKI ,  RUDOLPH ROSENTHAL

IPC: C07C201/14 ,  C07C205/02 ,  C07C205/15

CPC classification number: C07C201/14 ,  C07C205/02 ,  C07C205/15

公开(公告)号：US3118004A

公开(公告)日：1964-01-14

申请号：US19691862

申请日：1962-05-23

Applicant: PENNSALT CHEMICALS CORP

Inventor： MURRAY HAUPTSCHEIN ,  OESTERLING ROBERT E

IPC: C07C201/14 ,  C07C205/08

CPC classification number: C07C205/08