公开(公告)号：US20220002730A1

公开(公告)日：2022-01-06

申请号：US17269229

申请日：2019-08-23

申请人： City of Hope

发明人： Marcin Tomasz Kortylewski ,  Piotr Marek Swiderski

IPC分类号： C12N15/117 ,  A61K47/54 ,  A61P35/00

摘要： Disclosed herein, inter alia, are oligonucleotide inhibitors of the Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB) signaling pathway and methods of use thereof.

公开(公告)号：US20210269803A1

公开(公告)日：2021-09-02

申请号：US17251549

申请日：2019-06-17

申请人： City of Hope

发明人： Marcin Kortylewski ,  Piotr Marek Swiderski ,  Steven Rosen

IPC分类号： C12N15/117 ,  C12N15/113 ,  A61K47/54

摘要： Disclosed herein, inter alia, are oligonucleotide-based proteolysis targeting chimeras and methods of use thereof.

公开(公告)号：US20210261964A1

公开(公告)日：2021-08-26

申请号：US17260418

申请日：2019-07-18

申请人： THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY ,  OSAKA UNIVERSITY ,  TEIKYO UNIVERSITY

发明人： Taiki AOSHI ,  Shohei KOYAMA ,  Ryo SUZUKI

IPC分类号： C12N15/117 ,  A61K9/107 ,  A61K31/7088 ,  A61K47/28 ,  A61K47/24 ,  A61K47/54 ,  A61P35/00

摘要： An object is to provide a technology that can stably exhibit the effects of A-type CpG oligodeoxynucleotides. The object can be achieved by a lipid particle comprising an A-type CpG oligodeoxynucleotide.

公开(公告)号：US20210246452A1

公开(公告)日：2021-08-12

申请号：US16642792

申请日：2018-08-30

申请人： ARIZONA BOARD OF REGENT ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Hao YAN ,  Yung CHANG ,  Xiaowei LIU ,  Fei ZHANG ,  Xiaodong QI

IPC分类号： C12N15/117

摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

公开(公告)号：US20210230601A1

公开(公告)日：2021-07-29

申请号：US17050918

申请日：2019-04-25

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Hao YAN ,  Fei ZHANG ,  Xiaodong QI

IPC分类号： C12N15/117

摘要： In some embodiments, complex molecular knots with high crossing numbers are achieved by folding, following a prescribed folding order, single-stranded DNA or RNA of customized sequences into target shapes. Such complex molecular knots with high crossing numbers are useful for biomedical applications including use as immunostimulatory agents and/or protein hosts and carriers.

公开(公告)号：US20210207142A1

公开(公告)日：2021-07-08

申请号：US17070321

申请日：2020-10-14

申请人： City of Hope

发明人： Marcin Tomasz Kortylewski ,  Piotr Marek Swiderski

IPC分类号： C12N15/117 ,  C07H21/02 ,  A61K39/39 ,  C12N15/11 ,  A61K47/54 ,  C07H21/04 ,  A61K47/64

摘要： Described herein, inter alia, are STAT-binding nucleic acids-including compositions and methods of using the same.

公开(公告)号：US11028370B2

公开(公告)日：2021-06-08

申请号：US15994093

申请日：2018-05-31

申请人： The Trustees of the University of Pennsylvania

发明人： Katalin Kariko ,  Drew Weissman ,  Gary Dahl ,  Anthony Person ,  Judith Meis ,  Jerome Jendrisak

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N5/074 ,  C12N15/87 ,  C12N15/85 ,  A61K38/17 ,  A61K38/18 ,  A61K38/44 ,  A61K38/46 ,  A61K38/50 ,  A61K48/00 ,  C07K14/47 ,  C07K14/505 ,  C12N9/02 ,  C12N9/22 ,  C12N9/78 ,  C12N15/117

摘要： The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs.

公开(公告)号：US20210024895A1

公开(公告)日：2021-01-28

申请号：US16827098

申请日：2020-03-23

申请人： The Trustees of the University of Pennsylvania

发明人： Katalin Kariko ,  Drew Weissman ,  Gary Dahl ,  Anthony Person ,  Judith Meis ,  Jerome Jendrisak

IPC分类号： C12N5/074 ,  C12N15/87 ,  C12N15/85 ,  A61K38/17 ,  A61K38/18 ,  A61K38/44 ,  A61K38/46 ,  A61K38/50 ,  A61K48/00 ,  C07K14/47 ,  C07K14/505 ,  C12N9/02 ,  C12N9/22 ,  C12N9/78 ,  C12N15/117

摘要： The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodiments, the purified RNA preparations are substantially free of partial mRNAs, double-stranded RNAs, un-capped RNA molecules, and/or single-stranded run-on mRNAs.

公开(公告)号：US20210000916A1

公开(公告)日：2021-01-07

申请号：US16935534

申请日：2020-07-22

申请人： CYTLIMIC INC.

发明人： Tomoya MIYAKAWA ,  Shun DOI ,  Koji TAMADA

IPC分类号： A61K38/17 ,  A61K39/39 ,  A61K38/00 ,  A61P37/02 ,  A61K45/00 ,  A61P35/00 ,  A61K39/00 ,  A61K38/18 ,  C07K19/00 ,  C07K14/475 ,  C12N15/117

摘要： The present invention provides a medicine containing a Toll-like receptor agonist, LAG-3 protein, a variant or derivative thereof.

公开(公告)号：US20200276294A1

公开(公告)日：2020-09-03

申请号：US16595288

申请日：2019-10-07

申请人： University of Washington through its Center for Commercialization

发明人： Michael J. Gale, JR. ,  Gretja Schnell ,  Yueh-Ming Loo

IPC分类号： A61K39/12 ,  C07H21/04 ,  A61K45/06 ,  C12N15/117 ,  A61K39/39 ,  A61K31/00

摘要： Compositions and methods are provided that enable activation of innate immune responses through RIG-I like receptor signaling. The compositions and methods incorporate synthetic nucleic acid pathogen associated molecular patterns (PAMPs) that comprise elements initially characterized in, and derived from, the hepatitis C virus genome.