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公开(公告)号:US10357632B2
公开(公告)日:2019-07-23
申请号:US15144419
申请日:2016-05-02
发明人: Steve A. Herweck , Ronit R. Furman
IPC分类号: A61M25/00 , A61M25/01 , A61M5/00 , A61B6/12 , A61B34/20 , A61B5/00 , A61B5/055 , A61B8/08 , A61B90/00 , A61B6/00
摘要: A method and apparatus for fluid delivery enables navigation through tortuous, spatially restricted body anatomy to access narrow diameter body lumens for the continuous delivery of fluids, including therapeutic fluids, to the lumen in an atraumatic manner that avoids damage to the body lumen. The fluid delivery device can have a flexible conduit having a proximal end, a distal end, and a lumen extending along an interior of the flexible conduit providing a fluid flow path between the proximal and distal ends, where the lumen transitions into a micro-lumen exiting through a port through which a high concentration of fluid injected into the lumen exits laterally out along an image viewable zone at the distal end of the flexible conduit. The flexible conduit has a maximum outer diameter sized sufficient to navigate narrow diameter body lumens.
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公开(公告)号:US20190117364A1
公开(公告)日:2019-04-25
申请号:US16222566
申请日:2018-12-17
IPC分类号: A61F2/00
摘要: A deployment device for a flexible implant includes a housing and one or two chambers formed therein. When two chambers are included, the housing can have two elongate openings formed in its outer sides, each providing side access to one of the chambers, and the flexible implant can be rolled into a double-rolled configuration and placed in the chambers of the deployment device in such a way that a middle portion of the flexible implant is external to the housing. When the flexible implant is rolled and loaded in the deployment device, the flexible implant can extend out through open end(s) of the chamber(s) or can be encapsulated within the chamber(s). The flexible implant can be provided separate from the deployment device. The flexible implant can include a flexible base sheet including a body portion and a tab. A flexible separable layer can be removably disposed on the body portion.
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公开(公告)号:US20190105430A1
公开(公告)日:2019-04-11
申请号:US16213823
申请日:2018-12-07
IPC分类号: A61L31/08 , A61L29/14 , C09D191/00 , A61L29/08
摘要: Disclosed herein is the correlation of chemical properties of oils with the physical properties of a resulting cured oil composition. Also disclosed are biocompatible materials and coatings for medical devices prepared using enriched oils and methods for enhancing or modifying the physical and chemical characteristics of cured oils by enriching such oils with fatty acid alkyl esters. Methods of tailoring the properties of biocompatible materials and coatings to deliver one or more therapeutic agents are also provided.
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公开(公告)号:US10245137B2
公开(公告)日:2019-04-02
申请号:US14906853
申请日:2014-07-22
摘要: A vascular graft suitable for implantation, and more particular to a vascular graft having an expandable outflow region for restoring patency of the graft after implantation into a body lumen.
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公开(公告)号:US20190054053A1
公开(公告)日:2019-02-21
申请号:US16165628
申请日:2018-10-19
发明人: Thomas M. SWANICK , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS
IPC分类号: A61K31/20 , A61K38/13 , A61K31/496 , A61K31/4545 , A61K31/4353 , A61K31/00 , A61K9/70 , A61K9/14 , A61K9/10 , A61K31/7036 , A61L31/16 , A61K9/16 , A61K31/436 , A61K31/445 , A61K35/60 , A61L27/28 , A61L27/54 , A61L31/08 , A61K31/7028
摘要: The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
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公开(公告)号:US10188495B2
公开(公告)日:2019-01-29
申请号:US15033134
申请日:2014-10-31
发明人: Roger Labrecque , Stephanie Santos
IPC分类号: A61F2/00 , A61L31/10 , A61L31/14 , A61L24/00 , A61L27/16 , A61L27/28 , A61L27/34 , A61L27/50
摘要: A non-setting agent for positioning a surgical mesh prosthesis against a tissue defect during surgical hernia repair enables a surgeon to position the surgical mesh prosthesis at an optimal location against the tissue defect without pre-measuring suture location and pre-suturing. The surgical mesh prosthesis can be repositioned by removing and replacing, or by sliding, the mesh along the tissue defect without traumatizing the tissue. The positioning agent is provided with adhesion and lubricity characteristics providing an adhesion strength required to temporarily maintain the surgical mesh in place, otherwise unsupported, against tissue of a targeted tissue location, and providing a viscosity that permits removal and replacement, or slidable movement, of the surgical mesh along the tissue upon receipt of a non-gravitational external force applied to the surgical mesh so movement of the surgical mesh that is atraumatic to the tissue.
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公开(公告)号:US20180140705A1
公开(公告)日:2018-05-24
申请号:US15819304
申请日:2017-11-21
IPC分类号: A61K47/12 , A61K47/22 , A61L27/14 , A61L27/34 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/16
CPC分类号: A61K47/12 , A61K47/22 , A61L27/14 , A61L27/34 , A61L27/54 , A61L31/04 , A61L31/10 , A61L31/16 , A61L2300/606
摘要: The present invention is generally directed to materials, gels, coatings and films prepared using a biomaterial (e.g., a fatty acid-based material comprising a network of cross-linked fatty acids) and a fixating material, layer or film (e.g., a fixating material comprising Na-CMC). The materials, gels, coatings and films disclosed herein can be used to facilitate the delivery of one or more therapeutic agents to a targeted tissue and a desired rate of release.
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公开(公告)号:US09827352B2
公开(公告)日:2017-11-28
申请号:US14679368
申请日:2015-04-06
发明人: Keith M. Faucher , Hui Tang , Paul Martakos , Theodore Karwoski , Allison Sullivan , Greg Melville , Scott E. Corbeil
IPC分类号: A61L31/08 , A61K31/4353 , A61L31/16 , A61L31/14 , A61F2/82
CPC分类号: A61L31/08 , A61F2/82 , A61F2250/0067 , A61K31/4353 , A61L31/148 , A61L31/16 , A61L2300/404 , A61L2300/606 , A61L2420/06 , A61L2430/00
摘要: Fatty acid-based, pre-cure-derived biomaterials, methods of making the biomaterials, and methods of using them as drug delivery carriers are described. The fatty acid-derived biomaterials can be utilized alone or in combination with a medical device for the release and local delivery of one or more therapeutic agents. Methods of forming and tailoring the properties of said biomaterials and methods of using said biomaterials for treating injury in a mammal are also provided.
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公开(公告)号:US09801982B2
公开(公告)日:2017-10-31
申请号:US12075223
申请日:2008-03-10
CPC分类号: A61L31/10 , A61F2/0063 , A61F2/06 , A61F2250/0067 , A61L31/145
摘要: A barrier device is formed of a barrier component that can exhibit anti-inflammatory properties, non-inflammatory properties, and/or adhesion-limiting properties, as well as generate a modulated healing effect on injured tissue. The barrier component can be a non-polymeric cross-linked gel derived at least in part from a fatty acid compound, and may include a therapeutic agent. The barrier device can have anchoring locations to provide an area on the barrier device to interface with an anchoring mechanism. The anchoring locations can include openings and/or anchor elements. The barrier device can also include truss structures that provide additional strength to the barrier component. The barrier device is implantable in a patient for short term or long term applications, and can include controlled release of the therapeutic agent.
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公开(公告)号:US20170100228A1
公开(公告)日:2017-04-13
申请号:US14878091
申请日:2015-10-08
IPC分类号: A61F2/00
CPC分类号: A61F2/0063 , A61F2002/0072 , A61F2210/0076 , A61F2220/0025
摘要: A medical device including a first layer having an opening formed therein. A second layer is positioned with respect to the first layer to form a pocket therebetween. A support member is at least partially located in the pocket and reconfigurable for removal of the support member from the pocket via the opening. An affixation element located in the pocket between the support member and the second layer, and secured to the second layer. A method of implanting a medical device is also included.
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