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公开(公告)号：US20160324816A1
公开(公告)日：2016-11-10
申请号：US15216873
申请日：2016-07-22
发明人： Thomas M. SWANICK , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS
IPC分类号： A61K31/20 , A61K35/60 , A61K31/436 , A61K38/13 , A61L31/08 , A61L27/54 , A61L27/28 , A61K31/7036 , A61L31/16 , A61K9/16 , A61K31/445
CPC分类号： A61K31/20 , A61K9/10 , A61K9/145 , A61K9/16 , A61K9/7007 , A61K31/00 , A61K31/4353 , A61K31/436 , A61K31/445 , A61K31/4545 , A61K31/496 , A61K31/7028 , A61K31/7036 , A61K35/60 , A61K38/13 , A61L27/28 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/606
摘要： The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
摘要翻译： 本发明涉及脂肪酸类颗粒，以及制造这种颗粒的方法。 颗粒可以与另外的治疗剂相关联。 本文还提供了形成脂肪酸颗粒的方法，其包括将交联的脂肪酸衍生的生物材料与低温液体缔合; 并使生物材料/低温液体组合物分裂，从而形成脂肪酸颗粒。 该颗粒可用于各种治疗应用。
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公开(公告)号：US20190054053A1
公开(公告)日：2019-02-21
申请号：US16165628
申请日：2018-10-19
发明人： Thomas M. SWANICK , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS
IPC分类号： A61K31/20 , A61K38/13 , A61K31/496 , A61K31/4545 , A61K31/4353 , A61K31/00 , A61K9/70 , A61K9/14 , A61K9/10 , A61K31/7036 , A61L31/16 , A61K9/16 , A61K31/436 , A61K31/445 , A61K35/60 , A61L27/28 , A61L27/54 , A61L31/08 , A61K31/7028
摘要： The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
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公开(公告)号：US20150079191A1
公开(公告)日：2015-03-19
申请号：US14511765
申请日：2014-10-10
发明人： Roger LABRECQUE , Philip MCNAMARA , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS , Theodore KARWOSKI , Steve A. HERWECK , Keith M. FAUCHER , Thomas M. SWANICK
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric get. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alphalinolenic acid (ALA).
摘要翻译： 包含多个非聚合物交联的固化的非聚合凝胶。 非聚合交联是由选择的固化条件下固化油或油组合物得到所需量的交联以形成非聚合物的。 基于在凝胶注入后凝胶的降解速率来选择所需量的交联。 油或油组合物包含二十碳五烯酸（EPA），二十二碳六烯酸（DHA）或阿拉伯糖酸（ALA）中的一种或多种。
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公开(公告)号：US20210002394A1
公开(公告)日：2021-01-07
申请号：US17027014
申请日：2020-09-21
发明人： Thomas M. SWANICK
IPC分类号： C08F14/26 , C08J5/12 , B32B27/08 , B32B27/32 , B32B3/04 , B29C65/00 , B32B7/02 , B32B27/06 , B29C65/02 , B29C65/82
摘要： A method of making expanded fluoropolymer articles thermally bonds portions of expanded fluoropolymers together, without using an adhesive or crushing force, to produce stronger bonds at the joint between the expanded fluoropolymers than the bonds within the constituent expanded fluoropolymers. The method involves placing the portions of expanded fluoropolymers to be thermally bonded together in intimate contact with each other after wet-stretching the expanded fluoropolymers, and removing the wetting agent used to wet-stretch the expanded fluoropolymers, without subsequent expansion or stretching, to yield an expanded fluoropolymer article exhibiting unexpected and superior properties that can be used in a variety of medical and industrial applications.
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公开(公告)号：US20180133376A1
公开(公告)日：2018-05-17
申请号：US15817018
申请日：2017-11-17
发明人： Thomas M. SWANICK , Joe BIENKIEWICZ , Joseph FERRARO , Paul MARTAKOS , Keith M. FAUCHER , Alicia DALE
CPC分类号： A61L31/148 , A61F2/06 , A61F2250/0067 , A61L31/00 , A61L31/10 , A61L31/145 , A61L2420/02
摘要： Exemplary embodiments of the present invention provide adhesion barriers having anti-adhesion and tissue fixating properties. The adhesion barriers are formed of fatty acid based films. The fatty acid-based films may be formed from fatty acid-derived biomaterials. The films may be coated with, or may include, tissue fixating materials to create the adhesion barrier. The adhesion barriers are well tolerated by the body, have anti-inflammation properties, fixate, well to tissue, and have a residence time sufficient to prevent post-surgical adhesions.
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公开(公告)号：US20180200306A1
公开(公告)日：2018-07-19
申请号：US15841993
申请日：2017-12-14
发明人： Roger LABRECQUE , Philip MCNAMARA , Joseph FERRARO , Lisa ROGERS , Paul MARTAKOS , Theodore KARWOSKI , Steve A. HERWECK , Keith M. FAUCHER , Thomas M. SWANICK
IPC分类号： A61K35/60 , A61K38/13 , A61L31/14 , A61L31/10 , A61L31/00 , A61L2/20 , A61L2/08 , A61L2/07 , A61K47/14 , A61K47/12 , A61K31/355 , A61K31/225 , A61K9/06 , A61K9/00 , A61F13/02
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric gel. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alpha-linolenic acid (ALA).
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