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公开(公告)号：US20070191270A1
公开(公告)日：2007-08-16
申请号：US11234694
申请日：2005-09-22
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： G01N33/57484 , C07K14/47 , C07K14/705 , C12Q1/6886 , C12Q2600/136
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060193851A1
公开(公告)日：2006-08-31
申请号：US11396115
申请日：2006-03-31
申请人： Camellia Adams , Brigitte Devaux , Dan Eaton , Philip Hass , J. Judice , Daniel Kirchhofer , Shelley Suggett
发明人： Camellia Adams , Brigitte Devaux , Dan Eaton , Philip Hass , J. Judice , Daniel Kirchhofer , Shelley Suggett
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K38/00 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The invention provides for the isolation, identification, synthesis, expression and purification of antibodies reactive with factor IX (FIX)/factor IXa (IXa). In particular aspects, the invention provides human antibodies reactive with the human FIX Gla domain. The invention further provides compositions especially pharmaceutical compositions, articles of manufacture, and methods of inhibiting the activation of FIX and inhibiting FIX/IXa dependent coagulation.
摘要翻译： 本发明提供了与因子IX（FIX）/因子IXa（IXa）反应的抗体的分离，鉴定，合成，表达和纯化。 在具体方面，本发明提供与人FIX Gla结构域反应的人抗体。 本发明进一步提供组合物，特别是药物组合物，制品和抑制FIX活化和抑制FIX / IXa依赖性凝血的方法。
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公开(公告)号：US20060088534A1
公开(公告)日：2006-04-27
申请号：US10614959
申请日：2003-07-08
申请人： Camellia Adams , Brigitte Devaux , Dan Eaton , Philip Hass , J. Judice , Daniel Kirchhofer , Shelley Suggett
发明人： Camellia Adams , Brigitte Devaux , Dan Eaton , Philip Hass , J. Judice , Daniel Kirchhofer , Shelley Suggett
IPC分类号： A61K39/395 , A61K38/48 , C07K16/40
CPC分类号： C07K16/36 , A61K38/00 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The invention provides for the isolation, identification, synthesis, expression and purification of antibodies reactive with factor IX (FIX)/factor IXa (IXa). In particular aspects, the invention provides human antibodies reactive with the human FIX Gla domain. The invention further provides compositions especially pharmaceutical compositions, articles of manufacture, and methods of inhibiting the activation of FIX and inhibiting FIX/IXa dependent coagulation.
摘要翻译： 本发明提供了与因子IX（FIX）/因子IXa（IXa）反应的抗体的分离，鉴定，合成，表达和纯化。 在具体方面，本发明提供与人FIX Gla结构域反应的人抗体。 本发明进一步提供组合物，特别是药物组合物，制品和抑制FIX活化和抑制FIX / IXa依赖性凝血的方法。
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公开(公告)号：US20060073552A1
公开(公告)日：2006-04-06
申请号：US10243236
申请日：2002-09-12
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060073549A1
公开(公告)日：2006-04-06
申请号：US10242902
申请日：2002-09-13
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： C07K14/47 , G01N33/57484
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060073548A1
公开(公告)日：2006-04-06
申请号：US10242586
申请日：2002-09-11
申请人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
发明人： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC分类号： C07K14/47 , A61K38/00 , C07K14/705 , C12N9/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20060073547A1
公开(公告)日：2006-04-06
申请号：US10226486
申请日：2002-08-22
申请人： Luc Desnoyers , Dan Eaton , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Timothy Stewart , Colin Watanabe , William Wood , Zemin Zhang
发明人： Luc Desnoyers , Dan Eaton , Audrey Goddard , Paul Godowski , Austin Gurney , James Pan , Timothy Stewart , Colin Watanabe , William Wood , Zemin Zhang
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050227328A1
公开(公告)日：2005-10-13
申请号：US11129762
申请日：2005-05-13
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
IPC分类号： A61K38/00 , A61K39/395 , C07K14/47 , C07K14/705 , C07K16/28 , C12N5/10 , C12N15/12 , C12N15/62 , C12N15/63 , C07H21/04 , C07K16/18 , C12N9/00 , C12N15/09
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050176046A1
公开(公告)日：2005-08-11
申请号：US11046650
申请日：2005-01-28
申请人： Avi Ashkenazi , Dan Eaton , Audrey Goddard , Austin Gurney , William Wood , Thomas Wu
发明人： Avi Ashkenazi , Dan Eaton , Audrey Goddard , Austin Gurney , William Wood , Thomas Wu
IPC分类号： C07K16/44 , C07K16/46 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20050124789A9
公开(公告)日：2005-06-09
申请号：US09978824
申请日：2001-10-16
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Mickey Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Mickey Williams , William Wood
IPC分类号： A61K31/17 , A61K38/00 , A61K38/17 , A61K38/43 , A61K39/395 , A61K48/00 , C07H21/02 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/40 , C12N5/06 , C12N9/00 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4703 , C07K14/475 , C07K14/52 , C07K14/521 , C07K14/54 , C07K14/705 , C07K14/70503 , C07K14/70578 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N9/00 , C12N2799/026 , C12N2799/027 , G01N33/573 , G01N33/57484 , G01N33/68 , G01N2333/99 , G01N2800/042
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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