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公开(公告)号：US08557238B2
公开(公告)日：2013-10-15
申请号：US12724964
申请日：2010-03-16
Applicant: Napoleone Ferrara , Colin Watanabe , William I. Wood
Inventor： Napoleone Ferrara , Colin Watanabe , William I. Wood
IPC: A61K39/395 , C07K16/22 , C07K16/46
CPC classification number: C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
Abstract: The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
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公开(公告)号：US20100256226A1
公开(公告)日：2010-10-07
申请号：US12760354
申请日：2010-04-14
Applicant: NAPOLEONE FERRARA , COLIN WATANABE , WILLIAM I. WOOD
Inventor： NAPOLEONE FERRARA , COLIN WATANABE , WILLIAM I. WOOD
CPC classification number: A61K39/3955 , A61K38/00 , A61K38/1808 , C07K14/52 , C07K16/22 , C07K2317/76 , G01N33/74 , G01N2500/00
Abstract: The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
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公开(公告)号：US20100254999A1
公开(公告)日：2010-10-07
申请号：US12724964
申请日：2010-03-16
Applicant: NAPOLEONE FERRARA , COLIN WATANABE , WILLIAM I. WOOD
Inventor： NAPOLEONE FERRARA , COLIN WATANABE , WILLIAM I. WOOD
IPC: A61K39/395 , A61K38/18 , A61P35/00 , A61P5/00
CPC classification number: C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
Abstract: The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
Abstract translation: 本发明涉及本文称为EG-VEGF的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了筛选EG-VEGF调节剂的方法。 此外，本文描述了涉及调节细胞增殖和趋化性的方法和相关的治疗方法。
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公开(公告)号：US20090318340A1
公开(公告)日：2009-12-24
申请号：US11976812
申请日：2007-10-29
Applicant: Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Daniel Tumas , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: A61K38/17 , C07K14/435 , C07K16/00
CPC classification number: C07K14/705 , A61K38/00 , C07K14/54 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N2500/04
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20090136491A1
公开(公告)日：2009-05-28
申请号：US11907315
申请日：2007-10-11
Applicant: Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: A61K39/395 , C07K16/24 , A61P19/00
CPC classification number: A61K38/20 , C07K14/54 , C07K14/7155 , C07K2319/30 , C12N15/1136 , C12N2310/11 , C12N2310/12 , C12N2310/15
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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Patent Agency Ranking
公开(公告)号：US20090117114A1
公开(公告)日：2009-05-07
申请号：US11907316
申请日：2007-10-11
Applicant: Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: A61K39/395 , C07K16/00 , A61P37/00
CPC classification number: A61K38/20 , C07K14/54 , C07K14/7155 , C07K2319/30 , C12N15/1136 , C12N2310/11 , C12N2310/12 , C12N2310/15
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
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公开(公告)号：US20090035261A1
公开(公告)日：2009-02-05
申请号：US12214762
申请日：2008-06-19
Applicant: Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gumey , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gumey , Hanzhong Li , Kenneth Hillan , Sarah G. Hymowitz , Daniel Tumas , Melissa A. Starovasnik , Menno VanLookeren , Richard Vandlen , Colin Watanabe , P. Mickey Williams , William I. Wood , Daniel Yansura
IPC: A61K38/20 , C12N15/11 , C12N15/00 , C12N5/06 , C12N1/20 , C12N1/19 , C12P21/04 , G01N33/566 , A61P31/00 , C07K14/00 , C07K16/18 , A61K39/395 , G01N33/53 , C12Q1/68 , C12Q1/02
CPC classification number: C07K14/54 , A61K38/00 , C07K14/7155 , G01N33/6869 , G01N2500/04 , G01N2800/24
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and hosT-cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Abstract translation: 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含这些核酸序列的载体和hosT细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及与本发明的多肽结合的方法 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20070191270A1
公开(公告)日：2007-08-16
申请号：US11234694
申请日：2005-09-22
Applicant: Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
Inventor： Kevin Baker , Dan Eaton , Ellen Filvaroff , Audrey Goddard , J. Grimaldi , Austin Gurney , Victoria Smith , Jean Stephan , Colin Watanabe , William Wood , Zemin Zhang , Sherman Fong
CPC classification number: G01N33/57484 , C07K14/47 , C07K14/705 , C12Q1/6886 , C12Q2600/136
Abstract: The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20070178539A1
公开(公告)日：2007-08-02
申请号：US11697201
申请日：2007-04-05
Applicant: Audrey Goddard , Paul Godowski , Austin Gurney , Colin Watanabe , William Wood
Inventor： Audrey Goddard , Paul Godowski , Austin Gurney , Colin Watanabe , William Wood
IPC: G01N33/574 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/30
CPC classification number: G01N33/57492 , G01N33/6863
Abstract: The present invention is directed to novel cytokine receptors having sequence similarity to AF18497_1 and to nucleic acid molecules encoding those cytokine receptors. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Abstract translation: 本发明涉及与AF18497_1具有序列相似性的新型细胞因子受体以及编码这些细胞因子受体的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US20070020735A1
公开(公告)日：2007-01-25
申请号：US11529324
申请日：2006-09-29
Applicant: Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gumey , Kenneth Hillan , Sarah Hymowitz , Hanzhong Li , James Pan , Melissa Starovasnik , Daniel Tumas , Menno Lookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
Inventor： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gumey , Kenneth Hillan , Sarah Hymowitz , Hanzhong Li , James Pan , Melissa Starovasnik , Daniel Tumas , Menno Lookeren , Richard Vandlen , Colin Watanabe , P. Williams , William Wood , Daniel Yansura
CPC classification number: C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155
Abstract: The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Abstract translation: 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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