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    Cosmetic composition with an amphiphilic lipid phase
    41.
    发明申请
    Cosmetic composition with an amphiphilic lipid phase 审中-公开
    具有两亲性脂质相的化妆品组合物

    公开(公告)号：US20070065392A1

    公开(公告)日：2007-03-22

    申请号：US11484659

    申请日：2006-07-12

    Applicant: Jean-Thierry Simonnet

    Inventor： Jean-Thierry Simonnet

    IPC: A61K8/42

    CPC classification number: A61Q19/00 ,  A61K8/0295 ,  A61K8/14 ,  A61K8/42 ,  A61Q1/06 ,  A61Q19/007

    Abstract: A cosmetic makeup and/or care composition, including at least one amphiphilic lipid phase organized as a lamellar or cubic liquid crystal phase, wherein the lipid phase includes at least one urea-based compound of formula (I) or a salt, solvate, or isomer thereof, wherein R1, R2, R3, and R4 each independently represent a hydrogen atom, a C1-C4 alkyl group, or a C2-C6 hydroxyalkyl group that includes from 1 to 5 hydroxyl groups, wherein at least one of the radicals R1 to R4 represents a hydroxyalkyl group, the urea-based compound being present in the amphiphilic phase.

    Abstract translation: 一种化妆品化妆品和/或护理组合物，其包括组织为片状或立方液晶相的至少一种两亲性脂质相，其中所述脂质相包含至少一种式（I）的脲基化合物或其盐，溶剂合物或 其中R 1，R 2，R 3和R 4各自独立地表示氢原子 ，C 1 -C 4烷基或C 2 -C 6 -C 6羟烷基，其包括 1至5个羟基，其中基团R 1至R 4中的至少一个表示羟烷基，尿素基化合物存在于两亲相中。

    Nanoemulsion containing a hydroxylated urea compound
    43.
    发明申请
    Nanoemulsion containing a hydroxylated urea compound 审中-公开
    含有羟基化脲化合物的纳米乳液

    公开(公告)号：US20060193813A1

    公开(公告)日：2006-08-31

    申请号：US11350826

    申请日：2006-02-10

    Applicant: Jean-Thierry Simonnet

    Inventor： Jean-Thierry Simonnet

    IPC: A61K8/46

    CPC classification number: A61K8/06 ,  A61K8/062 ,  A61K8/37 ,  A61K8/42 ,  A61K8/585 ,  A61K8/894 ,  A61K8/922 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q19/00 ,  B82Y5/00

    Abstract: The invention relates to an oil-in-water nanoemulsion having an oily phase dispersed in an aqueous phase, the oil globules of which have a number-average size of less than 100 nm, containing: (i) at least one amphiphilic lipid comprising at least one nonionic amphiphilic lipid, and optionally at least one ionic amphiphilic lipid, the oily phase and the amphiphilic lipid being present at a content such that the oily phase/amphiphilic lipid weight ratio ranges from 3 to 10, and (ii) at least one hydroxylated urea derivative. Application in cosmetics, dermatology, and ophthalmology.

    Abstract translation: 本发明涉及一种油包水纳米乳液，其具有分散在水相中的油相，其油球的数均粒径小于100nm，其包含：（i）至少一种两亲脂质，其包含在 至少一种非离子两亲性脂质和任选的至少一种离子两亲性脂质，所述油相和所述两亲性脂质以使得油相/两亲脂质重量比范围为3至10的含量存在，以及（ii）至少一种 羟基化脲衍生物。 在化妆品，皮肤病学和眼科学中的应用。

    Nanoemulsion based on alkyl ether citrates and its uses in the cosmetics, dermatological, pharmacological and/or ophthalmological fields
    45.
    发明授权
    Nanoemulsion based on alkyl ether citrates and its uses in the cosmetics, dermatological, pharmacological and/or ophthalmological fields 失效
    基于烷基醚柠檬酸盐的纳米乳液及其在化妆品，皮肤病学，药理学和/或眼科领域中的应用

    公开(公告)号：US06413527B1

    公开(公告)日：2002-07-02

    申请号：US09478408

    申请日：2000-01-06

    Applicant: Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

    Inventor： Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

    IPC: A61K600

    CPC classification number: B82Y5/00 ,  A61K8/06 ,  A61K8/37 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/912 ,  Y10S514/937 ,  Y10S514/938

    Abstract: A nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising an anionic surfactant chosen from alkyl ether citrates and at least one oil having a molecular weight of greater than 400, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. It can constitute a composition for topical use, a pharmaceutical composition or an ophthalmological composition. The invention also relates to the use of the nanoemulsion according to the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

    Abstract translation: 纳米乳液，其平均粒径小于100nm的纳米乳液，包含选自烷基醚柠檬酸盐和至少一种分子量大于400的油的阴离子表面活性剂，油的重量比 相至表面活性剂的量为2至10.所获得的乳液在储存时是透明和稳定的。 它可以包含大量的油，同时保持良好的透明度并且同时具有良好的化妆品性质。 它可以构成用于局部使用的组合物，药物组合物或眼科学组合物。 本发明还涉及根据本发明的纳米乳剂在化妆品和皮肤病学领域中的用途，特别是用于保湿皮肤和/或粘膜以及用于治疗头发，在眼科领域中作为眼睛 用于治疗眼睛的乳液。

    Nanoemulsion based on oxyethylenated or non-oxyethylenated sorbitan fatty esters, and its uses in the cosmetics, dermatological and/or ophthalmological fields
    47.
    发明授权
    Nanoemulsion based on oxyethylenated or non-oxyethylenated sorbitan fatty esters, and its uses in the cosmetics, dermatological and/or ophthalmological fields 失效
    基于氧乙烯化或非氧乙烯化脱水山梨糖醇脂肪酸酯的纳米乳液及其在化妆品，皮肤病学和/或眼科领域中的应用

    公开(公告)号：US06335022B1

    公开(公告)日：2002-01-01

    申请号：US09459580

    申请日：1999-12-13

    Applicant: Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

    Inventor： Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

    IPC: A61K600

    CPC classification number: A61Q19/007 ,  A61K8/06 ,  A61K8/4993 ,  A61K9/0048 ,  A61K9/1075 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  A61Q5/00 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/938 ,  Y10S514/941 ,  Y10S514/942

    Abstract: The present invention relates to a nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising (1) a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from sorbitan fatty esters and oxyethylenated sorbitan fatty esters, (2) at least one oil having a molecular weight of greater than 400 and (3) at least one ionic amphiphilic lipid chosen from the group formed by the alkaline salts of dicetyl and dimyristyl phosphate, the alkaline salts of cholesterol sulphate, the alkaline salts of cholesterol phosphate, lipoamino acids, the sodium salts of phosphatidic acid, cationic amphiphilic lipids and alkylsulfonic derivatives, the ratio by weight of the amount of oily phase to the amount of surfactant ranging from 2 to 10. The surfactant used is, for example, chosen from sorbitan monostearate, sorbitan monopalmitate and sorbitan 20 EO tristearate. The emulsion obtained is transparent and stable on storage. It can comprise large amounts of oil while retaining good transparency and while having good cosmetic properties. The invention also relates to the use of the nanoemulsion according to the invention in the cosmetics and dermatological fields, in particular for moisturizing the skin and/or mucous membranes, as well as for treating the hair, and in the ophthalmological field, as an eye lotion for treating the eyes.

    Abstract translation: 本发明涉及一种纳米乳液，其油球的平均粒径小于100nm，其包含（1）在小于或等于45℃的温度下为固体的表面活性剂，选择该表面活性剂 脱水山梨醇脂肪酸酯和氧乙烯化脱水山梨糖醇脂肪酸酯，（2）至少一种分子量大于400的油和（3）至少一种选自二鲸蜡基和二肉豆蔻基磷酸酯的碱性盐形成的离子两亲性脂质， 胆固醇硫酸盐的碱性盐，胆固醇磷酸盐的碱性盐，脂氨基酸，磷脂酸的钠盐，阳离子两亲性脂质和烷基磺酸衍生物，油相量与表面活性剂的重量比为2〜 所使用的表面活性剂例如选自脱水山梨糖醇单硬脂酸酯，脱水山梨糖醇单棕榈酸酯和脱水山梨糖醇20EO三硬脂酸酯。 获得的乳液在储存时是透明和稳定的。 它可以包含大量的油，同时保持良好的透明度并且同时具有良好的化妆品性质。 本发明还涉及根据本发明的纳米乳剂在化妆品和皮肤病学领域中的用途，特别是用于保湿皮肤和/或粘膜以及用于治疗头发，在眼科领域中作为眼睛 用于治疗眼睛的乳液。

    Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological, pharmaceutical, and/or ophthalmological fields
    48.
    发明授权
    Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological, pharmaceutical, and/or ophthalmological fields 失效
    基于磷酸脂肪酸酯的纳米乳液及其在化妆品，皮肤病学，制药学和/或眼科领域中的应用

    公开(公告)号：US06274150B1

    公开(公告)日：2001-08-14

    申请号：US09468325

    申请日：1999-12-21

    Applicant: Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

    Inventor： Jean-Thierry Simonnet ,  Odile Sonneville ,  Sylvie Legret

    IPC: A61K700

    CPC classification number: A61Q19/00 ,  A61K8/06 ,  A61K2800/21 ,  A61K2800/413 ,  A61Q1/14 ,  B01F17/0064 ,  B82Y5/00 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/88 ,  Y10S514/912

    Abstract: The present invention provides a nanoemulsion, that includes: an oily phase dispersed in an aqueous phase; and at least one anionic surfactant selected from the group including phosphoric acid fatty esters and oxyethylenated derivatives thereof, and mixtures thereof; wherein the oily phase includes oil globules having a number-average size of less than 100 nm; wherein the oily phase includes at least one oil having a molecular weight of greater than 400; and wherein a weight ratio of the oily phase to the surfactant ranges from 2 to 10. The invention also provides a process for making the nanoemulsion, and methods for its use. The nanoemulsion is ideally transparent and stable on storage. It can ideally contain large amounts of oil while retaining good transparency and good cosmetic properties. The nanoemulsion is particularly useful in compositions, including topical, pharmaceutical, dermatological, cosmetic, opthalmic, and opthalmologic. The composition is also particularly useful in applications to the skin, hair, scalp, mucous membranes, and eyes.

    Abstract translation: 本发明提供一种纳米乳液，其包括：分散在水相中的油相; 和选自磷酸脂肪酯和其氧乙烯化衍生物的至少一种阴离子表面活性剂及其混合物; 其中油相包括数均分子量小于100nm的油球;其中油相包含至少一种分子量大于400的油; 并且其中油相与表面活性剂的重量比为2至10.本发明还提供了制备纳米乳剂的方法及其使用方法。 纳米乳液在储存时理想的透明和稳定。 它理想地含有大量的油，同时保持良好的透明度和良好的化妆品性能。 纳米乳液在组合物中特别有用，包​​括局部，药物，皮肤病学，化妆品，眼科和眼科学。 该组合物在对皮肤，毛发，头皮，粘膜和眼睛的应用中也特别有用。

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