公开(公告)号：US20100238890A1

公开(公告)日：2010-09-23

申请号：US12727899

申请日：2010-03-19

申请人： Shaomin Mo ,  John A. Gu ,  Jessica Y. Hsu ,  Ming Luo ,  Reza Ghanadan

发明人： Shaomin Mo ,  John A. Gu ,  Jessica Y. Hsu ,  Ming Luo ,  Reza Ghanadan

IPC分类号： H04W72/04

CPC分类号： H04W56/0015 ,  H04J3/0655 ,  H04W40/248 ,  H04W84/20

摘要： Time synchronization among nodes in a wireless mobile ad hoc network (MANET) is obtained using a cross layer approach. Each node maintains a routing table that contains entries corresponding to other nodes of the network that are one or more hops away from the node, and topology messages are exchanged periodically among the nodes in order to update their routing tables. A network master node is selected, and remaining nodes that are one or more hops away from the master node are defined as slave nodes. The master node includes master timing information the topology messages that it transmits. The timing information is concatenated to include a first time (T1) at which a topology message was received by the master from each of the slave nodes, and a second time (td) at which the master node transmits a topology message after receiving all the topology messages from the slave nodes.

摘要翻译： 使用跨层方法获得无线移动自组织网络（MANET）中的节点之间的时间同步。 每个节点维护路由表，该路由表包含与该网络的其他节点相对应的条目，该节点与节点之间的一个或多个跳点，并且在节点之间周期性地交换拓扑消息以更新其路由表。 选择网络主节点，并且远离主节点的一个或多个跳的剩余节点被定义为从节点。 主节点包括其发送的拓扑消息的主定时信息。 定时信息被连接以包括主机从每个从节点接收到拓扑消息的第一时间（T1）和主节点在接收到所有从机节点之后发送拓扑消息的第二时间（td） 来自从节点的拓扑消息。

公开(公告)号：US20100124205A1

公开(公告)日：2010-05-20

申请号：US12386107

申请日：2009-04-14

申请人： Reza Ghanadan ,  Jessica Hsu ,  Ming Luo ,  Shaomin Mo

发明人： Reza Ghanadan ,  Jessica Hsu ,  Ming Luo ,  Shaomin Mo

IPC分类号： H04J3/00

CPC分类号： H04W72/1278 ,  H04W48/08 ,  H04W84/18

摘要： Communications in a mobile network are scheduled by defining reservation frames having time slots during which network nodes can transmit certain traffic loads while avoiding interference. The nodes maintain maps that identify the slots as either free or reserved based on each node's existing reservations, and reservation information the node receives from neighboring nodes. A node wishing to transmit traffic determines the number of slots required to carry the traffic, selects a first set of slots from among those identified in its maps as free, and transmits a reservation initiation message (RIM) that identifies the first set of slots. Nodes receiving the RIM determine which, if any, of the first set of slots are already reserved based on their own maps, and transmit counter reservation initiation messages (CRIMs) if any slots are reserved. The CRIMs also identify those slots that the CRIM transmitting nodes determine to be currently free.

摘要翻译： 通过定义具有时隙的预留帧来调度移动网络中的通信，在该时隙期间网络节点可以在避免干扰的同时发送某些业务负载。 这些节点基于每个节点的现有预留来维护将时隙标识为空闲或保留的映射，以及节点从相邻节点接收的预留信息。 希望发送业务的节点确定携带业务所需的时隙数量，从其映射中标识的那些空闲时隙选择第一组时隙，并发送标识第一组时隙的预留发起消息（RIM）。 接收RIM的节点确定第一组时隙中的哪一个（如果有的话）已经基于它们自己的映射预留，并且如果保留了任何时隙，则发送计数器预留发起消息（CRIM）。 CRIM还识别CRIM发送节点确定当前是空闲的那些时隙。

公开(公告)号：US06812332B2

公开(公告)日：2004-11-02

申请号：US10348668

申请日：2003-01-21

申请人： Stephen C. Johnson ,  Ashraf Saeed ,  Ming Luo

发明人： Stephen C. Johnson ,  Ashraf Saeed ,  Ming Luo

IPC分类号： C07H1504

CPC分类号： C07H15/203 ,  C07H7/027 ,  C07H15/24 ,  C07H17/02 ,  C07H17/075

摘要： The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. In particular, this invention provides a novel class of effective compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

公开(公告)号：US06509359B1

公开(公告)日：2003-01-21

申请号：US09527189

申请日：2000-03-17

申请人： Wayne J. Brouillette ,  Venkatram Reddy Atigadda ,  Ming Luo ,  Yarlagadda S. Babu

发明人： Wayne J. Brouillette ,  Venkatram Reddy Atigadda ,  Ming Luo ,  Yarlagadda S. Babu

IPC分类号： A61K314418

CPC分类号： C07D207/27 ,  C07D207/26

摘要： A compound having the formula: wherein all variables are as defined in the specification, for use as a neuramninidase inhibitor.

摘要翻译： 具有下式的化合物：其中所有变量如说明书中所定义，用作神经氨酸酶抑制剂。

公开(公告)号：US6114386A

公开(公告)日：2000-09-05

申请号：US950235

申请日：1997-10-14

申请人： Ming Luo ,  Clinton L. White

发明人： Ming Luo ,  Clinton L. White

IPC分类号： C07C233/54 ,  C07D209/08 ,  C07D209/12 ,  C07D209/34 ,  C07D209/38 ,  C07D213/74 ,  C07D239/42 ,  C07D307/66 ,  C07C229/34 ,  A61K31/195

CPC分类号： C07D213/74 ,  C07C233/54 ,  C07D209/08 ,  C07D209/12 ,  C07D209/34 ,  C07D209/38 ,  C07D239/42 ,  C07D307/66

摘要： A sialidase inhibitor of the shown formula I: ##STR1## where dashed lines d.sub.1 and d.sub.2, X.sub.1, R.sub.1, R.sub.2, R.sub.6, R.sub.3, R.sub.4 and R.sub.5 are as described in the specification; or an analog, pharmaceutically acceptable salt, or derivative of the inhibitor, with the proviso that the inhibitor is not HANBA GBA or Neu5Ac2en. The inhibitor in a composition with a pharmaceutically acceptable carrier. Methods of making a pharmaceutical composition of an acceptable carrier and the inhibitor. Methods of inhibiting sialidase and methods of treating and preventing bacterial or trypanosomal infection using the inhibitor.

摘要翻译： 所示式I的唾液酸酶抑制剂：其中虚线d1和d2，X1，R1，R2，R6，R3，R4和R5如说明书中所述; 或抑制剂的类似物，药学上可接受的盐或衍生物，条件是抑制剂不是HANBA GBA或Neu5Ac2en。 具有药学上可接受的载体的组合物中的抑制剂。 制备可接受的载体和抑制剂的药物组合物的方法。 抑制唾液酸酶的方法和使用抑制剂治疗和预防细菌或锥虫感染的方法。

公开(公告)号：US5453533A

公开(公告)日：1995-09-26

申请号：US227549

申请日：1994-04-14

申请人： Ming Luo ,  Wayne J. Brouillette ,  Gillian Air

发明人： Ming Luo ,  Wayne J. Brouillette ,  Gillian Air

IPC分类号： A61K31/195 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/215 ,  A61K31/222 ,  A61P31/12 ,  A61P43/00 ,  C07C69/00 ,  A01N37/28 ,  A01N41/02 ,  C07C69/62

CPC分类号： A61K31/662 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/222

摘要： An influenza virus neuraminidase inhibitor, its analogs, its pharmaceutically acceptable salts, derivatives, and mixtures thereof having the following formula: ##STR1## where A is CO.sub.2 H, CO.sub.2 H.sub.3, NO.sub.2, SO.sub.3 H or PO.sub.3 H.sub.2, B is CH, N, O or S, R.sub.1 and R.sub.2 are H, NO.sub.2 or (CH.sub.m).sub.n X.sub.1 where m=1 or 2, n is an integer from 0 to 4 and X.sub.1 is guanidino, OH, NH.sub.2, SH, NO.sub.2, F, Cl, Br, I, CN, CF.sub.3, CO.sub.2 H, SO.sub.3 H or PO.sub.3 H.sub.2, R.sub.3 and R.sub.4 are H, (CH.sub.o).sub.p X.sub.2, (CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2, NH(CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2, NHCO(CH.sub.o).sub.p CH.sub.2 X.sub.2 or NHCO(CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2 where o=1 or 2, p is an integer from 0 to 4 and X.sub.2 is H, guanidino, OH, NH.sub.2, SH, NO.sub.2, CF.sub.3, CO.sub.2 H, SO.sub.3 H or PO.sub.3 H.sub.2 , R.sub.5 =H, OH, NH.sub.2, (CH.sub.k).sub.1 X.sub.3, CO(CH.sub.k).sub.1 X.sub.3, SO(CH.sub.k).sub.1 X.sub.3 or SO.sub.2 (CH.sub.k).sub.1 X.sub.3 where k=1 or 2, 1 is an integer from 0 to 4 and X.sub.3 is guanidino, OH, NH.sub.2, SH, NO.sub.2, CF.sub.3, CO.sub.2 H, SO.sub.3 H or PO.sub.3 H.sub.2, R.sub.6 is H, CH(OH)X.sub.4, CH(NH.sub.2)X.sub.4, COX.sub.4, SOX.sub.4, or SO.sub.2 X.sub.4, where X.sub.4 is H, CH.sub.3, CH.sub.3 CH.sub.2, CH.sub.3 CHCH.sub.3, CH.sub.3 CH.sub.2 CH.sub.2 or halogen substituted analogs of X.sub.4. The inhibitor in a composition with a pharmaceutically acceptable carrier. A method of inhibiting influenza virus neuraminidase where the inhibitor is administered to a subject in a pharmaceutically acceptable amount along with effective amounts of a pharmaceutically acceptable carrier. Methods of marking a pharmaceutical composition of an acceptable carrier and the inhibitor. Methods of treating and preventing a subject infected with influenza virus (type A or B) using the inhibitor.

摘要翻译： 流感病毒神经氨酸酶抑制剂，其类似物，其药学上可接受的盐，衍生物及其混合物具有下式：其中A是CO 2 H，CO 2 H 3，NO 2，SO 3 H或PO 3 H 2，B是CH，N，O或S， R 1和R 2是H，NO 2或（CH m）n X 1，其中m = 1或2，n是0至4的整数，X 1是胍基，OH，NH 2，SH，NO 2，F，Cl，Br，I， CF 3，CO 2 H，SO 3 H或PO 3 H 2，R 3和R 4是H，（CHo）pX 2，（CHo）pCHX 2 CH 2 X 2，NH（CHo）pCHX 2 CH 2 X 2，NHCO（CHo）pCH 2 X 2或NHCO（CHo）pCHX 2 CH 2 X 2，其中o = 0〜4的整数，X2为H，胍基，OH，NH2，SH，NO2，CF3，CO2H，SO3H或PO3H2，R5 = H，OH，NH2，（CHK）1X3，CO（CHK） CHK）1X3或SO2（CHK）1X3其中k = 1或2,1为0至4的整数，X3为胍基，OH，NH2，SH，NO2，CF3，CO2H，SO3H或PO3H2，R6为H，CH （OH）X4，CH（NH2）X4，COX4，SOX4或SO2X4，其中X4是H4，CH3，CH3CH2，CH3CHCH3，CH3CH2CH2或X4的卤素取代的类似物。 具有药学上可接受的载体的组合物中的抑制剂。 一种抑制流感病毒神经氨酸酶的方法，其中抑制剂与药学上可接受的量一起施用于受试者以及有效量的药学上可接受的载体。 标记可接受的载体和抑制剂的药物组合物的方法。 使用抑制剂治疗和预防感染流感病毒（A型或B型）的受试者的方法。

公开(公告)号：USD921961S1

公开(公告)日：2021-06-08

申请号：US29705917

申请日：2019-09-17

申请人： Ming Luo

设计人： Ming Luo

公开(公告)号：USD921960S1

公开(公告)日：2021-06-08

申请号：US29698419

申请日：2019-07-17

申请人： Ming Luo

设计人： Ming Luo

公开(公告)号：US08976728B2

公开(公告)日：2015-03-10

申请号：US12587615

申请日：2009-10-10

申请人： Reza Ghanadan ,  Jessica Hsu ,  Ming Luo ,  Shaomin Mo

发明人： Reza Ghanadan ,  Jessica Hsu ,  Ming Luo ,  Shaomin Mo

IPC分类号： H04W4/00 ,  H04J3/00 ,  H04W74/02

CPC分类号： H04W74/02

摘要： Message or traffic data is transmitted from a given radio or node for reception by one or more other nodes in a communications network, by arranging the node for transmitting the data according to a selected one of a number of different medium access protocols. The medium access protocol selected for a given message or traffic is determined according to one or more of (a) the size of the traffic, (b) the priority of the traffic, (c) the periodicity of the traffic, and (d) whether the traffic is broadcast or unicast to the other nodes in the network. Each radio includes one or more processor and memory modules configured to output messages or traffic for transmission from the radio according to the selected medium access protocol. By using distributed scheduling and traffic control to protect against hidden nodes, the radios can maintain agile portability in tactical urban environments.

摘要翻译： 消息或业务数据从给定的无线电或节点发送，以便由通信网络中的一个或多个其他节点接收，通过根据多个不同的媒体接入协议中选择的一个来安排用于发送数据的节点。 根据（a）流量大小，（b）流量的优先级，（c）流量的周期性，以及（d）流量的周期性等）中的一个或多个来确定针对给定消息或业务选择的媒体访问协议， 流量是否广播或单播到网络中的其他节点。 每个无线电装置包括一个或多个处理器和存储器模块，其被配置为根据所选择的介质访问协议从无线电输出消息或流量以进行传输。 通过使用分布式调度和流量控制来保护隐藏节点，无线电可以在战术城市环境中保持灵活的可移植性。

公开(公告)号：US08466177B2

公开(公告)日：2013-06-18

申请号：US12682341

申请日：2008-10-31

申请人： Ming Luo ,  Zhen Yang

发明人： Ming Luo ,  Zhen Yang

IPC分类号： A61K31/4439 ,  A61K31/426 ,  A61K31/427 ,  C07D277/36 ,  C07D277/34 ,  C07D417/06

CPC分类号： C07D417/06 ,  C07D277/36 ,  C07D413/14

摘要： Compounds that are useful in treating or preventing viral infections, such as influenza, are described herein. Further described are compositions made from these compounds and methods for using the compounds and their compositions in treating or preventing viral infections.

摘要翻译： 可用于治疗或预防病毒感染（例如流感）的化合物在本文中描述。 进一步描述的是由这些化合物制成的组合物和使用该化合物及其组合物治疗或预防病毒感染的方法。