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    Inhibitors of influenza virus neuraminidase and methods of making and using the same
    1.
    发明授权
    Inhibitors of influenza virus neuraminidase and methods of making and using the same 失效
    流感病毒神经氨酸酶抑制剂及其使用方法

    公开(公告)号：US5453533A

    公开(公告)日：1995-09-26

    申请号：US227549

    申请日：1994-04-14

    申请人： Ming Luo ,  Wayne J. Brouillette ,  Gillian Air

    发明人： Ming Luo ,  Wayne J. Brouillette ,  Gillian Air

    IPC分类号： A61K31/195 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/215 ,  A61K31/222 ,  A61P31/12 ,  A61P43/00 ,  C07C69/00 ,  A01N37/28 ,  A01N41/02 ,  C07C69/62

    CPC分类号： A61K31/662 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/222

    摘要： An influenza virus neuraminidase inhibitor, its analogs, its pharmaceutically acceptable salts, derivatives, and mixtures thereof having the following formula: ##STR1## where A is CO.sub.2 H, CO.sub.2 H.sub.3, NO.sub.2, SO.sub.3 H or PO.sub.3 H.sub.2, B is CH, N, O or S, R.sub.1 and R.sub.2 are H, NO.sub.2 or (CH.sub.m).sub.n X.sub.1 where m=1 or 2, n is an integer from 0 to 4 and X.sub.1 is guanidino, OH, NH.sub.2, SH, NO.sub.2, F, Cl, Br, I, CN, CF.sub.3, CO.sub.2 H, SO.sub.3 H or PO.sub.3 H.sub.2, R.sub.3 and R.sub.4 are H, (CH.sub.o).sub.p X.sub.2, (CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2, NH(CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2, NHCO(CH.sub.o).sub.p CH.sub.2 X.sub.2 or NHCO(CH.sub.o).sub.p CHX.sub.2 CH.sub.2 X.sub.2 where o=1 or 2, p is an integer from 0 to 4 and X.sub.2 is H, guanidino, OH, NH.sub.2, SH, NO.sub.2, CF.sub.3, CO.sub.2 H, SO.sub.3 H or PO.sub.3 H.sub.2 , R.sub.5 =H, OH, NH.sub.2, (CH.sub.k).sub.1 X.sub.3, CO(CH.sub.k).sub.1 X.sub.3, SO(CH.sub.k).sub.1 X.sub.3 or SO.sub.2 (CH.sub.k).sub.1 X.sub.3 where k=1 or 2, 1 is an integer from 0 to 4 and X.sub.3 is guanidino, OH, NH.sub.2, SH, NO.sub.2, CF.sub.3, CO.sub.2 H, SO.sub.3 H or PO.sub.3 H.sub.2, R.sub.6 is H, CH(OH)X.sub.4, CH(NH.sub.2)X.sub.4, COX.sub.4, SOX.sub.4, or SO.sub.2 X.sub.4, where X.sub.4 is H, CH.sub.3, CH.sub.3 CH.sub.2, CH.sub.3 CHCH.sub.3, CH.sub.3 CH.sub.2 CH.sub.2 or halogen substituted analogs of X.sub.4. The inhibitor in a composition with a pharmaceutically acceptable carrier. A method of inhibiting influenza virus neuraminidase where the inhibitor is administered to a subject in a pharmaceutically acceptable amount along with effective amounts of a pharmaceutically acceptable carrier. Methods of marking a pharmaceutical composition of an acceptable carrier and the inhibitor. Methods of treating and preventing a subject infected with influenza virus (type A or B) using the inhibitor.

    摘要翻译： 流感病毒神经氨酸酶抑制剂，其类似物，其药学上可接受的盐，衍生物及其混合物具有下式：其中A是CO 2 H，CO 2 H 3，NO 2，SO 3 H或PO 3 H 2，B是CH，N，O或S， R 1和R 2是H，NO 2或（CH m）n X 1，其中m = 1或2，n是0至4的整数，X 1是胍基，OH，NH 2，SH，NO 2，F，Cl，Br，I， CF 3，CO 2 H，SO 3 H或PO 3 H 2，R 3和R 4是H，（CHo）pX 2，（CHo）pCHX 2 CH 2 X 2，NH（CHo）pCHX 2 CH 2 X 2，NHCO（CHo）pCH 2 X 2或NHCO（CHo）pCHX 2 CH 2 X 2，其中o = 0〜4的整数，X2为H，胍基，OH，NH2，SH，NO2，CF3，CO2H，SO3H或PO3H2，R5 = H，OH，NH2，（CHK）1X3，CO（CHK） CHK）1X3或SO2（CHK）1X3其中k = 1或2,1为0至4的整数，X3为胍基，OH，NH2，SH，NO2，CF3，CO2H，SO3H或PO3H2，R6为H，CH （OH）X4，CH（NH2）X4，COX4，SOX4或SO2X4，其中X4是H4，CH3，CH3CH2，CH3CHCH3，CH3CH2CH2或X4的卤素取代的类似物。 具有药学上可接受的载体的组合物中的抑制剂。 一种抑制流感病毒神经氨酸酶的方法，其中抑制剂与药学上可接受的量一起施用于受试者以及有效量的药学上可接受的载体。 标记可接受的载体和抑制剂的药物组合物的方法。 使用抑制剂治疗和预防感染流感病毒（A型或B型）的受试者的方法。

    Electric reciprocating motion device with spring motor
    5.
    发明授权
    Electric reciprocating motion device with spring motor 有权
    带弹簧电机的电动往复运动装置

    公开(公告)号：US07960877B2

    公开(公告)日：2011-06-14

    申请号：US12454277

    申请日：2009-05-14

    申请人： Ming Luo

    发明人： Ming Luo

    IPC分类号： H02K33/00 ,  H02K41/02

    CPC分类号： H02K33/16 ,  A61C17/3418 ,  H02K33/04

    摘要： An electric reciprocating motion device includes a motor having a rotary shaft for outputting a reciprocating rotational power and a motion head coupling with the rotary shaft and being driven to move in a reciprocating motion along an axis of the rotary shaft and in a predetermined swing angle range. The motor is a spring motor including a motor unit and a torsion spring having two ends affixing at a motor housing and to the rotary shaft respectively. After the rotary shaft outputs a mechanical torque at one rotational direction, the torsion spring applies a spring force against the rotary shaft to drive the rotary shaft to rotate backward for generating the reciprocating rotational power. Using the spring motor in the electric reciprocating motion device, the device achieves the goals of simple mechanical structure, small volume, easy to install, and low in cost.

    摘要翻译： 电动往复运动装置包括具有用于输出往复旋转动力的旋转轴和与该旋转轴联动的运动头的马达，该马达被驱动沿着旋转轴的轴线往复运动并以预定的摆动角度范围 。 电动机是包括马达单元和扭簧的弹簧马达，所述扭力弹簧具有分别固定在马达壳体和旋转轴上的两端。 在旋转轴在一个旋转方向上输出机械扭矩之后，扭转弹簧向旋转轴施加弹簧力以驱动旋转轴向后旋转以产生往复旋转动力。 在电动往复运动装置中使用弹簧电机，实现了机械结构简单，体积小，安装方便，成本低的目的。

    Chromogenic substrates of sialidase and methods of making and using the same
    6.
    发明授权
    Chromogenic substrates of sialidase and methods of making and using the same 有权
    唾液酸酶的显色底物及其制备和使用方法

    公开(公告)号：US06844346B2

    公开(公告)日：2005-01-18

    申请号：US10328790

    申请日：2002-12-24

    申请人： Stephen C. Johnson ,  Ashraf Saeed ,  Ming Luo

    发明人： Stephen C. Johnson ,  Ashraf Saeed ,  Ming Luo

    IPC分类号： C07H7/027 ,  C07H15/203 ,  C07H15/24 ,  C07H17/02 ,  C07H17/075 ,  C07H15/04 ,  C07H17/04

    CPC分类号： C07H15/203 ,  C07H7/027 ,  C07H15/24 ,  C07H17/02 ,  C07H17/075

    摘要： The subject invention discloses materials and methods for the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including humans) origin. These compounds are based upon N-acetylneuraminic acid glycosides. In particular, this invention provides a novel class of these compounds as chromogenic substrates of these sialidases which yield chromogenic products after reactions catalyzed by sialidase take place. Also provided are methods of making these substrate compounds, methods of diagnosis and prognosis of sialidase related diseases using these substrate compounds.

    摘要翻译： 本发明公开了用于细菌，病毒，原生动物和脊椎动物（包括人）起源的唾液酸酶的显色底物化合物的设计，合成和生物化学评估的材料和方法。 这些化合物基于N-乙酰神经氨酸糖苷。 特别地，本发明提供了一类新颖的这些化合物作为这些唾液酸酶的显色底物，其在由唾液酸酶催化的反应后产生显色产物。 还提供了使用这些底物化合物制备这些底物化合物的方法，唾液酸酶相关疾病的诊断和预后的方法。

    Methods of inhibiting bacterial sialidase
    7.
    发明授权
    Methods of inhibiting bacterial sialidase 失效
    抑制细菌唾液酸酶的方法

    公开(公告)号：US5985859A

    公开(公告)日：1999-11-16

    申请号：US485380

    申请日：1995-06-07

    申请人： Ming Luo

    发明人： Ming Luo

    IPC分类号： A61K31/195 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/215 ,  A61K31/222 ,  A61P31/12 ,  A61P43/00 ,  A01N57/14 ,  A01N37/10 ,  A01N37/44 ,  A61K31/66

    CPC分类号： A61K31/662 ,  A61K31/185 ,  A61K31/192 ,  A61K31/196 ,  A61K31/222 ,  Y10S514/888

    摘要： A method of inhibiting bacterial sialidase comprising administering to a subject an inhibiting effective amount of a compound of formula I: ##STR1## wherein A is CO.sub.2 H, PO.sub.2 H, or SO.sub.2 H; B is N; R.sub.1 and R.sub.2 are H; R.sub.3 and R.sub.4 are, independently, H, OH, NO.sub.2, guanidino, or alkyl or alkenyl of from 1 to 3 carbons where the alkyl or alkenyl is unsubstituted or is substituted, independently, with one or more of OH, NH2, or halide; R.sub.5 is H; and R.sub.6 is COCH.sub.3, or COCI.sub.3 ; or an analog, pharmaceutically acceptable salt, derivative, or mixture thereof. A method of preventing a bacterial or trypanosomal infection using the compounds of formula I. A method of treating a bacterial or trypanosomal infection using the compounds of formula I. A pharmaceutical composition comprising a pharmaceutically acceptable carrier admixed with an inhibiting effective amount of a compound of formula I. A method of making a pharmaceutical composition, comprising admixing a pharmaceutically acceptable carrier with an inhibiting effective amount of a compound of formula I.

    摘要翻译： 一种抑制细菌唾液酸酶的方法，包括向受试者施用抑制有效量的式I化合物：其中A是CO 2 H，PO 2 H或SO 2 H; B是N; R1和R2是H; R 3和R 4独立地为1至3个碳的H，OH，NO 2，胍基或烷基或烯基，其中烷基或烯基是未取代的或被OH，NH 2或卤化物中的一种或多种独立地取代; R5是H; 并且R 6是COCH 3或COCl 3; 或其类似物，药学上可接受的盐，衍生物或其混合物。 一种使用式I化合物预防细菌或锥虫感染的方法。一种使用式I化合物治疗细菌或锥虫感染的方法。一种药物组合物，其包含药学上可接受的载体，其与抑制有效量的化合物 式I.制备药物组合物的方法，包括将药学上可接受的载体与抑制有效量的式I化合物混合。

    Spring motor
    9.
    发明授权
    Spring motor 有权
    弹簧马达

    公开(公告)号：US09306425B2

    公开(公告)日：2016-04-05

    申请号：US13980829

    申请日：2012-01-16

    申请人： Ming Luo

    发明人： Ming Luo

    IPC分类号： H02K3/51 ,  A61C17/34 ,  H02K33/00 ,  H02K33/02 ,  H02K7/14

    CPC分类号： H02K3/51 ,  A61C17/3418 ,  H02K7/14 ,  H02K33/00 ,  H02K33/02

    摘要： A spring motor, comprising a housing, a stator core, a rotor core, a rotation shaft, a rotor coil, an insulated coil connection wire, a torsion spring, a connection shaft, a cylindrical spiral spring, a round funnel-shaped rubber sealing element, a battery and a spring fixing connection sleeve; the rotor coil of the motor is connected to the terminal of a motor end cover after the insulated coil connection wire winds around the periphery of the rotation shaft continuously several times; the connection shaft is fixed on the rotation shaft, and the cylindrical spiral spring is sleeved on the periphery of the opened end of the connection shaft; the round funnel-shaped waterproof rubber sealing element is sleeved on the rotation shaft; the battery is placed in a rectangular battery holder, three side frames of the battery holder are each a fixed structure, and one side frame of the battery holder is a moveable structure; the spring fixing connection sleeve is sleeved on the rotation shaft, the rear end of the torsion spring is placed on one side of the spring fixing connection sleeve, and the spring fixing connection jacket, the torsion spring and the rotation shaft are fixed and connected with screws.

    摘要翻译： 一种弹簧马达，包括壳体，定子芯，转子芯，旋转轴，转子线圈，绝缘线圈连接线，扭簧，连接轴，圆柱形螺旋弹簧，圆锥形橡胶密封 元件，电池和弹簧固定连接套筒; 绝缘线圈连接线连续旋转几周后，电动机的转子线圈连接到电动机端盖的端子上; 连接轴固定在旋转轴上，圆筒形螺旋弹簧套在连接轴开口端的周边上; 圆锥形防水橡胶密封元件套在旋转轴上; 将电池放置在矩形电池座中，电池座的三个侧框架均为固定结构，电池座的一个侧框为可移动结构; 弹簧固定连接套筒套在旋转轴上，扭簧的后端位于弹簧固定连接套筒的一侧，弹簧固定连接套，扭簧和旋转轴固定并连接 螺丝